Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…The survival analysis revealed that GBM patients without gene fusions exhibited a longer median survival (737 days) compared to GBM patients with gene fusions (642 days), but without a statistical significancy. …”
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Association Between Artificial Liver Support System and Prognosis in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Cui K, Liu CH, Teng X, Chen F, Xu Y, Zhou S, Yang Q, Du L, Ma Y, Bai L

“…Subgroup analyses were conducted to test the robustness of the results.Results: A total of 589 hBV-ACLF patients were enrolled in this study (median age, 48.00 years [IQR,44.00– 55.00 years]; 70 [11.9%] female). …”
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Association between prognosis and the use of angiotensin‐converting enzyme inhibitors and/or angiotensin II receptor blockers in frail patients with heart failure with preserved ej... by Akihiro Sunaga, Shungo Hikoso, Shunsuke Tamaki, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Hiroyuki Kurakami, Tomomi Yamada, Tetsuhisa Kitamura, Taiki Sato, Bolrathanak Oeun, Hirota Kida, Yohei Sotomi, Tomoharu Dohi, Katsuki Okada, Hiroya Mizuno, Daisaku Nakatani, Takahisa Yamada, Yoshio Yasumura, Yasushi Sakata, OCVC‐Heart Failure Investigators

“…Secondary endpoints were all‐cause mortality and heart failure admission. Of 1059 patients, median age was 83 years and 45% were male. Kaplan–Meier analysis showed that the risk of composite endpoint (log‐rank P = 0.001) and all‐cause death (log‐rank P = 0.005) in patients with ACE‐I/ARB was lower in those with CFS ≥ 5, but similar between patients with and without ACE‐I/ARB in patients with CFS ≤ 4 (composite endpoint: log‐rank P = 0.830; all‐cause death: log‐rank P = 0.192). …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection by Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Zhen Zeng, Zhen Zeng, Zhen Zeng, Yushan Wu, Yushan Wu, Yushan Wu, Rui Cheng, Rui Cheng, Rui Cheng, Hao Lin, Hao Lin, Hao Lin, Jiangmei Pang, Jiangmei Pang, Jiangmei Pang, Fang Yin, Fang Yin, Fang Yin, Yongbin Jia, Yongbin Jia, Yongbin Jia, Lili Li, Lili Li, Lili Li, Hu Zhang, Hu Zhang, Hu Zhang

“…Plasma EBV DNA loads were significantly higher in the intestinal EBV infection group compared to the non-intestinal EBV infection group (Median: 2.02 × 102 copies/mL, interquartile range [IQR]: 5.49 × 101-6.34×103 copies/mL versus 4.2×101 copies/mL, IQR: 1.07 ×101-6.08×101 copies/mL; P < 0.0001). …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Relugolix was initiated a median of 4 months before SBRT initiation (IQR: 3.9–5.4), with 87% of patients reaching profound castration (<20 ng/dl). …”
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Predictors of late complications after coronary artery bypass grafting in patients with stable coronary heart disease by O.J. Zharinov, К.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

“…In unifactor analysis the features of patients with complications during 1-year observation, were earlier presence of AF, lower glomerular filtration rate (GFR) (median (quartile) 55 (44–68) versus 61 (52–74) ml/(min · 1,73 m2); p = 0.060); higher left atrium size (4.4 (4.3–4.9) cm vs. 4.3 (4.0–4.5) cm; p = 0.004); lower LV EF (47 (37–56) % vs. 53 (45–58) %; p = 0.033); higher end-diastolic volume index (70.4 (58.7–84.8) сm3/m2 vs. 59.1 (51.2–70.8) сm3/m2; p = 0.004), post-operative use of aldosterone antagonists (p = 0.051) and loop diuretics (p = 0.007), absence of statin therapy (p < 0.001). …”
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Concentrations and health risks of metal elements in ambient air PM2.5 in two urban districts of Hefei city from 2015 to 2023: analysis of monitoring data by Yu ZHU, Linling YU, Derui YAN, Changchun XIAO

“…Seasonally, the heavy metal concentrations were highest in winter, followed by the concentrations in spring, autumn, and summer. The median hazard quotients (HQ) of non-carcinogenic risk for all metals in both districts were less than 1. …”
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Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial by Patrick J E Bindels, Arthur M Bohnen, Gijs Elshout, Suzanne G M A Pasmans, Karlijn F van Halewijn

“…Finally, 32 patients (15%) were randomised and assigned to the trial (13 girls; 19 boys; median age 4.0 years).Interventions If cohort participants experienced a moderate flare-up (ie, need to intensify topical treatment from the child’s and/or parents’ point of view of AD and a three-item severity score from three to&lt;6 scored by their GP) during cohort follow-up, they were randomised to either the intervention group, a strong TCS (class III, fluticasone propionate 0.05%), or the control group, a mild TCS (class I, hydrocortisone acetate 1%).Primary and secondary outcome measures We measured outcomes at baseline and at 1, 4 and 24 weeks. …”
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CBCT Analysis of Mandibular Ramus as a Donor Site for Cortical Bone Graft: A Retrospective Analytical Study by Pallabi Das, Samiran Ghosh, Kaushik Dutta, Richi Burman, Amit Ray, Debolina Pramanick, Siddhartha Chatterjee, Somak Saha

