A novel mode of control of nickel uptake by a multifunctional metallochaperone. by Milica Denic, Evelyne Turlin, Valérie Michel, Frédéric Fischer, Mozhgan Khorasani-Motlagh, Deborah Zamble, Daniel Vinella, Hilde de Reuse

“…In vivo, a role of SlyD PPIase function was only revealed upon exposure to high nickel concentrations. …”
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Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms by Cécile Martel, Le Ha Huynh, Anne Garnier, Renée Ventura-Clapier, Catherine Brenner

“…Therefore, this implies a tight regulation of mitochondrial functions to ensure cell homeostasis. …”
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Magnetic susceptibility as an indication of reservoir properties of the Nubia Group in Aswan-Komombo, Southern Egypt by Ahmed Awad Abd El Rahman, Osama M. Elnaggar, Sherif F. Mohamed

“…Several relations constructed between (κ) as a function of iron oxides and the measured properties. …”
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Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway by Lanping Zhu, Yang Luo, Yaxin Liu, Siyuan Sun, Junjie Yuan, Lijun Zhang, Weilong Zhong, Shuang Ma, Zihan Yu, Jinjie Zhou, Xin Chen, Jingwen Zhao

“…CB also increased the expression of tight junction proteins and reduced permeability in mice and Caco2 cells. …”
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The Impacts of Simulated Microgravity on The Cell Viability and Claudin-1 and Claudin-3 Expression of MCF-7 Breast Cancer Cells by Margrita Adamian, Azadeh Hekmat, Zahra Hajebrahimi

“…It has been believed that microgravity directly can alter the structure, morphology, and function of biosystems and numerous research have been performed to recognize these alterations. …”
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Experimental Study on Shear Strength of Root Composite Tailing Soil Based on Interfacial Bonding by Qing Chao Yang, Zhe Hao, Sheng You Lei, Yan Chen, Hong Xia Shen, Ying Zhang, Qian Zhang, Da Teng

“…The results showed that ① the relationship between root diameter of A. fruticosa and tensile strength was power function. ② The bond between root and soil becomes more tight, and the pullout strength of the root system increases significantly. ③ When root soil area ratio (RAR) is the same, shear deformation capacity of root soil composite tailing soil increases with the increase of interface bonding strength. …”
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Loose binding of the DF axis with the A3B3 complex stimulates the initial activity of Enterococcus hirae V1-ATPase. by Md Jahangir Alam, Satoshi Arai, Shinya Saijo, Kano Suzuki, Kenji Mizutani, Yoshiko Ishizuka-Katsura, Noboru Ohsawa, Takaho Terada, Mikako Shirouzu, Shigeyuki Yokoyama, So Iwata, Yoshimi Kakinuma, Ichiro Yamato, Takeshi Murata

“…Vacuolar ATPases (V-ATPases) function as proton pumps in various cellular membrane systems. …”
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Clostridium butyricum: a promising approach to enhancing intestinal health in poultry by Xiaopeng Tang, Yan Zeng, Meijun Li

“…Clostridium butyricum (C. butyricum) is a probiotic bacterium that has been shown to be a promising candidate for improving intestinal function and subsequently optimizing poultry growth. …”
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Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures by Chengfeng Xing, Guili Liang, Xin Yu, Anxing Zhang, Xiang Luo, Yu Liu, Zengli Tang, Bian Wu, Zhengji Song, Danfeng Lan

“…Thus, intestinal organoids can present the three-dimensional structure and better simulate the physiological structure and function of the intestinal epithelium in vitro. Here, the crypts were isolated from the small intestine of mice; with the participation of major cytokines (EGF, Noggin, and R-Spondin 1 included), the intestinal organoids were established at a density of 100 crypts per well, containing intestinal stem cells (ISC), Paneth cells, goblet cells, and intestinal endocrine cells. …”
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NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME

“…Our findings suggest that probiotic-induced nanovesicles may influence CNS function through the gut–brain axis and help maintain gut homeostasis under stress. …”
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Examining Stromal Cell Interactions in an In Vitro Blood–Brain Barrier Model with Human Umbilical Vein Endothelial Cells by Andrea Margari, Simon Konig, Vignesh Jayarajan, Silvia Rizzato, Giuseppe Maruccio, Emad Moeendarbary

