Iridoids derived from Valeriana jatamansi Jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signali... by Yongzhi He, Yongzhi He, Yongzhi He, Jiachun Lu, Rizhao Pang, Lijuan Ding, Yunyun Wang, Hua Xiao, Chao Cheng, Yushan Luo, Xiaoming Hu, Wenchun Wang

“…However, the specific effects of IRFV on neuroinflammation and BSCB integrity remain unexplored.Methods and ResultsThis study aims to elucidate the functional significance and molecular mechanisms by which IRFV modulates neuroinflammation and preserves BSCB function following SCI. …”
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Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

“…Conclusion TZP ameliorates BBB dysfunction and protects against ischemic stroke by activating C/EBP-α signaling and restoring Claudin-1-mediated tight junction integrity. These findings suggest that TZP holds promise as a therapeutic agent for stroke, offering a novel strategy for maintaining BBB function and reducing neuronal damage. …”
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Effect of berberine on LPS-induced intestinal epithelial injury and m6A methylation in broilers by Lin Yuan, Wanli Li, Guoxi Li, Wei Jin, Bingxun Wang, Shengli Li, Haoyu Wang

“…The results revealed that the oral administration of LPS caused intestinal inflammation and cell apoptosis and disrupted the intestinal barrier and function. However, simultaneous administration of high-dose BBR alleviated LPS-induced adverse changes in intestinal morphology and mucosal barrier integrity by decreasing the expression of inflammatory cytokines and apoptotic proteins, increasing the expression of tight junction proteins, and inhibiting LPS-induced increases in m6A methylation and METTL3 expression. …”
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Penetration enhancer containing vesicles for dermal and transdermal drug delivery. A review by Fatma A. Sarhan, Riham I. El-Gogary, Manal Yassin Hamzaa, Mahmoud E. Soliman

“…This function may interfere or totally inhibit the drug delivery through the skin. …”
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The Beneficial Effects of a N-(1-Carbamoyl-2-phenyl-ethyl) Butyramide on Human Keratinocytes by Franca Oglio, Serena Coppola, Alessandra Agizza, Antonio Masino, Chiara Luongo, Roberta Di Santillo, Ludovica D’Auria, Roberto Russo, Ilaria Neri, Lucia Grumetto, Laura Carucci, Erika Caldaria, Rita Nocerino, Ritamaria Di Lorenzo, Antonio Calignano, Sonia Laneri, Lorella Paparo, Roberto Berni Canani

“…<b>Results:</b> FBA significantly enhanced keratinocyte proliferation at an optimal concentration of 0.1 mM. Tight junction protein expression increased, indicating improved barrier function. …”
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Development and Characterization of a Primary Ciliated Porcine Airway Model for the Evaluation of In Vitro Mucociliary Clearance and Mucosal Drug Delivery by Janik Martin, Veronika Neubauer, Rebecca Rittersberger, Simon Treitler, Patrick Kopp, Cemre Günday, Iman Shrimo, Annabelle Dabbars, Frank Rosenau, Akif Emre Türeli, Nazende Günday-Türeli, Oliver Haedicke-Peters, Katharina Schindowski

“…This model was evaluated for cell morphology, tight junction formation, ciliated and mucus-producing cells, barrier function, gene expression, and tracer/IgG transport. …”
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EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model by Wen-Guang Wang, Xuan Wang, Na Li, De-Xuan Kuang, Pin-Fen Tong, Cai-Xia Lu, Yuan-Yuan Han, Xiao-Mei Sun, Jie-Jie Dai, Long-Ding Liu

“…Scavenger Receptor Class B Member 2 (SCARB2) and Annexin A2 (ANXA2) were identified as potential functional receptors facilitating viral entry. EV-A71 infection led to the dysregulation of tight junction proteins, matrix metalloproteinases, and Major facilitator superfamily domain-containing protein 2a. …”
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Reward signalling in brainstem nuclei under fluctuating blood glucose. by Tobias Morville, Kristoffer H Madsen, Hartwig R Siebner, Oliver J Hulme

“…To test this hypothesis, we collected a large volume of functional MRI data from five human volunteers on four separate days. …”
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Stability and Finite-Time Synchronization Analysis for Recurrent Neural Networks with Improved Integral-Type Time-Varying Delays by Meng Li, Gulijiamali Maimaitiaili