“…Continuous variables (Mean, Median and Standard Deviation) were compared using Mann-Whitney U test or Kruskal Wallis Test as appropriate. …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn&rsquo;s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…Although several clinical risk factors for fibrous stenosis have been identified, such as perianal fistulizing disease, small bowel disease location, and deep mucosal ulceration, predicting fibrous stenosis remains challenging. …”
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Socio-Political Phenomenon of Changes in Citizenship in Guilan Province in Qajar Era by Mahdi Ebadi, Zoleykha Ghaffari roodsari

“…The construction of the Rasht-Tehran gravel road facilitated the movement of political and commercial representatives from foreign countries through the Caspian Sea and towards Tehran. …”
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Analyzing the Influence of Company's Business Strategy and Its Components as a Factor of Information Risk on Excess Stock Returns by Alireza Rahrovi Dastjerdi, Daryoosh Forooghi, Zahra Moradi

“…This study investigates the impact of a company's business strategy and its underlying components as information risk factors on the excess return of firms listed on the Tehran Stock Exchange (TSE). To address this objective, two hypotheses were formulated. …”
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Prevalence and predictors of permanent pacemaker implantation in patients with aortic stenosis undergoing transcatheter aortic valve implantation: a prospective cohort study by Erlend Eriksen, Ronak Rajani, Sahrai Saeed, Svein Rotevatn, Daanyaal Wasim, Øyvind Bleie, Abukar Mohamed Ali, Erik Jerome Stene Packer, Håvard Keilegavlen

“…The type of bioprosthesis, but not size, was associated with permanent pacemaker implantation (mechanically expandable valves OR 3.48, 95% CI 2.16 to 5.59; balloon-expandable valves OR 0.07, 95% CI 0.02 to 0.29, both p&lt;0.001)—irrespective of age and sex. During a median follow-up of 60.4 months (range 3–131 months), permanent pacemaker implantation following TAVI was not associated with all-cause mortality (HR 0.89; 95% CI 0.69 to 1.16, p=0.403).Conclusions In the current study, the rates of permanent pacemaker implantation following TAVI decreased substantially from the early low-volume phase to the late high-volume phase. …”
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Prospección del marchitamiento y cancro bacteriano del tomate en invernaderos del Cinturón Hortícola de La Plata by Jorgelina Rolleri, A.M. Romero

“…En aquellos lotes con antecedentes de la enfermedad sería importante incorporar la práctica del descanso o hacer rotaciones con otros cultivos; de no poder hacerse una rotación, los tomates de tipo cherri serían la mejor opción.…”
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Measurement report: Analysis of aerosol optical depth variation at Zhongshan Station in Antarctica by L. Chen, L. Chen, L. Zhang, Y. She, Z. Zeng, Y. Zheng, B. Tian, W. Zhang, Z. Liu, H. Che, M. Ding

“…Utilizing data from the CE318-T photometer spanning January 2020 to April 2023 at Zhongshan Station, we analyzed the seasonal, monthly, and diurnal variations in AOD and the Ångström exponent (AE). AOD median values increased from spring (0.033) to winter (0.115), while AE peaked during summer (1.010) and autumn (1.034), declining in winter (0.381), indicating a transition in dominant aerosol particle size from fine to coarse mode between summer and winter. …”
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Critical depth prediction based on in-situ stress and gas content model of deep coalbed methane in Liupanshui Coalfield in China by Fang Lv, Ruidong Yang, Wei Gao, Lingyun Zhao, Yaohui Liu, Zhihua Yan, Fulun Shi, Binxin Zhang, Jingui Tang, Tongsheng Yi

“…The hyperbolic regression algorithm was employed in order to derive both the envelope and median formulas for lateral pressure coefficient (k values). …”
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Residual Characteristics and Dietary Risk Assessment of Dinotefuran and Tolfenpyrad in Tea Processing by LI Chunyong, LÜ Ying, JIN Jing, WANG Xia, QIN Shu

“…In the case of the application of 20% dinotefuran·tolfenpyrad microemulsion at the recommended dose, both the national estimated daily intake (NEDI) for supervised trials median residue (STMR) adjusted with the drying factor of dinotefuran (containing its metabolites) in fresh tea leaves and that in dried tea leaves were 4.08 mg, accounting for 32.4% of the acceptable daily intake (ADI). …”
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Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…Results This integrated safety analysis included 6892 patients with PsO, 1401 with PsA, and 932 with axSpA. The median duration of IXE exposure was 478.5 days (1.3 years) for patients with PsO, 504.5 days (1.4 years) for patients with PsA, and 981.0 days (2.7 years) for patients with axSpA. …”
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To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…We established a prognostic risk assessment model based on 13 significant genes associated with HCC prognosis by Cox analysis and LASSO-Cox regression analysis. The median was used to divide these patients into high-risk and low-risk groups, and the prognosis of the high-risk group was worse than that of the low-risk group. …”
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