The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway by Kaifang Wang, Meiyan Sun, Zhaodong Juan, Jianxin Zhang, Yingui Sun, Guizhi Wang, Chunling Wang, Yanjing Li, Wenwen Kong, Lulu Fan, Yue Zhang, Hongxiang Zhao, Xiaoyong Zhao

“…In this study, we mainly explored the influence of P2X7R on the cognitive function of SAE and its molecular mechanism. We established a sepsis model using lipopolysaccharide (LPS) stimulation, followed by an assessment of cognitive function using Morris water maze, and then Western Blot was used to analyze the expression of tight junction proteins ZO-1 and Occludin in the hippocampus of mice. …”
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PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation by Xiaomin Zhang, Siyu Chen, Penghui Zhou, Danyang Wang, Liping Xu, Jingjing He, Wende Li, Xinxin Xiong, Ziqian Fang, Jianeng Zhang

“…In this study, we investigate the role of the PALS1-associated tight junction protein (PATJ), which contains 10 PDZ domains, in the formation of IS and its subsequent impact on T cell activation.Methods To elucidate the function of PATJ, we generated murine models with conditional T cell-specific knockout of Patj and assessed T cell activation both in vitro and in vivo within the context of infection and cancer. …”
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Home-Based Nonimmersive Virtual Reality Training After Discharge From Inpatient or Outpatient Stroke Rehabilitation: Parallel Feasibility Randomized Controlled Trial by Lisa Sheehy, Anne Taillon-Hobson, Heidi Sveistrup, Martin Bilodeau, Christine Yang, Vivian Welch, Hillel Finestone

“…Participants completed assessments of standing balance, gait, and general function, before and after the intervention, by a blinded assessor. …”
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Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption by Kai Tanaka, Tatsuki Mochizuki, Shogo Baba, Shigeto Kawai, Kiyotaka Nakano, Tatsuhiko Tachibana, Kohsuke Uchimura, Atsuhiko Kato, Takashi Miyayama, Tomohito Yamaguchi, Hiroshi Nishihara, Kimio Terao, Yasutaka Kato

“…Our model showed similarity to primary enterocytes in terms of the drug absorption-related gene expression profile, tight barrier function, tolerability toward artificial bile juice, drug transporter and metabolizing enzyme function, and nuclear receptor activity. …”
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Ergosterone ameliorates RRR-induced spleen deficiency by gut microbiota-gut metabolites and P38MAPK signaling pathway by Ying Liu, Ying Liu, Haiying Bao, Haiying Bao

“…ER can treat spleen deficiency syndrome by enhancing immune function, improving gastrointestinal function, repairing the intestinal barrier, and regulating intestinal flora and intestinal metabolites.…”
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Fecal microbiome analysis uncovers hidden stress effects of low stocking density on rainbow trout by Guglielmo Raymo, Fabiane Januario, Ali Ali, Ridwan O. Ahmed, Rafet Al-Tobasei, Mohamed Salem

“…In contrast, detrimental species such as S. putrifacens and P. putida were abundant in the low-stocking density fish. Functional microbiome profiling revealed vitamin B12 salvage and synthesis in moderate stocking densities, which may support intestinal tight junction function. …”
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High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats by Yong Wang, Wentao Qi, Ge Song, Shaojie Pang, Zhenzhen Peng, Yong Li, Panli Wang

“…Moreover, the higher level intake of fructose impaired intestinal barrier function due to the decrease of the expression of tight junction proteins (ZO-1 and occludin). …”
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A novel lutein-stevioside complex inhibits DSS-induced colitis by Yangyang Dong, Mengdi Hao, Yayuan Xu, Lei Feng, Dajing Li, Yunhe Lian, Di Wu, Zhuqing Dai

“…LUT and STE showed a synergistic effect in inhibiting colitis function. LUT and STE intervention could significantly improve the symptoms of DSS-induced colitis, including inhibiting weight loss, colon shortening, hematochezia, intestinal tissue damage, and secretion and expression of inflammatory factors. …”
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Drug- and Cell-Type-Specific Effects of ROCK Inhibitors as a Potential Cause of Reticular Corneal Epithelial Edema by Ursula Schlötzer-Schrehardt, Andreas Gießl, Matthias Zenkel, Alexander Bartsch, Naoki Okumura, Noriko Koizumi, Shigeru Kinoshita, Theofilos Tourtas, Friedrich E. Kruse

“…Whereas ripasudil improved the epithelial barrier function by upregulating major components of the tight and adherens junctions and reducing paracellular permeability, netarsudil had no or even adverse effects on the epithelial barrier properties by downregulating the expression levels of cell-junction-associated genes. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Additionally, the Cyn intervention group showed significant improvements in both the intestinal barrier structure (elevated tight junction protein levels and proper localization) and function (reduced serum FD4 levels, increased intestinal TEER, and decreased bacterial translocation rates in mesenteric lymph nodes [MLNs] and livers). …”
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A Novel Multi-Agent-Based Approach for Train Rescheduling in Large-Scale Railway Networks by Jin Liu, Lei Chen, Zhongbei Tian, Ning Zhao, Clive Roberts

