Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…Kenya has identified PCNs as a key reform to strengthen PHC delivery and has passed a law to guide its implementation. PCNs were piloted in two counties in Kenya in 2020 and implemented nationally in October 2023. …”
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Shedding light on the existence of Furan fatty acids in latex lipids across a wide diversity of Hevea brasiliensis genotypes by Chaisiri Kitpaosong, Siriluck Liengprayoon, Erwann Durand, Tucksin Lerksamran, Aurélie Daval, Eric Gohet, Lim Khan Tiva, Phean Chetha, Kong Mengchheang, Phen Phearun, Ung Rattana, Kim Chandy, Pol Sokea, Un Kim Eng, Kittipong Rattanaporn, Bruno Barea, Laurent Vaysse

“…In terms of yield per tapping PB235, RRIV4, RRIV2, IRCA41, IRCA18, PB324, IRCA814, IRCA323, and IRCA109 genotypes showed the highest production potential, with yields range of 1 367–2 446 mg furan fatty acid per tree per tapping. …”
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Regional adipose distribution and metabolically unhealthy phenotype in Chinese adults: evidence from China National Health Survey by Binbin Lin, Yaoda Hu, Huijing He, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Qihang Liu, Tianshu Xi, Zhiming Lu, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Guangliang Shan

“…Results: In non-obese individuals, metabolically unhealthy participants exhibited higher percent trunk fat and lower percent leg fat compared to healthy participants. Additionally, percent trunk fat increased and percent leg fat decreased with the number of metabolic abnormalities. …”
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…<h4>Methods</h4>We compared arterial blood oxygen levels in Sprague-Dawley rats after 7 days of ad libitum ELO or tap water consumption. Mitochondrial stress testing, and flow cytometry analysis of mitochondrial mass and membrane potential, were performed on human HepG2 cells cultured in four Dulbecco's Modified Eagle Medium media, made with ELO water or regular (control) water, at normal (5.5 mM) or high (25 mM) glucose concentrations. …”
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Development, validation, and reliability testing of the College Perspectives around Food Insecurity survey. by Jennette Kilgrow, Elyce Gamble, Amanda Meier, Kyle Lyman, Andrea Barney, Cade Kartchner, Paola Martinez, Kanae Lee, Carol Mathusek, Kelly Ang, Brooke M Green, Jinan Banna, Dennis L Eggett, Stephanie Grutzmacher, Jennifer A Jackson, Kendra OoNorasak, Nathan Stokes, Rickelle Richards

“…Researchers evaluated face validity through two rounds of cognitive interviews with college students 18+ years old (Round 1, n = 9; Round 2, n = 16) and tested survey reliability (n = 105). …”
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Cardiovascular risk profiling among South Asian adults in Hong Kong: a latent class analysis by Gary Ka-Ki Chung, Woohyung Lee, Danna Camille Vargas, Bulbul Sharma, Kai Sing Sun, Heidi Hung, Lee Sha Tong, Tsz Lui Tang, Hasiba Munir, Chi Yui Wong, Soniya Pun, Man Hin Chio, Eliza Lai-Yi Wong, Dong Dong, Eng-Kiong Yeoh

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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Conclusion: Although the systemic manifestations of SARS-CoV-2 infection are variegated, they are deeply interwoven by shared mechanisms. Two phases of extrapulmonary disease were identified: (a) an early phase with possible gastrointestinal, ocular and cutaneous involvement; and (b) a late phase characterised by multiorgan dysfunction and clinical deterioration. …”
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Effectiveness of nurse-led volunteer support and technology-driven pain assessment in improving the outcomes of hospitalised older adults: protocol for a cluster randomised control... by Max K Bulsara, Christopher Etherton-Beer, Rosemary Saunders, Kate Crookes, Mustafa Atee, Caroline Bulsara, Beverley Ewens, Olivia Gallagher, Renee M Graham, Karen Gullick, Sue Haydon, Kim-Huong Nguyen, Bev O'Connell, Karla Seaman, Jeff Hughes, Seng Giap Marcus Ang, Debra Scaini

“…Introduction Hospitalised older adults are prone to functional deterioration, which is more evident in frail older patients and can be further exacerbated by pain. Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.Methods and analysis This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. …”
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Analytical Accuracy of a Continuous Glucose Monitor in Adult Diabetic KetoacidosisTake-Home Points by Nathan L. Haas, MD, Lynn Ang, MD, Nazanene H. Esfandiari, MD, Ahsan M. Khan, MBBS, James A. Cranford, PhD, Ashley Cohen, MD, Jordan Sell, MD, Mostafa Abdel-Hamid, MD, Kevin E. Romanchik, BSN, RN, Frederick K. Korley, MD, PhD

