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Fluorescence Properties of Novel Multiresonant Indolocarbazole Derivatives for Deep-Blue OLEDs from Multiscale Computer Modelling
Published 2025-01-01“…Multiresonant fluorophores are a novel class of organic luminophores with a narrow emission spectrum. …”
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The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health
Published 2025-02-01“…The prevalence of AIVs in chickens, therefore, increases the risk of human infection. Notably, the main host of the novel H10N3 virus has shifted from waterfowl to chickens, and the virus can be transmitted between chickens via respiratory droplets, posing a potential risk of a pandemic within poultry populations. …”
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Tuberculosis vaccines and therapeutic drug: challenges and future directions
Published 2025-01-01“…Furthermore, the review delves into current TB therapeutics, particularly for multidrug-resistant tuberculosis (MDR-TB), exploring promising agents like bedaquiline (BDQ) and delamanid (DLM), as well as the potential of host-directed therapies. The hurdles in TB vaccine and therapeutic development encompass overcoming antigen diversity, enhancing vaccine effectiveness across diverse populations, and advancing novel vaccine platforms. …”
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Biological characterization of novel Escherichia coli O157:H7 phages and their bacteriostatic effects in milk and pork
Published 2025-02-01“…The optimal MOIs of vB_EcoP_SD2 and vB_EcoP_SD6 was 0.1 and 0.01, and temperature range for maintaining activity was 4°C to 55°C. The host range of vB_EcoP_SD2 and vB_EcoP_SD6 was 65% (13/20) and 55% (11/20), which was partially complementary to each other (75%, 15/20). …”
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Novel anti-inflammatory properties of mannose oligosaccharides in the treatment of inflammatory bowel disease via LGALS3 modulation
Published 2025-02-01“…Detailed molecular analyses further demonstrated that these changes in microbiota were associated with modifications in the host’s immune response, particularly through the suppression of key inflammatory pathways and cytokines involved in IBD progression. …”
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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based...
Published 2025-01-01“…Moreover, our results suggest that TKIs present promising opportunities as novel therapeutic agents against influenza-induced pneumonia.…”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba
Published 2024-05-01“…Therefore, there is an urgent need for more research on the pathogenesis of N. fowleri and the identification of novel targets for intervention. With the advances in genomic and proteomic technologies, new opportunities have emerged to explore the molecular biology of N. fowleri and its host response. …”
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Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4
Published 2025-02-01“…This study, for the first time, identifies a novel ubiquitin ligase, FBXO4 that targets the degradation of HPV E6 oncoprotein in the absence of E6AP in cervical cancer-derived cell lines. …”
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Novel H16N3 avian influenza viruses isolated from migratory gulls in China in 2023
Published 2025-01-01“…In this study, we isolated three novel H16N3 viruses from migratory gulls in East Asian–Australasian Flyway in eastern China in 2023, which are significantly different from previously identified isolates. …”
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91
The PANORAMIC Survey: Pure Parallel Wide Area Legacy Imaging with JWST/NIRCam
Published 2025-01-01Get full text
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Forecasting Chinese Wind Power Installed Capacity Using a Novel Grey Model with Parameters Combination Optimization
Published 2021-01-01“…The intermittent and uncertain characteristics of wind generation have brought new challenges for the hosting capacity and the integration of large-scale wind power into the power system. …”
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The feasibility of a novel national quality improvement programme for tobacco dependency treatment pathways in acute UK hospitals
Published 2025-01-01“…Barriers to QI include knowledge, costs and competing demands.This study aimed to evaluate the feasibility and effectiveness of a national QI programme hosted by the British Thoracic Society, focused on improving NHS tobacco dependency treatment in acute hospitals. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
Published 2022-10-01“…Moreover, the efficacy of NDCs is biased toward dependence on host expression of PD-L1.Conclusions The novel PD-L1/TLR7 dual-targeting NDC exhibited potent efficacy against heterogeneous tumors through orchestrating innate and adaptive immunity, which could act as a promising strategy to improve ICB therapy and shows prospects for clinical development.…”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response
Published 2025-01-01“…The observed disruption of actin dynamics and endosome-phagosome maturation underscores a novel mechanism by which Mtb evades host defenses. …”
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A novel Arabidopsis phyllosphere resident Protomyces species and a re-examination of genus Protomyces based on genome sequence data
Published 2021-03-01“…Consequently, we propose that Protomyces is not strictly associated only with the previously recognized host plants.…”
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