Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by Benjamin P. Rigby, Nicole Needham, Helen Grossi, Ivana Kamenska, Iain H. Campbell, Ben Meadowcroft, Frances Creasy, Cheryl Fisher, Pankaj Bahuguna, John Norrie, Gerard Thompson, Melissa C. Gibbs, Maja Mitchell-Grigorjeva, Ailsa McLellan, Tessa Moses, Karl Burgess, Rachel Brown, Michael J. Thrippleton, Harry Campbell, Daniel J. Smith, Sharon A. Simpson

“…Fidelity checklists completed by research dietitians were analysed using descriptive count and percentage statistics. Findings are reported post-hoc, following the analysis and publication of the main pilot study findings. …”
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Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults: A systematic review and meta-analysi... by Ben Singh, Cristina Cadenas-Sanchez, Bruno G.G. da Costa, José Castro-Piñero, Jean-Philippe Chaput, Magdalena Cuenca-García, Carol Maher, Nuria Marín-Jiménez, Ryan McGrath, Pablo Molina-García, Jonathan Myers, Bethany Gower, Francisco B. Ortega, Justin J. Lang, Grant R. Tomkinson

“…For both all-cause and CVD mortality, there were no statistically significant differences in RR per higher MET between objectively measured (RR range: 0.86–0.90) and maximal exercise-estimated (RR range: 0.85–0.86), submaximal exercise-estimated (RR range: 0.91–0.94), and non-exercise-estimated CRF (RR range: 0.81–0.85). …”
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Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa by Katrien F.M. Bracké, Laura Monteiro Rente Dias, Marisha N. Meijer, Cathelijne P.M. Steegers, Laurinde F. den Heijer, Tess van der Harst, Marjolein H.G. Dremmen, Meike W. Vernooij, Gwen C. Dieleman, Tonya White

“…Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms. …”
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External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…For sufficient power, patient reported outcomes of 471 patients must be collected 36 months after treatment initiation. Descriptive statistics and mixed-effects models are used to assess differences in HRQoL and functional outcomes over time between the patients treated with radical prostatectomy versus EBRT (+ ADT). …”
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Rewilding beech-dominated temperate forest ecosystems: effects on carbon stocks and biodiversity indicators by Markuljaková K, Mikoláš M, Svitok M, Meigs GW, Keeton WS, Kozák D, Pavlin J, Gloor R, Kalaš M, Ferenčík M, Ralhan D, Frankovič M, Hofmeister J, Dúhová D, Mejstrík M, Dušátko M, Veber A, Knír T, Svoboda M

“…We compared some of the best-preserved primary old-growth forests with adjacent secondary old-growth forests which have been allowed to undergo self-development for an extended period of seven decades in the ecologically and socially important beech-dominated forests of the Carpathian Mountains. Statistical analysis showed no significant differences in carbon stock and structural biodiversity indicators between the two forest categories. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…The main outcome measures were nitrite and pain. Results. Statistical analysis showed that the levels of NO were increased in the study group, and there was also a reduction in pain frequency using a pain frequency scale by day, week, and month. …”
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Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan by Wei-Jung Tseng, Jian-He Lu, How-Ran Chao, Ming-Hsien Tsai, Yu-Ting Chang, Liang-Jen Wang, Chih-Cheng Chen, Wan-Nurdiyana-Wan Mansor, Juliana Jalaludin, Chih-Lung Wang, Ying-I Tsai

“…Children’s serum TNF-α was significantly linked to PM2.5 exposure scenarios (p = 0.031) by the test of the multivariate analysis (adjusted R2 = 0.033, p = 0.039), but the other variables of age (p = 0.147) and gender (p = 0.291) were not statistically significant. In conclusion, serum TNF-α might be positively and significantly correlated with the longitudinal exposure of schoolchildren to PM2.5, especially among children living in TRAP-PM2.5 region.…”
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Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia by Anmut Endalkachew Bezie, Girum Tareke Zewude, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Asmare Asrat Yirdaw, Alebachew Bitew Abie, Giziew Abere

“…Variables found significant in the bivariable analysis were then exported into a multivariable logistic regression model to identify statistically significant variables at a p value < 0.05 and a 95% confidence interval.ResultsThe response rate was 95% (401/422). 97.5% of the participants were female, and the participants’ mean (standard deviation) age was 28.5 years (SD ± 5.8). …”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…The levels of both biomarkers were higher in 28-day non-survivors than in survivors, in patients with sepsis (EphA2:898.09 vs. 475.88 pg/mL, p < 0.001; Del-1:46.09 vs. 32.68 pg/mL, p = 0.193); however, only EphA2 was statistically significant. The area under the curve for the EphA2 was 0.74 in the receiver operating characteristic curve analysis for predicting 28-day mortality, whereas APACHE II, SOFA, and Del-1 showed values of 0.762, 0.614, and 0.595, respectively. …”
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Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome by Zhixiao Xu, Xiong Lei, Weiwei Chu, Luoqi Weng, Chengshui Chen, Chengshui Chen, Chengshui Chen, Ran Ye

“…These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. …”
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A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

