Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Treatment-emergent adverse events (TEAEs) were summarized through week 104. Results Of 313 patients randomized and treated, 224 (continuous upadacitinib n = 117; placebo/upadacitinib n = 107) completed 104 weeks of treatment. …”
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Efficacy of Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae) and Alternaria destruens (Ascomycota: Pleosporaceae) for managing Phenacoccus solenopsis Tinsley (Hemiptera:... by Mohamed El Aalaoui, Said Rammali, Fatima Zahra Kamal, Alin Ciobică, Bouchaib Bencharki, Abdellatif Rahim, Luminita Diana Hritcu, Laura Romila, Vasile Burlui, Mohamed Sbaghi

“…Treatment efficacy was evaluated weekly for five weeks, with predators released five days after fungal application. …”
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A systematic scoping review of latent class analysis applied to accelerometry-assessed physical activity and sedentary behavior. by Michael Kebede, Annie Green Howard, Yumeng Ren, Blake Anuskiewicz, Chongzhi Di, Melissa A Troester, Kelly R Evenson

“…The accelerometer-based variables in the LCA model included measures by day of the week (38%), weekday vs. weekend (13%), weekly average (13%), dichotomized minutes/day (13%), sex specific z-scores (13%), and hour-by-hour (13%). …”
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Postoperative Pain and Opiate Requirement is Increased Following Second-Side Surgery Among Patients Undergoing Staged Total Knee Arthroplasty by Vivek P. Chadayammuri, MD, Shuvalaxmi D. Haselton, MS, Elizabeth Diaz, PA-C, Roger H. Emerson, MD

“…Results: The mean interval between staged TKA was 8-weeks (standard deviation, 4.9-weeks). Preoperative VAS pain scores were significantly higher for the initial TKA, confirming that the more symptomatic knee was addressed first. …”
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Clinical course of spinal pain in adolescents: a feasibility study in a chiropractic setting by Steven J Kamper, Christopher G Maher, Mark J Hancock, Simon D French, Lise Hestbæk, Katherine A Pohlman, Michael S Swain, Laura RC Montgomery, Anika Young, Amber Beynon

“…Design Prospective feasibility study.Objectives To inform the design and conduct of a large-scale clinical cohort study investigating adolescents with moderate-to-severe spinal pain.Setting Chiropractic care in Sydney, Australia.Participants Adolescents aged 12–17 years with spinal pain (≥4/10 pain intensity score).Methods Adolescents and chiropractors completed baseline and week-12 follow-up questionnaires, with adolescents reporting pain intensity and recovery weekly via text messages during weeks 1–11. …”
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Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery by Jae Hyup Lee, Jin-Hyok Kim, Jin-Hwan Kim, Hak-Sun Kim, Woo-Kie Min, Ye-Soo Park, Kyu-Yeol Lee, Jung-Hee Lee

“…Patients received once-weekly BTDS (n=47; 5 μg/h titrated to 20 μg/h) or twice-daily TA (n=40; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks. …”
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Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis by Peter Anderson, Eileen F S Kaner, Jakob Manthey, Jürgen Rehm, Amy O'Donnell, Eva Jané Llopis

“…Objective To assess the immediate impact of the introduction of minimum unit pricing (MUP) in Scotland on alcohol consumption and whether the impact differed by sex, level of alcohol consumption, age, social grade and level of residential deprivation of respondents.Design Primary controlled interrupted time series analysis and secondary before-and-after analysis of the impact of introducing MUP in Scotland using alcohol consumption data for England as control.Setting Data from Kantar Worldpanel’s Alcovision survey, a continuous retrospective online timeline follow-back diary survey of the previous week’s alcohol consumption.Participants 53 347 women and 53 143 men.Interventions Introduction of a minimum price of 50 pence per UK unit (6.25 pence/g) for the sale of alcohol in Scotland on 1 May 2018.Main outcome measures Number of grams of alcohol consumed per week, in total, in off-trade (eg, at home) and in on-trade (eg, in pubs, restaurants).Results Primary interrupted time series analyses found that the introduction of MUP was associated with a drop in reported weekly total alcohol consumption of 5.94 g (95% CI 1.29 to 10.60), a drop in off-trade consumption of 3.27 g (95% CI −0.01 to 6.56) and a drop in on-trade consumption of 2.67 g (95% CI −1.48 to 6.82). …”
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Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

“…Objective Evaluate open-label sarilumab monotherapy in patients with rheumatoid arthritis switching from adalimumab monotherapy in MONARCH (NCT02332590); assess long-term safety and efficacy in patients continuing sarilumab during open-label extension (OLE).Methods During the 48-week OLE, patients received sarilumab 200 mg subcutaneously once every 2 weeks. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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Apoptosis in the liver of male <em>db/db</em> mice during the development of obesity and type 2 diabetes by S. V. Michurina, I. Yu. Ishchenko, S. A. Arkhipov, M. A. Cherepanova, D. V. Vasendin, E. L. Zavjalov

