Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets by Chun-Mei Wang, Ying-Jie Chen, Bo-Cheng Yang, Jia-Wen Yang, Wei Wang, Yang Zeng, Jun Jiang

“…Some research has suggested that vitamin D3 supplementation reduces thyroid inflammation, but this remains controversial.MethodsEAT was induced in female NOD/ShiLtJ mice by giving them water containing 0.05% sodium iodide, and 1μg/kg of 1α,25-(OH)2D3 was injected intraperitoneally every other day. After 8 weeks, the morphological architecture of the mouse thyroid follicles was examined by histological sections, thyroid autoantibodies and thyroid hormone concentrations were determined by enzyme-linked immunosorbent assays (ELISAs), and the major functions and subsets of B- and T-lymphocytes in the mouse thyroid were determined by tissue multiple immunofluorescence technology and ELISA.ResultsEAT caused thyroiditis follicle destruction and interfollicular lymphocyte infiltration in mice, increased concentrations of circulating thyroid autoimmune antibodies TG-Ab and TPO-Ab, and abnormal thyroid hormone levels. …”
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TEACHERS’ PROFILE, MOTIVATION, APTITUDE, AND SATISFACTION IN A VIRTUAL UPSKILLING ENVIRONMENT by Dave E. Marcial, Jan Cynth Palama, Fredlie Bucog, Steven Binarao

“…This online upskilling course ran for nine weeks. The core objective of this training program was to equip these educators with literacy and knowledge-deepening skills in online distance teaching. …”
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Effects of Acidification and Preservatives on Microbial Growth during Storage of Orange Fleshed Sweet Potato Puree by Joyce Ndunge Musyoka, George Ooko Abong', Daniel Mahuga Mbogo, Richard Fuchs, Jan Low, Simon Heck, Tawanda Muzhingi

“…Samples were inoculated with Escherichia coli and Staphylococcus aureus at levels of 5.2 x 109 cfu/100g and 1.5 x 109 cfu/100g, respectively, before being evaluated during storage for 10 weeks at prevailing ambient temperature (15-25°C) and refrigeration temperature (4°C). …”
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Salinity affects the lipid metabolism and intestinal microbial composition of swimming crab Portunus trituberculatus by Meimei Liu, Tong Li, Hao Zhang, Zi Wang, Xugan Wu, Jie He, Zhiguo Dong

“…This study investigated the hepatopancreatic index, hepatopancreatic lipid metabolism, physiological and biochemical indicators and gut microbiota of P. trituberculatus cultured at salinity 28 ‰, 25 ‰, 22 ‰ and 19 ‰ for 8 weeks. The results showed that the highest expression level of SREBP1, FAS, LPR1, ACOX and FABP was found in 19 ‰ group compared to the 28 ‰ group, along with the enzyme activities of CPT1 and FAS. …”
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A high offset stem design does not increase stem migration under full weight bearing in cementless total hip arthroplasty: a model-based RSA study by Tobias Reiner, Robert Sonntag, Jan Philippe Kretzer, Michael Clarius, Eike Jakubowitz, Stefan Weiss, Stefan Kinkel, Tilman Walker, Tobias Gotterbarm, Timo Albert Nees

“…Radiostereometric analysis (RSA) was employed to monitor stem migration at six weeks and three, six, twelve, and twenty-four months. …”
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Pulsed Radiofrequency of the Trigeminal Ganglion for Treating Postherpetic Neuralgia of the Ophthalmic Branch by Dong-Yang Liu, Jin-Sheng Chen, Ze-Zang Fang, Shao-Yan Liu, Li Wan

“…Only two patients had a recurrence of the severe burning pain and returned to the hospital for other medical therapies 2 weeks after the PRF procedure. No patient lost the corneal reflex. …”
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Characterization of Vaginitis Among Women Complaining of Genital Tract Symptoms by Hemin Muheddin Kareem, Muhammed Saed Qadir, Safa Bakr Karim, Solaf Jawhar Ali

“…In addition, the treatment of vaginitis can be done by topical application of Lidocaine 5% ointment (as a local anesthetic) nightly for seven weeks has been shown to decrease the pain of vaginitis in women.   …”
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Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Osteochondral explants were isolated from macroscopically preserved and lesioned areas of the joint and were kept in culture for two weeks, with or without exposure to 200ng/ml hrIL11. …”
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Maternal and Neonatal Outcomes of Syrian Adolescent Refugees and Local Adolescent Turkish Citizens: A Comparative Study at a Tertiary Care Maternity Hospital in Türkiye by Ceren Golbasi, Tayfun Vural, Burak Bayraktar, Hakan Golbasi, Alkim Gulsah Sahingoz Yildirim

“…Preterm birth rates and late preterm delivery prevalence (34-37 gestational weeks) were significantly higher in the adolescent Syrian immigrants' compared to the adolescent Turkish locals (p<0.001 and p<0.001, respectively). …”
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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir. by Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker

“…Calculated reactivation rates per pre-ART pVL were highest for RMs starting ART on days 5, 6, and 7 after which the rate of accumulation of the RCVR markedly decreased for RMs treated on days 9 and 12, consistent with multiphasic establishment and near saturation of the RCVR within 2 weeks post infection. Taken together, these data highlight the heterogeneity of the RCVR between RMs, the stochastic establishment of the very early RCVR, and the saturability of the RCVR prior to peak viral infection.…”
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Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention by Wan Zhou, Shan-Dong Ye, Chao Chen, Wei Wang

