La construction de la tour Saint-Laurent du palais des Papes (1353-1357) : nouveaux regards sur un chantier by Philippe Bernardi, Andreas Hartmann-Virnich, Dominique Vingtain

“…This project has enabled the team to retrace and to characterize the functioning of one of the major building programmes of its period in the south of France. …”
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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis by Zhiqi Xiong, Xiaolin Yang, Shule Wang, Caitlan J. Smart, Hazel M. Sisson, Zhenli Lin, Tianyu Hu, Yuting Ran, Chuyao Xu, Xiuna Yang, Yao Zhao, William J. Jowsey, Gregory M. Cook, Matthew B. McNeil, Luke W. Guddat, Zihe Rao, Bing Zhang

“…The stalk secures the tight association of the three MmpL5 subunits and exhibits intrinsic structural flexibility. …”
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Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification by Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget

“…Thus, improving the gut mucus barrier function in the context of uremic VC could be considered as a possible therapeutic strategy in CKD patients.…”
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Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization by Yu Zhao, Yueqing Zhou, Weipan Zhang, Mingzhe Liu, Jun Duan, Xiaopeng Zhang, Qiwang Ma, Yujia Wang, Yuzhen Zhang, Zhongliang Guo, Ting Zhang, Wei Zuo

“…Mechanistically, the engrafted human progenitor cells do not function by differentiating into mature alveolar cells in mouse lung; instead, they differentiate into saccular cells expressing multiple tight junction proteins such as CLDN4, which help the lung to re-establish epithelial barriers. …”
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Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease by Xin Wang, Huizhen Wang, Jiawen Li, Lanying Li, Yifan Wang, Aiqing Li

“…Differential phosphoproteins with tight functional connection were synapse proteins and microtubule-associated proteins, implying that high-salt diet disrupted brain’s structure and function. …”
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Comparative effects of different dietary pectin types on growth performance and intestinal health in pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) by Lulu Zhu, Xiaoxue Meng, Xuehan Wang, Jiongting Fan, Beiping Tan, Junming Deng

“…Daily growth coefficient and feed conversion ratio were calculated to assess growth performance, while intestinal mucosal barrier function as well as intestinal physical, chemical, immune, and biological barrier was evaluated to assess intestinal health. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…This study aimed to identify critical genes linking BBB function and neuroinflammatory activation, with the ultimate goal of evaluating potential therapeutic targets. …”
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An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism by Chuan Yang, Langlang Xie, Zihan Deng, Hongbo Ai, Tingwen Xiang, Xiaojing Yan, Zhiguo Ling, Shiyu Xiao, Yong Tang, Gang Huang, Fei Luo, Yueqi Chen

“…Specifically, GNS notably enriched the probiotic genus Ligilactobacillus while restoring intestinal barrier function by upregulating tight junction proteins Claudin-1 and ZO-1. …”
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Clinical outcomes of surgical management for rare types of progressive familial intrahepatic cholestasis: a case series by Kazunori Masahata, Takehisa Ueno, Kazuhiko Bessho, Tasuku Kodama, Ryo Tsukada, Ryuta Saka, Yuko Tazuke, Shuji Miyagawa, Hiroomi Okuyama

“…One patient each with familial intrahepatic cholestasis 1 (FIC1) deficiency and bile salt export pump (BSEP) deficiency died after LDLT, and the four remaining patients, one each with deficiency of FIC1, BSEP, multidrug resistance protein 3 (MDR3), and tight junction protein 2 (TJP2), survived. One FIC1 deficiency recipient underwent LDLT secondary to deterioration of liver function, following infectious enteritis. …”
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Human umbilical cord-derived mesenchymal stem cells attenate histaminergic effect of intestinal mucosa through bax/bcl-2 pathway in food allergic enteritis by Yuan Zhao, Weipeng Liu, Yabing Ding, Jie Zhou, Fan Zhang, Zhaoyan Wang, Qian Wang, Zuo Luan

“…These results reveal novel therapeutic potential for hUC-MSCs in maintaining epithelial homeostasis and intestinal barrier function in food allergy-associated enteritis, suggesting promising clinical applications for this disorder.…”
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Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier by Yang Liu, Qing Liu, Chengcheng Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

