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PANoptosis in Bacterial Infections: A Double-Edged Sword Balancing Host Immunity and Pathogenesis
Published 2025-01-01“…On the other hand, bacteria can exploit PANoptosis to evade host immune defenses. This dual nature underscores the potential of PANoptosis as a target for developing novel therapies against bacterial infections. …”
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Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells
Published 2014-01-01“…We have recently suggested a novel mechanism, autoendocytosis, for the entry of certain microbes into their hosts, with a key role played by the sphingomyelinase-catalyzed topical conversion of sphingomyelin to ceramide, the differences in the biophysical properties of these two lipids providing the driving force. …”
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Freshwater sponges in the southeastern U.S. harbor unique microbiomes that are influenced by host and environmental factors
Published 2025-01-01“…Bacterial taxa within the Gammproteobacteria, Alphproteobacteria, Bacteroidota (Flavobacteriia in particular), and Verrucomicrobia, were notable as enriched in the sponge relative to the surrounding water across sponge individuals with diverging microbial communities from the water. These results add novel information on the assembly and maintenance of microbial communities in an ancient metazoan host and is one of few published studies on freshwater sponge microbial symbiont communities.…”
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3D Localization of FRB 20190425A for Its Potential Host Galaxy and Implications
Published 2025-01-01“…In this paper, we introduce a novel approach to identifying potential host galaxies in three-dimensional space. …”
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Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease
Published 2018-01-01“…This case report highlights the importance of vigilance for severe side effects in novel immunosuppressive drug combinations.…”
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New Hosts of Simplicimonas similis and Trichomitus batrachorum Identified by 18S Ribosomal RNA Gene Sequences
Published 2013-01-01“…In this study, four trichomonad isolates were obtained from carabao, dog, and pig hosts using rectal swab. Genomic DNA was extracted using Chelex method and the 18S rRNA gene was successfully amplified through novel sets of primers and undergone DNA sequencing. …”
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Estimating the Burden of Cost in Chronic Graft-versus-Host Disease: A Human Capital Approach
Published 2016-06-01“…With advances in organ matching and preventing acute graft-versus-host-disease (aGvHD), chronic graft-versus-host disease (cGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) has become a focus of transplant-related morbidity and mortality. …”
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The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.
Published 2024-08-01“…The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here, we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. …”
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Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease
Published 2007-01-01“…The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease.…”
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Purpurin suppresses Salmonella invasion of host cells by reducing the secretion of T3SS-1 effector proteins
Published 2025-02-01“…Therefore, PPR represents a promising antivirulence drug that targets the T3SS of ST and may serve as a hit compound for the development of novel antivirulence drugs for the treatment of ST.…”
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An integrated approach using proximity labelling and chemical crosslinking to probe in situ host-virus protein–protein interactions
Published 2024-01-01“…Thus, the identification and characterization of such viral-host dependency factors has been an attractive area of research to provide novel antiviral targets. …”
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Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera)
Published 2025-01-01“…Our findings open novel perspectives on possible new therapies for DWV control by targeting specific host proteins.…”
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms
Published 2025-02-01“…Gut microbiota has emerged as a novel target in various host physiological disorders including aging. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication
Published 2025-01-01“…Overall, this research provides valuable insights into elucidating the function of the p17 protein and sheds light on the pathogenic mechanism involving ARV-induced cellular apoptosis while offering novel perspectives for exploring therapeutic targets against ARV.…”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds
Published 2018-01-01“…Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. …”
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