The Association of Mitochondrial tRNACys G5783A Mutation with Major Depressive Disorder in Two Han Chinese Families by Jing P, Yu H, Sun W, Liang M, Xia T, Yang H, Chen P, Li J, Zhang X

“…Pan Jing,1,2 Haihang Yu,1,2 Wenxi Sun,3,4 Ming Liang,5 Tingting Xia,5 Haidong Yang,6 Peng Chen,3,4 Jin Li,3,4 Xiaobin Zhang3,4 1Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Department of psychiatry, Ningbo Kangning Hospital, Ningbo, People’s Republic of China; 3Department of Psychiatry, Suzhou Guangji Hospital, Suzhou, People’s Republic of China; 4Department of Psychiatry, Affiliated Guangji Hospital of Soochow University, Suzhou, People’s Republic of China; 5Department of Psychiatry, Xiangshan Third People’s Hospital, Ningbo, People’s Republic of China; 6Department of Psychiatry, Lianyungang Fourth People’s Hospital, Lianyungang, People’s Republic of ChinaCorrespondence: Xiaobin Zhang, Department of Psychiatric, Suzhou Guangji Hospital, 11 Guangqian Road, Suzhou, Jiangsu, 215003, People’s Republic of China, Email zhangxiaobim@163.comObjective: In this study, we examined the genetic, medical, and molecular traits of two Han Chinese families with the tRNACys G5783A mutation to investigate the relationship between mitochondrial DNA (mtDNA) mutations and major depressive disorder (MDD).Methods: Clinical data and comprehensive mitochondrial genomes were collected from the two families. …”
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Results of Cultural Adaptation of Cognitive Stimulation Therapy (CST) for Elderly and Old Age People with Cognitive Impairment in Russia by A.A. Shvedovskaya, I.F. Roshchina, M.V. Kalantarova, A.I. Khromov

“…The dynamics of the demographic situation in the country shows that by 2030, the older generation will make up almost a third of the population. At the same time, Russia is among the countries with the largest number of people with dementia. …”
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Factors and Reasons Associated with Hesitating to Seek Care for Migraine: Results of the OVERCOME (US) Study by Robert E. Shapiro, Eva Jolanda Muenzel, Robert A. Nicholson, Anthony J. Zagar, Michael L. Reed, Dawn C. Buse, Susan Hutchinson, Sait Ashina, Eric M. Pearlman, Richard B. Lipton

“…The most common reasons participants stated for hesitating included (1) 44.2% wanting to try and take care of migraine on their own, (2) 33.8% feeling that their migraine or headache would not be taken seriously, (3) 29.2% thinking that their migraine was not serious/painful enough, and (4) 27.4% not being able to afford it or not wanting to spend the money. …”
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Evaluation of an Interdisciplinary Educational Program to Foster Learning Health Systems: Education Evaluation by Sathana Dushyanthen, Nadia Izzati Zamri, Wendy Chapman, Daniel Capurro, Kayley Lyons

“…The course covered a number of topics including background on LHS, establishing learning communities, the design thinking process, data preparation and machine learning analysis, process modeling, clinical decision support, remote patient monitoring, evaluation, implementation, and digital transformation. …”
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Echoes of Strain: A Two-Year Longitudinal Study on the Impact of China’s Zero-COVID Policy on College Students’ Insomnia and Depressive Symptoms by Wang S, Zou X, Tang Q, Zhang L, Liu X, Liu G, Tao Y

“…Three contemporaneous symptom networks and two cross-lagged panel networks were constructed.Results: In the current sample, the prevalence of clinically significant depressive symptoms was 6.1%, 8.9%, and 7.7% during the first, second, and third waves, respectively. The prevalence of clinically significant insomnia symptoms was 8.1%, 13.0%, and 14.1%. …”
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PENERAPAN MODEL LEARNING CYCLE 5E DENGAN PENDEKATAN SAINTIFIK UNTUK MENINGKATKAN SIKAP ILMIAH DAN HASIL BELAJAR SISWA PADA KONSEP USAHA DAN ENERGI by Sari Daulay, Dedy Hamdani, Desy Hanisa Putri

“…The results showed that the average score of scientific attitudes in cycle I was 64,54 (good criteria), in cycle II was 66,23 (very good criteria), and at cycle III was 67,37 (very good criteria).The average value of the learning outcomes of work and energy concepts in the first cycle of 77.71 with learning mastery 88.57%, on the second cycle of 83 with 96.28% learning mastery, and on the third cycle 90.28 with 100% complete learning mastery. …”
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Prospective multi-centre analysis of rural trauma team development training for medical trainees and traffic law enforcement professionals in Uganda: an interrupted time series stu... by Herman Lule, Micheal Mugerwa, Robinson Ssebuufu, Patrick Kyamanywa, Jussi P. Posti, Michael Lowery Wilson

