Effect of dietary Clostridium butyricum supplementation on growth performance, immune function, and intestinal health of hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus l... by Weijun Chen, Tao Song, Dong Li, Mingfan Chen, Pan Wang, Jidan Ye

“…IntroductionThe aim of this study is to investigate the effects of supplementing Clostridium butyricum (C. butyricum) on hybrid grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂), with a particular focus on its impact on growth performance, blood composition, intestinal antioxidant capacity, gut microbiota, tight junction protein (ZO-1) expression, and inflammatory gene expression. …”
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The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice by Chao Feng, Lu Wang, Huifang Bai, Qixing Huang, Shuang Liang, Ruiqi Liang, Jiahao Yu, Shun Wang, Hui Guo, Sayed Haidar Abbas Raza, Xiaofeng Shan, Dongxing Zhang, Wuwen Sun, Lei Zhang

“…Furthermore, oral administration of 1 × 109 PFU/ml vB_AceP_PAc (100 µl/mouse) in healthy mice significantly reduced inflammatory cytokine levels, increased tight junction molecule levels, and improved intestinal barrier function. …”
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Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications by Jiehong Zhou, Jianyu Lv, Xin Chen, Tian Li, Jianzhong Shen, Zhanhui Wang, Chongshan Dai, Zhihui Hao

“…Emerging evidence highlights puerarin’s capacity to enhance gut health in farm animals through four pivotal mechanisms: (1) optimization of intestinal morphology via crypt-villus architecture remodeling, (2) augmentation of systemic and mucosal antioxidant defenses through Nrf2/ARE pathway activation, and (3) reinforcement of intestinal barrier function by regulating tight junction proteins (e.g., ZO-1, occludin), mucin secretion, intestinal mucosal immune barrier, the composition of microbiota, and the derived beneficial metabolites; (4) regulating the function of the intestinal nervous system via reshaping the distribution of intestinal neurons and neurotransmitter secretion function. …”
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Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. by Alejandro P Adam, Anthony M Lowery, Nina Martino, Hiba Alsaffar, Peter A Vincent

“…TNF-α-induced p38 signaling was required for the synergistic effect on barrier function, and activation of the p38 MAPK alone was also able to induce changes in permeability only in monolayers with active SFKs. …”
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Multi-Omics Reveal the Improvements of Nutrient Digestion, Absorption, and Metabolism and Intestinal Function via GABA Supplementation in Weanling Piglets by Yan Zeng, Hong Hu, Yiwen He, Zhiying Deng, Yiting Guo, Xihong Zhou

“…Furthermore, increased lipase and trypsin activity, along with the elevated expression of tight junction proteins confirmed the beneficial effects of GABA on intestinal nutrient metabolism and barrier function. …”
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2’-Fucosyllactose modulates the function of intestinal microbiota to reduce intestinal permeability in mice colonized by feces from healthy infants by Qingxue Chen, Liu Yang, Fangqin Xiang, Ignatius Man-Yau Szeto, Yalu Yan, Biao Liu, Jinju Cheng, Lu Liu, Bailiang Li, Sufang Duan

“…In conclusion, 2’-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.…”
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Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids by Qingxue Chen, Ting Cao, Hongwei Tang, Linyi Zhou, Yuxuan Zheng, Jinju Cheng, Bailiang Li, Song Wang

“…The results showed that goat milk-based IF is associated with a functional immune advantage, due to the rise in the levels of immune-related cytokines interleukin (IL)-2 and IL-10, decreased levels of intestinal permeability markers D-lactic acid and endotoxin, and increased mRNA levels of intestinal tight junction proteins occludin and claudin. …”
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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

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Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…These findings indicated that rTsCTL vaccination impeded larval invasion and improved gut epithelial integrity and barrier function, reduced worm burdens, and relieved gut and muscle inflammation.…”
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Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolismResearch in context by Callie M. Weber, Bilal Moiz, Gabriel S. Pena, Marzyeh Kheradmand, Brooke Wunderler, Claire Kettula, Gurneet S. Sangha, J. Carson Smith, Alisa Morss Clyne

“…Two early pathologies of AD are degradation of tight junctions between brain microvascular endothelial cells (BMEC) and brain glucose hypometabolism. …”
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Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism by Yuge Chen, Xuejia Zhang, Xuejia Zhang, Shengbin Huang, Shengbin Huang, Maria Febbraio

“…Macrophage CD36 is a key functional player in metabolic expression profiles that determine phenotype. …”
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Structure dependent optical and conductive properties of HPMC:CoCl2 composites: A functional data analysis study by Gowtham G K, Thejas G. Urs

“…In addition, employing the tightly bound electron model, we detail the bandgap variation in these composites concerning the dopant concentration. …”
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A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development by Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa

“…Abstract Bone remodeling is tightly regulated by the RANK-RANKL-OPG axis to maintain skeletal integrity. …”
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Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition by Habtamu Ayalew, Changchun Xu, Assefa Adane, Astrid Lissette Barreto Sanchez, Siman Li, Jing Wang, Shugeng Wu, Kai Qiu, Guanghai Qi, Haijun Zhang

“…However, their effectiveness influenced with their developmental and functional stages during pre and post hatch periods of chick. …”
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Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages by Kevin Qiu, Duc C. Vu, Leran Wang, Nicholas N. Nguyen, Anna K. Bookstaver, Katia Sol-Church, Hui Li, Thang N. Dinh, Adam N. Goldfarb, Daniel G. Tenen, Bon Q. Trinh

“…Abstract The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level. However, how chromatin signatures are linked to this dynamic expression pattern across different blood cell lineages remains uncharacterized. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…Next, Interleukin 10 knock‐out (Il‐10−/−) mice were used to assess the biological functions of CrF‐EVs in spontaneous mesenteritis and colitis. …”
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Microbial and molecular signatures for enhanced gut health in pigs fed a diet with spray-dried plasma as functional protein source by Soumya K. Kar, Dirkjan Schokker, Carine van Vuure, Herman van Iersel, Amy C. Harms, Amy C. Harms, Leo Kruijt, Mari A. Smits, Mari A. Smits, Alfons J. M. Jansman

“…Overall, our results highlight the nutritional and functional value of SDP as functional dietary protein source.…”
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Combined Effects of Exercise and Vitamin D on Neuroinflammation, Blood-Brain Barrier Integrity, Oxidative Stress, and Cognitive Function in Nonpathological Mice by Taewan Kim, Donghyun Kim, Yoonhwan Kim, Jeonghyeon Kim, Seamon Kang, Jinkyung Cho

“…Vitamin D treatment significantly increased plasma interleukin-10 and tight junction protein levels, while exercise alone elevated hippocampal tumor necrosis factor-α. …”
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Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. by Tale Sliedrecht, Chao Zhang, Kevan M Shokat, Geert J P L Kops

“…<h4>Background</h4>Proper execution of chromosome segregation relies on tight control of attachment of chromosomes to spindle microtubules. …”
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p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases by Madison E. Gamble, Sruthi Sureshkumar, Maria Janina Carrera Espinoza, Natalie L. Hakim, Claudia M. Espitia, Fangchao Bi, Kevin R. Kelly, Wei Wang, Steffan T. Nawrocki, Jennifer S. Carew

“…In this review, we detail the structural and functional roles of p47phox, mechanisms of its regulation, and its multifaceted contributions to disease pathogenesis. …”
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