“…Glucose was measured every 5 minutes via Dexcom G6 CGM and compared with hourly POCBG measurements until resolution of DKA. …”
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WALLABY Pilot Survey: Star Formation Enhancement and Suppression in Gas-rich Galaxy Pairs by Qifeng Huang, Jing Wang, Xuchen Lin, Se-Heon Oh, Xinkai Chen, B. Catinella, N. Deg, H. Dénes, B. -Q. For, B. S. Koribalski, K. Lee-Waddell, J. Rhee, A. X. Shen, Li Shao, K. Spekkens, L. Staveley-Smith, T. Westmeier, O. I. Wong, A. Bosma

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Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) by Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa

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Real-world outcomes of prophylactic cranial irradiation utilization and efficacy for patients with extensive-stage small cell lung cancer treated with consolidative thoracic radiot... by Abdul H. Lone, Rohan Salunkhe, Vijithan Sugumar, Luna J. Zhan, Xiang Y. Ye, Andrea Bezjak, John Cho, Meredith E. Giuliani, Andrew J. Hope, Alexander Sun, Srinivas Raman, Penelope A. Bradbury, Lawson Eng, Natasha B. Leighl, Frances A. Shepherd, Adrian Sacher, Geoffrey Liu, Benjamin H. Lok

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Science highlights from the Kjell Henriksen Observatory on Svalbard by Katie Herlingshaw, Noora Partamies, Charlotte M. van Hazendonk, Mikko Syrjäsuo, Lisa J. Baddeley, Magnar G. Johnsen, Nina K. Eriksen, Ian McWhirter, Anasuya Aruliah, Mark J. Engebretson, Kjellmar Oksavik, Fred Sigernes, Dag A. Lorentzen, Takanori Nishiyama, Matthew B. Cooper, John Meriwether, Stein Haaland, Daniel Whiter

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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…Secondary objectives include assessment of overall survival, response rate, safety and quality of life measures. Two additional therapeutic arms are currently in development.Ethics and dissemination Central ethics approval was obtained from the Sydney Local Health District Ethics Review Committee, Royal Prince Alfred Hospital Zone, Sydney, Australia (Approval: 2022/ETH02230). …”
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Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

“…In conclusion, a third heterologous boosting with RBD–HR/trimer following two‐dose mRNA priming vaccination should be a superior strategy than a third homologous mRNA vaccine. …”
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WALLABY Pilot Survey and ASymba: Comparing H i Detection Asymmetries to the SIMBA Simulation by Mathieu Perron-Cormier, Nathan Deg, Kristine Spekkens, Mark L. A. Richardson, Marcin Glowacki, Kyle A. Oman, Marc A. W. Verheijen, Nadine A. N. Hank, Sarah Blyth, Helga Dénes, Jonghwan Rhee, Ahmed Elagali, Austin Xiaofan Shen, Wasim Raja, Karen Lee-Waddell, Luca Cortese, Barbara Catinella, Tobias Westmeier

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Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Comparison of histological, immunohistochemical, and molecular analyses including both RNA and DNA sequencing revealed that the PDX models recreate many of the features of metastatic AAs, but also displayed several differences between paired PDX and human tumors, highlighting the intratumoral heterogeneity of AAs within each patient. Notably tumors from two patients with primarily low-grade mucinous adenocarcinoma converted to high-grade histology in PDX. …”
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Reproductive efficiency of ewe lambs kept on tropical pastures under different feeding systems by L.M. Higano, C.C.B.F. Ítavo, L.C.V. Ítavo, G.S. Difante, G.K.A. Melo, P.C.G. Silva, K.L.S. Monteiro, E.S.M. Soares, T.F.F.S. Arco, P.B. Andrade, A.A.S. Miguel, F.G.G. Oliveira, E.L.M. Ribeiro, A.L.C. Gurgel

“…The performance was evaluated at the beginning of the experimental period and every 28 days until the end of the breeding season, the following data were observed: final body weight, average daily gain (ADG) and total weight gain (TWG). In the growth period, the lambs supplemented with 2.4% BW presented higher average daily gain, which resulted in higher total weight gain and final weight. …”
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Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism by Marte Svalastoga, Trine-Lise Larsen, Trine-Lise Larsen, Jorunn Brekke, Tone Enden, Hege Frøen, Herish Garresori, Eva Marie Jacobsen, Alina Carmen Porojnicu, Anne Hansen Ree, Anne Hansen Ree, Dag Torfoss, Elin Osvik Velle, Hilde Skuterud Wik, Waleed Ghanima, Waleed Ghanima, Per Morten Sandset, Per Morten Sandset, Anders Erik Astrup Dahm, Anders Erik Astrup Dahm

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