Automated classification of elongated styloid processes using deep learning models-an artificial intelligence diagnostics by Anuradha Ganesan, N. Gautham Kumar, Prabhu Manickam Natarajan, Jeevitha Gauthaman

“…Pre-processing included median filtering and resizing, with data augmentation applied to improve generalization. …”
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Prevalence of and factors associated with long COVID among diverse healthcare workers in the UK: a cross-sectional analysis of a nationwide study (UK-REACH) by Kamlesh Khunti, Katherine Woolf, Luke Bryant, Manish Pareek, Carolyn Tarrant, Christopher A Martin, Amani Al-Oraibi, Laura B Nellums

“…In terms of other demographic characteristics, the majority of those experiencing long COVID were female (80.0%) and were slightly older than those who did not experience long COVID (median age 46 (IQR 36–54)). In multivariable analyses of those who reported having had COVID-19, HCWs in nursing/midwifery roles (adjusted OR (aOR) 1.76, 95% CI 1.26 to 2.46; p=0.001) and allied health professions (aOR 1.42, 95% CI 1.05 to 1.93; p=0.023) had higher odds of experiencing long COVID compared with those in medical roles. …”
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EVALUACIÓn DEL KIT FISH FARMING FF1A ® PARA ANÁLI SIS DE CALIDAD DE AGUAS EN ACUICULTURA by HE. Higuera, JF. González

“…Para el nitrito, ésto sería de riesgo para especies muy susceptibles al mismo (ej. salmónidos, peces gato) mientras que para el amoniaco, imprecisiones en la cuantificación serían de alto riesgo para todas las especies dada la alta susceptibilidad a este metabolito.…”
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Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration in vitro and in vivo of breast cancer by Xiao He, Xianjie Cheng, Zhun Zhang, Lanhui Chen, Changjun Xie, Mengjie Tang

“…A risk prognostic model was constructed utilizing multivariable Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) analyses, and subsequently validated its predictive accuracy by stratifying patients according to the median risk score. Ultimately, some crucial independent prognostic genes were pinpointed and their expression, roles, and immune characteristics were explored in both laboratory and live models.ResultsFindings revealed 52 differentially expressed genes (DEGs), of which 21 were significantly linked to BRCA outcomes. …”
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Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial by Norberto Chavez-Tapia, Muneeba Ahsan Sayeed, Shobha Luxmi, Douglas J. Kasper, Fenchao Xue, Yang Shen, Weiliang Fan, Wei Yuan, Bin Du

“…. -24.2 [23.6]; P=0.0095), significantly reduced hospitalization duration after treatment (mean±standard deviation: [4.7±3.7] days vs. [8.6±5.6] days; P=0.0145) and respiratory failure incidence (8.3% vs. 38.1%; two-sided P=0.0291) during the study, and numerically shortened the time to clinical improvement in World Health Organization ordinal scale (median: 5.0 days vs. 9.0 days, P=0.0766). Conclusions: SIR1-365 was well tolerated and demonstrated a trend toward quicker recovery than placebo in hospitalized patients with severe COVID-19.Trial Registration ClinicalTrials.gov number: NCT04622332…”
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The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study by Fausto Negri, Luca Boeri, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Christian Corsini, Massimiliano Raffo, Giuseppe Fallara, Eugenio Ventimiglia, Luigi Candela, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Infertile men with discordant values were younger (median [interquartile range] 38.0 years [34–41 years] vs. 36.0 years [31–40 years]); had smaller testicular volume (TV) (12 mL [10–15 mL] vs. 15 mL [12–20 mL]); and, had more frequently a sperm DNA fragmentation test >30% (179 [59.1%] vs. 40 [78.4%]) than those with concordant values (all p<0.05). …”

Effectiveness of PK-Guided Personalized Recombinant FVIII Treatment in Patients with Hemophilia A: Clinical Case Experiences Based on an Observational Study by Mizoguchi Y, Hino M, Ueda H, Miyaguchi Y, Kobayashi M

“…Results are presented descriptively; however, for exploratory analysis, data before and after regimen adjustment were compared using the Wilcoxon signed-rank test.Results: Seven patients aged 3– 17 years (median age 13 years) participated in the study. Mean ABR for all bleeds decreased by 0.86 after PK-guided regimen adjustment. …”
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Comparison of Efficacy and Safety of First-Line Treatment Options for Unresectable Stage III Non-Small Cell Lung Cancer: A Retrospective Analysis by Luqing Zhao, Zhiting Zhao, Xiaoqi Yan, Fei Wu, Ning Sun, Renhong Guo, Shaorong Yu, Xiao Hu, Jifeng Feng

“…In wild-type driver genes group, the objective response rate (ORR), disease control rate (DCR), and median PFS (mPFS) were prolonged in the radiotherapy group compared to those in the nonradiotherapy group (ORR: 50.94% vs. 30.06%, p < 0.001; DCR: 98.11% vs. 80.37%, p < 0.001; and mPFS: 21.00 vs. 8.20 months, p < 0.001). …”
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Predictors of the Short‐Term Outcomes of Guillain–Barré Syndrome: Exploring Electrodiagnostic and Clinical Features by Yi‐Hsiang Chen, Chia‐Lun Wu, Wei‐Chieh Weng, Yi‐Chia Wei

“…Notably, the motor conduction features, including distal and proximal CMAP and MNCV of the median and tibial nerves (all p < 0.05), were particularly important electrodiagnostic features of outcome discrimination in the AIDP subgroup. …”
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Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…Ten patients, with a median of five prior lines of treatment, completed the efficacy evaluation (range, 3–8). …”
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Advancing cancer therapy with custom-built alternating electric field devices by Isobel Jobson, Nguyen T. N. Vo, Edward Kujawinski, Chris Denning, Snow Stolnik, Veeren M. Chauhan, Frankie Rawson

