Digital Exclusion and Depressive Symptoms among Older People: Findings from Five Aging Cohort Studies across 24 Countries by Jingjing Wang, Xinran Lu, Sing Bik Cindy Ngai, Lili Xie, Xiaoyun Liu, Yao Yao, Yinzi Jin

“…Methods: We analyzed data from 5 longitudinal cohorts: the Health and Retirement Study (HRS), the English Longitudinal Study of Aging (ELSA), the Survey of Health, Ageing and Retirement in Europe (SHARE), the China Health and Retirement Longitudinal Study (CHARLS), and the Mexican Health and Aging Study (MHAS). These cohorts consisted of nationwide samples from 24 countries. …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…The CR, PR, SD, PD, ORR, DCR, and grade ≥ 3 trAEs rate were 0.06 [95% confidence interval (CI), 0.04 to 0.07], 0.22 (95% CI, 0.16 to 0.30), 0.27 (95% CI, 0.23 to 0.31), 0.31 (95% CI, 0.20 to 0.44), 0.28 (95% CI, 0.21 to 0.37), 0.57 (95% CI, 0.47 to 0.67) and 0.26 (95% CI, 0.14 to 0.40), respectively. The median PFS and OS were 4.5 months and 13.7 months, respectively. …”
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Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes by Dorottya Fésü, Enikő Bárczi, Balázs Csoma, Lőrinc Polivka, Márton Boga, Gábor Horváth, János Tamás Varga, Szilvia Sebők, Veronika Müller

“…In the SOC + RDV group, the use of oxygen supplementation (94 vs. 80%, p = 0.005) and steroids (97 vs. 88%, p = 0.027) during infection were higher, while patients presented at their post-COVID visits earlier (median 68 vs. 97 days, p = 0.003). Complete or at least 50% symptom resolution were reported at a significantly earlier stage after infection in the SOC + RDV group compared to the SOC group (multivariable-adjusted HR = 2.28, 95% CI = 1.33–3.92, p = 0.003; and HR = 2.08, 95% CI = 1.43–3.02, p < 0.001; respectively). …”
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Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration by Kathleen A. McGinnis, Amy C. Justice, Amy C. Justice, Vincent C. Marconi, Vincent C. Marconi, Maria C. Rodriguez-Barradas, Maria C. Rodriguez-Barradas, Ronald G. Hauser, Ronald G. Hauser, Krisann K. Oursler, Krisann K. Oursler, Sheldon T. Brown, Kendall J. Bryant, Janet P. Tate, Janet P. Tate, for the Veterans Aging Cohort Study

“…We then applied VACS-CCI in PWH and compared its accuracy to age, VACS Index 2.0, CCI and VACS-CCI with CD4 and HIV RNA added.ResultsThe analytic sample consisted of 6,588,688 PWoH and 30,539 PWH. Among PWoH/PWH, median age was 65/55 years; 6%/3% were women; 15%/48% were Black and 5%/7% Hispanic. …”
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Disposition of emergency department patients presenting with angiotensin-converting enzyme inhibitor-induced angioedema by Blake Briggs, David Cline, Iltifat Husain

“…Those who were discharged from the ED with a median stay of 4 h had no increased risk of return to the ED versus those who were admitted. …”
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Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma by Ming Li, Zhiying Li, Hang Zhang, Hiroaki Wakimoto, Linlin Sun, Tiantian Wang, Shengli Zhou, Liyun Zhou

“…Only 72 patients (34.7%) received continued tumor therapy after craniotomy. 190 patients (91.3%) were successfully followed up. The median survival time was 11.5 months, and the 3-year survival rate was 15.7%. …”
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Epidemiological Changes in Hospitalized Bronchiolitis in Children Under 2 Years of Age in Hangzhou Before and After COVID-19 Restriction Easing by Xu X, Chen X, He J, Su L, Tong X, Sun Y, Huang S, Bai G, Chen Z

“…It also investigated seasonal variations in the incidence of bronchiolitis and pathogen distribution across different years.Results: This study included a total of 697 children with bronchiolitis, with a median age of 7.5 (4.2– 12.0) months. Of these, 68.9% were boys and 31.1% were girls. …”
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Relationship between prenatal mixed heavy metal/metalloid exposure and offspring cognitive and temperament development by XU Zujing, JIANG Yining, XU Jian

“…Based on prior research and multivariable linear regression models, four heavy metals/metalloid—chromium (Cr), manganese (Mn), arsenic (As), and lead (Pb)—were identified as potentially associated with cognitive and temperament development in children. The median concentrations of Mn, Pb, As, and Cr in the maternal venous blood during pregnancy were 3.32, 3.60, 2.03, and 1.78 μg/dL, respectively. …”
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Correlation Between the Inferior Vena Cava/Aorta (Ivc/Ao) Ratio and Serum Lactate Levels in Children With Renal Disorder by Hakim DDL, Widiasta A, Rachmadi D, Rahayunigsih SE, Apandi PR, Adrizain R, Martiano MRA

“…Spearman correlation analysis was conducted to assess their relationship.Results: The median (IQR) IVC/Ao ratio was 0.91 (0.70– 1.10), and serum lactate levels were 1.5 (1.1– 2.4) mmol/L. …”
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Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer by Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin

“…Six positive HRD patients and 5 negative HRD patients received maintenance PARPi. The median responsive interval of PARPi was 17 months in positive HRD patients and 3 months in negative HRD patients. …”
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Anogenital distance in water buffalo females and relationship with reproductive performance. Preliminary results by Héctor Nava-Trujillo, Simón Zambrano-Salas, Justin Dijak, Adriana Morgado-Osorio, Quintino D’Andrea