“…Results A total of 500 participants including: 66 (13.2%) traffic police officers, 30 (6.0%) intern doctors, 140 (28.0%) fifth year and 264 (52.8%) third-year medical students were trained. Among the 434 medical trainees who completed the trauma-based MCQ assessment, the median pre- and post-test scores were 60%, IQR (50–65) and 80%, IQR (70–85) respectively. …”
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ANAPUS GYVENIMO IR MIRTIES DUALIZMO: BUDISTINĖ EGZISTENCIJOS INTERPRETACIJA by Agnė Budriūnaitė

“…The buddhism offers another way of thinking by equalizing life and death and showing the illusiveness of ‘Self’. …”
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Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema by Sanjay Kumar Mishra, Pradeep Kumar, Amrita Joshi, Aman Saraf, Abhijeet Awasthi, Supriya Dhar, Khaleel M, Atul Kumar, Vipin Rana, Ravi D

“…The efficacy parameters included change in best corrected visusal acuity (BCVA), contrast and central macular thickness (CMT) on Optical Coherence Tomography. The average number of injections recd in each group were also calculated. …”
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Ethical education: Ways of moral consciousness development (understanding experience through Tyumen ethical and philosophical tradition) by E. N. Yarkova, A. G. Ivanov, Ya. V. Maltsev

“…The main methodological ideas were identified: the conjugation of the processes of the development of moral consciousness and a culture of thinking (F. A. Selivanov), the formation of moral consciousness through the actualisation of the opportunity to be a co-creator of public morality (V. …”
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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

“…Interpretation: In a nation-wide cohort of Lynch syndrome carriers, nearly one-third of eligible carriers did not undergo gynaecological surveillance. …”
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Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“… BackgroundPrimary intracranial germ cell tumors (iGCTs) are highly malignant brain tumors that predominantly occur in children and adolescents, with an incidence rate ranking third among primary brain tumors in East Asia (8%-15%). …”
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Sustainable development model toward environmentally friendly hospital by F, Aini, A. Irianto, S. Amar

“…Second, green innovation has a significant effect of 0.230 on the green hospital. Third, green human resource management has a significant effect of 0.235 on the green hospital. …”
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Phthalates toxicity in vivo to rats, mice, birds, and fish: A thematic scoping review by Mohammad Shah Alam, Zannatul Maowa, Mohammad Nazmol Hasan

“…Two authors independently extracted data using data extraction tools based on themes, while a third arbitrated if consensus was not met. A senior researcher developed the themes, which were further refined through discussions. …”
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MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…Background: Breast cancer had been the most frequently diagnosed cancer among women, making up nearly one-third of all female cancers. Hormone receptor-positive breast cancer (HR+BC) was the most prevalent subtype of breast cancer and exhibited significant heterogeneity. …”
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The Association of Retinal Disease with Vision Impairment and Functional Status in Medicare Patients by Vincent Garmo, Xiaohui Zhao, Carmen D. Ng, Aimee Near, Tania Banerji, Keiko Wada, Gary Oderda, Diana Brixner, Joseph Biskupiak, Ferhina S. Ali, Archad M. Khanani, Alicia Menezes, Ibrahim M. Abbass

“…Results: In patient cohorts with nAMD, DME, and RVO, approximately one-third (34.2%-38.3%) reported “a little trouble seeing” (vs 28.3% for controls), and 26%, 17%, and 9%, respectively, reported “a lot of trouble seeing/blindness” (vs 5% of controls). …”
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Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States by Ehab L. Atallah, Rodrigo Maegawa, Dominick Latremouille-Viau, Carmine Rossi, Annie Guérin, Eric Q. Wu, Pallavi Patwardhan

“…**Objectives:** Treatment patterns, healthcare resource utilization (HRU), and costs were evaluated among patients with CML who received third or later lines of therapy (3L+), a clinical population that has not been previously well-studied, with unmet treatment needs as TKI therapy has repeatedly failed. …”
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The added value and potential of long-term radio occultation data for climatological wind field monitoring by I. Nimac, J. Danzer, G. Kirchengast, G. Kirchengast

“…Second, to assess the possible added value of the RO-derived climatic winds in terms of their long-term stability, we test their consistency with the corresponding ERA5-derived winds. Third, by comparing the RO climatic winds to the original ERA5 winds, we evaluate the potential benefit of RO as an additional dataset for wind analyses and climate monitoring. …”
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To what extent are digital health interventions targeting HIV care cascade among mobile populations feasible, acceptable, and effective? A mixed methods systematic review protocol by Thulile Mathenjwa, Bessie Malila, Lucia Knight, Frank Tanser, Patricia Makwambeni, Tamsin K. Phillips

“…In case of disagreements, consensus will be sought from a third reviewer. Data synthesis will follow the Joanne Briggs Institute’s convergent segregated approach. …”
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Research on the deformation mechanism and law caused by the influence of seepage on foundation pit dewatering by Qingyuan Yang, Song Chen

“…The thickness of aquifer is relatively large, the aquifer is not completely isolated by the diaphragm wall, and the water flow inside and outside the foundation pit flows at the bottom of the diaphragm wall. …”
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