Incidence of opportunistic infections and its predictors among HIV/AIDS patients on antiretroviral therapy in Gondar University Comprehensive and Specialized Hospital, Ethiopia by Mequanente Dagnaw, Haileab Fekadu, Adhanom Gebre Egziabher, Tesfaye Yesfue, Meera Indracanti, Alemu Tebeje

“…During the follow-up period, the overall incidence of opportunistic infections was 4.1 (95 percent CI 3.74 to 4.44) per 10,000 person-year observation, with a median of 57 months (IQR = 40–69 months). Pneumocystis’ pneumonia at 90(16.51%) was the most encountered OI at follow-up. …”
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Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…Meta-analysis showed the ORR of CD30 CAR-T cell therapy for R/R cHL was 57% (95%CI 0.36–0.76, P = 0.50), with a CR of 34% (95%CI 0.13–0.64, P = 0.29) and a PR of 32% (95%CI 0.15–0.55, P = 0.12). With the median follow-up range from 9.5 to 71.5 months, the 1-year PFS was 39% (95% CI 0.30–0.49, P = 0.04), and the 1-year OS was 89% (95% CI 0.65–0.97, P = 0.005). …”
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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…In a small cohort study, 165 NSCLC patients and 147 noncancer controls were enrolled between Apr 2015 and Sep 2019 at the Masih Daneshvari Hospital, Tehran, Iran. Allele frequencies from the genomic DNA of blood cells were studied using PCR-RFLP and their association with the risk of lung cancer was evaluated. …”
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Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…All 28 participants who received at least one text message completed the study, indicating 100% retention. Median satisfaction score was 23/25 (range 12–25). …”
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Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study by Kai Yin, Lu Ding, Xueyan Li, Yuqi Zhang, Siyu Song, Liyuan Cao, Ruixue Deng, Min Li, Zirui Li, Qinjing Xia, Daqing Zhao, Xiangyan Li, Zeyu Wang

“…We conducted a two-sample MR analysis, and statistical analysis were performed using the inverse variance weighted (IVW) with the addition of the MR-Egger, weighted median (WM), constrained maximum likelihood and model averaging (cML-MA) to test for causal associations between lipid levels and DR. …”
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Contribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis by Arthur Mader, Dario Haeberli, Barbara Larcher, Jörn F. Dopheide, Christoph H. Saely, Christine F. Heinzle, Peter Amann, Marc Schindewolf, Andreas Festa, Heinz Drexel

“…Cardiovascular events were recorded over a median follow-up period of 7.1 years (Q1 = 3.6 years, Q2 = 7.1 years, Q3 = 11.3 years), covering a total of 9533 patient years. …”
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Association of triglyceride-glucose related indices with mortality among individuals with MASLD combined with prediabetes or diabetes by Yiheng Zhang, Juanli Wu, Tao Li, Yundong Qu, Yan Wang

“…Results In the cohort of patients with prediabetes or diabetes, 46.5% were diagnosed with MASLD. Over a median follow-up of 25.4 years, 1,163 individuals (53.9%) died, with 329 (15.3%) deaths attributed to cardiovascular causes and 78 (3.6%) to diabetes. …”
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Social issues in general practice – a survey assessing the interprofessional perspective of general practitioners and social workers regarding frequency, challenges, and needs by Tonia Gerber, Laura Diaz Hernandez, René Rüegg, Dunja Vetter, Andreas Zeller

“…Results Findings come from a sample of 143 GPs (mean age 54 years, 37.8% female) and 41 social workers (mean age 43 years, 75.6% female). GPs face a median of 3 patients with social problems per week (IQR 5.2). …”
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Association between the triglyceride-glucose index and liver fibrosis in adults with metabolism-related fatty liver disease in the United States: a cross-sectional study of NHANES... by Yuou Ying, Yuan Ji, Ruyi Ju, Jinhan Chen, Mingxian Chen

“…MAFLD was defined as a controlled attenuation parameter (CAP) score ≥ 248 dB/m accompanied by metabolic dysfunction. A median liver stiffness measurement ≥ 8.2 kPa was used to identify significant fibrosis (≥ F2). …”
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Aplicación del modelo "Antecedente-Comportamiento-Consecuencia" en la construcción de lumbreras y túneles Application of an "Antecedent-Behavior-Consequence" model... by Victor Jiménez Arguelles, Jesús A Bustamante, Luis A Rocha Chiu

“…The research is based on the data collected during two years in the construction of a deep drainage system in the Mexico City, which was carried out by four major Mexican construction companies. This research was developed from by external project monitoring, which allows using representative data without the problem of affect or benefit participating companies. …”
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Sacubitril/valsartan in patients with heart failure with reduced ejection fraction with end‐stage of renal disease by Seonhwa Lee, Jaewon Oh, Hyoeun Kim, Jaehyung Ha, Kyeong‐hyeon Chun, Chan Joo Lee, Sungha Park, Sang‐Hak Lee, Seok‐Min Kang

