Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway and gut m... by Lei Li, Lei Li, Lei Li, Jun Ma, Jun Ma, Zeshi Li, Zeshi Li, Juelin Chen, Jiawei Zhou, Yawei Wang, Yankun Pei, Yitong Gong, Jianyao You, Yangyang Cao, Man Wang, Jikuai Chen, Wenjun Chang, Weiyi Ma, Hanyu Zhu, Chuhan Xiang, Shuogui Xu, Qing Song, Qing Song

“…These findings suggest that HXZQD maintains intestinal homeostasis during EHS by preserving barrier function and modulating gut microbiota, offering a promising preventive approach for EHS management.…”
Get full text

Curcumin-loaded milk-derived sEVs fused with platelet membrane attenuate endothelial senescence and promote spinal cord injury recovery in diabetic mice by Yaozhi He, Siyuan Zou, Jiawei Wang, Wenbin Zhang, Sheng Lu, Mengxian Jia, Yumin Wu, Xiaowu Lin, Ziwei Fan, Qishun Liang, Yizhe Sheng, Qichuan Zhuge, Bi Chen, Minyu Zhu, Honglin Teng

“…In vitro, PM-sEVs-Cur effectively mitigated HG/IL-1β-induced HUVECs senescence by 54.19% ± 5.39% and increased expression of the tight junction protein ZO-1 by 4.33-fold. Mechanistically, Cur attenuated HUVECs senescence by activating the NRF2/HO-1 pathway. …”
Get full text

Effects of dietary Vitamin A on growth performance, antioxidant and immune capacity of mandarin fish (Siniperca chuatsi) by Xiaolu Yan, Lingcheng Pan, Min Zhao, Junkang Ma, Fubao Wang, Xuliang Zhai, Yang Xue, Haiping Liu, Yongjun Chen, Yuanfa He, Hongqin Li, Li Luo

“…This study investigated the effects of dietary vitamin A (VA) on growth performance, antioxidant capacity, immune function, and intestinal health in juvenile mandarin fish (Siniperca chuatsi). …”
Get full text

RNA-seq analysis of shrimp tropomyosin-induced allergic reactions through PI3K/Akt pathway by Yanchu Li, Yanchu Li, Yuying Yang, Junyao Li, Rui Guo, Zhiqiang Niu, Weicheng Hu, Shucheng Liu, Shucheng Liu, Shuai Wei, Shuai Wei

“…The results of ELISA and RT-qPCR showed that TM can exacerbate the allergic reaction by reducing the mRNA expression of tight junction (TJ) proteins (such as ZO-1, claudin-3, Occludin) in the jejunum, destroying the intestinal barrier function, increasing the permeability, and promoting the release of inflammatory factors (such as IL-8, TNF-α) and histamine. …”
Get full text

Exposure of broiler chickens to deoxynivalenol and Campylobacter jejuni induces substantial changes in intestinal gene expression by Wageha A. Awad, Daniel Ruhnau, Barbara Doupovec, Claudia Hess, Dian Schatzmayr, Michael Hess, Bertrand Grenier

“…The actual study also demonstrated that co-exposure of broiler chickens to DON and C. jejuni resulted in a decreased barrier function via downregulation of OCLD mRNA expression. …”
Get full text

Insights into intestinal barrier disruption during long-term gut Chlamydia colonization in mice: a single-cell transcriptomic approach by Ziqing Wan, Yicun Jiang, Sheng Xie, Jiao Wan, Youyou Huang, Luying Wang, Qi Zhang, Zengzi Zhou, Xin Sun, Chuqiang Shu, Chuqiang Shu, Tianyuan Zhang, Tianyuan Zhang, Qi Tian, Qi Tian

“…The impairment of epithelial barrier function and altered cellular crosstalk provide novel insights into its persistence strategies. …”
Get full text

Hybrid Materials Based on Carbon Nanotubes and Tetra- and Octa-Halogen-Substituted Zinc Phthalocyanines: Sensor Response Toward Ammonia from the Quantum-Chemical Point of View by Pavel Krasnov, Victoria Ivanova, Darya Klyamer, Dmitry Bonegardt, Aleksandr Fedorov, Tamara Basova

“…This paper presents the results of quantum-chemical modeling performed by the Density Functional-Based Tight Binding (DFTB) method to investigate the change in the band structure of hybrid materials based on carbon nanotubes and unsubstituted, tetra-, or octa-halogen-substituted zinc phthalocyanines upon the adsorption of ammonia molecules. …”
Get full text