“…Understanding the function of the blood–brain barrier (BBB) in health and disease, as well as improving drug delivery across the BBB, remains a critical priority in neuroscience research. …”
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Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy. by Eiki Sekine, Nora Schmidt, David Gaboriau, Peter O'Hare

“…Uncoating and nuclear entry was independent of proteasome function and resistant to inhibitors of nuclear export. …”
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Growth Characteristics of Sheep-Derived <i>Bacteroides fragilis</i> and Preliminary Research on Effects in Mice and Lambs by Cheng Cheng, Jinye Du, Jianping Tao, Darong Cheng

“…In a mouse model, <i>Bacteroides fragilis</i> intervention significantly alleviated colonic inflammation caused by <i>Enterohemorrhagic Escherichia coli</i> infection, enhanced tight junction protein expression, mitigated oxidative stress, and improved intestinal barrier function, with high-dose interventions showing superior effects. …”
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Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases by Xiaopei Zhang, Xiaopei Zhang, Manfei Fu, Yuanfei Wang, Tong Wu, Tong Wu

“…A detailed introduction of the structure and function of BBB was given based on the mechanism of BBB, while comparing with the pathological changes of BBB in neurodegenerative diseases (NDDs), including activation of endothelial cells, the loose of tight junction and increase of BBB permeability. …”
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RELATIONSHIP BETWEEN tcdA AND tcdB GENES OF Clostridium difficile WITH DIARRHEA DURATION IN ELDERLY PATIENTS: AN IMMUNOSENESCENCE EFFECT by Ni Luh Putu Harta Wedari, Stephen Todryk

“…BACKGROUND: C. difficile spread by faecal-oral route has two main virulence factors namely TcdA encoded by the tcdA gene acts as an enterotoxin, pro-inflammatory and fluid accumulation; and TcdB encoded by the tcdB gene is cytotoxic, causes disruption of the actin cytoskeleton, and causes disruption of tight junctions in colon cells. It remains a major global threat responsible for a significant morbidity in elderly patients due to the immunosenescence effect with declining function of T-cell and B-cell. …”
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Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-κB Signaling by Lei Zhu, Zhimin Dou, Wei Wu, Qiliang Hou, Sen Wang, Ziqian Yuan, Bin Li, Jian Liu

“…Very little is known about the mechanism of ghrelin and its receptor (GHSR) on the intestinal barrier and the immune function of macrophage regulation. Our research is to investigate the regulatory effect and molecular mechanism of the ghrelin/GHSR axis on intestinal dysfunction and macrophage polarization in septic rats. …”
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Entry Guidance for Hypersonic Glide Vehicles via Two-Phase hp-Adaptive Sequential Convex Programming by Xu Liu, Xiang Li, Houjun Zhang, Hao Huang, Yonghui Wu

“…A sensitivity-driven mesh refinement method then allocates collocation points based on their contribution to the objective function. Phase II applies residual-based refinement to reduce discretization errors. …”
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When sng meets acupuncture -- a paradigm-shift biomarker for translational research by Wei-Zen Sun, Chih-Cheng Chen, Jaung-Geng Lin

“…Sngception (sng-ception), a specific somatosensory function of acid-sensation or tether-mode mechano-sensation, may serve as the ideal molecular and physiological link between sng perception and needle manipulation (e.g., lifting, thrusting, and twisting). …”
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Impact of electric field and strain on the electronic thermal conductivity of topological crystalline insulator SnTe (001) by Ehsan Gholami, Farid Mohammadi, Mahdi Ebrahimi, Kavoos Mirabbaszadeh

“…In the present work we implement low-energy $$\overrightarrow{\text {k}}\cdot \overrightarrow{\text {p}}$$ theory and the Green’s function technique on the tight-binding Hamiltonian to study the major electronic properties and electronic thermal conductivity (ETC) of pristine TCI SnTe (001). …”
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Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review by Junkai Wen, Yuhua Lin, Yuhua Lin

“…They disrupt intestinal barrier function by reducing tight junction proteins, trigger chronic inflammation via pro-inflammatory cytokines, and cause gut microbiota dysbiosis. …”
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