RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation by Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo

“…Abstract Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. …”
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Well Performance from Numerical Methods to Machine Learning Approach: Applications in Multiple Fractured Shale Reservoirs by Kailei Liu, Boyue Xu, Changjea Kim, Jing Fu

“…Horizontal well fracturing technology is widely used in unconventional reservoirs such as tight or shale oil and gas reservoirs. Meanwhile, the potential of enhanced oil recovery (EOR) methods including huff-n-puff miscible gas injection are used to further increase oil recovery in unconventional reservoirs. …”
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Development characteristics and potential of fault-fracture reservoir in southwest margin of Ordos Basin by HE Faqi, LI Junlu, GAO Yilong, WU Jinwei, BAI Xingying, GAO Dun

“…The southwest margin of Ordos Basin has developed faults and fractures to varying scales, significantly enhancing the permeability of tight reservoirs and forming high-quality fault-fracture reservoirs against a backdrop of low permeability reservoir types. …”
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In-feed provision of binding proteins sustains piglet gut health and mitigates ETEC-induced post-weaning diarrhea by Jiajia Xu, Melania Andrani, Rikke Brødsgaard Kjærup, Tina Sørensen Dalgaard, Carsten Eriksen, Andreas Hougaard Laustsen, Susanne Brix, Sandra Wingaard Thrane, Nuria Canibe

“…Pelleted feed containing VHH constructs helped to preserve gut barrier integrity by maintaining levels of the tight junction protein occludin in the small intestine. …”
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Protective Role of Somatostatin in Sepsis-Induced Intestinal Barrier Dysfunction through Inhibiting the Activation of NF-κB Pathway by Xin Xu, Quanli Zhu, Guoliang Li, Junjian Ma, Zhijian Pan, Wei Wu

“…Somatostatin (SST) has a protective role in intestinal injury, inflammatory response, and intestinal mucosal barrier in rats with acute pancreatitis. However, its function in sepsis-induced intestinal barrier dysfunction remains largely unknown. …”
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Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs by Wei-Hsuan Hsu, You-Zuo Chen, Yi-Ting Chiang, Yi-Tsen Chang, Yi-Wen Wang, Kung-Ting Hsu, Yi-Yun Hsu, Pei-Ting Wu, Bao-Hong Lee

“…This study investigates how polystyrene-NP exposure disrupts the intestinal microenvironment and barrier function through bacteria-host interactions. Using in vivo models and bacterial sorting technology, we show that NP accumulation in the mouse intestine alters the expression of intestinal miR-501-3p and miR-700-5p, compromising tight junction protein ZO-1 and mucin (MUC)−13 expression, thereby increasing intestinal permeability. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Fecal 16S rRNA gene sequencing was performed to analyze alterations in the gut microbiota.ResultsThe results showed that high-dose thiamine supplementation for eight weeks could significantly alleviate symptoms of HFFD-induced obesity and improve HFFD-induced intestinal epithelial barrier dysfunction by enhancing the tight junction function. Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. …”
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Increased intestinal permeability and lipopolysaccharide contribute to swainsonine-induced systemic inflammation by Ling Lei, Dazhi Deng, Wenqian Xu, Mingyuan Yue, Dandan Wu, Keyi Fu, Zunji Shi

“…Long-term consumption of swainsonine could be poisonous to livestock, including facilitating apoptosis by impairing lysosomal function and inhibiting autophagic degradation, leading to liver inflammation and even death in livestock. …”
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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation by Dingwu Qu, Zhennan Gu, Saisai Feng, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai

“…The probiotic strains differed in regulating the intestinal microbiota, cytokines (IL-10, IL-1β and interferon (IFN)-γ), and tight junction function (Zonulin-1 and Occludin). …”
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Temporariness of textile architecture. A comparitive study on innovation by Carlotta Mazzola, Alessandro Liuti

“…The discussion pivots around the tight link between architectural and technological innovation, and how this often generates improvements in functional and environmental performances while enabling a more conscious resource allocation throughout the lifespan of a project.…”
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Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway by Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Zhiming Mu, Tao Tan, Huijuan Yin, Jianwu Dai, Yi Liu, Hongli Chen