Cytoprotective effects of curcumin on the state of the intestinal barrier in a model of LPS-induced inflammation by V. S. Nedzvetsky, O. V. Yanovska, D. F. Gufrij, O. A. Sheptukha, D. M. Masiuk

“…Intestinal barrier is functioning is susceptible to inflammatory complications. …”
Get full text

Evaluation of Dietary Bioactive Agents Against Aflatoxin B1 and Ochratoxin A-Induced Duodenal Toxicity in Rats by Sarra Rafai, Alessandra Cimbalo, Lara Manyes

“…Occludin expression, which supports tight junction integrity, remained largely unaffected. …”
Get full text

Depletion reveals role of bicarbonate in the photosynthetic electron transport chain of Limnospira maxima by Leslie Castillo, Stavroula Nicolaou, Colin Gates, Colin Gates

“…Efficient photosynthetic light reactions require tight balancing of electrons and protons. In photosystem II, bicarbonate is coordinated to a non-heme iron positioned between the acceptor-side plastoquinones QA and QB, modulating electron transfer. …”
Get full text

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review by Quang La, Aiman Baloch, David F. Lo

“…It examines key structural alterations, such as tight junction protein loss, endothelial dysfunction, and pericyte reduction, as well as functional changes including impaired immune regulation and transporter dysfunction. …”
Get full text

Liquid-liquid separation in gut immunity by Zhaoyang Wang, Zhaoyang Wang, Lili Zhou, Xiaolan Zhong, Yiguo Jiang, Yiguo Jiang, Zhentao Zhang, Wanglin Li, Wanglin Li, Wanglin Li

“…LLPS can contribute to the formation of tight junctions between intestinal epithelial cells and influence the colonization of probiotics in the intestine, thereby protecting the intestinal immune system by maintaining the integrity of the intestinal barrier and the stability of the microbiota. …”
Get full text

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma by Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa

“…The Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” …”
Get full text

Gain Characteristics of Hybrid Waveguide Amplifiers in SiN Photonics Integration with Er-Yb:Al₂O₃ Thin Film by Ziming Dong, Guoqing Sun, Yuqing Zhao, Yaxin Wang, Lei Ding, Liqin Tang, Yigang Li

“…Endowing silicon nitride photonic integrated circuits with efficient amplification enriches the integration of various active functionalities on silicon.…”
Get full text

Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly by Ian Y. Yen, Gregory B. Whitfield, John L. Rubinstein, Lori L. Burrows, Yves V. Brun, P. Lynne Howell

“…Abstract The type IV pilus family uses PilT/VirB11-like ATPases to rapidly assemble and disassemble pilin subunits. Among these, the tight adherence (Tad) pilus performs both functions using a single bifunctional ATPase, CpaF. …”
Get full text

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors... by Mark B. Plotnikov, Anna M. Anishchenko, Andrei I. Khlebnikov, Igor A. Schepetkin

“…Activation of the JNK signaling pathway has a negative effect on the functioning of the cellular elements of the neurovascular unit that form the BBB. …”
Get full text

Conjoint analysis of methylation, transcriptomic, and proteomic profiles in pemphigus vulgaris by Xiaojia Luo, Jianting Ouyang, Fuqiong Jiang, Yaozhong Zhang, Yuan Wang, Yongzhuo Wu, Lingyu Hu

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis highlighted notable pathway abnormalities, including those related to platelet activation, focal adhesions, tight junctions, and infectious inflammatory responses. …”
Get full text

A Two-Stage Evaluation Framework for Underground Space Development in Green Spaces: A Case Study of Binjiang District, Hangzhou by Qiuxiao Chen, Xiuxiu Chen, Hongbo Li, Xiaoyi Zhang, Geyuan Zhang

“…In the current context of tight constraints on land resources in major Chinese cities, the development of underground space in green spaces (USGSs) has become an important approach to exploit land use potential and alleviate the contradiction between human and land resources. …”
Get full text

Disruption of small intestinal mucosal homeostasis in mice with amiodarone induced steatohepatitis by Shoji Kawauchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Junichi Kunimasa, Yoshiyuki Rikitake

“…Villus shortening, changes in the localization of tight junction proteins, increased mucosal permeability, and altered intestinal microbiota were observed in the small intestines of AMD-treated mice. …”
Get full text

Negative feedback buffers effects of regulatory variants by Daniel M Bader, Stefan Wilkening, Gen Lin, Manu M Tekkedil, Kim Dietrich, Lars M Steinmetz, Julien Gagneur

“…Negative feedback is stronger not only for essential genes, indicating its functional relevance, but also for genes with low to middle levels of expression, for which tight regulation matters most. …”
Get full text