Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model by Daisuke Kitano, Suguru Migita, Yuxin Li, Yutaka Koyama, Katsunori Fukumoto, Sayaka Shimodai-Yamada, Akira Onishi, Daiichiro Fuchimoto, Shunichi Suzuki, Yoshiyuki Nakamura, Atsushi Hirayama, Hiroyuki Hao, Yasuo Okumura

“…Animals underwent DES implantation, followed by four weeks of treatment with either edoxaban monotherapy (3 mg/kg/day) or the DAPT regimen (aspirin 100 mg/day and clopidogrel 75 mg/day). …”
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Optimizing Muscle Performance in Young Soccer Players: Exploring the Impact of Resisted Sprint Training and Its Relationship with Distance Covered by Felipe Hermosilla-Palma, Juan Francisco Loro-Ferrer, Pablo Merino-Muñoz, Nicolás Gómez-Álvarez, Rodrigo Zacca, Hugo Cerda-Kohler, Ciro Brito, Jorge Pérez-Contreras, Moacyr Portes-Junior, Esteban Aedo-Muñoz

“…The sample consisted of 24 young soccer players (15.3 ± 0.68 years; 61.4 ± 7.08 kg; 1.60 ± 0.06 m) randomized into three groups (10, 20, and 30 m) and subjected to 12 sessions of resisted sprint training over six weeks. The volume was homogenized across groups, with a total distance of 120 m for each. …”
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Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level by Karl E. Havens, Kang-Ren Jin, Andrew J. Rodusky, Bruce Sharfstein, Mark A. Brady, Therese L. East, Nenad Iricanin, R. Thomas James, Matthew C. Harwell, Alan D. Steinman

“…The operation was intended to achieve lower water levels for at least 8 weeks during the summer growing season, and was predicted to result in a large-scale recovery of submerged vascular plants. …”
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Gambaran Tekanan Darah Tikus Wistar Jantan dan Betina Setelah Pemberian Diet Tinggi Garam by Mutia Lailani, Zulkarnain Edward, Rahmatina B Herman

“…High-salt diet (8%NaCl, 3ml/day) was given to the P group for four weeks. Blood pressure increased significantly in group P compared to group K, systolic blood pressure (SBP) 191±17mmHg (P) and 168±16mmHg (K) in (p<0.05), diastolic blood pressure (DBP) 162±17mmHg (P) and 139±13mmHg (K) in (p<0.05), mean arterial pressure (MAP) 176±17mmHg (P) and 156±15mmHg (K) in (p<0.05). …”
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Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) by Jesús Villora, José Antonio Pérez, Nieves Guadalupe Acosta, Deiene Rodríguez-Barreto, Pedro Juan Alonso, Mónica B. Betancor, Alexandr Torres, Sergio Álvarez, Covadonga Rodríguez

“…To explore this hypothesis, 60 Canarian male chickens at 18 weeks of age were divided into three groups and fed diets differing only in their FA formulation: soy oil (SO) rich in linoleic acid (LA, 18:2n-6); linseed oil (LO) rich in ALA; and EO, a balanced LA/ALA oil also rich in SDA and γ-linolenic acid (GLA, 18:3n-6). …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Methods: One-year-old female Sert-/- mice and their wild-type (WT) littermates were subjected to a control diet (CD) or the WD for a duration of three weeks. The WD had a higher caloric content and was characterized by an elevated saturated fat content (21%) compared to the CD (4.5%) and contained 0.2% cholesterol. …”
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Protein digestibility and ammonia excretion in catfish Clarias gariepinus culture by Bambang Gunadi, Enang Harris, Eddy Supriyono, . Sukenda, Tatag Budiardi

“…The experiment was conducted for six weeks. The results showed that the protein digestibility was 61.97±7.24%. …”
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Characterization of probiotic Bacillus sp. NP5 metabolites and their effect on female catfish broodstock re-maturation by Valensia Enzeline, Widanarni Widanarni, Agus Oman Sudrajat, Alimudin Alimudin

“…The supplementation demonstrated the best reproductive performance at 108 CFU/g treatment, with an increased GSI (14.74%), HSI (1.65%), gonad maturity rate, percentage of mature eggs (86.00%), re-maturation period (4 weeks), percentage of matured broodstock (100%), fecundity (243,605 eggs/broodstock), FR (98.74%), HR (80.62%), and SR (87.31%). …”
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Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…In PWH, IL-7 administration leads to increased numbers of circulating central memory and naïve T-cell phenotypes.Methods In this multicenter phase I study with a 3+3 dose escalation design, participants with KS with or without HIV received up to four intramuscular injections of IL-7 (NT-I7) every 9 weeks. The primary endpoint of the study was to evaluate safety over three escalating dose levels (DL) of NT-I7 (DL1:480 µg/kg, DL2: 960 µg/kg and DL3: 1200 µg/kg) and identify a maximum tolerated dose. …”
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Effects of taurine on growth performance, body composition and physiological responses of western white shrimp, Litopenaeus vannamei broodstock by Vahid Morshedi, Mahmoud Nafisi Bahabadi, Mansour Torfi Mozanzadeh, Amin Oujifard, Naser Agh, Khalegh Maneii, Ahmad Qasemi, Nehzat Bakhshi, Hadi Ebrahimi, Rezvan Tamadoni, Shirin Hamedi, Reza Bagherpour, Fatemeh Solimani

