Evaluating the Effectiveness, Safety, and Satisfaction Rates of Phenol 90%, Trichloroacetic Acid 100%, and Radiofrequency in Lateral Matricectomy for the Treatment of Ingrown Toena... by Mohammadreza Ghassemi, Zahra Keshavarz, Elham Behrangi, Afsaneh Sadeghzadeh Bazargan, Alireza Jafarzadeh, Azadeh Goodarzi

“…Preoperative assessments were conducted, and patients were followed up on the day after surgery and at Weeks 1, 2, and 3, as well as at Months 1, 2, 6, and 9 postoperatively (totaling nine assessments). …”
Get full text

Muscle metabolism in response to oxidized fish oil feed in juvenile Nile tilapia by Xinyuan Li, Lili Chen, Hua Wen, Xuan Wang, Di Peng, Jianmin Zhang, Yangyang Liu, Ming Jiang, Lixue Dong, Feng Huang, Juan Tian

“…To investigate the effect of oxidized fish oil on fish muscle metabolic responses and flesh quality, Nile tilapia (Oreochromis niloticus) weighing 13.73 ​± ​0.31 ​g were fed two diets for 12 weeks: a fresh fish oil (FFO) and a highly oxidized fish oil (OFO) diet. …”
Get full text

The Patient-Reported Outcomes Thermometer–5-Item Scale (5T-PROs): Validation of a New Tool for the Quick Assessment of Overall Health Status in Painful Rheumatic Diseases by Fausto Salaffi, Marco Di Carlo, Marina Carotti, Sonia Farah

“…The 5T-PROs was also administered a second time (two weeks after the initial administration) to a subset of sample (n = 426) to allow for calculation of test-retest reliability. …”
Get full text

The Acute VertEbRal AugmentaTion (AVERT) study: protocol for a randomised controlled, feasibility trial of spinal medial branch nerve block in hospitalised older patients with vert... by Avril Drummond, Opinder Sahota, Simon Bishop, Dritan Pasku, Apostolos Fakis, Anastasios Bastounis, Chia Wei Tan, Maribel Cameron, Yuriy Arlachov, Michal Czernicki

“…We therefore propose a prospective feasibility randomised controlled trial (RCT) to compare the role of MBNB to VP, in hospitalised older patients.Method A parallel, two-arm RCT with participants allocated on a 1:1 ratio to either standard care-VP or MBNB in hospitalised patients aged over 70 with acute osteoporotic vertebral fractures. Follow-up will be at weeks 1, 4 and 8 post intervention. The primary objective is to determine the feasibility and design of a future trial, including specific outcomes of recruitment, adherence to randomisation and safety. …”
Get full text

Effect of diet containing alfalfa (Medicago sativa) powder and leaf extract on hemolymph factors of western whiteleg shrimp (Litopenaeus vannamei) under low salinity stress by Kobra Babanejad Abkenar, Arash Akbarzadeh, Ahmad Noori, Mohammad Niroomand

“…Materials and methods: Shrimp were fed in seven treatments with three replications, including control (without ALP and ALE), ALP (60, 120, and 180 g/kg), and ALE (6, 12, and 18 g/kg) for nine weeks. Then, the shrimp were subjected to salinity stress at five ppt for 48 hours. …”
Get full text

IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…To evaluate the impact of IGF-1 deficiencies on interneuron development, IGF-1R levels were reduced in the neocortex of neonatal conditional IGF-1R knock out mice by viral injections. Four weeks later, this experimental maneuver resulted in similar reductions in interneuron connectivity. …”
Get full text

Perioperative outcomes of video-assisted versus right anterior thoracotomy mitral valve replacement: an observational study by Gehad Awad, Fetoh Alaaeldin Fetoh, Noureldin Noaman Gwely, Usama Hamza, Sameh Amer, Yomna Mohammed Yehya, Amr Abdellateef

