Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis by Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Ortega

“…For more than five decades, the field of Alzheimer’s disease (AD) has focused on two main hypotheses positing amyloid-beta (Aβ) and Tau phosphorylation (pTau) as key pathogenic mediators. In line with these canonical hypotheses, several groups around the world have shown that the synaptotoxicity in AD depends mainly on the increase in pTau levels. …”
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Aquaporin-2 in the early stages of the adenine-induced chronic kidney disease model. by Lucas H Oronel, Maria Ortiz, Carolina Yarza, Sofía Gayone, Carlos Davio, Mónica Majowicz, Maria Florencia Albertoni Borghese

“…This increase was mainly cytoplasmic, explaining the increased urinary volume of CKD rats and suggesting a possible non-canonical role for AQP2. In addition, Tolvaptan effectively inhibited the V2 receptor in both control and CKD rats, decreasing AQP2 expression and increasing diuresis. …”
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How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases by Wenyi Zhou, Mingyi Zhao

“…Understanding how the cardiovascular system develops and the pathological processes of cardiac disease will contribute to finding novel and preventive therapeutic methods. The canonical Hippo tumor suppressor pathway in mammalian cells is primarily composed of the MST1/2-SAV1-LATS1/2-MOB1-YAP/TAZ cascade. …”
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The Pre-Dawn of the Three Caverns Thought: An Examination Based on <i>Shangqing taiji yinzhu yujing baojue</i> by Ling Cao

“…It proposed the first viable approach to integrating emerging Daoist scriptural traditions, enabling the creation of the first canonical Daoist catalog, and laying the foundation for the compilation of the Daozang and the establishment of the Ordination Ranks 法位 system. …”
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Assessing the Black Sea Mesozooplankton Community Following the Nova Kakhovka Dam Breach by Elena Bisinicu, Luminita Lazar

“…Statistical methods, including correlation analysis, multidimensional scaling, <i>t</i>-tests, and canonical analysis, were employed to investigate the links between mesozooplankton communities and environmental variables. …”
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Analysis and Experimental Demonstration of Reflectarray Antennas in Quasi-Regular Lattices by Borja Imaz-Lueje, Juan Corcoles, Marcos R. Pino, Manuel Arrebola

“…This is particularly useful in non-canonical profile apertures, where the regular lattices do not adjust properly with the shape of the reflectarray and therefore exhibit less control of the reflected field in the aperture. …”
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Feasibility of Metatranscriptome Analysis from Infant Gut Microbiota: Adaptation to Solid Foods Results in Increased Activity of Firmicutes at Six Months by Floor Hugenholtz, Jarmo Ritari, Lotta Nylund, Mark Davids, Reetta Satokari, Willem M. de Vos

“…Moreover, Firmicutes and Actinobacteria, including the canonical Bifidobacteria as well as Collinsella, were found to be important contributors to carbohydrate fermentation and vitamin biosynthesis in the infant intestine. …”
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Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani by Sudipta Chakraborty, Kaushik Bhar, Sandip Saha, Rajarshi Chakrabarti, Anjali Pal, Anirban Siddhanta

“…Arsenic (III) at a relatively higher concentration (30 μg/mL) has been shown to have antileishmanial activity, but this concentration is reported to be toxic in several experimental mammalian systems. Nanosized metal (0) particles have been shown to be more effective than their higher oxidation state forms. …”
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Ablation of Hepatic Tumors through the Use of a Novel Magnetic Nanocomposite Probe: Magnetic Characterization and Finite Element Method Analysis by Yvonne Konku, John Kutor, Abu Yaya, Kwabena Kan-Dapaah

“…The authors recently proposed a novel system for thermoablation—based on nanoheating—that can potentially overcome limitations associated with previously reported techniques. …”
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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…In sum, our study reveals functions of ChREBP beyond its canonical roles in carbohydrate and lipid metabolism to include regulation of substrate transport, mitochondrial function, and energy balance.…”
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PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis by Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu

“…Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF‐κB signaling pathway. The canonical NF‐κB signaling protein P65 binds to the promoter region of CCL2, inducing its expression. …”
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Executioner caspases degrade essential mediators of pathogen-host interactions to inhibit growth of intracellular Listeria monocytogenes by Marilyne Lavergne, Raffael Schaerer, Sara De Grandis, Safaa Bouheraoua, Oluwadamilola Adenuga, Tanja Muralt, Tiffany Schaerer, Léa Chèvre, Alessandro Failla, Patricia Matthey, Michael Stumpe, Dieter Kressler, Pierre-Yves Mantel, Michael Walch

“…With that, we uncovered an underappreciated defense barrier and a non-canonical role of executioner caspases to degrade virulence mediators, thus impairing intracellular Listeria growth.…”
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Daily Activity Monitoring and Fall Detection Based on Surface Electromyography and Plantar Pressure by Xugang Xi, Wenjun Jiang, Zhong Lü, Seyed M. Miran, Zhi-Zeng Luo

“…A feature-level fusion method, named as the global canonical correlation analysis of weighting genetic algorithm, was proposed to reduce dimensions. …”
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Classical eikonal from Magnus expansion by Joon-Hwi Kim, Jung-Wook Kim, Sungsoo Kim, Sangmin Lee

“…Abstract In a classical scattering problem, the classical eikonal is defined as the generator of the canonical transformation that maps in-states to out-states. …”
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3 by Ling Ye, Shengqi Shen, Qiankun Mao, Hui Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu, Zilong Zhou, Rui Liu, Jian Li, Shi-ting Li, Ping Gao, Huafeng Zhang

“…Summary: Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. …”
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The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…Biologically, two forms of activated macrophages can be observed: classically activated macrophages (M1) and alternative activated macrophages (M2). Despite the canonical pathways that control this puzzle of macrophages polarization, recently, mTOR signaling pathway has been implicated as an important piece in determining the metabolic and functional differentiation of M1 and M2 profiles. …”
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Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease by Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M. Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P. Calvet, Darren P. Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao

“…By Gene Set Enrichment Analysis of 30655 genes, 13 of the top 20 downregulated gene ontology biological process gene sets and six of the top 20 curated gene set canonical pathways identified to be downregulated by PIOtreatment were related to cell cycle and proliferation, including EGF, PDGF and JNK pathways. …”
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Synthesis of BiOI-TiO2 Composite Nanoparticles by Microemulsion Method and Study on Their Photocatalytic Activities by Yunfang Chen, Xiaoxin Xu, Jianzhang Fang, Guangying Zhou, Zhang Liu, Shuxing Wu, Weicheng Xu, Jinhui Chu, Ximiao Zhu

“…This study was conducted to synthesize a series of nanosized BiOI-TiO2 catalysts to photodegrade Bisphenol A solution. …”
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Effects of Apatinib on the “Stemness” of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms by Bin Yang, Yan Wang, Zhuoying Chen, Yi-Ming Feng, Liang-Liang Shi

“…Tumor tissues were harvested after 2 weeks, and mRNA was extracted to detect changes in stemness-related genes (CD133, EPCAM, CD13, CD90, ALDH1, CD44, CD45, SOX2, NANOG, and OCT4) and Wnt/β-catenin, Hedgehog, and Hippo signal pathways. …”
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Comparison of mechanical properties of recent and 400-year-old European larch wood by Enej Lipovec Zupanc, Gorazd Fajdiga, Miha Humar

“…Therefore, we compared the mechanical properties of fresh European larch (Larix decidua) and 400-year-old larch found in the Ruard manor house on the Stara Sava in Jesenice, where the renovation of the Upper Sava Museum is currently underway. …”
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