A Novel In Vitro Primary Human Alveolar Model (AlveolAir™) for H1N1 and SARS-CoV-2 Infection and Antiviral Screening by Cindia Ferreira Lopes, Emilie Laurent, Mireille Caul-Futy, Julia Dubois, Chloé Mialon, Caroline Chojnacki, Edouard Sage, Bernadett Boda, Song Huang, Manuel Rosa-Calatrava, Samuel Constant

“…This model exhibited a functional barrier over a 30-day period, evidenced by high transepithelial electrical resistance (TEER). …”
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Polysaccharides derived from golden mushroom (Cantharellus cibarius Fr.) modulate gut microbiota and enhance intestinal barrier function to ameliorate dextran sulfate sodium-induce... by Yamina Alioui, Hidayat Ullah, Sharafat Ali, Mujeeb Ur Rahman, Maroua Elkharti, Nabeel Ahmed Farooqui, Ata Ur Rehman, Muhammad Ilyas, Duaa M. Alsholi, Nimra Zafar Siddiqi, Muhsin Ali, Liang Wang, Yi Xin

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The transcription factor MAZR preferentially acts as a transcriptional repressor in mast cells and plays a minor role in the regulation of effector functions in response to FcεRI s... by Anastasia Abramova, Shinya Sakaguchi, Alexandra Schebesta, Hammad Hassan, Nicole Boucheron, Peter Valent, Axel Roers, Wilfried Ellmeier

“…Mast cells are key players in type I hypersensitivity reactions in humans and mice and their activity has to be tightly controlled. Previous studies implicated the transcription factor MAZR in the regulation of mast cell function. …”
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Effects of short-chain fatty acid-producing probiotic metabolites on symptom relief and intestinal barrier function in patients with irritable bowel syndrome: a double-blind, rando... by Erfeng Li, Jie Wang, Bin Guo, Wenbin Zhang

“…In addition to fecal SCFA (FSCFA) levels, intestinal permeability (L/M ratio), tight junction proteins (TJP), serum/fecal inflammatory markers, and adverse event occurrence, the primary endpoint (PEP) evaluated was IBS Symptom Severity Scale (IBS-SSS) scores. …”
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Zinc Glycine supplementation improves bone quality in meat geese by modulating gut microbiota, SCFA's, and gut barrier function through Wnt10b/NF-κB axis by Zeshan Zulfiqar, Muhammad Arslan Asif, Mengqi Liu, Shuhang Zhang, Hamid reza Rafieian Naeini, Yalei Cui, Boshuai Liu, Yinghua Shi

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Engineering and Optimization of Quasi-Nondiffracting Helicon-Like Beams With an Evolutionary Algorithm by Bryce Schroeder, Zhen H. Zhu, Changliang Guo, Shu Jia

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Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs by Mehmet Saçma, Ali Hageb, Alex Zadro, Tanja Schuster, Mona Vogel, Karina Eiwen, Vadim Sakk, Hartmut Geiger, Hartmut Geiger

“…Aging is associated with a decline in the function of hematopoietic stem cells (HSCs). This decline in HSC function results in reduced hematologic regenerative capacity and an increased incidence of hematologic disorders. …”
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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA... by Carlos H. Trasviña-Arenas, Upeksha C. Dissanayake, Nikole Tamayo, Mohammad Hashemian, Wen-Jen Lin, Merve Demir, Nallely Hoyos-Gonzalez, Andrew J. Fisher, G. Andrés Cisneros, Martin P. Horvath, Sheila S. David

“…These results suggest that allosteric cross-talk between the DNA binding [4Fe-4S] cofactor and the base excision site of MUTYH regulate its DNA repair function.…”
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Probiotic Fermentation of <i>Astragalus membranaceus</i> and Raphani Semen Ameliorates Cyclophosphamide-Induced Immunosuppression Through Intestinal Short-Chain Fatty Acid-Dependen... by Yang Chen, Xiaoqing Wei, Binqi Rui, Yutong Du, Zengjie Lei, Xiujie Guo, Chaoran Wang, Donglin Yuan, Xiuli Wang, Ming Li, Binbin Hou, Yinhui Liu

“…These results suggest that PROAS enhances B lymphocyte function by increasing the regulation of intestinal microbiota to produce high levels of SCFA, repairs the intestinal barrier damage induced by CTX, and promotes intestinal mucosal immunity.…”
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Probiotic <i>Lacticaseibacillus paracasei</i> E10 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Enhancing the Intestinal Barrier and Modulating Microbiota by Yuanyuan Dai, Ziming Lin, Xiaoyue Zhang, Yiting Wang, Yingyue Sheng, Ruonan Gao, Yan Geng, Yuzheng Xue, Yilin Ren

“…Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder associated with gut microbiota dysbiosis and impaired intestinal barrier function. Probiotic interventions have shown potential in alleviating intestinal inflammation and restoring microbial balance. …”
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Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri: intraspecific and interspecific patterns by Chunxiu Lin, Yuxing Zheng, Bo Zhang, Guopeng Lin, Kexin Shang, Jianxin Zhao, Gang Wang, Wei Chen

