Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…Therefore, we performed bilateral common carotid artery stenosis (BCAS) to induce CCH on the leptin receptor- (LepR-) deficient db/db mice, aiming to evaluate the possible involvement of leptin in CCH-induced cognitive impairment, WMLs, and neuroinflammation, and further explore the effect of leptin on chronic hypoxia-induced inflammation using the BV2 microglial cell line. After four weeks of BCAS, wild-type mice showed significant working memory deficits, WMLs, activation of microglia and astrocytes, decrease in the number of oligodendrocytes, downregulation of myelin basic protein expression, and increase in the expression of TNF-α and IL-1β; however, four weeks of BCAS failed to induce significant changes in the LepR-deficient db/db mice but elevated the production of anti-inflammatory cytokines and activated the M2 microglia. …”
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Neethling Strain-Based Homologous Live Attenuated LSDV Vaccines Provide Protection Against Infection with a Clade 2.5 Recombinant LSDV Strain by Wannes Philips, Andy Haegeman, Nina Krešić, Laurent Mostin, Nick De Regge

“…Methods: For each vaccine, seven bulls were vaccinated and followed for three weeks to evaluate vaccine safety. Thereafter, vaccinated animals and non-vaccinated controls were challenged with a virulent clade 2.5 strain and followed for three more weeks to evaluate vaccine efficacy. …”
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Factors Associated with Placenta Praevia in Primigravidas and Its Pregnancy Outcome by Abdul Ghani Nur Azurah, Zakaria Wan Zainol, Pei Shan Lim, Mohd Nasir Shafiee, Nirmala Kampan, Wan Syahirah Mohsin, Norfilza Mohd Mokhtar, Muhammad Abdul Jamil Muhammad Yassin

“…For maternal outcomes, the nonprimigravidas required earlier delivery than primigravidas (35.76 ± 2.54 weeks versus 36.52 ± 1.95 weeks, P=0.03) and had greater blood loss (P=0.04). …”
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Effects of Dietary Coated Folic Acid and Folic Acid Addition on Lactation Performance, Rumen Fermentation, and Hepatic Lipid Content in Early Lactation Dairy Cows by Nan Sun, Songming Zou, Jiaxin Feng, Gang Guo, Qiang Liu, Yawei Zhang, Lei Chen, Wenjie Huo, Cong Wang

“…The experiment began 5 weeks before calving to 6 weeks after calving. When increasing the level of CFA, the fat-corrected milk (FCM), fat and protein yields, de novo fatty acid content, and feed efficiency increased linearly. …”
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Effects of acupuncture on earthquake survivors with major psychiatric disorders and related symptoms: A scoping review of clinical studies. by Chan-Young Kwon, Jungtae Leem, Da-Woon Kim, Hui-Ju Kwon, Hyun-Seo Park, Sang-Ho Kim

“…In general, the treatment period lasted between 4 and 12 weeks. Validated assessment tools for PTSD severity and accompanying symptoms were used for patients with PTSD, while the corresponding evaluation tools were used for patients with other diagnoses or clinical symptoms. …”
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Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction by Elizabeth J. Wright, Nigel W. Hodson, Michael J. Sherratt, Moustapha Kassem, Andrew L. Lewis, Christine Wallrapp, Nadim Malik, Cathy M. Holt

“…In vivo, qRT-PCR revealed large changes in the expression of several genes involved in extracellular matrix remodeling, which were altered following MSC ± GLP treatment. After four weeks, infarcted areas were imaged using atomic force microscopy, demonstrating significant alterations between groups in the structure of collagen fibrils and resulting scar. …”
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Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model by Wei Wang, Yunhao Wang, Tengfei Lou, Mingqian Ding, Juehong Li, Hao Xiong, Zhixiao Yao, Yingying Ma, Huajiang Chen, Shenghe Liu

“…In the rat laminectomy model after 4 weeks, magnetic resonance imaging of epidural fibrosis was least in the PCL-CEL group. …”
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Patient-reported Outcomes and Muscle Strength after a Physiotherapy-led Exercise and Support Brace Intervention in Patients with Acute Injury of the Posterior Cruciate Ligament: A... by Randi Gram Rasmussen, Julie Sandell Jacobsen, Birgitte Blaabjerg, Torsten Grønbæk Nielsen, Lene Lindberg Miller, Martin Lind

“…Isometric knee flexion strength of the injured knee increased 0.18 (95%CI 0.11-0.25) Nm/kg from 16 weeks after diagnosis to one-year follow-up, corresponding to an increase of 16%. …”
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The effectiveness of ERCP in managing preoperative complications of choledochal cysts in children and its role in facilitating early surgical intervention by Tian Zhang, Wenjie Wu, Yijun Shu, Hao Weng, Mingzhe Weng, Ying Zhou, Xuefeng Wang

“…There was no significant difference in primary outcomes, such as surgical duration, rate of minimally invasive surgery, conversion to open surgery, intraoperative bleeding volume, intraoperative blood transfusion, postoperative complications, or average length of hospital stay, between the early surgery group (≤2 weeks) and the late surgery group (>2 weeks).ConclusionsERCP was proved to be a safe and effective intervention for alleviating preoperative complications in pediatric patients with choledochal cyst. …”
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Preoperative vs Postoperative Patient Outcome and Recovery Expectations of Total Joint Arthroplasty by Siddhartha Dandamudi, BBA, Kyleen Jan, MD, Madelyn Malvitz, BS, Anne DeBenedetti, MSc, Omar Behery, MD, MPH, Brett R. Levine, MD, MS