“…Methods Six-month-old female APP/PS1 transgenic mice were subjected to PBM intervention (808 nm, 20 mW/cm2) for six weeks. Cognitive function was assessed using behavioral tests, while biochemical and histological analyses were conducted to evaluate BBB integrity, β-amyloid (Aβ) deposition, and protein expression related to tight junction proteins (TJs). …”
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Dietary baking soda (NaHCO3) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis by Shuai Liu, Yuchen Gao, Jun Luo, Yanhua Chen, Heng Cao, Zhuifeng Guo, Hongmin Zhou, Zhongwen Hong, Bowen Chen, Xiao Xu, Jingcheng Zhang, Nengliang Duan, Xiangcheng Zhan, Xudong Yao, Tiancheng Xie, Yunze Dong, Yunfei Xu

“…Additionally, it enhanced the intestinal barrier function by up-regulating the expression of tight junction proteins (ZO-1, occludin, and claudin 5), remodeling the gut microbiota, and reducing intestinal inflammation.Conclusion In summary, NaHCO3 exerted a protective effect via the gut-kidney axis in the urolithiasis mice model, suggesting its potential use as a dietary supplementation to be added to daily drinking water for the management of urolithiasis.…”
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Basic and practical analysis of LF-NMR and straightforward toolbox to its successful operation by Ali Asghari, Afroza Sultana, Seddik Khalloufi

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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…Through high-throughput model sensitivity analyses and virtual target perturbations in model-based single cells, our model predicted that targeting succinate could effectively reverse the detrimental cell phenotype of BMECs under oxygen and glucose deprivation/reoxygenation, a condition that mimics stroke pathogenesis, and we experimentally validated the utility of this new target in terms of regulating inflammatory factor production, free radical generation and tight junction protection in vitro and in vivo. Our work is the first that complementarily couples transcriptomic analysis with mechanistic systems-level pathway modeling in the study of BMEC function and endothelium-based therapeutic targets in ischemic stroke.…”
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The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25 by Victoria Tenhaken, Ole-Morten Seternes, Ingolf Cascorbi, Henrike Bruckmueller

“…The dual-specificity phosphatase 2 (DUSP2) is one of the essential negative regulators for the MAPK pathway, providing tight and efficient control of MAPKs under physiological conditions. …”
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Enrichment of short-chain fatty acid-producing bacteria by pH-responsive sodium alginate and chitosan-encapsulated quercetin by Qianyu Bai, Zhongling Zhao, Yujing Duan, Runqiu Cai, Yinzhu Chen, Chaoyu Zhou, Xinyuan Tian, Yifei Yang, Haiyan Wu, Mingju Li, Jia You, Qingyi Song, Hong Dong, Tianlong Liu

“…These changes contributed to improved intestinal barrier function, better metabolic processes, and stronger defense mechanisms, thereby ameliorating UC induced by 3% dextran sulfate sodium (DSS) in C57BL/6J mice. …”
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Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis by Yuan-Yuan Ding, Yuan-Yuan Ding, Xin-Yi Tang, Yu Tian, Feng-Long Zhang, Xiang Ding, Meng-Chun Qi, Wei Dong, Chen-Guang Liu

“…The severity of UC was evaluated through daily disease activity index (DAI) scoring; quantification of pro-inflammatory cytokines (TNF-α, IL-1β) via ELISA; histopathological analysis of colon sections with H&E staining; immunofluorescence detection of tight junction proteins (ZO-1, occludin); and 16S rRNA sequencing for gut microbiota.ResultsEDFM treatment significantly reduced the expression of pro-inflammatory cytokines (TNF-α and IL-1β), enhanced the expression of tight junction proteins (ZO-1 and occludin), and stimulated mucin (MUC2) production. …”
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Hepatic progenitor cells reprogrammed from mouse fibroblasts repopulate hepatocytes in Wilson’s disease mice by Kai Liu, Li Li, Yu He, Song Zhang, Hong You, Ping Wang

“…The replacement of disordered hepatocytes with functional hepatocytes can serve as a lifelong therapeutic strategy for the treatment of WD. …”
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Crocin nano-chitosan-coated compound mitigates hippocampal blood-brain barrier disruption, anxiety, and cognitive deficits in chronic immobilization stress-induced rats by Mohsen Khodadadi, Gila Pirzad Jahromi, Gholam Hossein Meftahi, Hossein Khodadadi, Mohammadmehdi Hadipour, Masoud Ezami

“…Stressful conditions can disrupt the central nervous system's normal homeostasis and physiological functions, resulting in blood-brain barrier malfunction, memory and learning impairment, anxiety, etc. …”
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The Ideal City by Federico M. Butera

“… The planetary boundaries transgressions show that the functional integrity of the biosphere is in great danger. …”
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