Does digital, multimedia information increase recruitment and retention in a children’s wrist fracture treatment trial, and what do people think of it? A randomised controlled Stud... by Jacqueline M Martin-Kerry, Peter Knapp, Steven Higgins, Rebecca Sheridan, Juul Achten, Duncan Appelbe, Louise Spoors, Thirimon Moe-Byrne, Daniel Perry, Jenny Roche

“…Almost all FORCE recruits were retained at the 6 weeks’ timepoint and there was no difference in retention rate between the information groups: MMI (473; 99.6%); PIS (481; 99.4%).Conclusions MMI did not increase recruitment or retention in the FORCE trial, but participants rated multimedia as easier to understand and were more likely to evaluate it positively.Trial registration number ISRCTN73136092 and ISRCTN13955395.…”
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Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting by Stefania Ronzoni, Shamim Rashid, Aimee Santoro, Elad Mei-Dan, Jon Barrett, Nanette Okun, Tianhua Huang

“…Methods A prospective cohort study involved pregnant individuals undergoing nuchal translucency scans between 11 and 14 weeks. Risk for preterm preeclampsia was assessed using the Fetal Medicine Foundation algorithm, which includes maternal risk factors, uterine artery Doppler, mean arterial pressure and serum markers (Placental growth factor, PlGF and Pregnancy-associated plasma protein-A, PAPP-A). …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Moreover, animals administered the CBF at 200 mg/kg/day presented a significant decline in their body weight gain, adipose tissue weight, plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C) level, and glycaemia after 10 weeks’ treatment. Accordingly, the CBF decreased the plasma atherogenic index and the LDL-C to HDL-C ratio and reduced the level of fats accumulated in the liver. …”
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden by Filipa Sampaio, Alkistis Skalkidou, Gerhard Andersson, Cornelia Weise, Johanna M. Hoppe, Maria Kleinstaeuber, Johan Vegelius, Erika Comasco, Maria Gröndal, Elisavet Kaltsouni, Felicia Sundström, Monica Buhrman

“…The current study aims to evaluate the effects and cost-effectiveness of an internet-delivered CBT (ICBT) intervention for PMDD incorporating skills training in emotion regulation and interpersonal effectiveness.Methods and analysis The study is a parallel two-group randomised controlled trial with 1:1 allocation to 8 weeks of therapist-guided ICBT or a waitlist control condition. …”
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JinQi Jiangtang Tablet Regulates Gut Microbiota and Improve Insulin Sensitivity in Type 2 Diabetes Mice by Ying Cao, Guowang Yao, Yuanyuan Sheng, Li Yang, Zixuan Wang, Zhen Yang, Pengwei Zhuang, Yanjun Zhang

“…Diabetic mice were orally treated with JQJT tablets for 5 weeks. Fasting blood glucose and the level of HbA1c were measured, and ITT were conducted to determine the insulin improvement effect of JQJT tablets. …”
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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…We hypothesized that: (1) applying melanoma-derived peptides topically, in proximity to LC, could be immunogenic and safe, with low vaccine-site toxicity and (2) topical toll-like receptor 7 (TLR7) agonist would increase immunogenicity of the peptide vaccine.Methods Twelve melanoma peptides plus a tetanus helper peptide were combined with granulocyte macrophage colony stimulating factor (GM-CSF) and were administered topically on days 1, 8, and 15, to 28 patients randomized to one of four adjuvant preparations: (1) incomplete Freund’s adjuvant (IFA); (2) IFA plus a TLR7 agonist (imiquimod) administered on days 0, 7, 14; (3) dimethyl sulfoxide (DMSO) or (4) DMSO+ imiquimod administered on day 0, 7, 14. Every 3 weeks thereafter (x 6), the peptides were combined with GM-CSF and were injected into the dermis and subcutis in an emulsion with IFA. …”
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Dim blue light at night worsens high-fat diet-induced kidney damage via increasing corticosterone levels and modulating the expression of circadian clock genes by Wenji Ren, Zixu Wang, Yulan Dong, Jing Cao, Ting Gao, Qingyun Guo, Yaoxing Chen

“…Herein, we fed mice a high-fat diet and gave them dim white (dWL), blue (dBL), green (dGL), and red (dRL) light for 12 weeks. Our results showed that both dWL and dBL tended to be more susceptible to damage to kidney dysfunction caused by a high-fat diet compared to LD, with more pronounced changes in dBL. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

“…After modeling, AS of 15 and 30 mg/kg was intraperitoneally injected into the mice of the AS15 and AS30 groups, respectively, and 200 mg/kg Met was given to those of the Met group by gavage, once per day, for 6 weeks. ELISA was used to detect serum testosterone (T), fasting insulin (FINS), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the LH/FSH ratio was calculated. …”
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Global disparities in cancer supportive care: An international survey by Alexandre Chan, Lawson Eng, Changchuan Jiang, Mary Dagsi, Yu Ke, Mary Tanay, Cristiane Bergerot, Niharika Dixit, Ana Cardeña Gutiérrez, Ana I. Velazquez, Farhad Islami, Enrique Soto‐Perez‐de‐Celis

“…The survey, available for 3 weeks, comprised sections covering (1) sociodemographic information; (2) clinical service/practice‐related disparities in their region/nation; (3) population groups facing disparities within their region or country. …”
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Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment by Sulai Liu, Xinyu Liu, Xuepeng Li, Ou Li, Weimin Yi, Junaid Khan, Pingzhou Yang, Chao Guo, Chuang Peng, Bo Jiang

“…One patient developed bile leakage after surgery, healed within 2 weeks after drainage. The postoperative hospital stay was 16 (13-24) days. …”
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Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining by Kristian Kjærgaard, Chris H. Dreyer, Nicholas Ditzel, Christina M. Andreasen, Li Chen, Søren P. Sheikh, Søren Overgaard, Ming Ding

