Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons by Emma C. Robinson, Anastazja M. Gorecki, Samuel R. Pesce, Vaishali Bagda, Ryan S. Anderton, Bruno P. Meloni

“…Thereafter, this study examined the therapeutic potential of the neuroprotective CARP, R18D (18-mer of D-arginine), to prevent the aforementioned PD pathogenic processes through a cell-free thioflavin-T (ThT) assay and in cortical neurons. Methods: To induce intracellular α-syn aggregation, rat primary cortical neurons were exposed to α-syn seed (0.14 μM) for 2 h to allow uptake of the protein, followed by R18D treatment (0.0625, 0.125, 0.25, 0.5 μM), and a subsequent measurement of α-syn aggregates 48 h later using a homogenous time-resolved fluorescence (HTRF) assay. …”
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Feasibility, User Acceptance, and Outcomes of Using a Cancer Prehabilitation App for Exercise: Pilot Cohort Study by Fuquan Zhang, Deepali Bang, Christine Alejandro Visperas, Mon Hnin Tun, San San Tay

“…Demographics, Fried Frailty Phenotype, prehabilitation duration, app use, and functional outcome measures (6-minute walk test [6MWT], 30-second sit-to-stand test [STS], timed up and go test [TUG], and Hospital Anxiety and Depression Scale [HADS]) were collected. …”
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Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis by Yuan Xu, Hongfei He, Haiyang Li

“…Upregulated genes were identified by a positive logFC (>0) and P < 0.05, while downregulated genes were characterized by a negative logFC (<0) and P < 0.05. …”
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Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging by Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Utkan, Nuh Zafer Cantürk

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FPGA-Based Distributed Union-Find Decoder for Surface Codes by Namitha Liyanage, Yue Wu, Siona Tagare, Lin Zhong

“…The Union-Find (UF) decoder is promising with an average time complexity slightly higher than <inline-formula><tex-math notation="LaTeX">$O(d^{3})$</tex-math></inline-formula>. …”
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Approximate Solutions of Combinatorial Problems via Quantum Relaxations by Bryce Fuller, Charles Hadfield, Jennifer R. Glick, Takashi Imamichi, Toshinari Itoko, J. Richard Thompson, Yang Jiao, M. Marna Kagele, W. Blom-Schieber Adriana, Rudy Raymond, Antonio Mezzacapo

“…We establish relations between the spectra of the relaxed Hamiltonians and optimal cuts of the original problems, via two quantum rounding protocols. The first one is based on projections to random magic states. …”
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Association between Chinese visceral adiposity index and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): a national cohort study by Kunhui Chang, Bo Li, Gang Wang, Hao Zhou, Yonghao Chen, Hongbing Gu

“…Eight obesity-related indices—namely Body mass index (BMI), Waist-height ratio (WHtR), Triglyceride-glucose.BMI (TyG.BMI), TyG. Waist circumference (TyG.WC), TyG.WHtR, CVAI, Visceral adiposity index (VAI), and A body shape index (ABSI)—were examined. …”
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Caries affected Dentin biomodification using Bromelain, Riboflavin photosensitizer via UVA, and Chitosan Nanoparticles on shear bond strength and microleakage scores: A SEM evaluat... by Khold Alahdal, Ahmed Maawadh, Laila AlDeeb, Thamer Almohareb, Ahoud S Alshamrani, Ali Alrahlah

“…However, Group 1 (No modifier) exhibited the lowest resin tag length (50.45 ± 2.37 μm). Conclusion: Caries-affected dentin modified with Bromelain resulted in satisfactory SBS with minimal microleakage scores. …”
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Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome by Wenxing Peng, Xiujin Shi, Xiaoyu Xu, Yang Lin

“…Conclusions. CYP2C19 and PON1 Q192R variants influence ADP-induced platelet inhibition by thrombelastography (TEG) in ACS patients with clopidogrel. …”
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Stability of Ternary Drug–Drug–Drug Coamorphous Systems Obtained Through Mechanochemistry by Ilenia D’Abbrunzo, Elisabetta Venier, Francesca Selmin, Irena Škorić, Enrico Bernardo, Giuseppe Procida, Beatrice Perissutti

“…DSC revealed a single T_g for most systems, indicating homogeneity. …”
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The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling by Zhenyu Zhang, Yina Gao, Yuanyuan Qian, Bowen Wei, Kexin Jiang, Zhiwei Sun, Feifan Zhang, Mingming Yang, Salem Baldi, Xiaoqi Yu, Yunfei Zuo, Shuangyi Ren

