Coculture with Eastern oysters is unlikely to reduce OsHV-1 impacts to farmed Pacific oysters: A modelling approach by Familusi Oluwatosin Adekunle, Gorka Bidegain, Tal Ben-Horin

“…In recent decades, the global expansion of Pacific oyster Magallana gigas aquaculture, driven by this species’ adaptability and rapid growth, has coincided with the emergence of novel and virulent microvariants (muvars) of Ostreid herpesvirus 1 (OsHV-1), causing significant industry losses. …”
Get full text

Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function. by Bo Ning Wang, Xin Zhuo Zhang, Jin Yi Wu, Zhao Yu Zhang, Pei Kun Cong, Wen Wen Zheng, Shao Rong Long, Ruo Dan Liu, Jing Cui, Zhong Quan Wang

“…<h4>Background</h4>C-type lectin (CTL) plays an important act in parasite adhesion, host's cell invasion and immune escape. Our previous studies showed that recombinant Trichinella spiralis C-type lectin (rTsCTL) mediated larval invasion of enteral mucosal epithelium. …”
Get full text

Helminth diversity of nutria (Myocastor coypus) across the Morava basin in the Czech Republic by Michal Benovics, Eva Nosková, Anna Klimešová, Lucie Škorpíková, Ema Jaššová, Jakub Drimaj, Jan Slováček, Ondřej Mikulka

“…The highest prevalence was observed for Strongyloides myopotami (78.3%) and Trichuris myocastoris (37.0%), both of which are host-specific nematodes of nutria. Only 2 trematode taxa were recorded (Echinostoma sp. and a representative of the family Psilostomidae). …”
Get full text

Determining the incidence, risk factors and biological drivers of irritable bowel syndrome (IBS) as part of the constellation of postacute sequelae of SARS-CoV-2 infection (PASC) o... by Erika Austhof, Kelly M Heslin, Xiaoxiao Sun, Kristen Pogreba Brown, Caitlyn M McFadden, Caroline Scranton, Ivan Vujkovic-Cviji, Dominic Rodriguez, Laura Falk, Gayatri Arani, Victoria Obergh, Kate Bessey, Kerry Cooper

“…Both samples will undergo a novel method to quantitate humoral and mucosal immune responses to host-derived faecal communities in conjunction with magnetic bead-based separation and high-depth shotgun microbial sequencing. …”
Get full text

Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology by Andrés F. Londoño, Ajay Sharma, Jared Sealy, Vipin S. Rana, Shelby D. Foor, Vera Y. Matrosova, Elena K. Gaidamakova, Robert P. Volpe, Michael J. Daly, Brian M. Hoffman, Utpal Pal, J. Stephen Dumler

“…B. burgdorferi appears to have evolved a system not to protect from irradiation, but presumably to protect from oxidative stress when cyclically transmitted from tick to mammalian host and back. These data also suggest a path forward in the development of novel vaccines against spirochete infections, including Lyme disease, through preparation involving the synthetic Mn2+-decapeptide-phosphate antioxidant complex MDP to provide B. burgdorferi epitope protection during sterilizing gamma-irradiation that eliminates growth. …”
Get full text

Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes by Xiaojing Wang, Tong Wang, Qian Zhang, Li Xu, Xinhua Xiao

“…These findings suggest that insulin may be a potentially novel and inexpensive intervention for prediabetes.…”
Get full text

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential by Wenhan Tian, Yuzeng Liu, Bo Han, Fengqi Cheng, Kang Yang, Weiyuan Hu, Dongdong Ye, Sujun Wu, Jiping Yang, Qi Chen, Yong Hai, Robert O. Ritchie, Guanping He, Juan Guan

“…During in vivo degradation, this material primarily undergoes host cell-mediated surface degradation, rather than bulk hydrolysis. …”
Get full text

Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications by Jialian Wang, Xingyu Tao, Zhengyang Liu, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu

“…Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a frequent and serious complication of sepsis that considerably impacts both short-term and long-term survival outcomes. …”
Get full text