“…Homozygous males of BKS.Cg-Dock7mLeprdb/+/+/J mice (db/db mice) are characterized by progressive obesity and the development of type 2 diabetes mellitus (DM2) with severe hyperglycemia at 4–8 weeks and organ lesions at 8–10 weeks of age. The aim of this research was to study the expression of molecular cell regulators of apoptosis in liver cells of db/db mice males at different stages of obesity and diabetes development (at the age of 10 and 18 weeks). …”
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Growth and survival of giant gourami juvenile immerse indifferent frequencies using recombinant growth hormone by Aras Syazili, . Irmawati, . Alimuddin, Komar Sumantadinata

“…Fish were kept in 7L aquaria during the first four weeks, transferred into 50L aquaria for two weeks, and then in hapa (2×1×1 m3 in size) for two weeks. …”
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Effectiveness of Spinal Stabilization Exercises on Movement Performance in Adults with Chronic Low Back Pain by Khalid Alkhathami, Yousef Alshehre, Kelli Brizzolara, Mark Weber, Sharon Wang-Price

“…All participants received their assigned intervention under supervision one to two times per week for the first four weeks and then were asked to continue their program at home for another four weeks. …”
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Study Comparison between Alcoholic Extract of Broccoli, Folic Acid and Ferrous Sulfate Against Damage of the Cardiovascular System Induced by Lead-acetate in Rabbits by Dina S Dheyab, Jawad K Arrak, Majida A J Al-Qayim

“…The results after the 4th week in the 2nd,3rd, 4th and 5th groups demonstrated a significant elevation (p≤0.05) in Troponin I, and platelets count while at the 8th week of the treatments, the mean values of Troponin I and platelets count reduced significantly(p≤0.05) .On the contrary, prothrombin time significantly (p≤0.05) decreased in the 4th week of exposed lead acetate  and significantly(p≤0.05) increased in T1F,T2FS,T3B at the 8th week of the treatments. …”
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Natural fermentation of bitter gourd (Momordica charantia) and noni fruit (Morinda citrifolia) in honey increases total phenol, total flavonoid, and antioxidant activity by Guardiola Esther Natalia, Sumitro Sutiman Bambang, Widyarti Sri

“…Total phenol (TPC), total flavonoid content (TFC), and antioxidant activity were measured every two weeks. TPC in fermented NF increased from 56.62 mg GAE/gr to 156.59 GAE in the 6-week. …”
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Relapse prevention among Iranian people who smoke through cognitive behavioral intervention: application of Marlatt’s model by Shahnaz Hajisahneh, Sakineh Rakhshanderou, Yadollah Mehrabi, Emran Mohammad Razzaghi, Leili Mazar, Mohtasham Ghaffari

“…The intervention group received cognitive behavioral therapy smoking cessation based on the Marlatt’s model for 8 sessions and each session was one hour weekly, and the control group received routine smoking cessation treatment trough 7 one-hour weekly sessions. …”
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The Effects of Chlormadinone Acetate on Lower Urinary Tract Symptoms and Erectile Functions of Patients with Benign Prostatic Hyperplasia: A Prospective Multicenter Clinical Study by Kiyohide Fujimoto, Yoshihiko Hirao, Yasuo Ohashi, Yasuhiro Shibata, Kohzo Fuji, Hidenori Tsuji, Katsuhito Miyazawa, Mikinobu Ohtani, Ryoji Furuya, Eitetsu Boku

“…Significant improvements were observed in IPSS from week 8 to week 48 (32 weeks after treatment). IPSS-QOL improvements were also significant from week 8 to week 48. …”
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Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail by Ewa Tomaszewska, Kamil Drabik, Kornel Kasperek, Piotr Dobrowolski, Monika Hułas-Stasiak, Renata Pyz-Łukasik, Waldemar Paszkiewicz, Monika Ziomek, Janine Donaldson, Katarzyna Dobrowolska, Artur Burmaczuk, Justyna Batkowska, Marcin B. Arciszewski, Siemowit Muszyński

“…This study investigated the effects of dietary glutamine (Gln) supplementation on the performance, carcass characteristics, blood biochemistry, intestinal morphology, and gut microbiota of laying quail over a 12-week period, with analyses conducted after 6 and 12 weeks of supplementation. …”
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A comparison of the efficacy of the effect of online versus face-to-face group counseling based on positive-approach on sexual intimacy of women after benign abdominal hysterectomy... by Orly Nazanin Kalimi, Tayebeh Mokhtari Sorkhani, Ali Dehghani, Mahshid Bokaie

“…In the Face-to-Face Group, the mean score increased from 70.21 ± 6.75 to 81.24 ± 5.55 at eight weeks and 85.03 ± 5.40 at twelve weeks (P < 0.001). …”
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Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…This study assessed airborne lunar dust exposure in rats on localized pulmonary and systemic immune parameters.MethodsRats were exposed to 0 (air only), 20.8 (low), and 60.6 (high) mg/m3 of respirable-size lunar dust for 4 weeks (6 h/day, 5 days/week). Rats were then euthanized either 1 day, 7 days, 4 weeks, or 13 weeks after the last exposure. …”
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Dynamics of soil nitrogen availability indices in a sandy clay loam soil amended with animal manures by Habeebah Adewunmi Saka, Jamiu Oladipupo Azeez, Joy Nwakaego Odedina, Shade John Akinsete

“…Also, N15P15K15 (0.4 t ha−1) was incorporated in three splits of 2, 8 and 14 weeks after incorporation (WAI) of manures as reference. …”
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