Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review by Wai Sinn Soh, Grace L. Burns, Tharindu Senanayake, Raquel Cameron, Kerith Duncanson, Guy D. Eslick, Sharmila S. Prasad, Stephen R. Smith, Simon Keely

“…Conclusion While surgical stress is one of the significant factor influencing NK cell cytotoxicity, this review indicates that perioperative intervention also contributes to decreased NK cell cytotoxicity. …”
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Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…Background Natural killer group 2D (NKG2D) is an activating receptor of natural killer (NK) cells and other lymphocytes that mediates lysis of malignant cells through recognition of stress-induced ligands such as MICA and MICB. …”
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…NKG2D, a homodimeric activating receptor expressed on NK cells, recognizes a diverse class of stress ligands expressed by cells experiencing infection, malignant transformation, chronic inflammation, and other cellular stresses. …”
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Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery by Jeng-Fu You, Cheng-Chi Lee, Yun-Shien Lee, Yih-Jong Chern, Chun-Kai Liao, Hung-Chih Hsu

“…Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. …”
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CT45A1‐mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell‐in‐cell structure, potentiating the progression of microsatellite... by Hao‐Wei Teng, Hsiang‐Yueh Huang, Chun‐Chi Lin, Yuh‐Ching Twu, Wen‐Hao Yang, Wen‐Chun Lin, Hsin‐Yi Lan, Yen‐Yu Lin, Wei‐Lun Hwang

“…Inactivating RHO‐ROCK/MLCK‐MLC2 signaling with small‐molecule inhibitors or short‐hairpin RNAs (shRNAs) targeting myosin light chain kinase (MYLK) abolished NK cell resistance and reduced the outer cell fate of CT45A1‐expressing MSI‐H CRC cells. …”
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Lessons Learned from Experimental Human Model of Zinc Deficiency by Ananda S. Prasad

“…Zinc supplementation improves cell-mediated immunity, decreases oxidative stress, and decreases generation of chronic inflammatory cytokines in humans. …”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Results:  Zinc was found to modulate the immune system, influencing T lymphocytes, B lymphocytes, macrophages, and natural killer cells. Deficiency weakened immune responses, increasing infection risk. …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Artificial intelligence prediction models and principal component analysis stress that RDEB is not solely confined to cutaneous issues but has complex systemic endotypes marked by immune dysregulation and hyperinflammation. …”
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Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…It further positively affects hematopoiesis and cytotoxic abilities of natural killer cells, and may act neuroprotective on a long-term basis. …”
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GITR-GITRL System, A Novel Player in Shock and Inflammation by Ludovic Tibor Krausz, Rodolfo Bianchini, Simona Ronchetti, Katia Fettucciari, Giuseppe Nocentini, Carlo Riccardi

“…It is expressed in several cells and tissues, including T cells, natural killer cells, and, at lower levels, in cells of innate immunity. …”
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How Red Tides Impact Manatees by Brittany Hall-Scharf, Armando J. Ubeda

“…Red tides, especially persistent blooms during winter months, can be one of the largest killers of Florida manatees, and they may become endangered again if they are subjected to increased mortality and stress. …”
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How Red Tides Impact Manatees by Brittany Hall-Scharf, Armando J. Ubeda

“…Red tides, especially persistent blooms during winter months, can be one of the largest killers of Florida manatees, and they may become endangered again if they are subjected to increased mortality and stress. …”
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