“…When used with the chemotherapeutic agent temozolomide, they extend median survival by five months. However, there is a space to design alternative systems that will be amenable for wider use in current research. …”
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Summer Research Internship Curriculum to Promote Self-Efficacy, Researcher Identity, and Peer-to-Peer Learning: Retrospective Cohort Study by Yulia A Levites Strekalova, Rachel Liu-Galvin, Samuel Border, Sara Midence, Mishal Khan, Maya VanZanten, John Tomaszewski, Sanjay Jain, Pinaki Sarder

“…The results of the retrospective pre-then-post survey indicated that there was a significant increase in students’ self-rated research abilities, evidenced by a significant improvement in the mean scores of the respondents when comparing reported skills self-assessment before and after the internship (improvement: median 1.09, IQR 0.88-1.65; W=52.5, P ConclusionsSummer internship programs can incorporate an academic enrichment curriculum with small-group peer learning in addition to a laboratory-based experience to facilitate increased student engagement, self-efficacy, and a sense of belonging in the research community. …”
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Comparison of Perioperative Outcomes of Holmium Laser Enucleation of the Prostate for Standard (≤149 ml) Versus Very Large (≥150 ml) Prostate Glands: Retrospective Analysis of a Pr... by Jacob Schmidt, Jorien Krediet, Holger Beutel, Ayoub Hidayat Allah, Nella Gagel, Isabel Lichy, Bernhard Ralla, Maha Ullmann, Robert Peters, Frank Friedersdorff, Martin Kanne

“…Group B had significantly longer median total operative time (76 vs 47 min; p < 0.001), enucleation time (42 vs 26 min; p < 0.001), coagulation time (11 vs 6 min; p < 0.001), and morcellation time (15 vs 7 min; p < 0.001). …”
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Characteristics, Incidence, and Management of Immune Checkpoint Inhibitors Related Cardiovascular Adverse Events in Real-World Practice-A Retrospective Study in Chinese Han Populat... by Wang RH, Chen Y, Lou YL, Lu YL, Xu HM

“…The management and outcomes of CVAEs were monitored over a median follow-up duration of 8 months.Results: Among the included 203 patients, 4.4% (9/203) developed CVAEs, including heart failure (n = 3), arrhythmia (n = 2), myocarditis (n = 2), and pericardial disease (n = 2), with a proportion (6/9) tending to be severe (grade 3 or grade 4). …”
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Developing a Machine Learning–Based Automated Patient Engagement Estimator for Telehealth: Algorithm Development and Validation Study by Pooja Guhan, Naman Awasthi, Kathryn McDonald, Kristin Bussell, Gloria Reeves, Dinesh Manocha, Aniket Bera

“…In our real-world tests on 438 video clips from psychotherapy sessions with 20 patients, in comparison to prior methods, positive correlations were observed between psychotherapists’ Working Alliance Inventory scores and our mean and median engagement level estimates. This indicates the potential of the proposed model to present patient engagement estimations that align well with the engagement measures used by psychotherapists. …”
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Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia by Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu

“…Baseline eGFR, creatinine, age, female sex, and BMI predicted the risk of overt TDF-associated nephrotoxicity. The median baseline KIM-1-to-creatinine and NGAL-1-to-creatinine ratios of the participants who developed overt TDF-associated nephrotoxicity and those who did not were not significantly different. …”
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Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…WHO bioassay tests revealed that the population of mosquitoes exhibited high levels of susceptibility (24-hour post-exposure mortality 98–100%) to both insecticides tested. The median knock-down time, KDT50, ranged from 6.6 to 81.4 minutes, while the KDT95 ranged from 21.6 to 118.9 minutes for 0.25% pirimiphos-methyl. …”
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Fully Covered Stent-TIPS for Advanced HCC Patients with Portal Vein Tumor Thrombus-Related Severe Symptomatic Portal Hypertension by Liu Z, Lyu T, Yang J, Xie Y, Fan S, Song L, Zou Y, Wang J

“…None of the patients experienced shunt-induced extrahepatic metastasis. The median OS was 6.0 months and the cumulative survival rates at 3, 6, 12 months were 80.0%, 52.0% and 21.3%.Conclusion: FCS-TIPS is safe and effective for treating PVTT-related severe SPH and can serve as a bridging therapy for advanced HCC.Keywords: fully covered stent, transjugular intrahepatic portosystemic shunt, hepatocellular carcinoma, portal vein tumor thrombus, symptomatic portal hypertension…”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…Group A also exhibited significantly higher rates of overall adverse events including hypertension, abdominal pain, leukopenia, thrombocytopenia, and hypoproteinemia as compared to Group B, although the incidence of hand-foot syndrome in Group A was significantly reduced as compared to Group B (13.3% vs 42.8%). The median progression-free and overall survival (PFS and OS) of patients in Group A were 13.2 and 28.8 months, with both being significantly higher than the corresponding intervals in Group B (5.7 and 10.8 months, respectively). …”
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Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty by Helena-Jamin Ly, Helena-Jamin Ly, Carina Ankarberg-Lindgren, Hans Fors, Hans Fors, Staffan Nilsson, Jovanna Dahlgren, Jovanna Dahlgren

“…The IGF-1 ≥2 SDS samples had a higher median (range) GH dose, 0.042 (0.02-0.10) mg/kg/day, compared with the IGF-1 &lt;2 SDS samples, 0.038 (0.01-0.10) mg/kg/day, p&lt;0.001. …”
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