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121
The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect
Published 2025-01-01“…Overall, we aimed to highlight new research areas in PCD and viruses, including introduction of new targets for the development of new antiviral drugs to modulate the cellular apoptotic machinery and novel inhibitors of host cell death pathways.…”
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122
A graph neural network approach for hierarchical mapping of breast cancer protein communities
Published 2025-01-01“…Further overlaps with breast cancer cell dependencies revealed SUPT6H and RAD21, along with their respective protein systems, HOST:37 and HOST:861, as potential biomarkers. Using gene-level perturbation data of the HOST:37 and HOST:861 gene sets, three FDA-approved drugs with high therapeutic value were selected as potential treatments to be further evaluated. …”
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123
Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages
Published 2025-01-01“…Temperate phages adopt the lysogenic mode of infection, where the genome integrates into the host cell genome forming a prophage. Prophages enable viral genome replication without host cell lysis, and often contribute novel and beneficial traits to the host genome. …”
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124
SFC-Based IoT Provisioning on a Hybrid Cloud-Fog Computing with a Minimized Latency
Published 2024-01-01“…To address this, IoT requests have been virtualized and organized in service function chaining (SFC), which requires a host among hybrid cloud-fog computing nodes. To find a suitable host for each service function (SF) request, a typical migration algorithm has been used. …”
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125
Biofilm-associated proteins: from the gut biofilms to neurodegeneration
Published 2025-12-01“…This review contributes to the understanding of complex interactions among the microbiota, transmissible elements, and host, which is crucial for developing novel therapeutic approaches to combat microbiota-related diseases and improve overall health outcomes.…”
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126
Population-level gut microbiome and its associations with environmental factors and metabolic disorders in Southwest China
Published 2025-02-01“…We revealed extensive novel associations between the host microbiome and common metabolic disorders. …”
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127
Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses
Published 2012-01-01“…Much of the current literature has focused on viral genetics and its impact on host immunity as well as novel risk factors for severe infection (particularly within the H1N1 pandemic). …”
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128
Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants
Published 2018-01-01“…A myriad of pathogens gain access to the host via the mucosal route; thus, vaccinations that protect against mucosal pathogens are critical. …”
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129
Research progress on the antiviral immune regulation of ubiquitin ligase F-box family
Published 2025-01-01“…Given the large number of FBP family members, further research is required on the functions and mechanisms of FBPs in virus-host interactions, to provide novel directions for the development of antiviral drugs.…”
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130
Neutrophil Reverse Migration Becomes Transparent with Zebrafish
Published 2012-01-01“…The precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. …”
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131
Unveiling the role of long non-coding RNAs in chicken immune response to highly pathogenic avian influenza H5N1 infection
Published 2025-01-01“…Overall, our study provides insights into the role of lncRNAs in the host's response to HPAIV H5N1 infection in chickens and highlights potential candidates for further investigation into host–pathogen interactions. …”
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132
PPARγ in Bacterial Infections: A Friend or Foe?
Published 2016-01-01“…In this review we discuss the role of PPARγ and its activation during bacterial infections, with focus on the potential of PPARγ agonists and perhaps antagonists as novel therapeutic modalities. We conclude that adjustment in the dosage and timing of PPARγ agonist administration, based on the competence of host antimicrobial defenses and the extent of inflammatory response and tissue injury, is critical for achieving the essential balance between pro- and anti-inflammatory effects on the immune system.…”
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133
Retrovirus Entry by Endocytosis and Cathepsin Proteases
Published 2012-01-01“…Entry of enveloped viruses into host cell cytoplasm is achieved by fusion between the viral envelope and host cell membranes at either the cell surface or intracellular vesicles. …”
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134
Transgressive hybrids as hopeful holobionts
Published 2025-01-01“…Supporting such a conclusion, the correlations that we find between hybrid microbiota and the hybrid niche indicate that hybridization might change host microbiota in ways that promote a shift or an expansion in host niche space. …”
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135
Reversible Data Hiding Using Two Marked Images Based on Adaptive Coefficient-Shifting Algorithm
Published 2012-01-01“…This paper proposes a novel form of reversible data hiding using two marked images by employing the adaptive coefficient-shifting (ACS) algorithm. …”
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136
Toward <i>Mycobacterium tuberculosis</i> Virulence Inhibition: Beyond Cell Wall
Published 2024-12-01“…The ability to disrupt the host’s innate and adaptive immunity, as well as natural persistence, complicates disease control. …”
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137
The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies
Published 2025-02-01“…Simultaneously, human factors such as declining immunity, aging populations, and increased use of immunosuppressive therapies are enhancing host susceptibility. This review explores the intricate relationship between climate change and fungal infections, highlighting pathogens that may demonstrate increased virulence and antifungal resistance, along with emerging novel pathogens. …”
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138
Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation
Published 2025-02-01“…ABSTRACT The marine ecosystem is characterized by a rich diversity of bacterial hosts and their phages. The propagation of phages is primarily limited by their ability to adsorb to host cells and is further challenged by various bacterial defense mechanisms. …”
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139
Six new species of zombie-ant fungi from Yunnan in China
Published 2023-05-01“…This study contributes towards a better understanding of the evolutionary relationship between hosts and fungi, and provides novel insights into the morphology, distribution, parasitism, and ecology of Ophiocordyceps unilateralis sensu lato. …”
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140
Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain
Published 2025-01-01“…Most studies have primarily investigated how gut bacteria modulate host epigenetics and gene expression; their impact on host alternative splicing, particularly in the brain, remains largely unexplored. …”
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