Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma by Leanne Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Rosalie Douglas, Niamh McCabe, Gerald Gavory, Xavier Jacq, Rebecca C. Fitzgerald, Richard D. Kennedy, Timothy Harrison, Richard C. Turkington

“…Abstract The incidence of oesophageal adenocarcinoma (OAC) has risen six-fold in western countries over the last forty years but survival rates have only marginally improved. …”
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Two rice cultivars recruit different rhizospheric bacteria to promote aboveground regrowth after mechanical defoliation by Changjin Jiang, Fei Wang, Jinling Tian, Wanyuan Zhang, Kabin Xie

“…After the leaves were removed, the Minghui63 seedlings displayed approximately 1.5- and 2.1-fold higher root exudation and leaf regrowth rates, respectively, than did the Nipponbare seedlings. …”
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Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…The survival rate remains low despite standard therapies, highlighting the urgent need for novel treatment strategies. Advanced imaging techniques, particularly magnetic resonance imaging (MRI), are crucial in assessing GBM. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker by Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir

“…Our findings could lead to the discovery of novel diagnostic, preventive and therapeutic strategies. …”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Bioassay results showed that sofalcone significantly enhanced the toxicity (more than 3-fold) of chlorpyrifos and lambda-cyhalothrin against S. exigua larvae. …”
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An automated privacy-preserving self-supervised classification of COVID-19 from lung CT scan images minimizing the requirements of large data annotation by Sadia Sultana Chowa, Md Rahad Islam Bhuiyan, Mst. Sazia Tahosin, Asif Karim, Sidratul Montaha, Md. Mehedi Hassan, Mohd Asif Shah, Sami Azam

“…Abstract This study presents a novel privacy-preserving self-supervised (SSL) framework for COVID-19 classification from lung CT scans, utilizing federated learning (FL) enhanced with Paillier homomorphic encryption (PHE) to prevent third-party attacks during training. …”
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Hybrid Offset Position Encoding for Large-Scale Point Cloud Semantic Segmentation by Yu Xiao, Hui Wu, Yisheng Chen, Chongcheng Chen, Ruihai Dong, Ding Lin

“…To address these issues, this paper summarizes the advantages and disadvantages of mainstream position embedding methods and proposes a novel Hybrid Offset Position Encoding (HOPE) module. …”
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Determination of In Vitro Antimicrobial Activity of Five Sri Lankan Medicinal Plants against Selected Human Pathogenic Bacteria by Manikkuwadura Hasara Nethmini De Zoysa, Hasanga Rathnayake, Ruwani Punyakanthi Hewawasam, Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne

“…Plants used in traditional medicine can be identified as potential candidates for the synthesis of novel drug compounds to act against antibiotic-resistant bacteria. …”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…Additionally, the optimized model predicted seven novel host-pathogen interactions. Finally, the model was implemented as a web application which is accessible at http://dfh3pi.covenantuniversity.edu.ng.…”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Thus, there is a need for novel diagnostic and prognostic biomarkers for UC. …”
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Advanced sleep disorder detection using multi-layered ensemble learning and advanced data balancing techniques by Muhammad Mostafa Monowar, S. M. Nuruzzaman Nobel, Maharin Afroj, Md Abdul Hamid, Md Zia Uddin, Md Mohsin Kabir, M. F. Mridha

“…To address these, we propose a novel coordination model aimed at improving detection accuracy and reliability through a multi-model ensemble approach. …”
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Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening by Beenish Majeed, Supannikar Tawinwung, Lance S. Eberson, Timothy W. Secomb, Nicolas Larmonier, Douglas F. Larson

“…Our results indicate that the IL-2/mAbCD25 complex effectively induced Treg phenotype expansion by 5-fold in the spleens with minimal effects on total CD4+ and CD8+ T-lymphocyte numbers. …”
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Enhancing Power Grid Reliability With Machine Learning and Auxiliary Classifier Generative Adversarial Networks: A Study on Fault Detection Using the Georgia Electric System Load D... by Hafeez Ur Rehman Siddiqui, Robert Brown, Adil Ali Saleem, Muhammad Amjad Raza, Sandra Dudley

“…This study introduces a novel integration of machine learning and data augmentation techniques for fault detection and classification, addressing gaps in data diversity and imbalance. …”
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Identification of the Highly Polymorphic Prion Protein Gene (<i>PRNP</i>) in Frogs <i>(Rana dybowskii</i>) by Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim

“…To evaluate the impact of the SNPs on protein aggregation propensity and 3D structure, we utilized AMYCO and ColabFold. We identified 34 novel genetic polymorphisms including 6 non-synonymous SNPs in the frog <i>PRNP</i> gene. …”
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Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic by Temitope Isaac Adelusi, Abdeen Tunde Ogunlana, Moyosoluwa Precious Oyewole, Taiwo Ooreoluwa Ojo, Olamide Tosin Olaoba, Elijah Kolawole Oladipo, Shopnil Akash, Samir Ibenmoussa, Mohammed Bourhia, Yousef A. Bin Jardan, Baye Sitotaw

“…Therefore, our objective is to develop a novel vaccine candidate targeting the dominant T-cell and B-cell epitopes of the immune system. …”
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High-coverage whole-genome sequencing of a Jakun individual from the “Orang Asli” Proto-Malay subtribe from Peninsular Malaysia by Wai-Sum Yap, Alvin Cengnata, Woei-Yuh Saw, Thuhairah Abdul Rahman, Yik-Ying Teo, Renee Lay-Hong Lim, Boon-Peng Hoh

“…Of these, 39,916 SNVs were novel (referencing dbSNP151), and 10,167 were nonsynonymous (nsSNVs), spanning 5674 genes. …”
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Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease by Zachary Kostamo, Manuel A. Ortega, Chavonna Xu, Patricia R. Feliciano, Elizabeth Budak, Daisy Lam, Valerie Winton, Rebecca Jenkins, Archita Venugopal, Margaret Zhang, John Jamieson, Brent Coisman, Kennedy Goldsborough, Britney Hernandez, Celeste K. Kanne, Erica N. Evans, Jordan Zgodny, Yankai Zhang, Jawa Darazim, Ashwin Patel, Michael A. Pendergast, John Manis, Adam J. Hartigan, Giuseppe Ciaramella, Seung-Joo Lee, S. Haihua Chu, Vivien A. Sheehan

“…The topology of the hemoglobin fold with the βΕ6Α mutation is similar to HbA in the oxy and deoxy states. …”
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Potential of emodepside for vector-borne disease control by Pattarapon Khemrattrakool, Thitipong Hongsuwong, Theerawit Phanphoowong, Patchara Sriwichai, Kittiyod Poovorawan, Joel Tarning, Kevin C. Kobylinski

“…The An. dirus emodepside LC50 was 4,623 [4,159–5,066] ng/ml which is > 100-fold greater than the peak concentrations seen in human. …”
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Convolutional Attention Based Mechanism for Facial Microexpression Recognition by Hafiz Khizer Bin Talib, Kaiwei Xu, Yanlong Cao, Yuan-Ping Xu, Zhijie Xu, Muhammad Zaman, Adnan Akhunzada

“…Using the ConvMixer architecture, we Proposed a novel technique for facial microexpression identification based on convolutional attention mechanism. …”
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PortNet: Achieving lightweight architecture and high accuracy in lung cancer cell classification by Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng

“…This study aims to develop a novel deep learning model to provide efficient, accurate, and cost-effective auxiliary diagnosis for the pathological types of lung cancer cells. …”
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