“…The anti-colitis activities of both strains involved various aspects of intestinal immune, physical, chemical, and biological barrier function. Strikingly, the tested strains exhibited considerable interspecies and intraspecies specificity in colitis amelioration. …”
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Music intervention mitigates LPS-induced gut barrier disruption and immune stress in broilers via TLR4/NF-κB regulation by Shengzi Jin, Haowen Wang, Haiyue Gong, Lu Guo, Haoran Zhang, Jiaqi Zhang, Qingqing Chang, Jianhong Li, Runxiang Zhang, Jun Bao

“…In this study, we investigated the effects of a music-enriched environment on growth performance, intestinal barrier function, and inflammatory responses in lipopolysaccharide (LPS)-induced immunostressed broilers. …”
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Early evolvability in arthropod tagmosis exemplified by a new radiodont from the Burgess Shale by Joseph Moysiuk, Jean-Bernard Caron

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Explorative Analysis of Antioxidant, Anti-Inflammatory, and Intestinal Barrier Protective Effects of In Vitro Digested Chickpea- and Dark Chocolate-Based Snack: Insights from Caco-... by Gaia de Simone, Laura Bonfili, Anna Maria Eleuteri, Laura Bordoni, Rosita Gabbianelli

“…Combining chickpeas with dark chocolate improves palatability and may enhance biological functionality, although mechanistic evidence is still limited. …”
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Microbial generalists as keystone species: constructing core network modules in the anthosphere of twelve diverse wild plant species by Jihoon Kim, Yingshun Cui, Kyong-Hee Nam, Jun-Woo Lee, Jong-Geol Kim, Seong-Jun Chun

“…Therefore, understanding the anthospheric microbiome is essential to explore the diversity, interactions, and functions of wildflowers that coexist in natural habitats. …”
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Analysis of Age-related Changes of Characteristics and High Frequency Symptoms in Pre-elderly and Elderly Inpatients by YUE Xiao, WANG Mei

“…Objective To analyze the characteristics of hospitalization, incidence of high-frequency symptoms and age-related changes for pre-elderly and elderly inpatients in recent 10 years, and to provide reference and direction for symptoms management, functional improvement in pre-elderly and elderly inpatients. …”
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A review of the FIVA project: Novel windows employing vacuum glazing products by Ulrich J. Pont, Peter Schober, Magdalena Wölzl, Matthias Schuss, Jakob Haberl

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Effects of dietary supplementation with novel organic rare earths on growth performance, gut and liver health, gut microbiota in golden pompano by Ming Li, Hui Liang, Rui Xia, Jian Zhang, Jie Chen, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…Finally, the novel organic rare earths altered the composition (enrichment of beneficial bacteria), diversity and the ratio of ‘Functional Group 2/Functional Group 1’ of gut microbiota, which may contribute to the enhancement in growth of golden pompano. …”
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Association of circulating 25-hydroxyvitamin D with time in range and insulin secretion in type 2 diabetes by Wenwen Jiang, Ling Li, Wei Wang, Yue Liang, Xiaoyong Bai, Yixin Xu, Qingyu Guo, Lichao Ge, Jingjing Liang, Bin Lu, Jiaqing Shao, Jiaqing Shao, Jiaqing Shao

“…Among the 911 enrolled subjects, 582 individuals underwent a 100g standardized steamed bread meal test to comprehensively evaluate the pancreatic β-cell secretory function.ResultsA higher TIR and time in tight range (TITR) were observed among individuals in the upper tertile for 25(OH)D, surpassing those in the middle and lower tertiles. …”
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The <i>n^th</i> Prime Exponentially by Matt Visser

“…From several recently developed known effective bounds on the prime counting function of the general form <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mrow><mo>|</mo><mi>π</mi><mrow><mo>(</mo><mi>x</mi><mo>)</mo></mrow><mo>−</mo><mi>Li</mi><mrow><mo>(</mo><mi>x</mi><mo>)</mo></mrow><mo>|</mo><mo><</mo><mi>a</mi><mspace width="0.277778em"></mspace><mi>x</mi><mspace width="0.277778em"></mspace><mrow><mo>(</mo><mo form="prefix">ln</mo><mi>x</mi><mo>)</mo></mrow></mrow><mi>b</mi></msup><mspace width="0.277778em"></mspace><mo form="prefix">exp</mo><mfenced separators="" open="(" close=")"><mo>−</mo><mi>c</mi><mspace width="0.277778em"></mspace><msqrt><mrow><mo form="prefix">ln</mo><mi>x</mi></mrow></msqrt></mfenced></mrow></semantics></math></inline-formula> for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>x</mi><mo>≥</mo><msub><mi>x</mi><mn>0</mn></msub></mrow></semantics></math></inline-formula> and known constants <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>{</mo><mi>a</mi><mo>,</mo><mi>b</mi><mo>,</mo><mi>c</mi><mo>,</mo><msub><mi>x</mi><mn>0</mn></msub><mo>}</mo></mrow></semantics></math></inline-formula>, we shall show that it is possible to establish exponentially tight effective upper and lower bounds on the prime number theorem. …”
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