“…Eligibility for the pilot randomized controlled trial included age ≥40 years, a diagnosis of PAD, and living in an area in the lowest 30% of super output area based on the Office for National Statistics. Interview participants were sampled purposively based on study group allocation. …”
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Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Prac... by O. S. Shifrin, E. A. Poluektova, A. V. Korolev, T. I. Semenova, M. V. Shein, G. N. Leksikova, O. A. Tokareva, O. E. Davydova, P. S. Andreev, S. E. Katorkin, A. A. Chernov, A. V. Zhuravlev, O. S. Sek, A. A. Kopina, N. Yu. Samokhina, Yu. V. Gorozhankina, M. F. Samigullin, V. S. Groshilin, E. N. Borisova, T. A. Petrova, I. Yu. Pirogova, S. V. Mednikov, N. V. Smagin, A. S. Sarsenbaeva, N. V. Smirnova, L. G. Kirsanova, N. M. Malyutina, M. A. Smirnova, E. N. Shleikova, V. T. Ivashkin

“…The total score of symptom intensity decreased from 5.6 at the inclusion visit, to 2.2 points at the second visit and to 0.9 points at the end of the observation. A statistically significant (p <0.05) positive dynamics was observed in relation to all evaluated symptoms (abdominal pain, constipation, diarrhea, flatulence, tenesmus). …”
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Land use variation impacts on trace elements in the tissues and health risks of a commercial fish by N.D. Takarina, O.M. Chuan, T.G. Pin, I. Femnisya, A. Fathinah, A.N.B. Ramadhan, R. Hermawan, A. Adiwibowo

“…Differences and correlation of heavy metal data in each tissue and location were statistically analyzed using Pearson correlation values (r), Analysis of Variance, and x2-test. …”
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The Thermal Tolerance of Springtails in a Tropical Cave, with the Description of a New <i>Coecobrya</i> Species (Collembola: Entomobryidae) from Thailand by Nongnapat Manee, Louis Deharveng, Cyrille A. D’Haese, Areeruk Nilsai, Satoshi Shimano, Sopark Jantarit

“…An increase in temperature from the control temperature significantly accelerated the developmental rate from egg to juvenile instars to adult with a statistical significance (<i>p</i> < 0.01). This study is the first attempt that provide information on the impact of increasing temperature on the population dynamics, reproductive capacity and life history of a subterranean tropical Collembola.…”
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Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2... by Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen

“…Mixed-effects logistic regression analysis results indicated a significant statistical association between PrEP persistence for at least three months and initiating PrEP at a private clinic [adjusted odds ratio [aOR] = 4.28; 95% confidence interval [CI]: 2.96–6.19], opting for TelePrEP (aOR = 3.42; 95% CI: 2.12–5.53), or being 20 years of age or older (aOR = 1.86; 95% CI: 1.62–2.13). …”
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Exploring dental students' knowledge on oral cancer prevention: a cross-sectional study in Moldova, Armenia, and Belarus by Olga Golburean, Diana Uncuta, Gayane Manrikyan, Natalia Shakavets, Izabella Vardanyan, Marina Markaryan, Ferda Özkaya, Daniela-Elena Costea, Tarig Al-Hadi Osman

“…The level of significance was set to 0.05 for all statistical tests. Results A total of 642 dental students participated in the study. …”
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Quality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil by Albert I Ko, Federico Costa, Hammed Mogaji, Nivison Nery, Hernan D Argibay, Jaqueline S Cruz, Ianei O Carneiro, Ricardo Lustosa, Mike Begon, Hussein Khalil

“…We describe the HRQOL of residents, explored participants’ perception about the pandemic, and the relationship between sociodemographic, economic and employment data on physical and mental health scores using both χ2 statistics and separate mixed-effects regression models.Results Most participants were female (58.9%), aged 18–45 years (45%), with nearly half (49.7%) employed before pandemic, of whom 38.8% lost jobs during the pandemic. …”
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Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms by Billy Ogwel, Vincent H. Mzazi, Alex O. Awuor, Caleb Okonji, Raphael O. Anyango, Caren Oreso, John B. Ochieng, Stephen Munga, Dilruba Nasrin, Kirkby D. Tickell, Patricia B. Pavlinac, Karen L. Kotloff, Richard Omore

“…While the random forest model showed slight deviations from perfect calibration, these deviations were not statistically significant (Brier score = 0.17, Spiegelhalter p-value = 0.219). …”
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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…A module of proteins was found to statistically correlate with the potency of IL-6 modulation, leading to the selection of one of the hUCMSCs as the most promising line. …”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…In multivariable Cox analysis the presence of significant coronary artery disease (hazard ratio [HR], 2.91; 95% CI, 1.30–6.51) and having a positive fractional flow reserve derived from computed tomography (HR, 4.11; 95% CI, 1.15–14.69) were independent predictors of major adverse cardiovascular events at 9 months, whereas sex was not statistically significant (p=0.13). Conclusions There are significant sex differences in the anatomico‐functional assessment of coronary artery disease leading to differences in clinical management, costs, and adverse events.…”
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