“…Compared with group NC, the levels of RBP4, TG, LDL-c, FPG, FINS, CRP, AI1, AI2, SBP, and HOMA-IR increased, while the levels of HDL-c, 25(OH)D, and HOMA-β decreased in groups DM1 and DM2. After 8 weeks of vitamin D supplementation in group DM3, the levels of 25(OH)D and HOMA-β increased and the levels of LDL-c, TC, HOMA-IR, FINS, CRP, RBP4, AI1, AI2, and SBP decreased significantly when compared with group DM2 (P<0.05); Pearson analysis showed that serum RBP4 was positively correlated with TG, FINS, HOMA-IR, SBP, CRP, and AI and negatively correlated with 25(OH)D. …”
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Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, A. A. Sheptulin, I. V. Mayev, Ye. K. Baranskaya, A. S. Trukhmanov, T. L. Lapina, S. G. Burkov, A. V. Kalinin, A. V. Tkachev

“…The efficacy control of antihelicobacter treatment should be carried out not earlier than 4 weeks after the end of eradication. Conclusion. Strict conformance of diagnostic algorithm for this category of patients as well as the eradication therapy protocol allows to decrease considerably the risk of recurrence of PUD and its complications.…”
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Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice by Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang

“…Administration of NST (40, 80 and 160 mg/kg) and the positive control of estradiol valerate (0.2 mg/kg) for 8 weeks significantly prevented bone loss induced by ovariectomy (OVX), increased the bone mass density (BMD), improved the bone microarchitecture and reduced urine calcium and deoxypyridinoline (DPD) in ovariectomized mice, while inhibited the increase of body weight without significantly affecting the uterus weight. …”
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Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

“…Liver biopsy confirmed disease recurrence; she received supportive treatment and unfortunately she died 2 weeks later. Conclusion. HEHE can have rapid and aggressive recurrence after liver transplantation.…”
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Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes by Bing-li Liu, Guo-ping Yin, Feng-fei Li, Yun Hu, Jin-dan Wu, Mao-yuan Chen, Lei Ye, Xiao-fei Su, Jian-hua Ma

“…Treatments were maintained for 2-3 weeks after the glycaemic target was reached. C-peptide and insulin and fructosamine were determined. …”
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Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs by Bryan Tegner Jacobson, Jessica DeWit-Dibbert, LaShae Zanca, Sobha Sonar, Carol Hardy, Michael Throolin, Patricia C. Brewster, Kaitlyn Andujo, Kerri Jones, Jonathon Sago, Stephen Smith, Lizabeth Bowen, Diane Bimczok

“…Lambs were inoculated with PBS (control) or with ceftiofur-treated nasal wash fluid obtained from sheep with natural M. ovipneumoniae infection, monitored for eight weeks, and subsequently euthanized. All lambs in the URT and LRT groups developed a stable infection with M. ovipneumoniae. …”
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Swiss chiropractic practice-based research network and musculoskeletal pain cohort pilot study: protocol of a nationwide resource to advance musculoskeletal health services researc... by Milo A Puhan, Viktor von Wyl, Alice Kongsted, Cesar A Hincapié, Léonie Hofstetter, Rahim Lalji

“…Surveys will be provided to patients prior to their initial consultation in clinics, 1 hour after initial consultation, and at 2, 6 and 12 weeks after initial consultation.Ethics and dissemination Ethics approval has been obtained from the independent research ethics committee of Canton Zurich (BASEC-Nr: 2021-01479). …”
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Evaluation of the relationship between worry and anxiety with the general health status of pregnant women at risk of diagnosing abnormalities by Maryam Hassanzadeh Bashtian, Morvarid Irani, Alireza Afshari-Safavi, Fatemeh Keramati, Roya Ram, Tooba Farazmand

“…Methods This descriptive-analytical cross-sectional study was conducted on 275 pregnant women with a gestational age of 16 to 18 weeks. They were referred by health centers, midwives, or gynecologists to determine fetal abnormalities according to the national guidelines of Iran for ultrasound scan anomalies. …”
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Experiences of and response to the COVID-19 pandemic at private retail pharmacies in Kenya: a mixed-methods study by Edwine Barasa, Sassy Molyneux, Jacinta Nzinga, Audrey Mumbi, Peter Mwangi Mugo, Daniella Munene, Collins Jaguga, Davy Odhiambo, Elizabeth Ominde-Ogaja, Mercy Maina, Michael Mungoma, Nadia Butt, Sultani Matendechero, Titus Kahiga, Eric Sedah, Sylvia Opanga

“…Objectives To assess experiences of and response to the COVID-19 pandemic at community pharmacies in Kenya.Design, setting and participants This was a mixed-methods study conducted from November 2020 to April 2021, targeting service providers in three counties (Nairobi, Mombasa and Kisumu), selected purposively to represent the main urban centres; pharmacies were selected randomly from a list of licensed pharmacies.Results Of 195 sampled pharmacies, 108 (55%) completed a questionnaire and 103 (53%) received a simulated client call; 18 service providers were interviewed. The initial weeks of the pandemic were characterised by fear and panic among service providers and a surge in client flow. …”
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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy by Tarek Kamal Abouzed, Seiichi Munesue, Ai Harashima, Yusuke Masuo, Yukio Kato, Khaled Khailo, Hiroshi Yamamoto, Yasuhiko Yamamoto

“…Salicylate (3 g/kg diet) or pyridoxamine (1 g/L drinking water; ~200 mg/kg/day) was given for 16 weeks to assess the development of diabetic nephropathy. …”
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