MiR-4298 and lncKRTAP5-6-3 regulated Cathepsin D expression through ERK-MAPK signaling pathway in chronic UVB-damaged HaCaT cells by Xinling Chen, Feng Zhou, Yao Lin, Yue Xia, Jie Zhang, Wenyi Hou, Yu Sun, Wei Lai, Yue Zheng

“…In HaCaT cells transfected with miR-4298 mimics and then irradiated by UVB for 7 days, the expression of lncKRTAP5-6-3 was increased to 0.5114 ± 0.1438 (P < 0.05)-fold, and the phosphorylation level of ERK signaling was decreased by 0.3880 ± 0.1185 (P < 0.01), while Cathepsin D expression was increased by 0.2617 ± 0.0749 (P < 0.0001) compared to the UVB-damaged group. …”
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The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer by Yao Yi, Yao Yi, Yu Zhong, Yu Zhong, Lianhua Xie, Lianhua Xie, Shuxian Lu, Shuxian Lu, Yifeng Zhang, Yifeng Zhang

“…Therefore, there is an urgent need to discover novel and targeted therapeutic strategies, particularly those focusing on the immune infiltrate in TNBC, to enhance diagnosis and prognosis for affected individuals.MethodsThe gene co-expression network and gene ontology analyses were used to identify the differential modules and their functions based on the GEO dataset of GSE76275. …”
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Identification of PET/CT radiomic signature for classification of locally recurrent rectal cancer: A network-based feature selection approach by Sara Dalmonte, Maria Adriana Cocozza, Dajana Cuicchi, Daniel Remondini, Lorenzo Faggioni, Paolo Castellucci, Andrea Farolfi, Emilia Fortunati, Alberta Cappelli, Riccardo Biondi, Arrigo Cattabriga, Gilberto Poggioli, Stefano Fanti, Gastone Castellani, Francesca Coppola, Nico Curti

“…Feature selection was performed using a novel approach derived from gene expression analysis, based on the DNetPRO algorithm. …”
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Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses by Sarah Buddle, Leysa Forrest, Naomi Akinsuyi, Luz Marina Martin Bernal, Tony Brooks, Cristina Venturini, Charles Miller, Julianne R. Brown, Nathaniel Storey, Laura Atkinson, Timothy Best, Sunando Roy, Sian Goldsworthy, Sergi Castellano, Peter Simmonds, Heli Harvala, Tanya Golubchik, Rachel Williams, Judith Breuer, Sofia Morfopoulou, Oscar Enrique Torres Montaguth

“…Abstract Background Metagenomics is a powerful approach for the detection of unknown and novel pathogens. Workflows based on Illumina short-read sequencing are becoming established in diagnostic laboratories. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…The most altered genes were Cd8b, Ccl25, Cd3e, Cd27, Cd247, Cd3d, Ccr9, Cd2, Cd8a and were decreased by a log2fold change of > 2 (P < 0.05) in the female fetal lungs. …”
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Twisted holography by Kevin Costello, Davide Gaiotto

“…Abstract We derive and test a novel holographic duality in the B-model topological string theory. …”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds by Zhuo Deng, Jing Wang, Wentao Lyu, Xuwen Wieneke, Robert Matts, Xi Ma, Guolong Zhang

“…Novel alternatives to antibiotics are needed for the swine industry, given increasing restrictions on subtherapeutic use of antibiotics. …”
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Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families by Abdulfatah M. Alayoubi, Ambreen Ijaz, Abdul Wali, Jamil A. Hashmi, Azizah Alharbi, Sulman Basit

“…The frequency and pathogenicity of the identified mutations were assessed using various online bioinformatics tools.Results WES identified a novel nonsense variant (c.367C > T) in the PEX19 gene in family A patients. …”
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Flexible Sierpinski Carpet Fractal Antenna on a Hilbert Slot Patterned Ground by Vasa Radonić, Keith Palmer, Goran Stojanović, Vesna Crnojević-Bengin