“…Shrimp broodstock were disinfected with formalin (100 ppm, 30 s). Following two weeks of acclimatization to the husbandry system, the shrimp broodstock were placed in two 4000-L circular fiberglass tanks. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…The trials’ assessment time points were between 6 and 16 weeks after randomisation. Meta-analyses showed evidence of a beneficial effect of duloxetine on depressive symptoms (mean difference −1.81, Hamilton Depression Rating Scale (HDRS-17) points; 95% CI −2.34 to −1.28; heterogeneity I2=0.0%; 12 trials) and quality of life (mean difference −3.79 points, 95% CI −5.11 to −2.46; I2=0.0%; three trials), but the effect sizes were below our predefined minimal clinically important differences. …”
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Pre-existing IgG antibodies to HCoVs NL63 and OC43 Spike increased during the pandemic and after COVID-19 vaccination by Zahra Hasan, Kiran Iqbal Masood, Marc Veldhoen, Shama Qaiser, Marta Alenquer, Mishgan Akhtar, Sadaf Balouch, Junaid Iqbal, Yaqub Wassan, Shahneel Hussain, Khalid Feroz, Sajid Muhammad, Atif Habib, Akbar Kanji, Erum Khan, Afsar Ali Mian, Rabia Hussain, Maria Joao Amorim, Zulfiqar A. Bhutta

“…Vaccinees were sampled prior to vaccination as well after 6, 12 and 24 weeks after COVID-19 inactivated (Sinovac), or mRNA (BNT162b2) vaccine administration.PPC sera showed seropositivity of 15 % to SARS-CoV-2, whilst it was 45 % in the HC 2021 group. …”
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Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model by Emma Steijvers, Yunshong Shi, Hong Lu, Weixin Zhang, Yitian Zhang, Feihu Zhao, Baichuan Wang, Louise Hughes, Jake E. Barralet, Giulia Degli-Alessandrini, Igor Kraev, Richard Johnston, Zengwu Shao, Frank H. Ebetino, James T. Triffitt, R. Graham G. Russell, Davide Deganello, Xu Cao, Zhidao Xia

“…We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2–4 weeks. A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle. …”
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Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…Online assessments will be carried out at baseline, end of intervention and follow-up (weeks 0, 4 and 12 post-randomisation, respectively). …”
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Exploring the potential of black soldier fly live larvae as a sustainable protein source for laying hens: A comprehensive study on egg quality by Arianna Cattaneo, Erminia Sezzi, Marco Meneguz, Roberto Rosà, Davide Santori, Sofia Cucci, Rosalba Roccatello, Francesca Grosso, Stefano Mercandino, Valeria Zambotto, Eugenio Aprea, Pavel Solovyev, Luana Bontempo, Angela Trocino, Gerolamo Xiccato, Sihem Dabbou

“…To this aim, 108 Lohman Brown hens were housed in 27 cages (9 replicates per treatment, 4 birds per pen) and monitored between 16 and 34 weeks of age. The hens were split into three experimental groups: a control group fed a commercial diet, and two experimental groups fed the same commercial diet plus 15% or 30% of live BSFL, as fed basis on the expected daily feed intake (DFI). …”
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Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance by Alexandre Díaz-Pons, Sergio Castaño-Castaño, Víctor Ortiz-García de la Foz, Ángel Yorca-Ruiz, Carlos Martínez-Asensi, Eva Munarriz-Cuezva, Rosa Ayesa-Arriola

“…Neurodevelopment was assessed using the Neonatal Behavioral Assessment Scale (NBAS) at six weeks of age. Trimester of infection was considered in the main analyses. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…Only low-risk births were included (singleton, term-gestation [≥37 weeks], cephalic presentation, and first birth to exclude women who had a prior cesarean delivery). …”
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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

“…We conducted bulk RNA sequencing on peritoneal exudate cells (PECs) and spleen cells (SPC) at two and four weeks following adoptive cell transfer. We also analyzed cells from healthy, untreated mice. …”
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Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity by Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Reza Khorasani, Hamed Haghi-Aminjan, Mahdi Gholami, Mahban Rahimifard, Mona Navaei-Nigjeh, Mohammad Abdollahi

“…Methods: Forty-eight adult healthy male wistar rats aged 7–8 weeks were divided into eight for this research. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…A comprehensive analysis of the multi-level bioinformatic analysis, including protein-protein interactions (PPI) and functional pathways of the targets, was conducted, followed by verification through immunohistochemistry (IHC) to clarify SHSY’s pharmacological basis and action mechanisms in treating GD.ResultsAfter 8 weeks of treatment, SHSY significantly reduced serum T4 and TRAb levels in GD mice and enhanced the morphology of thyroid tissues. …”
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