Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models by Alexander J. Szalai, Mark A. McCrory, Dongqi Xing, Fadi G. Hage, Andrew Miller, Suzanne Oparil, Yiu-Fai Chen, Michelle Mazzone, Richard Early, Scott P. Henry, Thomas A. Zanardi, Mark J. Graham, Rosanne M. Crooke

“…Likewise in human CRP transgenic mice treated for 2 weeks with a human CRP-specific ASO, blood human CRP was reduced by >70% and carotid artery patency was improved (2 weeks after surgical ligation). …”
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Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…There was a marked difference in the etiology of DEK by gender: DM phenotypes including polyuria, polydipsia, and hyperglycemia (nonfasting blood glucose over 300 mg/dl) were found in male rats aged over 10 weeks but not in female rats. The cumulative incidence of DM in DEK males at the age of 30 weeks was 44.8%. …”
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Comparing growth velocity of HIV exposed and non-exposed infants: An observational study of infants enrolled in a randomized control trial in Zambia. by Obvious Nchimunya Chilyabanyama, Roma Chilengi, Natasha Makabilo Laban, Masuzyo Chirwa, Michelo Simunyandi, Luiza Miyanda Hatyoka, Innocent Ngaruye, Najeeha Talat Iqbal, Samuel Bosomprah

“…<h4>Method</h4>Our study used data from the ROVAS II study (PACTR201804003096919), an open-label randomized control trial of two verses three doses of live, attenuated, oral RotarixTM administered 6 &10 weeks or at 6 &10 weeks plus an additional dose at 9 months of age, conducted at George clinic in Lusaka, Zambia. …”
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Glimepiride monotherapy versus combination of glimepiride and linagliptin therapy in patients with HNF1A-diabetes: a protocol for a randomised, double-blinded, placebo-controlled t... by Torben Hansen, Tina Vilsbøll, Filip Krag Knop, Alexander Sidelmann Christensen, Heidi Storgaard, Sofie Hædersdal

“…We hypothesise that low dose of SU in combination with a dipeptidyl peptidase 4 inhibitor provides a safer and more efficacious treatment in patients with HNF1A-diabetes compared with SU as monotherapy.Methods and analysis In a randomised, double-blinded, crossover study, patients with HNF1A-diabetes will randomly be assigned to 16 weeks of treatment with glimepiride+linagliptin, 4 weeks of washout and 16 weeks of treatment with glimepiride+placebo (or vice versa). …”
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A Case of Placental Mesenchymal Dysplasia by Shigeki Taga, Junko Haraga, Mari Sawada, Aya Nagai, Dan Yamamoto, Ryoji Hayase

“…A 30-year-old woman, gravida 3, para 3, presenting with placentomegaly, was referred to our department at 18 weeks of gestation. An ultrasonography revealed a normal fetus with a large multicystic placenta, measuring 125 × 42 × 80 mm. …”
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Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy by Su Mi Lee, Seuk Hee Chung, Yongjin Park, Mi Kyoung Park, Young Ki Son, Seong Eun Kim, Won Suk An

“…Proteinuria levels were unchanged after 12 weeks compared with baseline values in both groups. …”
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Nucleos(t)ide Analog Treatment Discontinuation in Chronic Hepatitis B Virus Infection: A Systematic Literature Review by Robert Gish, Kosh Agarwal, Anadi Mahajan, Supriya Desai, Saifuddin Kharawala, Rob Elston, Joyeta Das, Stuart Kendrick, Vera Gielen

“…HBsAg loss was reported in 25 studies, with overall median HBsAg loss rates ranging from 2% at 24 weeks (5 studies) to 11% at 192 weeks (2 studies) post NA cessation. …”
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Exchange Nailing for Aseptic Nonunion of the Femoral Shaft after Intramedullary Nailing by Sung-Soo Ha, Chang-Wug Oh, Jae-Wook Jung, Joon-Woo Kim, Kyeong-Hyeon Park, Seong-Min Kim

“…The average time to achieve union was 23.1 weeks (range, 13.7–36.9 weeks). The three failures involved nonunion at the isthmic level (three of 15 cases), not at the infraisthmic level (zero of 15 cases). …”
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A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder: Part 1 – Overview and Summary by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…Multiple databases (including Web of Science, EMBASE and PubMed) were searched to identify all studies published from January 1980 through March 2009 that evaluated the effectiveness of any clearly defined treatment for acute (less than two weeks), subacute (two to 12 weeks) or chronic (longer than 12 weeks) WAD. …”
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Influence of Supplemental Dietary Cholesterol on Growth Performance, Indices of Stress, Fillet Pigmentation, and Upper Thermal Tolerance of Female Triploid Atlantic Salmon (Salmo s... by Eric H. Ignatz, Rebeccah M. Sandrelli, Sean M. Tibbetts, Stefanie M. Colombo, Fábio S. Zanuzzo, Ashley M. Loveless, Christopher C. Parrish, Matthew L. Rise, A. Kurt Gamperl