“…The mean dose of SV was 90 ± 43 mg/day at baseline and 123 ± 62 mg/day at last follow‐up (follow‐up duration: median 132 days). The level of hsTnT was significantly reduced from 236.2 ± 355.3 to 97.0 ± 14.0 pg/mL (P = 0.002), and the sST2 level was significantly reduced from 40.4 ± 44.0 to 19.6 ± 14.1 ng/mL (P = 0.005). …”
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Association between different insulin resistance indices and all-cause mortality in patients with diabetic kidney disease: a prospective cohort study by Huan Zhu, Yinmei Chen, Dexin Ding, Hui Chen

“…Moreover, to verify the consistency of our results, stratified analyses and interaction tests were conducted across variables including age, gender, Body Mass Index (BMI), hypertension, and cardiovascular status.ResultsThis research involved a group of 1,588 individuals diagnosed with DKD. Over a median observation period of 74 months, 630 participants passed away. …”
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Small Intestinal Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular Tachycardia in Chronic Heart Failure with Left Ventricular Systolic Dysfunction by M. V. Fadeeva, M. R. Skhirtladze, V. T. Ivashkin

“…However, in patients with SIBOS, higher CRP values were observed (median and interquartile range: 3.6 (2.5; 4.1) vs 2.15 (0.4; 5.1); p = 0.041). …”
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Diagnostic and Predictive Values of Inflammatory Factors in Pathology and Survival of Patients Undergoing Total Cystectomy by Xingxing Tang, Yudong Cao, Jia Liu, Shuo Wang, Yong Yang, Peng Du

“…Only NLR (AUC=0.706, cut‐off value=3.12, sensitivity=75.00%, specificity=70.00%, P=0.014), dNLR (AUC=0.700, cut‐off value=2.49, sensitivity=66.67%, specificity=76.67%, P=0.015), and SII (AUC=0.704, cut‐off value=463.56, sensitivity=100.00%, specificity=40.00%, P=0.004) had a diagnostic value for lymph node metastasis. The median follow-up time was 31 months, and there was no significant difference in OS between the two groups for all IFs. …”
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Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…ABSTRACT Background Glioblastoma (GBM) is the most common primary brain tumor in adults and has a median survival of less than 15 months. Advancements in the field of epigenetics have expanded our understanding of cancer biology and helped explain the molecular heterogeneity of these tumors. …”
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Soluble galectin-4 in colorectal cancer is associated with tumor progression, but is not a predictor of the disease outcome by Elena Y. Yakunina, Olga V. Kovaleva, Ruslan A. Zukov, Alexey N. Gratchev, Sergey S. Salamatin, Sofya O. Kochkina, Zaman Z. Mammadli, Nikolay E. Kushlinskii

“…The control group consisted of 30 healthy donors (mean age, 53 years). Results: The median concentration of galectin-4 in the CRC patients was higher than in the control group (531.9 [350.6–1380] pg/mL vs. 330.1 [173.0–566.4] pg/mL, p = 0.0004). …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Methods Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61–145). GFR was estimated by serum creatinine (eGFRcre) every 24 weeks before and after switch. …”
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Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study by Sudeshna Das, Yao Ge, Yuting Guo, Swati Rajwal, JaMor Hairston, Jeanne Powell, Drew Walker, Snigdha Peddireddy, Sahithi Lakamana, Selen Bozkurt, Matthew Reyna, Reza Sameni, Yunyu Xiao, Sangmi Kim, Rasheeta Chandler, Natalie Hernandez, Danielle Mowery, Rachel Wightman, Jennifer Love, Anthony Spadaro, Jeanmarie Perrone, Abeed Sarker

“…ResultsOur framework achieves comparable median scores in terms of relevance, length, hallucination, coverage, and coherence when evaluated using GPT-4 and Nous-Hermes-2-7B-DPO, evaluated for 20 queries with 76 samples. …”
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Neonatal and Maternal Risk Factors for Indirect Hyperbilirubinemia: A Cross-Sectional Study from Bahrain by Hasan M. Isa, Noor Y. AlBuainain, Fatema Y. Bunajem, Abdulrahman S. Masood, Yusuf A. Bucheery

“…Among those, 209 (51%) were males and 275 (68.1%) were Bahraini. The median indirect bilirubin level at presentation was 218 (interquartile range, 174-270) μmol/L. …”
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Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations by Muhammad Asif, Abrar Hussain, Abdul Wali, Nazeer Ahmed, Irfan Ali, Zafar Iqbal, Muhammad Amir, Muhammad Shafiq, Mahmood Rasool

“…In this study, 72 (54.96%) were males and 59 (45.03%) were females with a median age of 38.5 years. CBC values in the diagnosis process showed that 75 patients had high values of WBC being >100×103/μl, while 71 (58.01) patients exhibited reduced values of hemoglobin, i.e., <10.00 mg/dl, and high values of PLTs>100 were observed in 40 (30.53%) patients. …”
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