Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients by Amalia Azzariti, Simona De Summa, Tommaso M. Marvulli, Ivana De Risi, Giuseppe De Palma, Roberta Di Fonte, Rossella Fasano, Simona Serratì, Sabino Strippoli, Letizia Porcelli, Michele Guida

“…Results No biomarker showed statistically significant differences between responders and non-responders. …”
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Optimisation of controlled reproduction protocol in broadhead catfish (Clarias macrocephalus Günther, 1864) using Ovopel™: Effect of different hormonal treatment methods on reprodu... by Nguyễn Ngọc Quyến, Nguyễn Thanh Tâm, Thạch Anh Pha, Lý Anh Thuật, Nguyễn Ngọc Lợi, Nguyễn Thị Trúc Quyên, László Horváth, Tamás Müller

“…The values viz. pseudo-gonadosomatic index (PGSI, %), fertilisation rate (FR, %), hatching rate (HR, %), and survival rate (SR, %) showed considerable individual changes among treatments; nevertheless, there was no statistically significant difference between these average parameters of treated batches (P > 0.05). …”
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Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness by Abrar Ahmad Chughtai, Chandini Raina MacIntyre, Yi Zhang, Quanyi Wang, Bayzidur Rahman, Haiyan Zhang, Holly Seale, Daitao Zhang, Yanhui Chu

“…Since 43 index cases in the control arm also used a mask during the study period, an as-treated post hoc analysis was performed by comparing outcomes among household members of index cases who used a mask (mask group) with household members of index cases who did not use a mask (no-mask group).Main outcome measure Primary outcomes measured in household members were clinical respiratory illness, ILI and laboratory-confirmed viral respiratory infection.Results In an intention-to-treat analysis, rates of clinical respiratory illness (relative risk (RR) 0.61, 95% CI 0.18 to 2.13), ILI (RR 0.32, 95% CI 0.03 to 3.13) and laboratory-confirmed viral infections (RR 0.97, 95% CI 0.06 to 15.54) were consistently lower in the mask arm compared with control, although not statistically significant. A post hoc comparison between the mask versus no-mask groups showed a protective effect against clinical respiratory illness, but not against ILI and laboratory-confirmed viral respiratory infections.Conclusions The study indicates a potential benefit of medical masks for source control, but is limited by small sample size and low secondary attack rates. …”
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Community-Based Assessment of Knowledge, Attitudes, and Practices Towards COVID-19: an Epidemiological Survey in Kurdistan Region, Iraq by Zhino Rawf Ali, Bayan Omar Sharif, Aram Salih Mohammed Amin Kamali, Varin Tofiq Abbas, Azad Karim Ahmed, Shaho Osman Mahmood, Chiman Jamal ahmed, Sarwat Ahmed Abdulqader

“…0.05 was considered statistically significant. The findings of the current study concluded that the main way for obtaining knowledge of the participants was social media and it was much more than ministry of health, WHO and CDC together. …”
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Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women by Haiying Chen, Wenjing Yan, Xueyan Wu, Yuanyuan Li

“…Results: Trimester-specific Al exposure throughout pregnancy was found to have a negative impact on fetal growth and birth parameters. Besides, statistically significant interactions were detected between biparietal diameter (BPD) (Pinteraction = 0.007), head circumference (Pinteraction = 0.026) at 16 weeks’ gestation in the first trimester, BPD (Pinteraction = 0.015) at 24 weeks’ gestation in the second trimester, BPD (Pinteraction = 0.014) at 31 weeks’ gestation in the second trimester and BPD (Pinteraction = 0.035) at 37 weeks’ gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. …”
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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Maria Fernanda Setúbal Destro Rodrigues, Ana Eliza Castanho Garrini dos Santos, Marcelo Mendes Pinto, Dácio Antonio Pantano Junior, Aldo Brugnera Jr, Fátima Antonia Aparecida Zanin

“…A p<0.05 will be considered indicative of statistical significance. After determining the normality of the data, the Kruskal-Wallis test will be used for non-parametric data. …”
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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study by Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

“…We were able to validate the cut-off and found that EASIX ≥3 was associated with more than twofold increased risk for NRM in multivariate analysis (HR=2.18, 95% CI 1.2 to 3.94; p=0.01). No statistically significant difference could be observed for the incidence of relapse.Conclusions The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…Data was subsequently analyzed using thematic analysis and descriptive statistics.ResultsSuccessful implementation of PCNs was positively correlated with robust county-level leadership, prioritization of PHC funding, intersectoral collaboration, and joint planning initiatives. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…STUDY DESIGN: Analysis was conducted using vital records data from the National Center for Health Statistics birth records. Only low-risk births were included (singleton, term-gestation [≥37 weeks], cephalic presentation, and first birth to exclude women who had a prior cesarean delivery). …”
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Effectiveness of flipped classrooms in Chinese students of clinical medicine major undergoing clinical practice: a meta-analysis by Xinrui Sun, Xin Yuan, Linyu Zhang, Yi Zhang, Xue Xiao, Hanmin Liu, Fang Ma