“…A total of 73.1% of postoperative patients requested additional weeks of PT. Only 52.1% or patients had a long-term follow-up plan in place. …”
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The Effects of Low-Level Laser Therapy, 670 nm, on Epiphyseal Growth in Rats by Adriana Regina de Andrade, Anamaria Meireles, Elisangela Lourdes Artifon, Rose Meire Costa Brancalhão, José Roberto Leonel Ferreira, Gladson Ricardo Flor Bertolini

“…After completion of protocol they were kept until they were 14 weeks of age and then submitted to a radiological examination (evaluation of limb length) and euthanised. …”
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Effectiveness of a Foam Roller Warm-Up in Professional Basketball Players: A Randomized Controlled Trial by Daniel Casado, Ivan Nacher, Juan Pardo, Javier Reina

“…Outcomes were measured at three time points: before the protocol was initiated, at the end of the protocol (at 12 weeks), and after a one-month follow-up period (at 16 weeks)…”
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Lighting quality evaluation on growth performance and feather pecking behavior of broilers by Chenghao Pan, Rong Xiang, Jinming Pan

“…One hundred and twenty 49-day-old Youhuang broilers were randomly distributed into 3 lighting treatment groups (warm white, cold white and red) and reared for 4 weeks. The results showed that the lighting had no significant effect on the growth performance (P > 0.05). …”
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Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats by Lin Zhang, Hua Peng, Jin Xu, Yixin Xu, You Yin, Bin He, Jianhua Zhuang

“…RT-PCR was used to measure the mRNA expression of IL-1β and TNF-α in the hippocampi of all groups; western blot was used to measure the protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 in the hippocampi of all groups at weeks 1, 2, 3, and 4 after modeling. Results. At weeks 1, 2, 3, and 4 after modeling, there were no significant differences between the control group and the DOPS group in the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 (all P>0.05); the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly increased, while the phosphorylation of MKP-1 was decreased in the model group compared with the control group. …”
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Impacts of Elevated Atmospheric CO2 and O3 on Paper Birch (Betula papyrifera): Reproductive Fitness by Joseph N. T. Darbah, Mark E. Kubiske, Neil Nelson, Elina Oksanen, Elina Vaapavuori, David F. Karnosky

“…Under elevated CO2, plant dry mass increased by 9 and 78% at the end of 3 and 14 weeks, respectively. Also, the root and shoot lengths, as well as the biomass of the seedlings, were increased for seeds produced under elevated CO2, while the reverse was true for seedlings from seeds produced under the elevated O3. …”
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Lack of Intensity Control during an Exercise Program Is Related to a Limited Effect on Variables Responsible for Blood Pressure Regulation in Hypertensive Older Adults by Roberta Fernanda da Silva, Thaís Amanda Reia, André Mourão Jacomini, Anderson Bernadino da Silva, Henrique dos Santos Disessa, Henrique Luiz Monteiro, Anderson Saranz Zago

“…To compare the effect of an intensity-controlled exercise program (ICEP) and a nonintensity-controlled exercise program (non-ICEP) on the variables responsible for blood pressure regulation in hypertensive older adults. 95 hypertensive older adults (65.40 ± 7.48 years/22 males and 73 females) performed hemodynamic, functional fitness, and biochemical evaluations before and after 12 weeks of the multicomponent exercises which included walking, muscle strength, hydrogymnastics, Pilates, dynamic balance, agility, flexibility, and others. …”
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Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice by Yangwenjie Wang, Yang Xiang, Ruiqi Wang, Xiangning Li, Jianxiong Wang, Siwang Yu, Ying Zhang

“…On the third day after completion of a 6-weeks HIIT protocol, an exhaustive treadmill test was conducted in all mice. …”
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Hepatoprotective Effects of Nasturtium Officinale and Allium Polyanthum Extracts on CCL4- Induced Hepatic Damage In Albino Rats by Shkar Rzgar K.Rostam, Zana Hassan Ibrahim, Rebaz Rebwar Mala, Soran Qadir Abdul

“…Except for NC, all other groups were exposed to CCl4 at every 72 hours for 3 weeks to induce hepatic damage. Corresponding treatments were established to the respective groups during study period. …”
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Pre-Operative Scapular Rehabilitation for Arthroscopic Repair of Traumatic Rotator Cuff Tear: Results of a Randomized Clinical Trial by Luane Landim de Almeida, Adriano Fernando Mendes Júnior, José da Mota Neto, Leandro Furtado De Simoni, Karine Helena Souza Lopes, Paloma Carvalho Guimarães, Brenda Iasmin de Oliveira Valério, Aaron Sciascia

“…All participants underwent preoperative rehabilitation for six weeks, consisting of mobility exercises of the cervical spine, elbow, wrist, and hand, and analgesics education. …”
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A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis by Alireza Askari, Fatemeh Sadat Hasheminasab, Fatemeh Sadat Hasheminasab, Omid Sadeghpour, Mohammad Mehdi Naghizadehd, Seyed Ali Ravansalar, Aida Iraji, Mohammad Hashem Hashempur

“…They used their respective topical treatments thrice daily for 4 weeks. Various measurements were taken at the beginning of the study, 2, and 4 weeks after starting the intervention, including the 8-m walk test, knee pain (based on visual analog scale), flexion angle of the knee joint, analgesic consumption, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.ResultsNo significant differences were observed between the basil oil and diclofenac gel groups in any of the measured outcomes. …”
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