Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…The majority of studies (89%) employed treadmill training, while 11% used voluntary wheel running, with training protocols consisting of 5 days per week for 4 weeks.ResultsExercise training reduced extracellular glutamate (Glu) and increased the expression of GLT-1, GS, Gln, and mGluR2/3 while down-regulating VGULT1 in the presynaptic terminal of the glutamatergic neurons within the nigrostriatal pathway in PD animal models. …”
Get full text

Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…A maximum of four HLA-matched peptides were selected based on the preexisting IgG responses specific to 32 different peptides, which consisted of a single HCV-derived peptide at core protein positions 35–44 (C-35) and 31 peptides derived from 15 different tumor-associated antigens (TAAs), followed by subcutaneous administration once per week for 8 weeks. Peptide-specific cytotoxic T lymphocyte (CTL) and IgG responses were measured before and after vaccination. …”
Get full text

Comparative effects of xylitol and erythritol on modulating blood glucose; inducing insulin secretion; reducing dyslipidemia and redox imbalance in a type 2 diabetes rat model by Nontokozo Z. Msomi, Ochuko L. Erukainure, Veronica F. Salau, Kolawole A. Olofinsan, Md. Shahidul Islam

“…In the present study, the effects of xylitol and erythritol were comparatively investigated on blood glucose, insulin level, dyslipidemia, pancreatic islet morphology and β-cell function, and redox imbalance in a type 2 diabetes (T2D) model of rats. Seven-week-old male Sprague-Dawley rats were randomly divided into 8 groups: Normal Control (NC), Diabetic Control (DC), Diabetic Xylitol 5 % (DX5), Diabetic Xylitol 10 % (DX10), Diabetic Xylitol 20 % (DX20), Diabetic Erythritol 5 % (DE5), Diabetic Erythritol 10 % (DE10), and Diabetic Erythritol 20 % (DE20). …”
Get full text

A Case of Granulomatosis with Polyangiitis in Pregnancy by Rashid Naseem Khan, Aliya Naseem, Muhammad Athar Khan, Qurat ul Ain Qurat ul Ain, Mamoona Hashim, Hafiza Laila Hashim Khan

“…Her thrombocytopenia was managed with transfusions, and regular prenatal ultrasounds were conducted. At 36 weeks, an elective cesarean delivered a healthy 2.4 kg baby. …”
Get full text

Trans-escapho-perilunate fracture-dislocation. Case Presentation by Yaniel Truffin Rodriguez, Osmany Pérez martínez, Sergio Miguel Samón Matos, Horacio Samuel Suárez Monzón

“…The scaphoid synthesis was maintained for eight weeks and the immobilization was withdrawn at 12 weeks after consolidation of the scaphoid fracture.…”
Get full text

Anesthetic Management for Cesarean Delivery in a Patient with a Gigantic Intracranial Tumor by C. dos Santos e Santos, C. L. Mason, J. S. Neill, B. E. Grayson, A. Calimaran, D. R. Bacon

“…A 31-year-old G5P1 patient with unremarkable past medical history at 29 weeks of gestation was diagnosed with a gigantic left frontotemporal brain mass. …”
Get full text

Extreme Rhabdomyolysis, Acute Renal Failure, and Protracted Ileus in a Case of Legionella Pneumonia by C. Laivier, M.-O. Bleuze, P. Hantson, J. Devos

“…Hemodialysis was required for a period of 5 weeks with a full renal recovery. Pneumonia required respiratory support but for a limited period of 6 days. …”
Get full text

Mild Clinical Presentation of Acute Fatty Liver in the Second Trimester of Pregnancy by Alaeddine Yassin, Walid Denguezli, Anissa Fessi, Leila Njim, Raja Falah, Abdelfattah Zakhama, Mohamed Sakouhi

“…We report a case of 29 years old woman who was diagnosed with acute fatty liver of pregnancy at 23 weeks of gestation with unusual evolution (pregnancy prolonged until 36 weeks of gestation) to draw attention on the possibility of occurrence of this pathology in the second trimester of pregnancy even with a milder clinical presentation and course.…”
Get full text

EBV Infection Unmasking a Choledochal Cyst in an Infant by Hassan El Khatib, Batoul Kawtharany, Diyaa Mohammad, Mohammad Siblini, Nahida El-Rifai

“…It usually manifests as a transitory elevation of transaminases in up to 80% to 90% of patients, and they normalize by 2 to 6 weeks. A cholestatic pattern with elevated gamma-glutamyl transferase (γGT) and alkaline phosphatase (ALP) is common, in up to 60% in young adults. …”
Get full text

