Therapeutic Drug Monitoring-Guided Linezolid Therapy for the Treatment of Multiple Staphylococcal Brain Abscesses in a 3-Month-Old Infant by Anna Cascone, Maia De Luca, Raffaele Simeoli, Bianca Maria Goffredo, Laura Cursi, Costanza Tripiciano, Lorenza Romani, Stefania Mercadante, Martina Di Giuseppe, Francesca Ippolita Calo Carducci, Davide Luglietto, Paola Bernaschi, Laura Lancella

“…A two-stage surgical drainage approach, consisting of repeated pus aspiration through an intracystic catheter, was then performed to achieve a significant reduction in abscess size. After nine weeks of antibiotic therapy, the patient was discharged in good clinical condition. …”
Get full text

Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections by Hyo Jun Ahn, Dong Pil Kim, Myeong Su Chu, Hyeon Jeong Yun, Seok-Hwan Kim, Seung Woo Lee, Dong Soo Lee

“…H. pylori eradication was confirmed by a 13C-urea breath test at 6–8 weeks after the end of treatment. Results. Of 84 patients included in the analysis, the eradication rate was 88.8% in the per protocol group (n=80). …”
Get full text

Comparison of the conceive-design-implement-operate model and lecture-based learning in teaching the “healthcare-associated infections” course by Yu Chen, Rui Zhang, Zhenke Zhou, Min Hong, Zheng Huang, Heling Wen, Lei Peng

“…The effectiveness of these pedagogical approaches was evaluated by comparing pre-and post-training test scores, and we used the Course Experience Questionnaire (CEQ) to collect students’ feedback on the course and teaching.ResultsCompared to traditional LBL method, the CDIO model significantly improved the overall scores and practical application scores of nursing students in the HAI course, with these advantages still retained after 24 weeks. Additionally, preliminary results show that students in the CDIO model scored higher on CEQ categories such as good teaching, clear goals and standards, appropriate assessment, generic skills, and independence, but they also reported an increased workload.ConclusionOur research is the first to apply the CDIO framework to nursing education in HAI courses, enhancing nursing students’ practical application skills, particularly in the sustained retention in this area. …”
Get full text

Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank by Lili Pan, Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin

“…Cox proportional hazards models and Fine-Gray competing risk models were employed to evaluate the association between DII and CLD incidence, adjusting for potential confounders.ResultsOur analysis included 121,329 participants with a median follow-up of 604.43 weeks, during which 4,018 developed CLD. A higher DII, indicating a more inflammatory diet, was associated with a 16% increased risk of CLD [hazard ratio (HR) = 1.162, P = 0.001], with each unit increase in DII elevating the risk by 3.3% (HR: 1.033, P < 0.001). …”
Get full text

Effects of natural carotenoid (carrot and red bell pepper) on growth performance, digestive enzymes and antioxidant enzymes in koi, Cyprinus rubrofuscus by Abbas Zamani

“…The effect of prepared diets was evaluated on growth performance, digestive enzymes (trypsin and amylase) and antioxidant activity including superoxide dismutase (SOD) and catalase in koi (weight: 1.10 ± 0.20 g) for 8 weeks. Results and discussion: The results obtained from body weight gain, specific growth rate and condition factor showed that there was no significant difference among the experimental diets, although they were higher in D2, D3 and D4 compared to D1. …”
Get full text

Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort by Sandrine Jousse-Joulin, Alain Saraux, Thierry Marhadour, Divi Cornec, Gilles Chiocchia, Valérie Devauchelle-Pensec, Gabriel J Tobón, Dewi Guellec, Morgane Milin, Olivier Vittecocq

“…Objectives To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.Methods We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm3, at baseline and after 3 years. …”
Get full text

Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…Here, we showed that as compared to naive control, daily IP injection of the Dianeal PD solution for 6 weeks without pMSC treatment significantly reduced UF, which was associated with an increase in both PM thickness and blood vessel, while pMSC treatment prevented the UF loss and reduced PM injury and blood vessels. …”
Get full text

The Bile Acid Metabolism of Intestinal Microorganisms Mediates the Effect of Different Protein Sources on Muscle Protein Deposition in <i>Procambarus clarkii</i> by Xiaodi Xu, Xiaochuan Zheng, Qunlan Zhou, Cunxin Sun, Aimin Wang, Aimin Zhu, Yuanyuan Zhang, Bo Liu

“…This study established an all-animal protein source (AP) and an all-plant protein source group (PP), with a feeding period of 8 weeks (four replicates per group, 45 individuals per replicate). …”
Get full text

Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach by Liwen Huang, Xinghuai Sun, Gang Luo, Shuai Liu, Rui Liu, Behzad Mansouri, Vicky wing lai Wong, Wen Wen, Hong Liu, Ai-Hou Wang

“…Ten patients with anisometropic amblyopia older than age 14 (average age: 26.7) were recruited and received ISVA treatment for 6 weeks, with 2 training sessions per day. Results. …”
Get full text

Prevalence and risk factors of gestational diabetes mellitus among pregnant women in northern Vietnam: a cross-sectional study by Hieu Minh Le, Thi Ai Nguyen, Dang Kien Nguyen, Ditte Søndergaard Linde, Ib Christian Bygbjerg, Jens Søndergaard, Thanh Duc Nguyen, Bay Quang Nguyen, Ngoc-Anh Thi Dang, Xuan Bai Nguyen, Dan W. Meyrowitsch, Christina A. Vinter, Tine M. Gammeltoft, Vibeke Rasch

