Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage by Vemula Sravathi, Madhuri Doppalapudi, Ravi Kumar Yadala, Anilkumar Banothu, Vijaya Kumar Anumolu, Hanuman Donga Durga Veera, Bhaskar Debbarma

“…VIS also improves intestinal barrier by increasing the expression of tight junction occludin, as confirmed through RT-PCR. …”
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Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. by Bo Hu, Sezgi Arpag, Xuebao Zhang, Wiebke Möbius, Hauke Werner, Gina Sosinsky, Mark Ellisman, Yang Zhang, Audra Hamilton, Jonathan Chernoff, Jun Li

“…The spaces between layers of myelin are sealed by myelin junctions. This tight insulation enables rapid conduction of electric impulses (action potentials) through axons. …”
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Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke by Lingyun Bai, Na Li, Huiqin Li, Yuxuan Dai, Yi Bai, Feiyu Ma, Dujuan Sha, Shengnan Xia, Yun Xu, Xiang Cao

“…CeO2 effectively scavenged reactive oxygen species (ROS), improving mitochondrial function and inhibiting neuronal apoptosis, while Ac2-26 upregulated tight junction proteins to enhance BBB integrity. …”
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Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia by Adnan Akif, Thi Thanh My Nguyen, Langni Liu, Xiaotian Xu, Amol Kulkarni, Jianxiong Jiang, Yang Zhang, Jiukuan Hao

“…Results AMS-17 treatment improved cognitive function, enhanced blood-brain barrier (BBB) integrity, and promoted remyelination in VaD mice. …”
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Immunomodulatory Effects of a Standardized Botanical Mixture Comprising <i>Angelica gigas</i> Roots and <i>Pueraria lobata</i> Flowers Through the TLR2/6 Pathway in RAW 264.7 Macro... by Seo-Yun Jang, Hyeon-A Song, Min-Ji Park, Kyung-Sook Chung, Jong Kil Lee, Eun Yeong Jang, Eun Mi Sun, Min Cheol Pyo, Kyung-Tae Lee

“…<b>Background</b>: As the population ages, enhancing immune function is crucial to mitigating age-related physiological decline. …”
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Bile acid disorders and intestinal barrier dysfunction are involved in the development of fatty liver in laying hens by Lihua Zhao, Qiuyu Jiang, Jiaqi Lei, Jian Cui, Xianjie Pan, Yuan Yue, Bingkun Zhang

“…These insights indicate that regulating bile acids and enhancing intestinal barrier function may become new preventive and therapeutic strategies for fatty liver in the near future.…”
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Targeting Inflammation and Skin Aging via the Gut–Skin Axis: The Role of <i>Lactiplantibacillus plantarum</i> HY7714-Derived Extracellular Vesicles by Hayera Lee, Yun-Ha Lee, Dong-Ki Hong, Sung-Jun Mo, Soomin Jeon, Soo-Dong Park, Jae-Jung Shim, Jeong-Lyoul Lee, Jae-Hwan Lee

“…Inflammation was induced using a gut-on-a-chip, and changes in cell morphology and barrier function were analyzed. Extracellular vesicles (EVs) derived from HY7714-improved intestinal cell structure repaired damage and restored tight junction integrity. …”
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The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling by Kara A Nelson, Kari F Lenhart, Lauren Anllo, Stephen DiNardo

“…Consistency of niche position suggests that placement is important for niche function. However, the complexity of most niches has precluded a thorough understanding of how their proper placement is established. …”
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Thermo-Hydro-Mechanical Coupling Numerical Simulation on Mechanical Heterogeneity of Coal Rock by Shuiqing Hu, Daobing Wang, Yipeng Li, Xiongfei Liu, Fujian Zhou, Meng Wang, Chunming He, Bo Yu

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Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells by Huan Lan, Lu-Ying Zhang, Wen He, Wan-Ying Li, Zhen Zeng, Bo Qian, Chengqiang Wang, Jia-Le Song

“…Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of various intestinal diseases. …”
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Bifidobacterium bifidum CCFM1389 Regulates Intestinal Motility Disorder by Repairing the Enteric Nervous System and Intestinal Barrier by HUANG Yin, LI Jiazhen, LIU Wenxu, XUE Yifan, ZHU Shengnan, WANG Linlin, WANG Gang

“…CCFM1389 also significantly elevated the gene expression of tight junction proteins (Occludin, Claudin-3 and ZO-1), alleviating intestinal barrier damage, and its effect was more pronounced than that of the positive strain CCFM1167. …”
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High expression of partitioning defective 3–like protein is associated with malignancy in colorectal cancer by Taiyuan Li, Xiaoyang Liu, Qunguang Jiang, Xiong Lei, Dongning Liu

