CircRNA-Disease Associations Prediction Based on Metapath2vec++ and Matrix Factorization by Yuchen Zhang, Xiujuan Lei, Zengqiang Fang, Yi Pan

“…Circular RNA (circRNA) is a novel non-coding endogenous RNAs. Evidence has shown that circRNAs are related to many biological processes and play essential roles in different biological functions. …”
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The IclR-family transcriptional regulator XyrR controls flotation, motility, antibiotic production and virulence in Serratia sp. ATCC 39006 by Carlo Miguel Castro Sandoval, Carlo Miguel Castro Sandoval, George P. C. Salmond

“…Regulation of GVs and secondary metabolites in S39006 can be coordinated but such pleiotropy is still poorly understood. To uncover novel inputs to this complex regulatory network, we used transposon mutagenesis to identify a mutant with an insertion in an IclR-type transcriptional regulator gene. …”
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Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…Abstract The global race against antimicrobial resistance requires novel antimicrobials that are not only effective in killing specific bacteria, but also minimize the emergence of new resistances. …”
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Early detection of canine hemangiosarcoma via cfDNA fragmentation and copy number alterations in liquid biopsies using machine learning by Soohyun Ko, Jinhee Jang, Sun Shin Yi, Sun Shin Yi, ChangHyuk Kwon

“…Additionally, we identified seven novel genomic gains and nine losses in the hemangiosarcoma samples. …”
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Associations Between Albumin/Neutrophil-to-Lymphocyte Ratio Score and New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction Undergoing PCI by Yang SB, Zhao HW

“…Moreover, when divided into three groups according to the tertile of ANS, patients in tertile 1 (lowest in ANS) showed a 2.214-fold increased risk of NOAF in comparison to those in the tertile 3 (HR, 2.214; 95% CI 1.804– 5.101; P = 0.029).Conclusion: ANS is a robust tool for the prediction of NOAF in AMI patients underwent PCI. …”
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Silybin Cocrystals with Improved Solubility and Bioavailability by Bingqing Zhu, Zhenfeng Ding, Xiaoyi Rong, Shengqiang Li, Xuefeng Mei

“…Pharmacokinetic studies in rats revealed that the cocrystal exhibited a 16-fold increase in bioavailability compared to the raw Silybin extract, outperforming the commercial Silybin–phosphatidylcholine complex. …”
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Embedded Vehicle Routing Problem: A Modeling and Optimization Framework for Real-World Multi-Purpose Truck Network by Tipaluck Krityakierne, Chanon Boonkangwan, Chanoknun Phunnasorn, Wasakorn Laesanklang

“…This paper introduces original contributions to the field of vehicle routing problems, specifically addressing the optimization of multi-purpose truck routing within the agricultural third-party logistics domain. The study presents a novel approach aimed at optimizing the routing of a 3PL provider’s truck fleet, considering efficient commodity delivery and hygienic practices for transporting agricultural products. …”
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Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…Study findings may lead to novel therapeutic targets. This trial is registered with ClinicalTrials.gov identifier: NCT00970034.…”
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Acyl-CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic-Associated Steatohepatitis by Elisa Pasini, Cristina Baciu, Marc Angeli, Bianca Arendt, Diogo Pellegrina, Jüri Reimand, Keyur Patel, George Tomlinson, Mohammad T. Mazhab-Jafari, Lakshmi P. Kotra, Sandra Fischer, Johane P. Allard, Atul Humar, Mamatha Bhat

“…ACOT1 expression was 3-fold higher in MASH as compared to steatosis. In patient samples, ACOT1 was significantly correlated with the severity of MASH as reflected by the nonalcoholic fatty liver disease score. …”
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Total Organic Carbon Content Prediction in Lacustrine Shale Using Extreme Gradient Boosting Machine Learning Based on Bayesian Optimization by Xingzhou Liu, Zhi Tian, Chang Chen