Genome‐wide association study of tuberculosis in the western Chinese Han and Tibetan population by Hao Bai, Mengyuan Song, Shikun Lei, Lin Jiao, Xuejiao Hu, Tao Wu, Jiajia Song, Tangyuheng Liu, Wu Peng, Zhenzhen Zhao, Zirui Meng, Binwu Ying

“…To gain greater insight into the host susceptibility to TB, we perform a two‐stage genome‐wide association study to identify the susceptible loci of TB. …”
Get full text

Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research by Zhanpeng Chen, Qiong Wang, Quan Ma, Jinyun Chen, Xingxing Kong, Yuqin Zeng, Lanlan Liu, Shuihua Lu, Xiaomin Wang

“…Transcriptomics is a highly effective tool for the development of novel anti-tuberculosis drugs. However, most studies focus only on changes in gene expression levels at specific time points. …”
Get full text

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

“…Abstract Background Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role in successful wound healing. …”
Get full text

Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. …”
Get full text

Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

“…However, the tumor-signal-dependent nature of this approach results in low sensitivity in precancerous and early CRC stages. Here we propose the host immune response to the onset of cancer as an alternative approach for early detection of CRC.Methods We perform whole transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from individuals with CRC, precancerous lesions or negative colonoscopy in two independent cohorts using next-generation sequencing.Results We discover and validate novel early CRC RNA biomarkers. …”
Get full text

Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…Due to the complex natures of dietary food components, it is difficult to elucidate how the compounds affect host health. Dietary food often selectively presents its mechanism of action on different cell types, and participates in the modulation of targeted cells and their microenvironments within organs. …”
Get full text

Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Analysis of vB_Kpn_HF0522 characteristics, including optimal multiplicity of infection (MOI), one-step growth curve, host range, stability in different environments, and adsorption capacity. …”
Get full text

Genome evolution following an ecological shift in nectar-dwelling Acinetobacter by Vivianna A. Sanchez, Tanya Renner, Lydia J. Baker, Tory A. Hendry

“…ABSTRACT The bacterial genus Acinetobacter includes species found in environmental habitats like soil and water, as well as taxa adapted to be host-associated or pathogenic. High genetic diversity may allow for this habitat flexibility, but the specific genes underlying switches between habitats are poorly understood. …”
Get full text

The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Mohamed, Moubarak, Keneth Iceland, Kasozi, Helal F., Hetta, Hazem M., Shaheen, Abdur, Rauf, Hayder M., Al-kuraishy, Safaa, Qusti, Eida M., Alshammari, Emmanuel Tiyo, Ayikobua, Fred, Ssempijja, Adam Moyosore, Afodun, Ritah, Kenganzi, Ibe Michael, Usman, Juma John, Ochieng, Lawrence Obado, Osuwat, Kevin, Matama, Ali I., Al-Gareeb, Emmanuel, Kairania, Monica, Musenero, Susan, Christina Welburn, Gaber, El-Saber Batiha

“…Novel therapies for the treatment of COVID-19 are continuing to emerge as the SARS-Cov- 2 pandemic progresses. …”
Get full text

Protein identification using Cryo-EM and artificial intelligence guides improved sample purification by Kenneth D. Carr, Dane Evan D. Zambrano, Connor Weidle, Alex Goodson, Helen E. Eisenach, Harley Pyles, Alexis Courbet, Neil P. King, Andrew J. Borst

“…This issue is particularly problematic for self-assembling protein nanomaterials, where unexpected geometries may reflect novel assembly states, cross-contamination, or native proteins originating from the expression host. …”
Get full text

Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa by Rieneke Weij, Stephanie E. Baker, Tara R. Edwards, Job Kibii, Georgina Luti, Robyn Pickering

“… South Africa is host to the single richest early hominin fossil record worldwide, including many examples of the endemic species Australopithecus africanus fossils. …”
Get full text

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. Finally, the esophageal microbiome could be the protagonist to be investigated, deepening our understanding of the subtle association between the host microbiota and tumor development.…”
Get full text