Changes in the Physicochemical Quality Characteristics of Cabbage Kimchi with respect to Storage Conditions by Su-Yeon You, Ji-Su Yang, Sung Hyun Kim, In Min Hwang

“…In this study, the changes in pH, organic acid content, acidity, and salinity of kimchi prepared at 0 days, stored 1–8 weeks at 4 and 10°C, and stored at room temperature for two days were analyzed. …”
Get full text

More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens by Lotte Vrijders, Erwin Ho, Danielle Van der Beek, Inge Vrelust, Heleen Nailis

“…A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. …”
Get full text

Listeria monocytogenes Meningoencephalitis and Cerebral Abscess in a Heart Transplant Recipient by Paul C. Adjei

“…He was therefore treated with penicillin monotherapy for eight weeks with complete resolution of his brain lesions and without any residual neurologic deficits.…”
Get full text

Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report by Boban Gjakov, Darja Kopač, Mateja Vukmanič Pohar, Miha Lučovnik

“…We present a case of an otherwise healthy G3P1 women with mild symptoms of SARS-CoV-2 infection at 23 6/7 weeks of gestation. At 25 2/7 weeks, she presented with signs and symptoms of preterm labor and decreased fetal movements. …”
Get full text

Primary Meningococcal Type C Arthritis: A Case Report and Literature Review by Maximiliano Barahona, Jaime Catalan, Yoshiro Sato, Jaime Hinzpeter

“…He received a treatment consisting of 2 arthroscopies and 5 weeks of antibiotics. At five weeks he returned to work and at 2 months he resumed sports (jogging and soccer) without complaints. …”
Get full text

Doppler Impedance Changes at the Fetal Brain Vessels in a Pregnancy Affected with a Multiple Combination of Uteroplacental Anomalies by José Morales-Roselló, Núria Peralta Llorens

“…This cerebral low-impedance state, usually found before labor, and considered an adaptive mechanism developed to protect the fetus at term from labor asphyxia, was present for an unknown reason at 20 weeks. After the patient was treated with vaginal progesterone, the cervix shortening improved and markedly, at the same time, the cerebral vascular resistances increased and maintained an adequate for gestational age impedance until delivery at 34 weeks. …”
Get full text

A Case of Painful Growing Abdominal Wall Mass during Pregnancy Requiring Resection in the Second Trimester by Shlomo M. Stemmer, Cintia Gomes, Elyce H. Cardonick

“…Due to pain and rapid growth, surgical resection was done at 25 weeks of pregnancy. Histopathological examination revealed a desmoid tumor. …”
Get full text

Severe Clostridial Pyomyoma following an Abortion Does Not Always Require Surgical Intervention by Daphna Stroumsa, Eliel Ben-David, Nurith Hiller, Drorith Hochner-Celnikier

“…A 41-year-old primigravida presented with abdominal pain and fever, one day following dilatation and curettage at 20 weeks of gestation. Her abdomen was diffusely tender, with a uterus enlarged to 20 weeks' gestation. …”
Get full text

Swim Training Attenuates Inflammation and Improves Insulin Sensitivity in Mice Fed with a High-Fat Diet by Guangzeng Zhang, Pengfei Yu, Xiaomeng Liu

“…To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. …”
Get full text

Effectiveness of the BNT162b2 XBB.1.5-adapted vaccine against COVID-19 hospitalization related to the JN.1 variant in Europe: a test-negative case-control study using the id.DRIVE... by Jennifer L. Nguyen, Marianna Mitratza, Hannah R. Volkman, Leonie de Munter, Thao Mai Phuong Tran, Catia Marques, Mustapha Mustapha, Srinivas Valluri, Jingyan Yang, Andrés Antón, Irma Casas, Eduardo Conde-Sousa, Laura Drikite, Beate Grüner, Giancarlo Icardi, Gerrit Luit ten Kate, Charlotte Martin, Ainara Mira-Iglesias, Alejandro Orrico-Sánchez, Susana Otero-Romero, Gernot Rohde, Luis Jodar, John M. McLaughlin, Kaatje Bollaerts

“…Protection was sustained through five months; VE was 52.2% (95% CI 41.3–61.1) 2 to <4 weeks after vaccination, 48.9% (95% CI 17.9–68.2) at 4 to <8 weeks, and ranged from 54.6% to 59.5% at 4-week intervals from 8 to <22 weeks. …”
Get full text

A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 4 – Noninvasive Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…Multiple databases (including Web of Science, EMBASE and PubMed) were searched to identify all studies published from January 1980 through March 2009 that evaluated the effectiveness of any clearly defined treatment for acute (less than two weeks), subacute (two to 12 weeks) or chronic (longer than 12 weeks) WAD. …”
Get full text