A novel lectin from mushroom Phellodon melaleucus displays hemagglutination activity, and antitumor activity in a B16 melanoma mouse model by Yuanhui Li, Peng Wang, Zejun Zhang, Qinghong Liu

“…A novel lectin (termed PML) was purified from fruiting bodies of the edible mushroom Phellodon melaleucus (division Basidiomycota) by ion exchange, hydrophobic interaction, and gel filtration chromatographies, with overall titer recovery ~60 % and 20-fold purification. …”
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Predictors of 7-day symptomatic hemorrhagic transformation in patients with acute ischemic stroke and proposal of a novel screening tool: A retrospective cohort study by Mehmet Muzaffer Islam, Cemrenur Uygun, Melike Delipoyraz, Merve Osoydan Satici, Servan Kurt, Enis Ademoglu, Serkan Emre Eroglu

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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…In healthy tissues, binding to EpCAM and CD3 is greatly reduced by a novel, dual CAB selection, where each binding domain is independently blocked by the presence of physiological chemicals known as Protein-associated Chemical Switches (PaCS). …”
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A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

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Novel Human Induced Pluripotent Stem Cell-Based Model for Retinal Pigment Epithelial Cells to Reveal Possible Disease Mechanisms for Macular Degeneration in Pseudoxanthoma Elasticu... by Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman

“…Future validation of the novel findings with additional PXE patients will be important.…”
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Dynamic assessment of long-term survival in survivors with stage III non-small cell lung cancer: a novel conditional survival model with a web-based calculator by Xiangdi Meng, Xiangdi Meng, Peihe Wang, Jie Liu, Daqing Sun, Zhuojun Ju, Yuanyuan Cai

“…The model performed with an excellent concordance index (C-index) of 0.71 (95% CI: 0.70–0.72), and a median time-dependent AUC of 0.71–0.73 from 200 iterations 5-fold cross-validation.ConclusionThe study demonstrated the improvement in real-time OS over time in stage III NSCLC survivors and developed the novel CS-nomogram to provide patients with updated survival data. …”
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Development of a novel predictive model for a successful stone removal after flexible ureteroscopic lithotripsy based on ipsilateral renal function: a single-centre, retrospective... by Hong Li, Liang Zhou, Xi Jin, Yucheng Ma, Zhongyu Jian, Liyuan Xiang, Deyi Luo, Kun-Jie Wang

“…The mean area under the curve, based on 1000 iterations and 10-fold validation, was 0.715 (95% CI 0.714 to 0.716). …”
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In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosom... by Khyber Shinwari, Mikhail A. Bolkov, Muhammad Yasir Akbar, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, Valery. A. Chereshnev

“…These mutations are shown to destabilize structure and disrupt ELANE protein activation, splicing, and folding and might diminish trypsin-like serine protease efficiency. …”
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Recovering Uniform Coverage in a 3D Survey: Case Study from Onshore Southern India by K. Shukla, P. Jaiswal, C. S. Singh

“…The two strategies, employed together, increased the fold to 90% of full fold at the target area maintaining its uniformity. …”
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Albumin as an Effective Auxiliary Agent for the Enriched Extraction of Anthraquinones and Curcumin from Plant Matrices by Chiara Collevecchio, Salvatore Genovese, Francesco Epifano, Lorenzo Marchetti, Serena Fiorito

“…The addition of albumin provided an increase in the yields of aloe emodin in the range 7.8–50.4-fold; of rhein in the range 6.1–14.1-fold; of emodin in the range 19.7–39.7-fold; of chrysophanol in the range 15.1–28.7-fold; and, finally, of curcumin of 32.1-fold. …”
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Movie scene segmentation using object detection and set theory by Ijaz Ul Haq, Khan Muhammad, Tanveer Hussain, Soonil Kwon, Maleerat Sodanil, Sung Wook Baik, Mi Young Lee

“…In this article, we investigated this problem through a novel intelligent Convolutional Neural Network (CNN) based three folded framework. …”
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Enhanced production of ginsenoside compound K by synergistic conversion of fermentation with Aspergillus tubingensis and commercial cellulase by Yong-In Lee, Woo-Seok Song, Deok-Kun Oh

“…This approach led to a 2.0-fold increase in concentration and a 1.7-fold increase in productivity when compared with traditional fermentation using the same strain. …”
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The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited. by Mounia Lahfa, Philippe Barthe, Karine de Guillen, Stella Cesari, Mouna Raji, Thomas Kroj, Marie Le Naour-Vernet, François Hoh, Pierre Gladieux, Christian Roumestand, Jérôme Gracy, Nathalie Declerck, André Padilla

“…Combining experimental protein structure determination and in silico structure modeling we validated the presence of the conserved MAX effector core domain in 77 out of 94 groups of orthologs (OG) identified in a previous population genomic study. Four novel MAX effector structures determined by NMR were in remarkably good agreement with AlphaFold2 (AF2) predictions. …”
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An Effective Methodology for Diabetes Prediction in the Case of Class Imbalance by Borislava Toleva, Ivan Atanasov, Ivan Ivanov, Vincent Hooper

“…The methodology is tested with two versions of cross validation that are appropriate in cases of class imbalance—k-fold cross validation and stratified k-fold cross validation. …”
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An Optimal Algorithm for Determining Risk Factors for Complex Diseases: Depressive Disorder, Osteoporosis, and Fracture in Young Patients with Breast Cancer Receiving Curative Surg... by Chieh-Yu Liu, Chun-Hung Chang

“…This study proposed a novel algorithm to investigate the risk factors for complex diseases. …”
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In Vitro Antibacterial Activity and Mode of Action of Piper betle Extracts against Soft Rot Disease-Causing Bacteria by Punyisa Charirak, Rapeepun Prajantasan, Kantapon Premprayoon, Nikom Srikacha, Khakhanang Ratananikom

“…ECC growth was destroyed within 6 and 8 hours after treatment with the ethanol extract at 4-fold MIC and 2-fold MIC, respectively. The ethanol extract of P. betle showed promising activity against ECC, with the potential for further development as a novel alternative treatment to control phytobacteria.…”
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Portrait de l’artiste en jeune femme : Wormwood (1890) de Marie Corelli by Laurence Talairach-Vielmas

“…This time, Corelli’s moralizing vignettes are two-fold. She uses absinth to criticize degeneration both in society and in art, denouncing naturalism — a literary genre known to be written by men for men, thereby suggesting that women can only write domestic novels. …”
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EGFR-targeting RNase A-cetuximab antibody-drug conjugate induces ROS-mediated apoptosis to overcome drug resistance in KRAS mutant cancer cells by Bita Jafary, Mostafa Akbarzadeh-Khiavi, Hamed Farzi-Khajeh, Azam Safary, Khosro Adibkia

“…Compared to free Cet, RN-PEG-Cet demonstrated a ~ 2-fold increase in apoptosis and a ~ 3.5-fold increase in ROS production. …”
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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. by Lance D Eckerle, Michelle M Becker, Rebecca A Halpin, Kelvin Li, Eli Venter, Xiaotao Lu, Sana Scherbakova, Rachel L Graham, Ralph S Baric, Timothy B Stockwell, David J Spiro, Mark R Denison

“…We report here the engineering and recovery of nsp14-ExoN mutant viruses of severe acute respiratory syndrome coronavirus (SARS-CoV) that have stable growth defects and demonstrate a 21-fold increase in mutation frequency during replication in culture. …”
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Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…Whereas the amide-linked conjugate (5) was determined to have 2-fold greater bactericidal potency [MBC 1 µg/mL (1.2 µM] than ester-linked (4). …”
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