RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation by Matthew W. Haemmerle, Kirill Batmanov, Sabyasachi Sen, Matthew J. Varney, Alexander T. Utecht, Austin L. Good, Andrea V. Scota, Sarah A. Tersey, Louis R. Ghanem, Caroline C. Philpott, Doris A. Stoffers

“…Objectives: Tight control of β cell mRNA translation plays a central role in regulating glucose homoeostasis and β cell health. …”
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LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model by Wei-Xin Kong, Zhi-Ling Zhang, Jin Li, Si Zhu, Chong Li, Xiao-Li Dong, Ting-Ting Gan, Di Hu, Feng-Chu Liang, Ping-Yi Xu, Wen-Yuan Guo

“…Lymphocyte activation gene 3 (LAG3) is involved in intestinal inflammation, regulates CD4 + T cell proliferation and function, and can specifically bind to pathological α-syn during cell-to-cell transmission. …”
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Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota... by Eslam Ghaleb, Yamina Alioui, Jamalat Yazeed, Natheer Wahan, Ahmed Bashah, Ali AL-waqeerah, Aamna Atta, Yuxin Sun, Yi Xin, Liang Wang, Bin Feng, Weifeng Mao

“…Additionally, LDP improved intestinal barrier function by reducing MPO activity and enhancing occludin and ZO-1 expression. 16S rRNA sequencing revealed a significant restoration of gut microbiota diversity, with an increase in beneficial bacteria Muribaculaceae, Lactobacillus, and Lachnospiraceae, and a reduction in pathogenic bacteria Escherichia-Shigella. these findings suggest that LDP exhibits therapeutic effects in DSS-induced colitis through anti-inflammatory properties, enhancement of intestinal barrier function, and modulation of gut microbiota. …”
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CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis by Cláudia S. Rodrigues, Matilde Canto, Raquel Torres, Violeta Railean, Sofia S. Ramalho, Carlos M. Farinha, Ines Pankonien, Margarida D. Amaral

“…Moreover, treatment with CFTR modulators (CFTRm) partially restored tight junction integrity by increasing claudin-1 levels and E-/N-cadherin ratio in both mutant cells. …”
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Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility by Yifei Hu, Shunjie Zheng, Jing Xu, Yufang Zhao, Jianbao Wang, Zenghui Fang, Lanfang Zhou

“…FMT experiments demonstrated that mice receiving GDM-associated microbiota developed increased systemic inflammation and compromised intestinal barrier function, as evidenced by the downregulation of tight junction proteins (ZO-1, occludin, claudin-1, mucin1). …”
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469 Identification of gut barrier protective fruits and vegetables for Latin American infants by Brian Piccolo, Leslie Tabor-Simecka, Nicole Knox, Ashley M. McAmis, Ahmad Ud Din, Andrew P. Neilson, D. Keith Williams, Jerry Simecka, Mario G. Ferruzzi

“…We also expect that exposure to fruit and vegetable fermenta will increase gene expression of tight junctions compared to exposure to media and human milk. …”
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Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…However, further research is needed to explore the clinical functional effects of knee laxity.…”
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Maternal lead exposure impairs offspring growth and intestinal microbiota via AMPK/ULK1 pathway activation by Yuanyuan He, Miaosen Wang, Miao An, Md. F. Kulyar, Ming Li, Huifen Xu, Yaping Wang

“…The present study indicated that lead exposure decreased growth performance and impaired the function of the colon, spleen, testes, and kidneys in the next generation of mice. …”
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Sulfide Quinone Oxidoreductase Alleviates Acute Ulcerative Colitis by Regulating Mitochondrial Dysfunction by Hailin Ma, Shuilian Fu, Chujun Huang, Na Han, Fangfang Cai, Dangran Li, Jian Cheng, Hongqin Zhuang, Zi‐Chun Hua

“…Intestinal epithelial cells specific knockout of SQOR (SqorCKO) mice were more susceptible to acute ulcerative colitis (UC) with lower hydrogen sulfide (H2S) levels, and the absence of SQOR caused a breakdown of the epithelial barrier through disruption of the tight junction proteins. Furthermore, analysis of the mitochondrial morphology and functions revealed increased mitochondrial damage when SQOR deficiency. …”
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Effects of Lactic Acid and Glyceryl Lactate on Growth Performance, Antioxidant Capacity, and Intestinal Health of Piglets by Shuaiju Guo, Huiling Chu, Bangwang Peng, Junlong Niu, Xiaopeng Yang, Yongpeng Guo, Zhixiang Wang, Wei Zhang

“…In conclusion, glyceryl lactate and its combination with lactic acid improved piglet growth performance by enhancing intestinal barrier function, antioxidant capacity, microbial community structure, and SCFA production.…”
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Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity by Yongfa Jing, Dongli Yan