“…While recent research has introduced intelligent solutions to railway traffic management, the tight interdependence of train timetables and the intrinsic complexity of railway networks have hindered the scalability of these approaches to large-scale systems. …”
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Distributed Tracking-ADMM Approach for Chance-Constrained Energy Management with Stochastic Wind Power by Wenjuan Li, Yungang Liu, Huijun Liang, Yongchao Man, Fengzhong Li

“…With the available wind power characterized by Weibull distribution, the chance constraints can be converted into deterministic ones by the derived analytical form of inverse cumulative distribution function. Although the original problem is transformed into a typical convex optimization problem, the tight coupling of constraints presents challenges to the design of distributed strategy. …”
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Trans-synaptic molecular context of NMDA receptor nanodomains by Michael C. Anderson, Poorna A. Dharmasri, Martina Damenti, Sarah R. Metzbower, Rozita Laghaei, Thomas A. Blanpied, Aaron D. Levy

“…Abstract Tight coordination of spatial relationships between protein complexes is required for cellular function. …”
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Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway by Wenfang Yang, Ruoxi Cheng, Mengbin Qin, Xiaoping Pan, Yanlin Tan, Kaoyan Feng, Jinxiu Zhang, Jiean Huang

“…BackgroundTricellulin belongs to the TAMP family of proteins and is primarily localized at the tricellular tight junctions. While its role in the progression of cancer has been reported, its importance in the progression of colorectal cancer (CRC) remains unclear.ObjectiveThis study aimed to determine the function and mechanism of tricellulin in CRC progression.MethodsThe proteins expression in cells and/or tissues was determined by Western blot, immunohistochemistry staining, and/or RT-qPCR analyses. …”
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Lysosome-derived biomarkers for predicting survival outcome in acute myeloid leukemia by Gongchang Li, Yangyang Miao, Fang Yuan, Weiran Zhang, Yali Wu, Liqiang Zhu

“…Abstract Lysosomes have a tight connection to cancer and can eliminate cancer cells. …”
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Elucidating Key Motifs Required for Arp2/3-Dependent and Independent Actin Nucleation by Las17/WASP. by Ellen G Allwood, Joe J Tyler, Agnieszka N Urbanek, Iwona I Smaczynska-de Rooij, Kathryn R Ayscough

“…Actin nucleation is the key rate limiting step in the process of actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific times and at defined regions of the cell. …”
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Early Fault-Tolerant Quantum Algorithms in Practice: Application to Ground-State Energy Estimation by Oriel Kiss, Utkarsh Azad, Borja Requena, Alessandro Roggero, David Wakeham, Juan Miguel Arrazola

“…In particular, we examine the computation of the cumulative distribution function (CDF) of the spectral measure of a Hamiltonian and the identification of its discontinuities. …”
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Aging aggravates cognitive dysfunction in spontaneously hypertensive rats by inducing cerebral microvascular endothelial dysfunction. by Mei Wu, Dandan Li, Feng Qiu, Huifang Nie, Rui Fang, Ziyan Zhong, Hui Yang, Xiaoyuan Lin, Xiangyuan Wang, Hongbo Wen, Lijun Gong, Pan Meng

“…Subsequently, the pathological results showed that the pathological changes of brain microvessels and their structural and functional damage were more significant. After that, the results of molecular experiments showed enormous changes in endothelial damage indicators (nitric oxide (NO), endothelin (ET-1), platelet endothelial cell adhesion molecule-1(CD31) and endothelial tight junction protein), aggravation of blood-brain barrier (BBB) damage, microglial activation and upregulation of pro-inflammatory cytokines. …”
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Comprehensive techno-environmental evaluation of an isolated PV/wind/biomass hybrid microgrid employing various battery technologies: A comparative analysis. by Mohammed Alqahtani, Saeed Alhajri, Ahmed S Menesy, Ali Maher Mohammed, Hamdy M Sultan, Muhammad Khalid

“…Across multiple simulations, ZOA displayed superior stability and convergence characteristics, evidenced by its tight objective function range and lower relative error metrics. …”
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Inactivated Cells and Metabolites of <i>Saccharomyces boulardii</i> Alleviate Inflammation Damage in Caco-2 Monolayer Cells and Mice with Ulcerative Colitis by Yuxin Jin, Zehui Niu, Menglin Feng, Huilian Che, Zhihong Liang

“…In dextran sulfate sodium (DSS)-induced colitis mice, HIC, CFS, and Arg alleviate symptoms such as weight loss and colonic damage while suppressing the upregulation of pro-inflammatory factors and the downregulation of tight junction proteins. Moreover, these postbiotics help restore the gut microbiota composition and functionality in colitis mice, with potentially superior regulatory effects compared to sulfasalazine (SASP). …”
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