“…There was a gradual reduction in VAS in both groups along the period of 3 months postoperatively without significant differences between the two groups in 2 weeks and 3 months postoperatively. Conclusions VAMVR and ATMVR could be considered safe, feasible approaches with favorable perioperative surgical and echocardiographic results. …”
Get full text

Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The mean sternal notch-to-nipple and upper breast-to-nipple distances decreased postoperatively by 22% and 43%, respectively, and remained stable over a mean time of 110.1 ± 65.58 weeks. The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. …”
Get full text

Diagnosis and Treatment of Sepsis in a Fourteen-year-old Patient: A case study of pulmonary inflammatory discharge without typical features of respiratory tract infection by Bartłomiej Żaczek, Jakub Kozłowski, Alicja Kamińska, Wojciech Kupczak, Kinga Bujak, Aleksandra Kocjan, Ismael Alsoubie, Natalie Papachristoforou, Wojciech Kaźmierski, Mateusz Ziomek, Paulina Lis, Marta Czubaj-Kowal

“…This article presents the case of a 14-year-old patient who was admitted to the Paediatric Unit due to a high fever (up to 42 degrees Celsius) lasting from five days and severe pain in the area of the lower ribs on the left side, at the site of an injury that occurred two weeks earlier. Conclusion. In the case of unclear symptoms of high fever and indicators of inflammation, a broad diagnostic spectrum is necessary, including imaging and laboratory tests and specialist consultations. …”
Get full text

Intrauterine growth‐restricted pregnant rats, from placental ischemic dams, display preeclamptic‐like symptoms: A new rat model of preeclampsia by Jonna Smith, Madison Powell, Whitney Cromartie, Savanna Smith, Kylie Jones, Angie Castillo, Jordan Shaw, Joseph Editone III, Ahfiya Howard, Robert Tatum, Alex Smith, Brandon Fisher, George W. Booz, Mark Cunningham

“…Offspring from NP and RUPP dams were mated at 10 weeks of age to generate pregnant IUGR (IUGR Preg) and pregnant control (CON Preg) rats. …”
Get full text

Deriving and validating a risk prediction model for long COVID-19: protocol for an observational cohort study using linked Scottish data by Jennifer K Quint, Aziz Sheikh, Chris Robertson, Srinivasa Vittal Katikireddi, Emily Moore, Colin R Simpson, Luke Daines, Eleftheria Vasileiou, Syed Ahmar Shah, Rachel H Mulholland, Vicky Hammersley, Steven Kerr, Ting Shi, David Weatherill, Elisa Pesenti

“…Introduction COVID-19 is commonly experienced as an acute illness, yet some people continue to have symptoms that persist for weeks, or months (commonly referred to as ‘long-COVID’). …”
Get full text

Preliminary Effectiveness of a Telehealth-Delivered Exercise Program in Older Adults Living With and Beyond Cancer: Retrospective Study by Emily R Dunston, Sonal Oza, Yang Bai, Maria Newton, Leslie Podlog, Kish Larson, Darren Walker, Rebecca W Zingg, Pamela A Hansen, Adriana M Coletta

“…All baseline measures were repeated after 12-weeks of telehealth exercise. Change scores were calculated for all assessments and compared to minimal clinically important difference (MCID) values for assessments with published MCIDs. …”
Get full text

FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents by Gabrielle Araujo do Nascimento, Neiva Leite, Lupe Furtado-Alle, Mayza Dalcin Teixeira, Ricardo Lehtonen Rodrigues de Souza, Gerusa Eisfeld Milano, Larissa Rosa da Silva, Juliana Pizzi, Wendell Arthur Lopes, Maria de Fátima Aguiar Lopes, Ana Cláudia Kapp Titski, Luciane Viater Tureck

“…The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. …”
Get full text

Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptoz... by Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen

“…Rats were randomly divided into normal control rats (NC group), diabetic rats without drug treatment (DM group), and diabetic rats treated with TGT (1, 3, or 6 mg/kg/day, respectively) for 8 weeks. The results showed that 24 h proteinuria and urinary N-acetyl-glucosaminidase (NAG) in diabetic rats were decreased by TGT treatment without affecting blood glucose. …”
Get full text