“…Firstly, a sufficient criterion for universal asymptotic stability of RNNs with integral time-varying delays is obtained by estimating a tight upper bound of augmented Lyapunov-Krasovskii functional (LKF) derivative with inequality scaling technique and mutually convex combined inequality. …”
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Deciphering Autoimmune Pancreatitis, a Great Mimicker: Case Report and Review of the Literature by Satya Allaparthi, Mohammed Sageer, Mark J. Sterling

“…Workup showed elevated liver function tests (LFT) suggestive of obstructive jaundice, MRCP done showed diffusely enlarged abnormal appearing pancreas with loss of normal lobulated contours, and IgG4 antibody level was 765 mg/dL. …”
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Isolation, establishment, and characterization of immortalized ileum bovine intestinal epithelial cell line by Hannah K. Piper, Mitchell J. Wiese, Mitchell J. Poss

“…Abstract Primary intestinal epithelial cells are a powerful tool to study tight junction protein function and barrier integrity of epithelial cells. …”
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P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL

“…There is increasing evidence that supports the interaction between gut microbiota and brain development and function, contributing to define the concept of the “microbiota-gutbrain axis”1-3. …”
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DNMT3a-Mediated Enterocyte Barrier Dysfunction Contributes to Ulcerative Colitis via Facilitating the Interaction of Enterocytes and B Cells by Bo Cheng, Ai-mei Rong, Wenlu Li, Xiuqian Bi, Xinguang Qiu

“…This study was aimed at exploring the effect of DNMT3a on enterocyte barrier function in the progression of UC and the underlying mechanism. …”
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Postbiotic Intervention in Sarcopenia: The Role of <i>Lactiplantibacillus plantarum</i> HY7715 and Its Extracellular Vesicles by Kippeum Lee, Soo Dong Park, Joo Yun Kim, Jae Jung Shim, Jae Hwan Lee

“…In intestinal Caco-2 cells, HY7715-derived EVs improved barrier function by upregulating tight junction proteins (ZO-1, occludin, and claudins), and effectively reduced LPS-induced inflammation. …”
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The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy. by Xueyan Lin, Zhengchao Zhang, Yi Lin, Shiyun Lu, Rongrong Chen

“…The Morris water maze (MWM) test was used to assess cognitive function in MHE rats following treatment with rifaximin and lactulose. …”
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Anti-epileptic and gut-protective effects of trioctanoin and the critical role of gut microbiota in a mouse model of epilepsy by Fei Yu, Jia-Lin Ji, Ying Wang, Yi-Di Liu, Yi-Mei Lian, Meng-Zhen Wang, Zheng-Xu Cai

“…Gut microbiota structure and function affect metabolism, gut health, and behavioral responses and are regulated by dietary factors. …”
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Improvement of Lactiplantibacillus plantarum MWFLp-182 on oxidative deficits induced by in 2,2’-azobis(2-methylpropionamidine) dihydrochloride and the relating key gene analysis by Hui Nie, Xutong Ma, Fanyu Kong, Yanghe Luo, Guangqing Mu, Xiaomeng Wu

“…The genes tpx, trxA, trxB, npr, nrdH, dps, recA, gpx, gshA and arsC in this strain were related to antioxidant function; the key genes involved in antioxidant function were further investigated. …”
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Aerobic exercise alleviates cognitive impairment in T2DM mice through gut microbiota by Shuping Ruan, Juan Liu, Xiaoqing Yuan, Xinhua Ye, Qing Zhang

“…The fear conditioning test was performed to assess cognitive function. Intestinal mucosa samples were collected to evaluate the expression of intestinal tight junction proteins. …”
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Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models by Hongbo Cheng, Yijiao Men, Yaqing An, Jiegang Yu, Gengshen Zhang, Jiaming Li, Xiaoliang Wang, Guozhu Sun, Yang Wu

“…This results in the degradation of tight junction proteins and increased BBB permeability. …”
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Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability by Bin Gao, Luca Maccioni, George Kunos, Szabolcs Dvorácskó, Grzegorz Godlewski, Resat Cinar, Malliga R Iyer

“…In addition, targeting intestinal CB1R and downstream ERK1/2 was able to reverse this process, with subsequent upregulation of tight junction proteins and increased villi length, thus improving gut barrier function. …”
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