TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

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The Dominant Role of the Water Column in Nitrogen Removal and N2O Emissions in Large Rivers by Junfeng Wang, Xinghui Xia, Shaoda Liu, Sibo Zhang, Ling Zhang, Chenrun Jiang, Zhenrui Zhang, Yuan Xin, Xin Chen, Jing Huang, Jiaao Bao, William H. McDowell, Greg Michalski, Zhifeng Yang, Jun Xia

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Outpatient Versus Inpatient Total Joint Arthroplasty: Do Medically and Socially Complex Patients Require More Resources but Achieve Similar Outcomes? by Justin Leal, BS, Christine J. Wu, MD, Niall H. Cochrane, MD, Thorsten M. Seyler, MD, PhD, William A. Jiranek, MD, Samuel S. Wellman, MD, Michael P. Bolognesi, MD, Sean P. Ryan, MD

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Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Sever... by Bradley A. Dengler, Oliver Karam, Colleen A. Barthol, Aaron Chance, Laura E. Snider, Clare M. Mundy, Michael T. Bounajem, William C. Johnson, Moustafa M. Maita, Paola M. Mendez-Gomez, Ali Seifi, Shaheryar Hafeez

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Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment by Morgan T. Sutton, David Fletcher, Santosh K. Ghosh, Aaron Weinberg, Rolf van Heeckeren, Sukhmani Kaur, Zhina Sadeghi, Adonis Hijaz, Jane Reese, Hillard M. Lazarus, Donald P. Lennon, Arnold I. Caplan, Tracey L. Bonfield

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Rurality and Outcomes of Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke by Cassidy Lavin, Jacob Epstein, Alvin Huanwen Chen, Minahil Cheema, Jerry Yang, Alexa Aquino, Angie Chan, Nancy Le, Gillian Cooper, Ambra Palushi, Chad Schrier, Dheeraj Gandhi, Seemant Chaturvedi, Jessica Downing, Quincy K. Tran

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Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease by Lynn Cotterill, Debbie Payne, Scott Levison, John McLaughlin, Emma Wesley, Mark Feeney, Hilary Durbin, Simon Lal, Alistair Makin, Simon Campbell, Stephen A Roberts, Catherine O’Neill, Cathryn Edwards, William G Newman

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Water-Based Supplementation Technology for Grazing Cattle in the Tropics: A Large-Scale Commercial Case Study by Eliéder Prates Romanzini, Vivienne McCollum, Sarah Mcilveen, Evandro Maia Ferreira, William Luiz de Souza, Marcelo Augusto Oliveira Castro, Priscila Arrigucci Bernardes, Ryan J. Batley, Mark G. Trotter, Diogo Fleury Azevedo Costa

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Minimizing Honey Bee Exposure to Pesticides by James D. Ellis, Jeanette Klopchin, Eileen Buss, Frederick M. Fishel, William H. Kern, Catharine Mannion, Eugene McAvoy, Lance S. Osborne, Michael Rogers, Malcolm Sanford, Hugh Smith, Phillip Stansly, Lukasz Stelinski, Susan Webb

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Minimizing Honey Bee Exposure to Pesticides by James D. Ellis, Jeanette Klopchin, Eileen Buss, Frederick M. Fishel, William H. Kern, Catharine Mannion, Eugene McAvoy, Lance S. Osborne, Michael Rogers, Malcolm Sanford, Hugh Smith, Phillip Stansly, Lukasz Stelinski, Susan Webb

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Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering by William S. Grubbe, Bixia Zhang, Aileen Kauffman, Fabian Byléhn, Kasia Padoł, Hae-Gwang Jung, Seung Bum Park, Jessica M. Priest, Engin Özkan, Juan J. de Pablo, T. Jake Liang, Minglei Zhao, Juan L. Mendoza

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The Florida Plant Diagnostic Network by Aaron J. Palmateer, Carrie L. Harmon, Amanda Hodges, Natalia Peres, Kuang Ren Chung, Pamela D. Roberts, Lyle Buss, William T. Crow, Jiannong Xin, Robert J. McGovern, James W. Kimbrough, Timur M. Momol

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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

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Inpatient service utilization amongst infants diagnosed with Respiratory Syncytial Virus infection (RSV) in the United States. by Jason R Gantenberg, Kathryn D Thompson, Robertus van Aalst, David M Smith, Megan Richards, Christopher B Nelson, William V La Via, Sandra S Chaves, Angela M Bengtson, David A Savitz, Andrew R Zullo

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The Investigation of Mixed Ferrofluids Containing Iron Oxide nanoparticles and Microspheres by Sharanabasava V. Ganachari, Veerabhadragouda B. Patil, Nagaraj R. Banapurmath, Manzoore Elahi M. Soudagar, Kiran Shahapurkar, Ashraf Elfasakhany, Mishal Alsehli, Akshata Yavagal, Pradyumna Mogre, Vijayakumar M Hiremath, Shankar A. Hallad

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Lifestyle Intervention Improves Heart Rate Recovery from Exercise in Adults with Type 2 Diabetes: Results from the Look AHEAD Study by Paul M. Ribisl, Sarah A. Gaussoin, Wei Lang, Judy Bahnson, Stephanie A. Connelly, Edward S. Horton, John M. Jakicic, Tina Killean, Dalane W. Kitzman, William C. Knowler, Kerry J. Stewart, Look AHEAD Research Group

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Effectiveness of Frequent Point-of-Care Molecular COVID-19 Surveillance in a Rural Workplace: Nonrandomized Controlled Clinical Trial Among Miners by Akshay Sood, William “Cotton” Jarrell, Xin W Shore, Nestor Sosa, Alisha Parada, Nicholas Edwardson, Alexandra V Yingling, Teah Amirkabirian, Qiuying Cheng, Ivy Hurwitz, Linda S Cook, Shuguang Leng, Orrin B Myers, Douglas J Perkins

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Evaluating biomarkers in canine cytotoxic interface dermatitis reactions to account for clinical and histopathological similarities and differences by Shriya Kannan, Neil B. Wong, Grace E. Ryan, Nia E. R. James, Ayodeji Ajayi, Janet E. Lubov, Clement N. David, Linda Wrijil, Nicholas A. Robinson, Kelly Hughes, Ramon M. Almela, Jillian M. Richmond

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Detection of Circulating Tumor DNA in Patients with Thyroid Nodules by Krupal B. Patel, Nicholas Cormier, James Fowler, Allison Partridge, Julie Theurer, Morgan Black, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, William Stecho, Christopher Howlett, Muriel Brackstone, John W. Barrett, Anthony Nichols

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Evolution of the umbilical cord blood proteome across gestational development by Leena B. Mithal, Nicola Lancki, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Nathaniel J. Rhodes, Byoung-Kyu Cho, William A. Grobman, Judd F. Hultquist, Denise Scholtens, Karen K. Mestan, Patrick C. Seed

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