“…However, common TOC prediction methods rely on empirical formulas, and their applicability varies widely from region to region. In this study, a novel data-driven Bayesian optimization extreme gradient boosting (XGBoost) model was proposed to predict the TOC content using wireline log data. …”
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Evaluation of N-NOSE as a surveillance tool for recurrence in gastric and esophageal cancers: a prospective cohort study by Sayuri Iitaka, Akihiro Kuroda, Tomonori Narita, Hideyuki Hatakeyama, Masayo Morishita, Umbhorn Ungkulpasvich, Takaaki Hirotsu, Eric di Luccio, Koichi Yagi, Yasuyuki Seto

“…Results In cases of recurrence with vascular invasion, the chemotaxis index at 100-fold urine dilution was significantly elevated compared to the non-recurrence group. …”
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Understanding the impact of summer festival on the dynamic of micropollutant delivery to coastal wastewater treatment plant by Agne Jucyte-Cicine, Elise Lorre, Jolita Petkuviene, Zita R. Gasiunaite, Ema Durcova, Irma Vybernaite-Lubiene, Mindaugas Zilius

“…These findings provide novel insights into how temporal gatherings can increase pollution levels in the coastal areas of the Baltic region and highlight the potential for this pollution to be inadequately retained in treatment facilities, posing risks to the marine environment.…”
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Optimized Naive-Bayes and Decision Tree Approaches for fMRI Smoking Cessation Classification by Amirhessam Tahmassebi, Amir H. Gandomi, Mieke H. J. Schulte, Anna E. Goudriaan, Simon Y. Foo, Anke Meyer-Baese

“…This paper aims at developing new theory-driven biomarkers by implementing and evaluating novel techniques from resting-state scans that can be used in relapse prediction for nicotine-dependent patients and future treatment efficacy. …”
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A quantum-optimized approach for breast cancer detection using SqueezeNet-SVM by Anas Bilal, Ali Alkhathlan, Faris A. Kateb, Alishba Tahir, Muhammad Shafiq, Haixia Long

“…The novel Q-BGWO-SQSVM model outperforms the state-of-the-art classification methods and offers accurate and reliable early breast cancer detection, which is essential for further healthcare development.…”
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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…These findings highlight the role of lncRNAs as multi-level regulators in the complex network of post-stroke mechanisms, providing novel insights into the pathophysiological processes of stroke.…”
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QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite by Namrata Gautam, Debopriya Dutta, Saurabh Mittal, Perwez Alam, Nasr A. Emad, Mohamed H. Al-Sabri, Suraj Pal Verma, Sushama Talegaonkar

“…Abstract The repercussions of hormone replacement therapy (HRT) and bisphosphonates pose serious clinical challenges and warrant novel therapies for osteoporosis in menopausal women. …”
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Synergistic potential of α-Phellandrene combined with conventional antifungal agents and its mechanism against antibiotic resistant Candida albicans by Riya Bhattacharya, Prashant Sharma, Debajyoti Bose, Manish Singh

“…This study investigates a novel approach on the potential fungicidal effects of α-Phellandrene combinations with fluconazole and amphotericin B against antibiotic resistant C. albicans. …”
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Prediction of circRNA-miRNA Associations Based on Network Embedding by Wei Lan, Mingrui Zhu, Qingfeng Chen, Jianwei Chen, Jin Ye, Jin Liu, Wei Peng, Shirui Pan

“…circRNA is a novel class of noncoding RNA with closed-loop structure. …”
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Contribution of OqxAB Efflux Pump in Selection of Fluoroquinolone-Resistant Klebsiella pneumoniae by Orsolya Szabo, Bela Kocsis, Nikolett Szabo, Katalin Kristof, Dora Szabo

“…However, increasing ciprofloxacin promoted oqxB expression as it reached fold increase of 15.8–22.8, while oqxA expression was maintained (2−ΔCt = 2-2.15). …”
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Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition. by Tiffany M Halvorsen, Kaitlin A Schroeder, Allison M Jones, Disa Hammarlöf, David A Low, Sanna Koskiniemi, Christopher S Hayes

“…Using forward genetic approaches, we identify novel receptors for the group 5 and 6 ionophores. …”
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