Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation by Shahida A. Khan, Ashraf Ali, Sarah A. Khan, Solafa A. Zahran, Ghazi Damanhouri, Esam Azhar, Ishtiaq Qadri

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Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy by Julia Uffenorde, Mehran Hariri, Eleftherios Papalanis, Annika Staffas, Josefine Berg, Bo Stenerlöw, Hanna Berglund, Christer Malmberg, Diana Spiegelberg, Diana Spiegelberg

“…BackgroundGlioblastoma (GBM) is the deadliest form of brain cancer, impacting both adults and children, marked by exceptionally high morbidity and mortality rates, even with current standard treatments such as surgery, radiation therapy, and chemotherapy. …”
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Value of Perfusion CT in the Prediction of Intracerebral Hemorrhage after Endovascular Treatment by Friederike Austein, Antonia Carlotta Fischer, Jens Fiehler, Olav Jansen, Thomas Lindner, Susanne Gellißen

“…Intracerebral hemorrhage (ICH) is a serious complication of endovascular treatment (EVT) in stroke patients with large vessel occlusion (LVO) and associated with increased morbidity and mortality. Aims. Identification of radiological predictors is highly relevant. …”
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Evaluation of Hydatid Cyst Cases: A Single-center Retrospective Study by Suzan Şahin, Bülent Kaya

“…Conclusion: Although observed worldwide, CE maintain their importance in terms of morbidity and mortality, particularly in developing countries.…”
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Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders by Vikas R. Dharnidharka, Marianna B. Ruzinova, Chun‐Cheng Chen, Priyanka Parameswaran, Harry O'Gorman, Charles W. Goss, Hongjie Gu, Gregory A. Storch, Kristine Wylie

“…Abstract Posttransplant lymphoproliferative disorders (PTLDs), 50%‐80% of which are strongly associated with Epstein‐Barr virus (EBV), carry a high morbidity and mortality. Most clinical/epidemiological/tumor characteristics do not consistently associate with worse patient survival, so our aim was to identify if other viral genomic characteristics associated better with survival. …”
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Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine by Luciano Rezende Vilela, Lindisley Ferreira Gomides, Bruna Araújo David, Maísa Mota Antunes, Ariane Barros Diniz, Fabrício de Araújo Moreira, Gustavo Batista Menezes

“…Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. …”
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Management of acute bacterial meningitis in a limited resource setting: an Egyptian consensus model by Samy Zaky, Mohamed Elbadry, Maysaa A. Saeed, Hanaa Fathelbab, Fatma Abdelsalam, Mohammed Gamal Abdel-Hamid, Alshaimaa Eid, Asmaa Bakr, Amira Maher, Mona Mohammed Abdelrahman, Mohamed A. Metwally, Mahmoud Saad Berengy, Enaam Ali AlMowafy, Hassan Goabar, Amin Abdel Baki, Ahmed Corie, Osama Hammad, Entesar Elsharkawy, Ahmed Saad, Fatma Ali-Eldin, Ahmed Mahdy, Ramadan Zaky, Reham Hammad, Gamal Essmat

“…Abstract Acute bacterial meningitis (ABM) is an emerging disease with high morbidity and mortality. It is a globally serious disease and is considered endemic in Egypt, affecting all age groups and being common in low-standard and overcrowded areas. …”
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Safety and Efficacy in Mitral Regurgitation Management with the MitraClip^® G4 System: Insights from a Single-Center Study by Georgios E. Papadopoulos, Ilias Ninios, Sotirios Evangelou, Andreas Ioannidis, Vlasis Ninios

“…Background: Mitral regurgitation (MR) is a common valvular disorder linked to high morbidity and mortality. For patients unsuitable for surgery, transcatheter mitral edge-to-edge repair (TEER) with the MitraClip^® G4 system offers an alternative. …”
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Time to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia by Befekadu Tesfaye Oyato, Teshome Ketema Sime, Tirunesh Debele, Husen Zakir Abasimel, Fikadu Tolesa Alemu, Samuel Boja Asfaw, Wuletaw Tadesse Mekonnin, Hana Israel Gesisa, Elleni Tesfaye Kebede

“…Abstract Background Neonatal sepsis remains one of the most common causes of morbidity and mortality among neonates in developing countries. …”
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IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

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Cytoreductive Nephrectomy and Nephrectomy/Complete Metastasectomy for Metastatic Renal Cancer by Paul Russo, Mark Synder, Andrew Vickers, Varuni Kondagunta, Robert Motzer

“…Sixty-four percent of patients had a single site of metastatic disease, with lung the most common, followed by bone, adrenal, brain, and liver. Sixty-one patients (67%) had nephrectomy with removal of all metastatic sites (nephrectomy/complete metastasectomy) and 30 (33%) had cytoreductive nephrectomy alone. …”
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…Early infection of both tissue and immune cells, such as macrophages, leading to pyroptosis-mediated inflammasome production in an organ system critical for systemic oxygenation likely plays a central role in the morbidity wrought by SARS-CoV-2. Delayed transcription of Type I and Type III interferons by SARS-CoV-2 may lead to early disinhibition of viral replication. …”
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Real‐world clinical diagnostics of heart failure patients with reduced or preserved ejection fraction by Jenni Huusko, Timo Purmonen, Iiro Toppila, Mariann Lassenius, Heikki Ukkonen

“…HFpEF {4580 [inter‐quartile range (IQR): 2065–9765] vs. 2900 [2065–9765] ng/L, P < 0.001}. Baseline co‐morbidities differed between HFpEF and HFrEF groups. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. …”
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Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…Specific Pathogen-Free (SPF) animals are bred and maintained to exclude pathogens associated with significant morbidity or mortality, which may pose a risk to research replicability. …”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Glioblastoma (GBM) is the most malignant human brain tumour, characterized by rapid progression, invasion, intense angiogenesis, high genomic instability, and resistance to therapies. …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Deep phenotyping, including targeted metabolomics, transcriptomics, and brain magnetic resonance imaging (MRI), was performed. …”
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Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study by Rajish S. K. Shil, Adam Seed, Nkongho Egbe Franklyn, Brendan F. Sargent, Greta K. Wood, Yun Huang, Katherine C. Dodd, James B. Lilleker, Thomas A. Pollak, Sylviane Defres, Thomas M. Jenkins, Nicholas W. S. Davies, David A. Cousins, Michael S. Zandi, Thomas A. Jackson, Laura A. Benjamin, Ava Easton, Tom Solomon, John R. Bradley, Patrick F. Chinnery, Craig J. Smith, Timothy R. Nicholson, Alan Carson, Rhys H. Thomas, Mark Alexander Ellul, Nicholas W. Wood, Gerome Breen, Benedict Daniel Michael, the COVID-CNS Study Group

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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…Ischemic stroke, resulting from the obstruction of blood flow to the brain, remains a leading cause of morbidity and mortality worldwide. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Potential subjects have an interest in exploring alternatives to the high morbidity of a traditional allograft.  This subject population retains the autonomous choice to pursue a standard-of-care allograft or to enroll in xenograft research. …”
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