Highly-sensitive quantification of carbamazepine and identification of its degradation and metabolism products in human liver by high performance liquid chromatography – High resol... by Andrei Pirogov, Ekaterina Shirokova, Samvel Barsegyan, Nikita Gandlevskiy, Valeriya Akimova, Alessandro Barge, Aleksander Nosyrev

“…The maximum concentration decline is observed during the first week of storage (on average by 20 %), and then the concentration approximately halves over 8 weeks. …”
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Multicenter Randomized Controlled Trial Comparing the Contribution of Proxabrushes with Regular Toothbrushes and Only Regular Toothbrushes to the Oral Health of Thai Elderly by Orachad Gururatana, Warangkana Vejvithee, Narisa Ekpatcha

“…Participants in the test group used proxabrushes and regular toothbrushes, and participants in the control group used only regular toothbrushes for 6 weeks. Plaque accumulation, gingival status, and oral healthcare data were collected at baseline and at 6-week follow-up. …”
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WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota by Qi Sun, Bai-Rong Li, Dong-Hao Li, Xiao-Ying Wang, Qian-Yi Wang, Zhi-Meng Jiang, Shou-Bin Ning, Tao Sun

“…The dietary intervention lasted 17 weeks, with DSS given in the final week. Colonic inflammation was assessed by body weight, disease activity index, and histopathology. …”
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A novel technique of cryodenervation for murine vagus nerve: implications for acute lung inflammation by Di Wu, Ximing Liao, Jing Gao, Kun Wang, Wujian Xu, Feilong Wang, Zhixian Jin, Dandan Wu, Qiang Li, Wei Gao

“…Cholinergic parasympathetic nerve in the mouse lung coming from vagus nerve was activated at the initial stage (1 week) after VSCD, and blocked 3 weeks later. By use of the ALI mouse model, we found that VSCD effectively decreased pulmonary inflammation and tissue damage in the ALI mice. …”
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Exploring the Effect of Sampling Frequency on Real-World Mobility, Sedentary Behaviour, Physical Activity and Sleep Outcomes Measured with Wearable Devices in Rheumatoid Arthritis:... by Javad Sarvestan, Kenneth F. Baker, Silvia Del Din

“…Eleven people with active RA newly starting an arthritis drug completed clinical assessments at 4-week intervals for 12 weeks. Participants wore an Axivity AX6 wrist device (sampling frequency 100 Hz) for 7 days after each clinical assessment. …”
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The Escalating Magnitude of COVID-19 Infections among the Northeastern Ethiopia Region: A Community-Based Cross-Sectional Study by Zeleke Geto, Saba Gebremichael, Melaku Ashagrie Belete, Alemu Gedefie, Genet Molla, Melkam Tesfaye, Wondmagegn Demsiss, Daniel Gebretsadik

“…The first laboratory-confirmed cases of COVID-19 were detected in the fourth week of the study period, that is, from July 24 to July 31, 2020, and the peak prevalence was observed in the last two weeks. …”
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Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens by Haitong Zhao, Lianxiang Guo, Ming Yan, Yue Sun, Yan Hong, Mingkun Zhu

“…This investigation focused on the effects of chlorogenic acid (CGA) on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens. Two hundred forty 43–week-old Hy-Line Brown laying hens were randomly distributed into 4 treatments receiving 0, 400, 600, and 800 mg/kg CGA for twelve weeks. …”
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An AI-Based Digital Scanner for <i>Varroa destructor</i> Detection in Beekeeping by Daniela Scutaru, Simone Bergonzoli, Corrado Costa, Simona Violino, Cecilia Costa, Sergio Albertazzi, Vittorio Capano, Marko M. Kostić, Antonio Scarfone

“…In this study, the scanner was tested for 17 weeks, receiving sheets from 5 beehives every week, and checking the accuracy, reliability, and speed of the method compared to conventional human visual inspection. …”
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Mobile Phone App to Promote Lifestyle Change in People at Risk of Type 2 Diabetes: Feasibility 3-Arm Randomized Controlled Trial by Gyri Skoglund, Gunvor Hilde, Pernille Lunde, Venessa Vera Cruz Naceno, Cecilie Fromholt Olsen, Birgitta Blakstad Nilsson

“…MethodsA 3-arm feasibility RCT lasting 12 weeks was designed. Participants were recruited from 9 general practitioners in Norway. …”
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Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review by Pan J, Li Z, Ye C, Zhang X, Yang Q, Zhang X, Zhou Y, Zhang J

