ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction by Karim Ullah, Lizhuo Ai, Yan Li, Lifeng Liu, Qin Zhang, Kaichao Pan, Zainab Humayun, Lin Piao, Albert Sitikov, Qiong Zhao, Qiaozhu Su, Willard Sharp, Yun Fang, David Wu, James K. Liao, Rongxue Wu

“…HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. Here, we show that inducible, adult endothelial-specific deletion of Hif2α in mice leads to increased mortality, cardiac leakage, inflammation, reduced heart function, and adverse remodeling after MI. …”
Get full text

The Effects of Recombinant pBD2 on the Growth Performance, Antioxidant Capacity, Immune Function, Intestinal Barrier, and Microbiota of Weaned Piglets by Zhanwei Teng, Qing Meng, Mengting Ren, Bingke Lv, Liping Yuan, Ningning Zhang, Qinghua Wang, Kun Zhang, Chunli Li

“…The results revealed that pBD2 significantly increased the total weight gain and average daily weight gain (<i>p</i> < 0.05), the contents of T-AOC, SOD, IgM, and IL-10 in serum (<i>p</i> < 0.05), the villus-to-crypt ratios, and the expression of tight-junction proteins ZO-1 and claudin-1 (<i>p</i> < 0.05) in the small intestine. …”
Get full text

The effects of copper-loaded montmorillonite on intestinal morphology, microbiota, barrier function, antioxidant capacity, and gut-related gene expression in broilers by Xinru Hu, Yiwen Rao, Peiqianng Yuan, Xingyong Chen, Cheng Zhang

“…Furthermore, it reduced serum biomarkers of intestinal permeability (diamine oxidase and D-lactic acid), while upregulating the mRNA abundance of tight junction proteins (Zonula occludens-1 and occludin) and mucin-2. …”
Get full text

<i>Artemisia annua</i> Residue Regulates Immunity, Antioxidant Ability, Intestinal Barrier Function, and Microbial Structure in Weaned Piglets by Jinjie Hu, Miaomiao Bai, Yueyao Xing, Junhong Liu, Kang Xu, Xia Xiong, Hongnan Liu, Yulong Yin

Get full text

HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1 by Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa

“…We previously reported findings showing that junctional adhesion molecule 1 (JAM1), a tight junction-associated protein, has an important role to maintain epithelial barrier function in gingival tissues, which prevents penetration of bacterial virulence factors, such as lipopolysaccharide (LPS) and peptidoglycan (PGN). …”
Get full text

Repression of Connexin26 hemichannel activity protects the barrier function of respiratory airway epithelial cells against LPS-induced alteration by Tina Lehrich, Anne Dierks, Masina Plenge, Helena Obernolte, Klaudia Grieger, Katherina Sewald, Frederic Rodriguez, Lucie Malet, Peter Braubach, Florence Bedos-Belval, Anaclet Ngezahayo

“…Parallel to barrier alteration, a reduced tight junction organization rate (TiJOR) of claudin-4 (CLDN4) by 75% was observed within an application time of 3 h. …”
Get full text

Matrix-free human 2D organoids recapitulate duodenal barrier and transport properties by Kopano Valerie Masete, Dorothee Günzel, Jörg-Dieter Schulzke, Hans-Jörg Epple, Nina A. Hering

“…As this coat could potentially act as a diffusion barrier, we aimed to generate robust human duodenum-derived organoid monolayers that do not need a gelatinous matrix for anchorage to improve upon existing models to study epithelial transport and barrier function. Results We characterized these monolayers phenotypically regarding polarization, tight junction formation and cellular composition, and functionally regarding uptake of nutrients, ion transport and cytokine-induced barrier dysfunction. …”
Get full text

Covalent Grafting of Inorganic Selenium to the Water-Soluble and Nondigestive Chinese Yam Polysaccharides Causes Greater Protection of IEC-6 Cells with Acrylamide Injury by Zhen-Xing Wang, Li-Li Zhang, Xin-Huai Zhao

“…Acrylamide, a harmful substance generated during the normal thermal treatment of foods, has been shown to adversely affect human health, particularly the vital intestinal barrier function. Meanwhile, natural polysaccharides are recognized to exert an important biofunction in the intestine by protecting barrier integrity. …”
Get full text

Effects of dietary supplementation levels of vitamin A and vitamin D3 on growth performance, jejunal function, and tibia development in goslings from 1 to 28 days of age by Zixin Huang, Zhenming Fu, Jian Wang, Zhi Yang, Jun Wang, Jun Yu, Zhiyue Wang, Haiming Yang

“…This study explored the interaction effects of dietary Vitamin A (VA) and Vitamin D3 (VD3) on growth performance, jejunal function, and tibia development in goslings, aiming to identify any synergistic outcomes that may reshape nutritional strategies for geese production. …”
Get full text

One-step synthesis of fluorine-functionalized intercalated graphene with adjustable layer spacing for both enhanced physical and chemical hydrogen storage by Chaojie Liu, Yongyang Zhu, Anqi Zu, Yike Liu, Zhiyang Zhang, Junjie Guo, Chuo Lian, Muen Zou, Shun Wang

“…Here for the first time, we develop a fluorine-functionalized intercalated graphene with adjustable layer spacing by one-step solvothermal process, using fluorinated organic molecules as both intercalation and function agents. …”
Get full text