“…Water buffalo cows with at least one previous calving were categorized as short or long AGD based on the median AGD. The calving-to- conception interval was modeled against the AGD category using a variance analysis adjusted by parity and season of calving. …”
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Obsessive-compulsive personality disorder increases cognitive inflexibility in people with coronary artery disease by Agne Stanyte, Naomi A. Fineberg, Julija Gecaite-Stonciene, Aurelija Podlipskyte, Julius Neverauskas, Alicja Juskiene, Vesta Steibliene, Nijole Kazukauskiene, Julius Burkauskas

“…Methods: Seventy-eight adults (median age 59 [53.0–66.0] years) with CAD were tested within three days of hospital admission for cardiac rehabilitation occurring within two weeks of experiencing an episode of unstable angina or myocardial infarction. …”
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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Patients receiving nivolumab plus ipilimumab, compared with patients receiving anti-PD-1 monotherapy or BRAF/MEK inhibitors, had favourable baseline prognostic factors, such as younger age, fewer or smaller brain metastases, better Eastern Cooperative Oncology Group performance status and less frequently elevated lactate dehydrogenase. Median follow-up times were 15.4 months (range 0.1 to 37.0), 13.3 months (range 0.3 to 36.6) and 13.9 months (range 1.9 to 36.5), respectively. …”
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Analyzing the Effect of Dividends on Default Probability According to Signaling and Agency Theories by Alireza Najjarpour, Saeed Fathi, Ali Foroush Bastani

“…The statistical population comprises companies listed on the Tehran Stock Exchange and the Iran Farabourse, with the exclusion of financial companies, those with more than six months of consecutive trading suspension, and those that have experienced trading suspension for more than twenty percent of their market lifespan. …”
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Intensive Blood Pressure Control and Diabetes Mellitus Incidence for Patients with Impaired Fasting Glucose: A Secondary Analysis of SPRINT by Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan

“…A total of 3310 participants were included in our primary outcome analysis (median age 67 years, 29% female). There were 293 participants who developed T2D among the intensive BP control group and 256 participants who developed T2D among the standard BP control group, resulting in 56.87 (50.36–63.39) versus 49.33 (43.29–55.37) events per 1000 person-years of treatment (HR 1.18 [95% CI, 1.00–1.40], P=0.052). …”
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Impact of healthcare-associated infections on in-hospital outcomes during the COVID-19 era: a multicenter comparative study of 20,942 isolated microorganisms from ICU patients by Armin Khavandegar, Zeinab Siami, Aziz Rasouli, Pershang Nazemi, Anoosha Gull

“…In the present study, we aimed to compare the frequency of HAIs in ICU-admitted cases within and before the COVID-19 era.MethodsThis multicenter retrospective study applied a descriptive-analytical approach to investigate the frequency of HAIs in the ICU departments of hospitals affiliated with Tehran University of Medical Sciences from 2017 to 2022.ResultsOverall, 14,268 cases with 20,942 isolated microorganisms were recruited for this study, with 8,289 (58.1%) of them being male and 5,975 (41.9%) being female. …”
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Level of Satisfaction Among Patients Using Insulin Administered by Pen vs Vial/Syringe. An Observational Prospective Study by Valladales-Restrepo LF, Delgado-Araujo AC, Oyuela-Gutiérrez MC, Ospina-Arzuaga HD, Machado-Alba JE

“…The change in the type of insulin delivery device (ie, from pen to vial/syringe, and from vial/syringe to pen) was evaluated during a 1-year follow-up.Results: A total of 382 patients from 75 cities were selected, with a median age of 66.0 years, and 56.3% were women, and 65.2% were treated with long-acting insulins. …”
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The effectiveness of convalescent plasma administered on the first day of admission for COVID-19 patients: an open-label randomized controlled trial by Saeed Mohammadi, Mandana Pouladzadeh, Hamidreza Kouhpayeh, Shamsi Okati, Mehdi Safdarian, Peyman Eshghi, Parastoo Moradi Choghakabodi, Shahabeddin Mashaei, Sharareh Sanei Sistani, Yalda Khani, Soheila Nasizadeh, Ahmad Reza Shamshiri, Amir Teimourpour, Haijuan Wang

“…The mortality rate in the treatment group was 11.2% (13/116), compared to 17.2% (20/116) in the control group (P = 0.130). The median hospital stay was 7 days (95% CI: 6–8 days) for the treatment group and 6 days (95% CI: 5–7 days) for the control group (P = 0.560). …”
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Measuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya by Victor Omollo, Stephanie D. Roche, Shengruo Zhang, Magdalene Asewe, Bernard K. Rono, Benn Kwach, Greshon Rota, Patricia Ong’wen, Kendall Harkey, Josephine Odoyo, Daniel Were, Kenneth Ngure, Elizabeth A. Bukusi, Katrina F. Ortblad

“…Among those reached, the majority (63%, 742/1178) were women, the median age was 26 years (IQR 22–31), and few (4%, 51/1178) reported any prior PrEP use. …”
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Examining the Impact of Cognitive and Emotional Factors on Consumer Behavioral Responses in Online Behavioral Advertising by Hossein Norouzi, Bahareh Osanlou, Ali Saleh Gohari

“…Methodology This survey research adopts an applied approach and targets Internet users from Tehran Universities as the study population. A total of 385 questionnaires were distributed among the sample members. …”
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