“…Accordingly, postsmolt female triploid salmon were exposed to an incremental temperature challenge (+0.2°C day-1) to mimic conditions that they experience in sea cages in the summer, with temperature held at both 16 and 18°C for several weeks [i.e., 3 weeks at 16°C, followed by an increase at 0.2°C day-1 to 18°C (10 days), then 5 weeks at 18°C] to prolong their exposure to elevated temperatures. …”
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Influence of advanced maternal age and gestational age on the morphology of human placenta by Jovičić Sanja, Ljubojević Vesna, Barudžija Maja, Amidžić Ljiljana, Škrbić Ranko, Nikolić Ivan R.

“…Methods: In this research 30 placentas of healthy pregnant women, aged from 18 to 42 years and from 36 up to 41 weeks of gestational age were used for analyses. …”
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Suppressive Activity of a Macrolide Antibiotic, Roxithromycin, on Pro-Inflammatory Cytokine Production in Vitro and in Vivo by H. Suzaki, K. Asano, S. Ohki, K. Kanai, T. Mizutani, T. Hisamitsu

“…However, pretreatment for more than 7 weeks dramatically suppressed the cytokine appearance in the extracts.…”
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Analysis of intracranial lesions in patients with HIV-associated cryptococcal meningitis by Wei Song, Li Liu, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen, Renfang Zhang, Yinzhong Shen

“…Throughout treatment, 32.7% (52/159) developed new or worsened lesions. Mortality rates at 2 weeks, 8 weeks, and 2 years for those with detected lesions were 3%, 7.6%, and 13.2%, respectively. …”
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Effects of aquatic exercise compared with land-based exercise on the body composition and function of older adults with sarcopenia: protocol for a randomised controlled trial by Na Li, Fang Cheng, Jinfeng Yang, Yuanpeng Liao, PeiJie Sun, Weicheng Yang, Jinqi Yang, Jianxin Ran

“…Assessments will be conducted four times: initially (before intervention), after 8 weeks (intermediate), after 16 weeks (final) and 16 weeks after the end of intervention (follow-up). …”
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Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report by Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, Takehiko Fujino

“…Ten (10) patients received oral administration of 1 mg/day of purified ether phospholipids derived from scallop for 24 weeks. Clinical symptoms and blood tests were checked at 0, 4, 12, 24, and 28 weeks. …”
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LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord by Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao

“…We found that PWT50 decreased (P<0.05) 3 days post-PNI surgery in the LIFU− and LIFU+ groups and increased (P<0.05) after 4 weeks of LIFU stimulation. The expression of p-CREB and CaMKIV decreased (P<0.05) and that of KCC2 increased (P<0.05) after 4 weeks of LIFU stimulation, but that of p-ERK1/2 (P>0.05) was unaffected. …”
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Cardiac Rehabilitation in Women and Men after an Acute Myocardial Infarction by Elizabeth Sellén Sanchén, Vivian Gil García, Nordan Pedroso Almarales, Yunior Rodríguez López, Joaquín Sellén Crombet

“…The sample consisted of 65 patients. who underwent a stress test and echocardiogram before discharge and 6 weeks after rehabilitation. Survival was evaluated at five years. …”
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A Comparative Analysis of Endoscopic Carpal Tunnel Release Performed Under Wide-Awake, Local Anesthesia, No Tourniquet in an Office-based Procedure Room Versus Operating Room Setti... by Madison Milhoan, MD, Winston Scambler, BS, William F. Pientka, II, MD

“…Results: Average follow-up was 6.8 weeks. One hundred and twenty-four in-office WALANT procedures and 162 in-operating room procedures were included. …”
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Role Of Low Dose Aspirin In Preventing Preterm Birth In Patients With Previous History Of Preterm Delivery by Maliha Sadaf, Aasia Saleem, Tallat Farkhanda, Khansa Iqbal, Sabeen Ashraf, Amna Iftikhar

“… Objective: Preterm birth (PTB) occurs between 24-37 weeks of gestation. The important risk factor for PTB is a previous PTB and currently progesterone is used for the management of recurrent spontaneous PTB. …”
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Comparison of the Retinal Straylight in Pseudophakic Eyes with PMMA, Hydrophobic Acrylic, and Hydrophilic Acrylic Spherical Intraocular Lens by Ya-wen Guo, Jun Li, Hui Song, Xin Tang

“…Straylight was measured using C-Quant at 1 week and 1 month postoperatively in natural and dilated pupils. …”
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