Exploring the Role of Salt Supplementation on Milk Composition, Fatty Acids, and Insulin Response in Lactating Camels by Riyadh S. Aljumaah, Ahmed A. K. Salama, Mutassim M. Abdelrahman, Moez Ayadi, Gerardo Caja, Mohammed A. Alshaikh, Mohammed A. Al-Badwi, Abdulkareem M. Matar

“…Twelve multiparous female camels were used in a crossover design with two treatments: control concentrate (CON; 1.3% salt) and high-salt concentrate (SAL; 3.9% salt). Each period lasted 3 weeks, with camels switched between treatments in the second period. …”
Get full text

Trends in depressive symptoms among high school students with and without health-risk behaviors in the United States: A population-based studyResearch in context by Tanner J. Bommersbach, Mark Olfson, Taeho Greg Rhee

“…Depressive symptoms were defined as past-year feelings of sadness/hopelessness almost every day for ≥2 weeks impacting usual activities. 24 health-risk behaviors across five categories (violence, substance use, sexual, physical/sedentary, and weight-related) were considered. …”
Get full text

Elements of Success After Metatarsectomy Healing of Neuropathic Diabetic Foot Ulcers by Hossein Hemmati, Behrang Motamed, Sedighe Masoudi Taramsari, Mohammad Taghi Ashoobi, Mohaya Farzin, Habib Eslami Kenarsari, Rastin Hosseinzaeh Asli, Zahra Abbasi Ranjbar, Milad Sarafi

“…Patients were followed up for two weeks, one month, and three months after surgery and were evaluated for complete recovery, partial recovery, and no response. …”
Get full text

Subchronic cyanuric acid treatment impairs spatial flexible behavior in female adolescent rats through depressing GluN2B-dependent neuronal and synaptic function by Wei Sun, Haiyang Yu, Xiaoliang Li, Yiwen Wan, Yazi Mei, Yang Yang, Lei An

“…CA was intraperitoneal treated with 20 or 40 mg/kg/day to adolescent female rats for 4 consecutive weeks. Multiple behavioral tests were employed to assess spatial cognition, learning strategy, locomotion and motivation. …”
Get full text

The effects of diacylglycerol edible oil intervention in patients with chronic metabolic syndrome combined with asymptomatic hyperuricemia: study protocol for a multicenter, prospe... by Gui-yu Li, Cui-feng Zhu, Zhao-qi Huang, Chun-li Piao, Jia-jun Yu, Li Wang, Qiang Zeng, Yu-yu Lei, Yue Li, Xiao-ling Zhu, Zhen-tian Zhang, Tian-hua Huang, Meng-shuang Li, Shu-zhong Lin, Nai-wen Zhang, Fangyingnan Zhang, Yong-hua Wang, Dan-ping Xu

“…Group A will receive DAG-rich oil (≥ 80%) and group B will receive conventional cooking oil (triacylglycerol (TAG)-rich oil) for 12 weeks. Serum uric acid level is the primary outcome. …”
Get full text

First-in-human phase 1 study of the arginase inhibitor INCB001158 alone or combined with pembrolizumab in patients with advanced or metastatic solid tumours by Michael Smith, Aung Naing, Todd Bauer, Kyriakos P Papadopoulos, Osama Rahma, Elena Garralda, Glenn J Hanna, Michael J Pishvaian, Xuejun Chen, Sven Gogov, Omar Saavedra, Howard Kallender, LuLu Cheng, Emil Kuriakose

“…Objective The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.Methods and analysis In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion was conducted in tumour-type cohorts (with or without prior anti−PD-1/PD-L1 (programmed death protein 1/programmed death ligand 1) therapy).Results A total of 107 patients received INCB001158 50–150 mg two times per day as monotherapy, and 153 patients, including 6 with moderate renal impairment, received INCB001158 50–100 mg two times per day combined with pembrolizumab. …”
Get full text