“…The doses of cells in the implants were 0.5 × 106, 1.0 × 106, or 1.5 × 106 A-CEAC and 0.5 × 106 BM-CEAC, respectively. After eight weeks, bone volume versus total tissue volume (BV/TV) was quantified using histomorphometry. …”
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Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Animals were then exposed to electric fields (100 kHz, 50-60 V/m) for 10 hours a day for three weeks. Two kidney samples and two liver samples from different animals in each group were collected for observation of structural damage to the organs. …”
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Healthcare resource utilisation and costs of hospitalisation and primary care among adults with COVID-19 in England: a population-based cohort study by Carmen Tsang, Robert Wood, Tendai Mugwagwa, Kiran K Rai, Jingyan Yang, Theo Tritton, Jennifer L Nguyen, Kathleen Michelle Andersen, Maya Reimbaeva, Leah J McGrath, Poppy Payne, Bethany Emma Backhouse, Diana Mendes, Rebecca Butfield, Kevin Naicker, Mary Araghi

“…Patients with a COVID-19-related hospitalisation within 84 days of a positive test were included in the hospitalised cohort.Main outcome measures Primary and secondary care HCRU and associated costs ≤4 weeks following positive COVID-19 test, stratified by age group, risk of severe COVID-19 and immunocompromised status.Results Among the hospitalised cohort, average length of stay, including critical care stays, was longer in older adults. …”
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The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…Female E3L.GK+/−, E3L, and GK+/− mice were fed fat- and cholesterol-containing diets for 37 weeks, and plasma parameters were measured throughout. …”
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Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association wi... by Aamina Alim, Ting Li, Tanzeela Nisar, Zeshan Ali, Daoyuan Ren, Yueyue Liu, Xingbin Yang

“…In general, the above abnormalities were improved after 10 weeks intervention of ACF, ACP, and ACFP. Especially, ACFP considerably ameliorated HF-induced abnormal changes in body weight gain, serum TC, TG, LDL-C and HDL-C levels, as well as serum and hepatic SFAs, MUFAs and PUFAs contents. …”
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Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia by V. T. Ivashkin, I. V. Maev, Yu. A. Shelygin, E. K. Baranskaya, S. S. Belous, E. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. V. Veselov, E. G. Grigoryev, N. V. Kostenko, V. N. Kashnikov, V. F. Kulikovskiy, I. D. Loranskaya, O. S. Lyashenko, E. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, O. Yu. Fomenko, D. A. Khubezov, E. Yu. Chashkova, G. I. Chibisov, M. V. Shapina, A. A. Sheptulin, O. S. Shifrin, A. S. Trukhmanov, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, O. Yu. Zolnikova, N. V. Korochanskaya, S. N. Mammayev, I. B. Khlynov, V. V. Tsukanov

“…IBS is a functional bowel disorder manifested with recurrent, at least weekly, abdominal pain with the following attributes (any two leastwise): link to defecation, its frequency or stool shape. …”
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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016–2021) by El Khalef Ishagh, Marc Talatou Ouédraogo, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N.’Zue Kofi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Charles S. Wiysonge, Blanche-Philomene Melanga Anya, Manengu Casimir Tshikolasoni

“…The data included information about the person's background, vaccinations, medical history, cVDPV, AFP cases, stool samples, how quickly AFP cases were reported, how complete weekly zero reporting (WZR) was, and non-polio enteroviruses (NPEV). …”
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Effect of nonsteroidal anti-inflammatory drugs on neonatal calf diarrhea when administered at a disease alert generated by automated milk feeders by A. Welk, M.C. Cantor, H.W. Neave, J.H.C. Costa, J.L. Morrison, C.B. Winder, D.L. Renaud

“…Body weight was recorded at birth and weekly thereafter. A subset of calves (n = 32) were fitted with IceQube pedometers at 3 d of age to measure activity behaviors (lying time and step count). …”
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Relation among zootechnical performance, biochemical indicators, water quality, and small invertebrates (zooplankton) abundance reared in biofloc-supplemented systems by Ahmed Said Al-Souti, Marwa M. Zaher, Amr M. Helal, Dina T. Meshhal, Mansour D. H., Afify D. G. Al-Afify, Mohamed M. Rafaey, Abeer El-Saharty, Ehab El-Haroun, Marian G. Nassif, Abdallah Tageldein Mansour, Abdallah Tageldein Mansour, Mohamed Ashour

“…Fish weights were recorded weekly to adjust the feeding rate at 3% of their biomass using a commercial diet. …”
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Modelling the seasonal dynamics of Aedes albopictus populations using a spatio-temporal stacked machine learning model by Daniele Da Re, Giovanni Marini, Carmelo Bonannella, Fabrizio Laurini, Mattia Manica, Nikoleta Anicic, Alessandro Albieri, Paola Angelini, Daniele Arnoldi, Federica Bertola, Beniamino Caputo, Claudio De Liberato, Alessandra della Torre, Eleonora Flacio, Alessandra Franceschini, Francesco Gradoni, Përparim Kadriaj, Valeria Lencioni, Irene Del Lesto, Francesco La Russa, Riccardo Paolo Lia, Fabrizio Montarsi, Domenico Otranto, Gregory L’Ambert, Annapaola Rizzoli, Pasquale Rombolà, Federico Romiti, Gionata Stancher, Alessandra Torina, Enkelejda Velo, Chiara Virgillito, Fabiana Zandonai, Roberto Rosà

“…In our study, we utilized a recently published dataset documenting egg abundance observations of Aedes albopictus collected using ovitraps. and a set of environmental predictors to forecast the weekly median number of mosquito eggs using a stacked machine learning model. …”
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