“…Recently, partitioning defective 3–like protein has been demonstrated with tumor-promoting function by disrupting tight junction, inhibiting tumor suppressor liver kinase B1, and maintaining mammary stem cells. …”
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The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease by Carlo Acierno, Riccardo Nevola, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…A key aspect of MASLD pathogenesis is the dysfunction of intestinal barriers, including mechanical, immunological, and microbial alterations that amplify liver damage. The disruption of tight junctions and increased intestinal permeability allow microbial products, such as lipopolysaccharides, to enter the bloodstream, triggering liver inflammation via Kupffer cell activation. …”
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Protective Effects of a Polyherbal Mixture on Intestinal Injury via the NF-κB Signaling Pathway and Gut Microbiota Modulation in Hyperuricemic Mice by Haoluan Wang, Yu Xi, Fengju Gu, Linlin Peng, Jian Li

“…By UPLC–MS analysis, 154 compounds of PHT persisted in the gut, suggesting that these compounds are likely to modulate both intestinal barrier function and gut microbiota. These findings suggest that this PHT may have potential as a functional food for the prevention of hyperuricemia.…”
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Mung Bean Peptides Alleviate Dextran-Sulfate-Sodium-Induced Colitis Symptoms in Mice by Protecting the Intestinal Mechanical Barrier and Regulating Gut Microbiota by Chong Xu, Jingjing Diao, Yuchao Feng, Shu Zhang, Yanan Sheng, Changyuan Wang

“…MBPs restored intestinal barrier function by upregulating the expression of ZO-1 and claudin-1 proteins within the colonic tissue of mice with DSS-induced colitis, thereby treating UC. …”
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On the Structure of Rationality in the Thought and Invention or Creation of Physical Theories by Michel Paty

“… We want to consider anew the question, which is recurrent along the history of philosophy, of the relationship between rationality and mathematics, by inquiring to which extent the structuration of rationality, which ensures the unity of its function under a variety of forms (and even according to an evolution of these forms), could be considered as homeomorphic with that of mathematical thought, taken in its movement and made concrete in its theories. …”
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Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers by Gerui Zhang, Ainul Zahra, Tianrui Yang, Qiyu Guo, Yan Sun, Yuhang Zhang, Yupeng Gao, Yuxi Zhang, Mingyue Wang, Jingshuo Gong, Haibin Huang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…We find that feed supplementation with YL-EF25 and YL-EF32 reduced the lesion score of challenged chicks (p &lt; 0.05), with increased tight junction-related gene expression (Occludin and ZO-1) and decreased proinflammatory cytokine (TNF-α and IFN-γ) expression in jejunum compared with NE-induced broilers (p &lt; 0.05). …”
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Identification of the early and late responder genes during the generation of induced pluripotent stem cells from mouse fibroblasts. by Jihwan Park, Yoo-Wook Kwon, Seokjin Ham, Chang-Pyo Hong, Seonghye Seo, Moon Kyung Choe, So-I Shin, Choon-Soo Lee, Hyo-Soo Kim, Tae-Young Roh

“…A comparative investigation of the iPSCp generated by unwanted reprogramming showed that the two groups of genes on the pathway from somatic cells to iPSC might function as sequential reprogramming-competent early and late responders to the induction stimulus. …”
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Integrated transcriptomics and metabolomics reveal multi-target mechanisms of tannins against Clostridium perfringens and necrotic enteritis by Huiping Xu, Lu Gong, Yuming Guo

“…In an in vitro C. perfringens-infected intestinal cell model, PGG and TA bound α toxin, significantly reduced the mRNA expression of inflammatory factors, and improved intestinal barrier function and cell viability. Compared to PGG, TA exhibited stronger inhibitory activity against C. perfringens and binding to α toxin. …”
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ShenQiGan Extract Repairs Intestinal Barrier in Weaning-Stressed Piglets by Modulating Inflammatory Factors, Immunoglobulins, and Short-Chain Fatty Acids by Rongxia Guo, Chenghui Jiang, Yanlong Niu, Chun Niu, Baoxia Chen, Ziwen Yuan, Yongli Hua, Yanming Wei

“…We aimed to examine the effects of ShenQiGan extract (CAG) on intestinal barrier function and explore the underlying molecular mechanisms in stress-challenged weaned piglets. …”
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