Articular Cartilage Repair Using Marrow Stimulation Augmented with a Viable Chondral Allograft: 9-Month Postoperative Histological Evaluation by James K. Hoffman, Sandra Geraghty, Nicole M. Protzman

“…The present report describes treatment of a trochlear defect with marrow stimulation augmented with this novel chondral allograft, along with nine month postoperative histological results. …”
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Protein multiplicity: exemplifying an overwhelmingly likely pattern of molecular evolution? by Les Hatton, Greg Warr

“…We observe over 13 million multiplicious proteins, ranging from the highly conserved (including histones, components of photosystems, and the electron transport chain) to the rapidly evolving viral proteins that are involved in infection and adaptation to novel host species. CoHSI predicts that when considered globally across all three domains of life and the viruses, multiplicity will show a distinctive variant of the Zipfian distribution. …”
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A Perspective Review on Thermal Conductivity of Hybrid Nanofluids and Their Application in Automobile Radiator Cooling by Wisdom Etabiese Ukueje, Fidelis Ibiang Abam, Anthony Obi

“…Hybrid nanofluids developed with the fusion or suspension of two or more different nanoparticles in a mixture as a novel heat transfer fluid are currently of interest to researchers due to their proven better measured thermal conductivities. …”
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Fractal-Shaped Metamaterials and Applications to Enhanced-Performance Devices Exhibiting High Selectivity by He-Xiu Xu, Guang-Ming Wang, Chen-Xin Zhang

“…Novel single negative metamaterial (MTM) transmission lines (TLs) are presented and studied in microstrip technology. …”
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Comprehensive Insights into Monkeypox (mpox): Recent Advances in Epidemiology, Diagnostic Approaches and Therapeutic Strategies by Suresh Kumar, Dhanyashri Guruparan, Kalimuthu Karuppanan, K. J. Senthil Kumar

“…Diagnostic innovations, such as improved molecular assays, have enhanced detection accuracy, while novel therapeutic strategies, including antiviral drugs and vaccines, show promise in mitigating outbreaks. …”
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ZnFe2O4-TiO2 Nanoparticles within Mesoporous MCM-41 by Aidong Tang, Yuehua Deng, Jiao Jin, Huaming Yang

“…A novel nanocomposite ZnFe2O4-TiO2/MCM-41 (ZTM) was synthesized by a sol-gel method and characterized through X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), N2 adsorption-desorption, Raman spectroscopy, and ultraviolet visible (UV-vis) spectrophotometry. …”
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Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19 by Maryam Pourhajibagher

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the host cells by binding the viral surface spike glycoprotein (SG) to angiotensin-converting enzyme 2. …”
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Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…From the haunting reappearances of familiar adversaries like influenza to the unexpected onslaught of novel viruses such as SARS-CoV-2, this era has borne witness to a diverse array of health crises that have tested the resilience of societies worldwide. …”
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Co-Infection of <i>Culex tarsalis</i> Mosquitoes with Rift Valley Fever Phlebovirus Strains Results in Efficient Viral Reassortment by Emma K. Harris, Velmurugan Balaraman, Cassidy C. Keating, Chester McDowell, J. Brian Kimble, Alina De La Mota-Peynado, Erin M. Borland, Barbara Graham, William C. Wilson, Juergen A. Richt, Rebekah C. Kading, Natasha N. Gaudreault

“…Reassortment events can produce novel genotypes with altered virulence, transmission dynamics, and/or mosquito host range. …”
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Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases by Jovany J. Betancourt, Minna Ding, J. Marina Yoder, Issa Mutyaba, Hannah M. Atkins, Gabriela De la Cruz, David B. Meya, Kirsten Nielsen

“…Ultimately, we show that C3HeB/FeJ mice latently infected with C. neoformans form non-necrotic granulomas and could provide a novel mouse model to investigate host immune response profiles.…”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. …”
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The impact of aging on neutrophil functions and the contribution to periodontitis by Zi Wang, Anish Saxena, Wenbo Yan, Silvia M. Uriarte, Rafael Siqueira, Xin Li

“…Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues. …”
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Mimosa diplotricha (Fabaceae) Recruits Native Pollinators, But Does it Matter? by I.N. Egbon, O.P. Nzie, J. Rotimi

“…In sum, that the population of M. diplotricha is still  expanding in Nigeria against the backdrop of their utilisation by native pollinators is suggestive of a continual recruitment of the pollinators, which may prefer the novel host within a mosaic of widely scattered native flowering plants. …”
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Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Thus, based on the vital role of gut microbiota on bone health, it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of osteoporosis. …”
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Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. by William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard, Judd F Hultquist

“…Taken together, these results suggest that the release of P-TEFb from cellular SECs may be a novel route for HIV-1 latency reactivation.…”
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Alzheimer’s Disease and <i>Porphyromonas gingivalis</i>: Exploring the Links by Ivana Shawkatova, Vladimira Durmanova, Juraj Javor

“…This review underscores the need for further investigation into <i>P. gingivalis</i>-mediated mechanisms and their interplay with host responses. Understanding these interactions could provide critical insights into novel strategies for reducing AD risk through periodontal disease management.…”
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MicroRNA-155: Regulation of Immune Cells in Sepsis by Ming Chen, Fuquan Wang, Haifa Xia, Shanglong Yao

“…MicroRNAs are small noncoding RNAs which regulate gene expression at the posttranscriptional level. miR-155 is encoded by the miR-155 host gene (miR155HG), also known as the noncoding B cell integration cluster (BIC). …”
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Marine Diterpenoids as Potential Anti-Inflammatory Agents by Yisett González, Daniel Torres-Mendoza, Gillian E. Jones, Patricia L. Fernandez

“…Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Vesicular Stomatitis Virus (VSV) has emerged as a promising candidate for various clinical applications, including vaccine development, virus pseudotyping, and gene delivery. Its broad host range, ease of propagation, and lack of pre-existing immunity in humans make it ideal for therapeutic use. …”
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Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates by Gregory S. Lambert, Rebecca J. Kaddis Maldonado, Leslie J. Parent

“…Retroviral genome selection and virion assembly remain promising targets for novel therapeutic intervention. Recent studies have demonstrated that the Gag proteins of Rous sarcoma virus (RSV) and human immunodeficiency virus type-1 (HIV-1) undergo nuclear trafficking, colocalize with nascent genomic viral RNA (gRNA) at transcription sites, may interact with host transcription factors, and display biophysical properties characteristic of biomolecular condensates. …”
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