“…Histological analysis demonstrated that SPs restored intestinal architecture, as evidenced by reduced epithelial damage scores (P < 0.05), increased expression of tight junction proteins (occludin and ZO-1), and improved intestinal permeability (P < 0.05). …”
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Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. by Talita B Gagliardi, Monty E Goldstein, Daniel Song, Kelsey M Gray, Jae W Jung, Maxinne A Ignacio, Kimberly M Stroka, Gregg A Duncan, Margaret A Scull

“…Finally, RV-C15 infection resulted in a temporary loss in epithelial barrier integrity and the translocation of tight junction proteins while a reduction in mucociliary clearance indicated cytopathic effects on epithelial function. …”
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3D Spheroids — a Cellular Model for Studying the Effects of Hypoxia on the Epicardial Microenvironment by K. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, D. O. Traktuev, M. T. Rasulova, E. V. Parfenova

“…The epicardium, the outer, tightly adjoining layer of the cardiac wall formed by epicardial mesothelial cells, collagen and elastic fibers, has gained special relevance as an important participant of reparative processes. …”
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Fecal Microbiota Transplantation Activity of <i>Floccularia luteovirens</i> Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal... by He Ma, Abdul Mueed, Yanxu Ma, Muhammad Ibrahim, Ling Su, Qi Wang

“…Moreover, FFLP1s mitigated oxidative stress by activating the Nrf2/Keap1 signaling pathway and strengthened the intestinal barrier function by upregulating the expression level of tight junction proteins (occludin, claudin-1, MUC-2, and ZO-1). …”
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Fructose aggravating colon barrier dysfunction by decreasing gut bacteria metabolites indole-3-carboxaldehyde and inhibiting activation of aryl hydrocarbon receptor in vivo and in... by Ge Song, Shaojie Pang, Wenting Peng, Wei Fang, Yong Wang, Rui Liu, Qianyun Gan, Wentao Qi

“…The mechanism of fructose impairing colon barrier is unrevealed.MethodsNormal and dextran sulfate sodium (DSS)-induced Sprague-Dawley rats fed by 35% fructose diets were used to evaluate colon barrier functions. Microbiome and metabolome were applied to screen potential biomarker bacteria and metabolites induced by fructose. …”
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MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo by Jakob J. Prömer, Sara Wolske, Perrine Castets, Geeske M. van Woerden, Cinzia Barresi, Kevin C. O’Connor, Ruth Herbst

“…Abstract The neuromuscular junction (NMJ) is the unique interface between lower motor neurons and skeletal muscle fibers and is indispensable for muscle function. Tight control of its localized formation at the center of every muscle fiber, and maintenance throughout lifetime are sustained by muscle-specific kinase (MuSK). …”
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Understanding Pathways from Cognitive Biases to the Risk of Psychosis: A Network Analysis Approach by Xi C, Wang S

“…Depressive symptom nodes serve as critical mediators between subjective cognitive problems and PLEs, underscoring their pivotal function in driving the development of PLEs among adolescents with cognitive biases. …”
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Tandem mass tag-based proteomics technology analyzing the effects of seawater slurry ice-assisted preservation on muscle proteins of Larimichthys crocea by ZHAO Yuehan, MEI Guangming, ZHANG Xiaojun, XU Dan, ZHENG Bin, DENG Shanggui

“…GO analysis showed that the differential proteins were mainly involved in cellular process, biological regulation, cell and intracellular components, binding function, and catalytic activity. COG/KOG analysis showed that the functional activities of differential proteins were mainly concentrated in cytoskeleton, carbohydrate transport and metabolism, signal transduction mechanisms and posttranslational modification, protein turnover, and chaperones. …”
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Silkworm pupa peptide ameliorates dextran sulfate sodium-induced colitis by enhancing gut barriers and modifying gut flora by Yaxi Zhou, Diandian Wang, Hao Duan, Shiqi Zhou, Jinhong Guo, Yu Guo, Jian Zhao, Wenjie Yan

“…In addition, our research findings demonstrated that SPP restored intestinal barrier function by increasing the production of tight junction proteins such as zonula occludens-1 (ZO-1), claudin-1, claudin-3, occludin, and adherens junction protein E-cadherin1. …”
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3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis by Mingzhi Yang, Zipeng Jiang, Lutong Zhou, Nana Chen, Huan He, Wentao Li, Zhixin Yu, Siming Jiao, Deguang Song, Yizhen Wang, Mingliang Jin, Zeqing Lu

“…Histopathological and immunofluorescence analyses further demonstrated that the synbiotic treatment significantly ameliorated colonic injury, enhanced barrier function, restored goblet cell counts, increased glycoprotein content in crypt goblet cells, and upregulated the expression of tight junction proteins (ZO-1, occludin, and claudin-1). …”
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