“…Discontinuation of mesalazine led to symptom resolution in all patients, with 93.3% improving within a week. Alternative treatments or switching to other forms of 5-aminosalicylic acid may be considered for ongoing management. …”
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Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs by Yuanyuan Zhao, Jinfeng Bi, Jianyong Yi, Jian Peng, Qiancheng Ma

“…In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R2 = –0.990), subcutaneous adipose accumulation (R2 = –0.930), serum triglyceride elevation (R2 = –0.879), acetate (R2 = 0.955) and propionate concentration reduction (R2 = 0.985) were suppressed by pectin from 1% to 12%, indicating dose response to pectin consumption. …”
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RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development by Zhouyiyuan Xue, Abdur Rahman Ansari, Xing Zhao, Kun Zang, Yu Liang, Lei Cui, Yafang Hu, Ranran Cheng, Xiaolong Zhang, Juming Zhong, Huazhen Liu

“…Therefore, the thymuses from chickens at different stages of development (at weeks 0, 1, 5, 9, 18, and 27) were used in the present study. …”
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Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical tr... by Eliete Bouskela, Gabriela Andrade Paz, Marcus VDS Rangel, Caio Luan Farias, André Luiz Conveniente Soares, Erica Langner, Tatiana Teixeira, Patrícia M L Dutra, Paulo Farinatti, Maria das Graças C Souza, Juliana P Borges

“…Patients with CAD aged 40–70 will undergo exercise training (three times per week for 12 weeks). A healthy reference group will also be included. …”
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Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats by Silvia Granata, Camilla Morosini, Maria Chiara Valerii, Ivan Fagiolino, Stefano Sangiorgi, Severino Ghini, Enzo Spisni, Fabio Vivarelli, Lucy C. Fairclough, Moreno Paolini, Donatella Canistro

“…Although the levels of toxicants in the mainstream are significantly lower than those observed in tobacco smoke, some recent studies have raised concerns about potential health risks associated with their use, particularly regarding their effects on male gonadal function, which remain largely unexplored.MethodsAdult male Sprague-Dawley rats were exposed, whole body, 5 days/week for 4 weeks to HnB mainstream.ResultsThe expression of the cell cycle regulators Bax/Bcl-2 ratio is not affected, along with no changes in p-38. …”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…Patients aged 18–75 years with gastric adenocarcinoma (stage cT3–4 and/or N + M0) underwent neoadjuvant FLOT therapy (four preoperative and four postoperative 2-week cycles) at Shanghai East Hospital. Laparoscopic gastrectomy was scheduled 3-4 weeks after completion of the last cycle of preoperative chemotherapy. …”
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Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals by Surachat Buddhisa, Nattaphol Prakobkaew, Piyapong Prasertsri, Sudarat Boonpitak, Puttipong Poncumhak, Orachorn Boonla

“…Methods: The number of 48 overweight and obese individuals was divided into 4 groups (n = 12/group) and total 40 participants were completed the 8-week program: 1) control group (n = 8), 2) PA group (n = 12); received PA at 150 mg/day, 5 days/wk, 3) square-stepping HIIT (n = 9); received square-stepping HIIT training for 15 min/day, 3 days/wk, 8 weeks and 4) HIIT+PA group (n = 11). …”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride (CCl4) for 12 weeks. Starting at week 7, SXN was administered intraperitoneally to the mice in the treatment group. …”
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A Personalized Muscle–Tendon Assessment and Exercise Prescription Concept Reduces Muscle–Tendon Imbalances in Female Adolescent Athletes by Theresa Domroes, Kolja Weidlich, Sebastian Bohm, Falk Mersmann, Adamantios Arampatzis

“…In the intervention group, athletes with a deficit in tendon stiffness (strain ≥ 9%; n = 6) or no muscle–tendon imbalances (strain between 4.5% and 9%; n = 15) performed exercises (3x/week for 32 weeks) with a personalized load to reach ~ 6.2% tendon strain to predominantly promote tendon or both muscle and tendon adaptation. …”
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Development and validation of the Information Literacy Measurement Scale (ILMS-34) in Chinese public health practitioners by Hui Li, Ke-Ying Li, Xia-Rong Hu, Xuan Hong, Yan-Ting He, Hua-Wei Xiong, Yi-Li Zhang

“…Other psychometric testing included item analysis, Cronbach's α coefficient, three-week test–retest reliability, and known-group validity. …”
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Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea by Rong Jiang, Qiru Wang, Huifen Zhai, Xiaohua Du, Shibo Sun, Haoyan Wang

“…Sestrin2 levels decreased after four-week nCPAP treatment (pre-nCPAP 5.21 ± 2.32 ng/mL, post-nCPAP 4.01 ± 1.54 ng/mL; P=0.004). …”
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