“…A 2-hour 75 g oral glucose tolerance test was conducted at 24–28 weeks of gestation. GDM was diagnosed according to the World Health Organization 2013 criteria. …”
Get full text

Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma by Xue Lu, Zhu-Xia Tan, Ya-Xin Yao, Ze-Yan Li, Yan-Yan Zhu, Qian-Qun Yang, Zhao Li, Kun Peng, Yan Wang, De-Xiang Xu

“…BALB/c mice on postnatal day (PND) 28 were exposed to ddH2O or NaAsO2 aerosol for 4 hours daily over 5 consecutive weeks via respiratory tract. Mice were sensitized by intraperitoneal injection of ovalbumin (OVA) combined with Alum Adjuvant on PND42 and PND56. …”
Get full text

Differences in Physical and Psychological Parameters in Sub-Elite, Male, Youth Soccer Players with Jumper's Knee Following Physical Therapy Compared to Healthy Controls: A Longitud... by Marc Niering, Thomas Muehlbauer

“… # Methods All subjects were tested four times (start of the season \[T1\], 6 \[T2\], 16 \[T3\], and 20 \[T4\] weeks after the start of the season). Outcome measures included muscle power (drop jump, jump-and-reach), change of direction speed \[CODS\] (acyclic sprint), speed (tapping, 30-m linear sprint), endurance (Yo-Yo intermittent recovery test level 1), the Achievement Motives Scale (AMS) Sport, and injury-/pain-related data. …”
Get full text

20(S)-Ginsenoside Rg3 Protects Kidney from Diabetic Kidney Disease via Renal Inflammation Depression in Diabetic Rats by Tong Zhou, Lin Sun, Shuo Yang, You Lv, Yue Cao, Xiaokun Gang, Guixia Wang

“…In order to detect the protective effect of 20(S)-Rg3 on diabetic kidney disease (DKD), diabetic rat models which were established by administering high-sugar, high-fat diet combined with intraperitoneal injection of streptozotocin (STZ), and age-matched wild-type (WT) rat were given 20(S)-Rg3 for 12 weeks, with three groups: control group (normal adult rats with saline), diabetic group (diabetic rats with saline), and 20(S)-Rg3 treatment group (diabetic rats with 20(S)-Rg3 (10 mg/kg body weight/day)). …”
Get full text

Effects of Tannic Acid Supplementation of a High-Carbohydrate Diet on the Growth, Serum Biochemical Parameters, Antioxidant Capacity, Digestive Enzyme Activity, and Liver and Intes... by Yi Wang, Jianjun Wu, Luoxin Li, Yuanfeng Yao, Chiqing Chen, Yucong Hong, Yi Chai, Wei Liu

“…Five diets were prepared, including a positive control (dietary carbohydrate level, 16%, LC0), a negative control (dietary carbohydrate level, 21%, HC0), and three TA-supplementation diets based on the negative control diet with TA addition at 200, 400, and 800 mg/kg, respectively. After 8 weeks of feeding, the results showed that compared with the LC0 diet, 400–800 mg/kg dietary TA significantly improved the survival rate of largemouth bass (P<0.05) while significantly reducing its weight-gain rate and specific growth rate (P<0.05). …”
Get full text

Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…Twenty-eight patients with coronary artery disease and who underwent DES implantations were randomly assigned to pioglitazone (30 mg/d; PIO) or placebo (control; Con) treatment in addition to optimal standard therapy. After 12 weeks of treatment, plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) were significantly decreased in PIO group compared to the Con group (P=0.035, 0.011, 0.008, and 0.012, resp.). …”
Get full text

Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…After treatment within 5 weeks, compared with the model group, the administered group improved the changes of tumor pathomorphology. …”
Get full text

A novel approach for managing the incisions of tibial plateau fractures with soft tissue swelling by Yang Zhang, Yangyang Zhao, Shuanggong Liu, Zihan Yao, Zikang Jin, Wanli Ma

“…The VAS and WOMAC scores were reduced in both groups (P < 0.05); Group A had lower VAS scores two weeks after surgery. There was no statistically significant difference in the WOMAC score between the groups. …”
Get full text

Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study by Abebayehu Melesew Mekuriyaw, Muhabaw Shumye Mihret, Ayenew Engida Yismaw

“…Preterm birth refers to a birth of a baby before 37 completed weeks of gestation and after fetal viability. It is now the leading cause of new born deaths. …”
Get full text

A Prospective Study of Tuberculosis Drug Susceptibility in Sabah, Malaysia, and an Algorithm for Management of Isoniazid Resistance by Muhammad Redzwan S. Rashid Ali, Uma Parameswaran, Timothy William, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo, Nicholas M. Anstey, Anna P. Ralph

“…Median delay to commencement of the second-line regimen was 13 weeks. Among 15 inpatients with suspected TB, 2 had multidrug resistant TB (one extensively drug resistant), 2 had INH-R, and 4 had NTM. …”
Get full text

Endoprosthetic Reconstruction for a Displaced Atypical Femoral Fracture in a Cancer Patient with Poor Prognosis by Hironari Tamiya, Hiroki Hagizawa, Takaaki Nakai, Yoshinori Imura, Takaaki Tanaka, Kazuya Oshima, Toshikazu Ito, Norifumi Naka, Shigeyuki Kuratsu

“…Thus, we performed endoprosthetic reconstruction for a displaced atypical femoral fracture in a breast cancer patient with poor prognosis to enable walking in the early stage after the operation. Two weeks after the operation, she could successfully walk. …”
Get full text