“…The Cochran Q test and the I2 statistic were used for heterogeneity analysis. The funnel plots were used to assess the publication bias. …”
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Gender differences of health literacy in persons with a migration background: a systematic review and meta-analysis by Elke Kalbe, Nicole Skoetz, Christiane Woopen, Digo Chakraverty, Annika Baumeister, Angela Aldin, Ümran Sema Seven, Ina Monsef

“…As heterogeneity between studies was high and the difference became statistically insignificant when excluding studies with a high risk of bias, this result must be interpreted with caution. …”
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Factors and barriers to sulfadoxine-pyrimethamine uptake for intermittent preventive treatment during pregnancy in Ghana by Akua Kumi Yeboah, Patrick Ohemeng Gyaase, Richmond Bediako Nsiah, Regina Amoa-Tutu, Saida Abdul-Rahman Zakaria, Lynna Naa Adede Obeng, Frank Prempeh, Phenihas Kwadwo Opoku, Amos Andoono, Gilbert Elara Dagoe, Kwame Kusi Agyemang, Jonathan Mawutor Gmanyami, Dominic Nyarko, Paul Kofi Awuah, Gifty Sefaah Owusu, Solomon Anum-Doku

“…Data were gathered through pretested questionnaires, and statistical analyses included descriptive, bivariate, and multivariate methods, with logistic regression used to assess relationships at a significance level of α = 0.05. …”
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Machine learning reveals sex differences in distinguishing between conduct-disordered and neurotypical youth based on emotion processing dysfunction by Gregor Kohls, Erik M. Elster, Peter Tino, Graeme Fairchild, Christina Stadler, Arne Popma, Christine M. Freitag, Stephane A. De Brito, Kerstin Konrad, Ruth Pauli

“…The “differential threshold” hypothesis suggests greater emotion dysfunction in conduct-disordered girls than boys, but previous research using conventional statistical analyses has failed to support this hypothesis. …”
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An evidence-based tailored eHealth patient education tool for patients with knee osteoarthritis: A randomized controlled trial by Chong Li, Chuanmei Zhu, Kangping Song, Xiaona Xiang, Xiaoyi Wang, Jing Hu, Zhao Li, Yi Deng, Daoxin Jiang, Lixin Guo, Ting Ren, Luwen Zhu, Haibo Ai, Shaojun Zhang, Zhongliang Liu, Yonghong Yang, Siyi Zhu, Chengqi He

“…Measurements were taken at baseline, post-intervention (T1), 1-month (T2), 3-month (T3), and 6-month (T4) follow-up. Statistical analyses, including ANOVA and chi-square tests, were employed to compare outcomes between the groups. …”
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Feasibility of remote robot empowered teleultrasound scanning for radioactive patients by Ying Liang, Lu Wang, Manuel Escobar Amoresa, Zirui Jiang, Bo Yu, Jiami Li, Man Lu

“…In addition, there was no statistical difference between two scans with regard to image quality score (29.28 ± 0.47vs29.31 ± 0.44, P = 0.97), comfort score (10vs10, P > 0.99), tension score (0vs0, P > 0.99) and fear score (0.09vs0, P = 0.32). …”
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Effect of Transcranial Direct-Current Stimulation and Task-Oriented Training on Electroencephalography-Based Motor Recovery Chronic Stroke: A Randomized Clinical Trial by Maryam Zolghadr, Shohreh Noorizadeh Dehkordi, Javad Sarrafzadeh, Saeed Talebian, Hassan Haddadzade Niri, Marzieh Yassin

“…The experimental group displayed increased alpha and beta powers and decreased theta without statistical significance. Conclusion: The increase in the relative power of low frequencies and the decrease in high frequencies in the sham group, which were more prominent than the increases in alpha and beta bands’ relative power and the decrease in theta in the experimental group, can indicate that the real-tDCS can prevent the recovery drop of relative powers. …”
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Home-based strength and balance exercises for fall prevention among older individuals of advanced age: a randomized controlled single-blind study by Jian Zhou, Bo Liu, Jian-fang Xu, Fu-bai-hui Wang, Hui Ye, Jin-Ping Duan, Xin-wen Cui

“…We conducted a comprehensive geriatric assessment (self-care ability, muscle strength, mobility, cognition, and psychological status) at baseline and 12 months later and dynamic posture mapping for balance and gait.Results The test group had a decreased risk of falls compared to the control group (25.4%vs.44.3%, respectively; RR = 0.747; 95% CI: 0.551–0.975; p = 0.027). There was no statistically significant difference in the fall rate between the two groups (0.48 falls per person-year vs. 0.67 falls per person-year, respectively; IRR: 0.708; 95% CI: 0.394–1.275; p = 0.251). …”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…We confirm that the excess of a quiescent fraction is larger for higher-mass galaxies. This is the first statistical evidence for the mass-dependent environmental quenching at work in clusters even at z  ∼ 2.…”
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Pierre et carrières dans la Saintonge antique : identification, usages et diffusion by Jacques Gaillard, Egle Conforto

“…Any archaeological sample, tested using this process in the hopes of confirming a specific quarry as its place of origin, must, statistically speaking, possess the same discriminating characteristics and fit into the ranges of the graphic synthesis of the quarry in question. …”
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