Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis by Caroline Almeida Soares, João Gouveia Fiuza, Cláudio André Melo Rodrigues, Nuno Craveiro, Júlio Gil Pereira, Paula Cristina Ribeiro Fernandes Sousa, Diana Catarina Pinto Martins, Eugénia Maria Cancela, Maria Paula Ministro dos Santos

“…IBD is in fact a CV risk factor and tight inflammation control may reduce CV risk.…”
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Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets by Hongtu Li, Abraham Neelankal John, Takahiro Nagatake, Yoko Hamazaki, Fang‐Xu Jiang

“…The functional state (FS) of adult pancreatic islets is regulated by a large array of regulatory molecules including numerous transcription factors. …”
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A genome-wide association study of pulmonary function measures in the Framingham Heart Study. by Jemma B Wilk, Ting-Hsu Chen, Daniel J Gottlieb, Robert E Walter, Michael W Nagle, Brian J Brandler, Richard H Myers, Ingrid B Borecki, Edwin K Silverman, Scott T Weiss, George T O'Connor

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Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota by Jun Wen, Yue Wu, Fengfeng Zhang, Yanchu Wang, Aifen Yang, Wenwen Lu, Xiaofeng Zhao, Huaping Tao

“…Hypoxia caused significant structural abnormalities in the ileum and distal colon of neonatal mice, including increased numbers of F4/80+ cells (p = 0.0031), swollen mucus particles (p = 0.0119), and disrupted tight junction. At the genetic level, hypoxia caused dysregulation of the expression of genes involved in intestinal barrier function, including antimicrobial activity, immune response, intestinal motility, and nutrient absorption. …”
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Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function by Jinli Huang, Hongyu Qiao, Qiuhong Li, Yi Zhang, Chenyu Zhang, Hui Su, Xin Sun

“…In addition, gut structure was impaired, and expression of tight junction-related proteins was reduced in Spp1−/− mice, which disrupted gut barrier function. …”
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The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights by Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich

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When patient-reported respiratory symptoms shed light on pathophysiology in adult asthma: a cross-sectional study by Gilles Louis, Benoit Pétré, Bernardo Sousa-Pinto, Jean Bousquet, Éric Van Ganse, Florence Schleich, Renaud Louis

“…The intensity of asthma symptoms (dyspnea, wheezing, chest tightness, cough, and airway secretion) was measured using five-point Likert scales (5 expressing the greatest intensity). …”
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The effect of occlusal balance and prosthesis on occlusal function of patients after dental implant restoration by Yanli Zhang, Baorong Zhang

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DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers by Colm Doyle, Krzysztof Herka, Sean M. Flynn, Larry Melidis, Somdutta Dhir, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian

“…G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin interactions; however, the functional importance of G4s within enhancers remains unclear. …”
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Importance of the actual plant height in modulating the within-community spectrum of plant form and function by Dong He, En-Rong Yan, En-Rong Yan, Li-Ting Zheng, Yan-Jun Song, Xiao-Dong Yang, Wen-Hui You, J. Hans C. Cornelissen

“…Maximum height (Hmax) is a principal driver or correlate of interspecific variation in many plant functional traits. Still, it remains unclear why leaf resource economic traits are invariant with Hmax at global scale and why broad-scale interspecific trait correlations are not retained at local scale. …”
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Structutal-functional heart state in patients with henoch-schönlein purpura depending gallbladder condition by L. M. Strilchuk, О. М. Radchenko, S. M. Stadnik, A. L. Filipiuk, R. R. Guta

“…The heart and GB conditions in patients with HSP are tightly connected. The worsening of GB condition was accompanied by worsening of structural and functional heart parameters. …”
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Structural and functional investigation of DinG containing a 3′–5′ exonuclease domain by Tianwen Gao, Wanshan Hao, Jin Gao, Yiyang Sun, Yukang Sun, Jieyu Yang, Kaiying Cheng

“…These results support a model in which SaDinG functions as a coordinated nuclease-helicase machine specifically adapted for DNA crosslink repair, with its dual enzymatic activities being tightly regulated by physiological ATP concentrations.IMPORTANCEDNA helicases and exonucleases play essential roles in genome maintenance; however, little is known about bacterial helicase-exonuclease fusion proteins. …”
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In Vitro Prevention of Salmonella Lipopolysaccharide-Induced Damages in Epithelial Barrier Function by Various Lactobacillus Strains by Chun-Yan Yeung, Jen-Shiu Chiang Chiau, Wai-Tao Chan, Chun-Bin Jiang, Mei-Lien Cheng, Hsuan-Liang Liu, Hung-Chang Lee

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The effects of restraint stress and orthodontic tooth movements on the intestinal epithelial structure and metabolic function in rats. by Ye Cheng, Yue Li, Ziqing Fan, Nannan Wang, Min Wang, Yanfen Li, Chao Liu, Huang Li, Fuhua Yan

“…Colonic epithelial tissue disruption, mucus cells reduction, and a decreased expression of intestinal tight junction proteins were observed in the CO, SC, and SO groups. …”
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Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function by Celia Segui-Perez, Liane Z. X. Huang, Fernanda L. Paganelli, Elke Lievens, Karin Strijbis

“…We previously reported that the transmembrane mucin MUC13 localizes to the apical and lateral membrane and regulates epithelial tight junction strength. Here, we screened probiotic bacterial strains for their capacity to modulate MUC13 and enhance intestinal barrier function. …”
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Improved Hip Flexibility and Gluteal Function Following a Daily Lunge-and-Reach Stretching Intervention by Brent A. Ehresman, B.J. Lehecka, Damien Hiser, Levi Koster, Jessica Wietharn

“…# Background A sedentary lifestyle contributes to hip flexor tightness. Some evidence suggests that tight hip flexors may contribute to impairments in gluteal function…”
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α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance by Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Richard Pestell, Shinya Tanaka, Celine Malleval, Jerome Honnorat, Ahmed Idbaih, Lucie Martin, Hélène Castel, Frédéric Checler, Cristine Alves da Costa

“…Abstract Several studies have shown that Parkinson’s disease causative gene products, including α-synuclein (α-syn), display tight links with the tumor suppressor p53. The purpose of this study is to determine the implication of α-syn in glioblastoma development and elucidate how it elicits a tumor suppressor function. …”
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Dynamic Functional Ability in Lacrosse Players in Relation to Development of Sport-Related Onset of Musculoskeletal Pain by Zane Thompson, Joseph G. Wasser, Kevin R. Vincent, Heather K. Vincent

“…Thomas test (hip flexibility), Ober's test (iliotibial band tightness), and Ely's test (rectus femoris tightness) were performed. …”
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The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations by Beric R. Henderson

“…BRCA1 nuclear transport and ubiquitin E3 ligase enzymatic activity are tightly regulated by the BRCA1 dimeric binding partner BARD1 and further modulated by cancer mutations and diverse signaling pathways. …”
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Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis. by Radhika Mathur, James L Yen, Peter Kaiser

“…Abundance of substrate receptor subunits of Cullin-RING ubiquitin ligases (CRLs) is tightly controlled to maintain the full repertoire of CRLs. …”
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