“…This paper presents a novel design of fractal antenna on a flexible substrate that operates in UMTS band (universal mobile telecommunication system, 1.92–2.17 GHz). …”
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Enhancing augmented reality with machine learning for hands-on origami training by Mikołaj Łysakowski, Jakub Gapsa, Chenxu Lyu, Thomas Bohné, Sławomir Konrad Tadeja, Piotr Skrzypczyński, Piotr Skrzypczyński

“…A novel approach to training dataset preparation was introduced, which improves the accuracy of detecting and assessing origami folding stages. …”
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Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity‐Switching, Self‐Immobilizing, Near‐Infrared Fluorogenic β‐Lactamase Probe Enriched within Bacteria... by Fangfang Chen, Yuyao Li, Yan Peng, Yifan Zhu, Gao He, Zhengwei Zhang, Hexin Xie

“…The discovery of effective therapies against antibiotic‐resistant pathogens has become an urgent need, necessitating innovative approaches to accelerate the identification and development of novel antibacterial agents. On the other hand, the expression of the β‐lactam‐hydrolyzing enzyme (β‐lactamase), the major cause of bacterial resistance to β‐lactam antibiotics, provides a distinctive opportunity to visualize bacterial infection, evaluate the efficacy of existing antibiotics, screen for novel antibacterial agents, and optimize drug dosing regimens in live animals. …”
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Design of Low-Profile Frequency-Selective Rasorbers Based on Three-Legged Loaded Element by Yu Qiang, Dongfang Zhou, Qikun Liu, Zhenning Yao

“…A novel low-profile dual-polarization frequency-selective rasorber (FSR) with a transmissive window in the absorption band is proposed in this paper. …”
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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy by Tom Verfaillie, Maria Salazar, Guillermo Velasco, Patrizia Agostinis

“…Different physiological and pathological conditions can perturb protein folding in the endoplasmic reticulum, leading to a condition known as ER stress. …”
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CLAIRE: a contrastive learning-based predictor for EC number of chemical reactions by Zishuo Zeng, Jin Guo, Jiao Jin, Xiaozhou Luo

“…Remarkably, CLAIRE significantly outperformed the state-of-the-art model by 3.65 folds and 1.18 folds, respectively. Its high accuracy positions CLAIRE as a promising tool for retrosynthesis planning, drug fate prediction, and synthetic biology applications. …”
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Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity. by Siddhi Omkar, Megan M Mitchem, Joel R Hoskins, Courtney Shrader, Jake T Kline, Nitika, Luca Fornelli, Sue Wickner, Andrew W Truman

“…Further investigation uncovered a novel role for Ydj1 acetylation in stabilizing ribosomal subunits and ensuring translational fidelity. …”
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Maxwell origami tube by Rinki Imada, Tomohiro Tachi

“…This work highlights the versatility of Maxwell lattices and provides a theoretical foundation for designing novel mechanical metamaterials.…”
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Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption by Arundhati Banerjee, Sujay Ray

“…Moreover, evaluation from varied energy calculations, folding rate, and net area for solvent accessibility implied the active participation of MDM2 with DHFR. …”
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Simulation Analysis of the Aerodynamic Performance of a Bionic Aircraft with Foldable Beetle Wings in Gliding Flight by Caidong Wang, Yu Ning, Xinjie Wang, Junqiu Zhang, Liangwen Wang

“…Based on the four-plate mechanism theory, a novel bionic flapping aircraft with foldable beetle wings was designed. …”
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A fully differential switched‐capacitor integrator based programmable resolution hybrid ADC architecture for biomedical applications by Sreenivasulu Polineni, Rekha S., M. S. Bhat

“…Abstract A novel switched‐capacitor integrator based programmable resolution analog to digital converter (ADC) architecture is proposed. …”
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Dysmorphic Facial Features and Other Clinical Characteristics in Two Patients with PEX1 Gene Mutations by Mehmet Gunduz, Ozlem Unal

“…Dysmorphic facial features including broad nasal root, low set ears, downward slanting eyes, downward slanting eyebrows, and epichantal folds were common findings in two patients. Molecular genetic analysis indicated homozygous novel IVS1-2A>G mutation in Case I and homozygous p.G843D (c.2528G>A) mutation in Case II in the PEX1 gene. …”
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