Silybin Cocrystals with Improved Solubility and Bioavailability by Bingqing Zhu, Zhenfeng Ding, Xiaoyi Rong, Shengqiang Li, Xuefeng Mei

“…Pharmacokinetic studies in rats revealed that the cocrystal exhibited a 16-fold increase in bioavailability compared to the raw Silybin extract, outperforming the commercial Silybin–phosphatidylcholine complex. …”
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Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…Study findings may lead to novel therapeutic targets. This trial is registered with ClinicalTrials.gov identifier: NCT00970034.…”
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Acyl-CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic-Associated Steatohepatitis by Elisa Pasini, Cristina Baciu, Marc Angeli, Bianca Arendt, Diogo Pellegrina, Jüri Reimand, Keyur Patel, George Tomlinson, Mohammad T. Mazhab-Jafari, Lakshmi P. Kotra, Sandra Fischer, Johane P. Allard, Atul Humar, Mamatha Bhat

“…ACOT1 expression was 3-fold higher in MASH as compared to steatosis. In patient samples, ACOT1 was significantly correlated with the severity of MASH as reflected by the nonalcoholic fatty liver disease score. …”
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Total Organic Carbon Content Prediction in Lacustrine Shale Using Extreme Gradient Boosting Machine Learning Based on Bayesian Optimization by Xingzhou Liu, Zhi Tian, Chang Chen

“…However, common TOC prediction methods rely on empirical formulas, and their applicability varies widely from region to region. In this study, a novel data-driven Bayesian optimization extreme gradient boosting (XGBoost) model was proposed to predict the TOC content using wireline log data. …”
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Optimized Naive-Bayes and Decision Tree Approaches for fMRI Smoking Cessation Classification by Amirhessam Tahmassebi, Amir H. Gandomi, Mieke H. J. Schulte, Anna E. Goudriaan, Simon Y. Foo, Anke Meyer-Baese

“…This paper aims at developing new theory-driven biomarkers by implementing and evaluating novel techniques from resting-state scans that can be used in relapse prediction for nicotine-dependent patients and future treatment efficacy. …”
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A quantum-optimized approach for breast cancer detection using SqueezeNet-SVM by Anas Bilal, Ali Alkhathlan, Faris A. Kateb, Alishba Tahir, Muhammad Shafiq, Haixia Long

“…The novel Q-BGWO-SQSVM model outperforms the state-of-the-art classification methods and offers accurate and reliable early breast cancer detection, which is essential for further healthcare development.…”
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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…These findings highlight the role of lncRNAs as multi-level regulators in the complex network of post-stroke mechanisms, providing novel insights into the pathophysiological processes of stroke.…”
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QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite by Namrata Gautam, Debopriya Dutta, Saurabh Mittal, Perwez Alam, Nasr A. Emad, Mohamed H. Al-Sabri, Suraj Pal Verma, Sushama Talegaonkar

“…Abstract The repercussions of hormone replacement therapy (HRT) and bisphosphonates pose serious clinical challenges and warrant novel therapies for osteoporosis in menopausal women. …”
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Synergistic potential of α-Phellandrene combined with conventional antifungal agents and its mechanism against antibiotic resistant Candida albicans by Riya Bhattacharya, Prashant Sharma, Debajyoti Bose, Manish Singh

“…This study investigates a novel approach on the potential fungicidal effects of α-Phellandrene combinations with fluconazole and amphotericin B against antibiotic resistant C. albicans. …”
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Prediction of circRNA-miRNA Associations Based on Network Embedding by Wei Lan, Mingrui Zhu, Qingfeng Chen, Jianwei Chen, Jin Ye, Jin Liu, Wei Peng, Shirui Pan

“…circRNA is a novel class of noncoding RNA with closed-loop structure. …”
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Contribution of OqxAB Efflux Pump in Selection of Fluoroquinolone-Resistant Klebsiella pneumoniae by Orsolya Szabo, Bela Kocsis, Nikolett Szabo, Katalin Kristof, Dora Szabo

“…However, increasing ciprofloxacin promoted oqxB expression as it reached fold increase of 15.8–22.8, while oqxA expression was maintained (2−ΔCt = 2-2.15). …”
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Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition. by Tiffany M Halvorsen, Kaitlin A Schroeder, Allison M Jones, Disa Hammarlöf, David A Low, Sanna Koskiniemi, Christopher S Hayes

“…Using forward genetic approaches, we identify novel receptors for the group 5 and 6 ionophores. …”
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Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…The survival rate remains low despite standard therapies, highlighting the urgent need for novel treatment strategies. Advanced imaging techniques, particularly magnetic resonance imaging (MRI), are crucial in assessing GBM. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…Our findings could lead to the discovery of novel diagnostic, preventive and therapeutic strategies. …”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Bioassay results showed that sofalcone significantly enhanced the toxicity (more than 3-fold) of chlorpyrifos and lambda-cyhalothrin against S. exigua larvae. …”
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Hybrid Offset Position Encoding for Large-Scale Point Cloud Semantic Segmentation by Yu Xiao, Hui Wu, Yisheng Chen, Chongcheng Chen, Ruihai Dong, Ding Lin

“…To address these issues, this paper summarizes the advantages and disadvantages of mainstream position embedding methods and proposes a novel Hybrid Offset Position Encoding (HOPE) module. …”
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Determination of In Vitro Antimicrobial Activity of Five Sri Lankan Medicinal Plants against Selected Human Pathogenic Bacteria by Manikkuwadura Hasara Nethmini De Zoysa, Hasanga Rathnayake, Ruwani Punyakanthi Hewawasam, Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne

“…Plants used in traditional medicine can be identified as potential candidates for the synthesis of novel drug compounds to act against antibiotic-resistant bacteria. …”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…Additionally, the optimized model predicted seven novel host-pathogen interactions. Finally, the model was implemented as a web application which is accessible at http://dfh3pi.covenantuniversity.edu.ng.…”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Thus, there is a need for novel diagnostic and prognostic biomarkers for UC. …”
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Advanced sleep disorder detection using multi-layered ensemble learning and advanced data balancing techniques by Muhammad Mostafa Monowar, S. M. Nuruzzaman Nobel, Maharin Afroj, Md Abdul Hamid, Md Zia Uddin, Md Mohsin Kabir, M. F. Mridha

“…To address these, we propose a novel coordination model aimed at improving detection accuracy and reliability through a multi-model ensemble approach. …”
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