“…We first confirmed the strain-specific effects of A. muciniphila on intestinal barrier regulation and found that this phenomenon may be explained by the different abilities of strains to affect tight junction protein expression in enterocytes. …”
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Integration of Stromal Cells and Hydrogel Below Epithelium Results in Optimal Barrier Properties of Small Intestine Organoid Models by Melis Asal, Maria Thon, Taco Waaijman, Hetty J. Bontkes, Sandra J. van Vliet, Reina E. Mebius, Susan Gibbs

“…Therefore, the aim of this study was to determine whether these stromal cells or ECM were beneficial or detrimental to barrier function when incorporated into an organotypic human small intestine model. …”
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Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism by Zhaowei Bian, Ziyang Li, Hao Chang, Jun Luo, Shiyan Jian, Jie Zhang, Peixin Lin, Baichuan Deng, Jinping Deng, Lingna Zhang

“…The relative mRNA expression of genes associated with the tight junction protein, aryl hydrocarbon receptor, and Trp transporters in the colon were upregulated. …”
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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…The effects of TSG-6 on colonic inflammation and intestinal barrier function were investigated. Label-free quantitative proteomic analysis was performed on intestinal samples to explore the mechanism and therapeutic target of TSG-6. …”
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Mosla Chinensis Extract Enhances Growth Performance, Antioxidant Capacity, and Intestinal Health in Broilers by Modulating Gut Microbiota by Wei Wang, Yuyu Wang, Peng Huang, Junjuan Zhou, Guifeng Tan, Jianguo Zeng, Wei Liu

“…In the duodenum and cecum, MCE significantly upregulated the expression of tight junction proteins Claudin-1, and Occludin, with the high-dose group showing the strongest effect on intestinal barrier protection (<i>p</i> < 0.05). …”
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Microbial Ecology and Metabolism of Emerging Adulthood: Gut Microbiome Insights from a College Freshman Cohort by Alex E. Mohr, Paniz Jasbi, Irene van Woerden, Jinhua Chi, Haiwei Gu, Meg Bruening, Corrie M. Whisner

“…Furthermore, exploration of stability within dynamic microbiomes among the longitudinal cohort experiencing shifts in community types revealed that microbiome taxa at the genus level exhibited significantly higher total variance than estimated functional and fecal metabolomic features. This suggests tight control of function and metabolism, despite community shifting. …”
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Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis by Peilin Li, Peilin Li, Yusuke Inoue, Daichi Sadatomi, Sachiko Mogami, Daisuke Miyamoto, Toshiyuki Adachi, Tomohiko Adachi, Akihiko Soyama, Kengo Kanetaka, Weili Gu, Susumu Eguchi

“…DKT restored mucosal integrity by enhancing the expression of tight junction proteins (CLDN-3) and nutrient transporters (B0,+AT, EAAT3), and by reducing oxidative stress and epithelial cell death. …”
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Acetylation of α-tubulin restores endothelial cell injury and blood–brain barrier disruption after intracerebral hemorrhage in mice by Xuejiao Lei, Eryi Sun, Xufang Ru, Yulian Quan, Xuezhu Chen, Qian Zhang, Yougling Lu, Qianying Huang, Yujie Chen, Wenyan Li, Hua Feng, Yang Yang, Rong Hu

“…Together, our findings highlighted α-Ac-Tub as a therapeutic target for restoring BBB function and reducing brain injury after ICH.…”
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Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation... by Huihui Gao, Hangming Bai, Yanyan Su, Yuting Gao, Hui Fang, Donghang Li, Youren Yu, Xing Lu, Dasheng Xia, Daqing Mao, Yi Luo

“…These microbiota changes were associated with impairment of intestinal barrier integrity, as evidenced by reduced levels of mucins, tight junction proteins, and antimicrobial peptides, along with a decrease in Treg cells and an increase in Th17 and Th1 cells. …”
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κ-carrageenan oligosaccharides alleviate MDP induced rumen epithelial cell inflammatory damage by inhibiting the activation of NOD2/NF-κB pathway by Yimei Xiao, Yimei Xiao, Xiaolin He, Xiaolin He, Jian Ma, Chunmei Du, Shangquan Gan, Fuquan Yin, Fuquan Yin

“…KOS exerted anti-inflammatory effects by scavenging ROS, improving tight junction barrier function, and inhibiting activation of the NOD2/NF-κB signaling pathway.ConclusionPretreatment with 75 μg/mL KOS for 9 h effectively alleviated MDP-induced inflammatory damage in ORECs by inhibiting the activation of the NOD2/NF-κB pathway.…”
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