“…On the other hand, metabolomics revealed that Lyn/RUVBL1 regulates the expression of PGE2 through the enzyme COX2, thereby promoting arachidonic acid (AA) metabolism. CUT‐Tag showed that Lyn/RUVBL1 silencing reduces the H3K27ac level in the COX2 promoter. …”
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The Relationship between the Activity Balance Confidence and Mobility Tests among Older Adults in Indonesia by Indri Hapsari Susilowati, Sabarinah Sabarinah, Susiana Nugraha, Sudibyo Alimoeso, Bonardo Prayogo Hasiholan, Supa Pengpid, Karl Peltzer

“…The dependent variable is the mobility test, including a gait test using TUG (times up and go) to see how the subjects stand, walk, and turn around; a balance test (four stages); and a strength test (30-second chair stand). …”
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Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning by Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

“…Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. …”
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Influence of strength and power training on the rate of force development, peak force and functional mobility in elderly people with Parkinson's disease: a randomized controlled tr... by Késia Maísa do Amaral Felipe, Késia Maísa do Amaral Felipe, Patrícia de Aguiar Yamada, Tamires Meneghetti, Flávia Roberta Faganello-Navega, Flávia Roberta Faganello-Navega

“…FM was also assessed using the following tests: gait speed test (GS), Timed Up and Go (TUG), Short Physical Performance Battery (SPPB), Unified Parkinson's Disease Rating Scale (UPDRS); parallel feet on a force platform. …”
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Mitigation of Mycotoxin Content by a Single-Screw Extruder in Triticale (<i>x Triticosecale</i> Wittmack) by Breda Jakovac-Strajn, Janja Babič, Lato Pezo, Vojislav Banjac, Radmilo Čolović, Jovana Kos, Jelena Miljanić, Elizabet Janić Hajnal

“…The temperature at the end plate of the extruder ranged between 97.6 and 141 °C, the absolute pressure was from 0.10 to 0.42 MPa, the mean retention time of material in the barrel was between 16 and 35 s, and the specific energy consumption was from 91.5 to 186.6 Wh/kg. According to the standard score, the optimum parameters for the reduction of the content of analysed mycotoxins were <i>M</i> = 24 g/100 g, <i>FR</i> = 25 kg/h, <i>SS</i> = 480 RPM, with a reduction of 3.80, 60.7, 61.5, 86.5, 47.7, and 55.9% for DON, 3-AcDON, 15-AcDON, HT-2, TEN, and AME, respectively. …”
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Effects of Fasudil on Patients with Pulmonary Hypertension Associated with Left Ventricular Heart Failure with Preserved Ejection Fraction: A Prospective Intervention Study by Xiang Zhang, Xueming Zhang, Saihua Wang, Jun Luo, Zhihong Zhao, Changzhu Zheng, Jieyan Shen

“…Besides, the RPH group demonstrated a greater transpulmonary pressure gradient (TPG) and pulmonary vascular resistance (PVR) than the PPH group (p<0.01 for both) as well as pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (mPAP) (p<0.01 for both), which fits the feature of RPH. …”
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Risk Factors For Progression From Biochemical Leak to Clinically Relevant Postoperative Pancreatic Fistula After Pancreaticoduodenectomy. The Key of the Lock: Prognostic Nutritiona... by Mehmet Can Aydin, Oguzhan Ozsay, Kagan Karabulut, Recep Bircan, Fatih Atalay, Mehmet Batuhan Ors

“…A total of 71 patients who developed POPF were included in the study and divided into two groups: 52 patients remained in the BL stage and 19 patients progressed from BL to CR-POPF. …”
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Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

“…FFA2 agonist 4-CMTB or TUG-1375 promoted the expression of the hypertrophy markers ANF and BNP and increased cell surface area in vitro, which was further strengthened by FFA2 overexpression, suggesting that FFA2 might contribute to cardiomyocyte hypertrophy. …”
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ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages by Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng

“…Differentially expressed or regulated proteins were identified in interfered ADAM-10 (sh ADAM-10) macrophages using tandem mass tag (TMT) proteomics. The changes and regulatory role of ADAM-10 during LPS-induced inflammatory response in normal, interfering, and overexpressing ADAM-10 (EX ADAM-10) cells were determined. …”
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Starches Modified by Combination of Phosphorylation and High-Voltage Electrical Discharge (HVED) Treatment by Ivanka Grgić, Marijana Grec, Artur Gryszkin, Tomasz Zięba, Mirela Kopjar, Đurđica Ačkar, Antun Jozinović, Borislav Miličević, Sandra Zavadlav, Jurislav Babić

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