Effect of Blending Cotton/Bamboo on UV Protection and Functional Purposes of Trilobal Polyester Microfibers Knitted Fabrics Using Different Structures by Marwa A. Ali, Khaled Mohamed Seddik

“…Knitted samples were produced from two different structures according to their tightness factor (single jersey and fleece structures), the various functional properties of the produced fabrics, such as mass per unit area, thickness, air and water permeability, and bursting strength, were tested. …”
Get full text

Acupuncture Alters Brain’s Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial by Yahui Wang, Mengxin Lu, Ruoyi Liu, Liping Wang, Yue Wang, Lingling Xu, Kang Wu, Chen Chen, Tianzhu Chen, Xinyue Shi, Kuangshi Li, Yihuai Zou

“…Neuroimaging studies have confirmed that acupuncture can promote static functional reorganization in poststroke patients with motor dysfunction. …”
Get full text

Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus by Jeffrey M. Boyd, Kylie Ryan Kaler, Karla Esquilín-Lebrón, Ashley Pall, Courtney J. Campbell, Mary E. Foley, Gustavo Rios-Delgado, Emilee M. Mustor, Timothy G. Stephens, Hannah Bovermann, Todd M. Greco, Ileana M. Cristea, Valerie J. Carabetta, William N. Beavers, Debashish Bhattacharya, Eric P. Skaar, Lindsey N. Shaw, Timothy L. Stemmler

Get full text

KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension by Yinzhen Chen, Mingfu Chen, Ridong Zhou, Jichang Zheng, Gongxin Yang, Meiyu Chen, Jing Tu, Hongming Lin, Hu Zhao, Chen Lin, Xiaobin Chen

“…Abstract Background Pregnancy induced hypertension (PIH) is characterized by aberrant uterine arterial remodeling, a process tightly associated with an imbalance between placental growth factor (PlGF) and soluble fms like tyrosine kinase 1 (sFlt 1) as well as the down regulation of matrix metalloproteinases 2/9 (MMP 2/9). …”
Get full text

Fermented defatted rice bran-derived gut Clostridium butyricum improved the gut barrier function by regulating HIF-1 signaling pathway by Weifa Su, Zipeng Jiang, Tao Gong, Man Du, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang

“…In this study, a mouse model together with fecal microbiota transplantation (FMT) was utilized to study the effects and mechanisms of fermented DFRB (FR) on gut barrier function. We found that FR improved the intestinal morphology, gut tight junction proteins, mucin, antimicrobial peptides, and interleukin 22 (IL-22) and promoted the gut Clostridium butyricum and butyrate. …”
Get full text

Does Syndesmotic Fixation Technique Impact Complication Rates and Functional Outcomes Measured by PROMIS Scores Following Operative Repair of Ankle Fractures? by Steven Hadley BA, Rachel Bergman MD, John Peabody MD, Sarah Westvold MPH, Ryan Filler MD, Milap Patel DO, Anish Kadakia MD

“…While traditionally performed with syndesmotic screws, recent techniques including the Syndesmosis TightRope® XP (TightRope, Arthrex) and InternalBrace™ (IB, Arthrex) have been developed to optimize natural flexibility and movement of the syndesmosis. …”
Get full text

CCL2 Inhibitor Bindarit Improve Postoperative Cognitive Function by Attenuating Pericyte Loss-Related Blood–Brain Barrier Disruption and Neuroinflammation by Hui Yuan, Bo Lu, Daofan Sun, Junping Chen, Xiangming Fang

“…Immunofluorescence analysis revealed that Bindarit treatment mitigated the reduction in capillary length and tight junction (TJ) protein expression, specifically claudin-5 and occludin, which was seen with decreased PC coverage. …”
Get full text

Bovine colostrum-derived extracellular vesicles protect against non-alcoholic steatohepatitis by modulating gut microbiota and enhancing gut barrier function by Daye Mun, Sangdon Ryu, Daniel Junpyo Lee, Min-Jin Kwak, Hyejin Choi, An Na Kang, Dong-Hyun Lim, Sangnam Oh, Younghoon Kim

“…Furthermore, BCEV treatment promoted the production of tight junction proteins and mucin in the gut, reinforcing intestinal barrier integrity. …”
Get full text

Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota by Ye Shiqing, Lu Xinjie, Zhu Xiaotong, Chen Jiayan, Lu Jiahai, Chen Xiaodong, Lou Yongliang, Li Xiang

“…In APP/PS1 mice, CBM588 improved cognitive function and alleviated colonic tissue pathology by modulating tight junction proteins (upregulating Claudin 1, ZO-1, and Occludin) and reducing inflammatory cytokines (IL-6, IL-1β, and TNF-α mRNA). …”
Get full text

X-RAY PROGRESSION AND ITS IMPACT ON THE FUNCTIONAL STATUS OF PATIENTS WITH EARLY RHEUMATOID ARTHRITIS DURING A 5-YEAR FOLLOW-UP by Yu. A. Ermakova, D. E. Karateev, E. L. Luchikhina, N. V. Demidova, A. V. Smirnov

“…Therapy response was monitored applying the tight control strategy. Main clinical and laboratory parameters, DAS28, and HAQ scores, and functional class and hand and foot X-ray were recorded every year.Results and discussion. …”
Get full text