Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy by Jian Huang, Shuangna Song, Yihua Yin, Yinyan He, Huimin Wang, Ye Gu, Laman He, Xintao Wang, Xiaocao Miao, Zhigang Zhang, Xueli Zhang, Yiran Li, Yiran Li

“…Importantly, by using an organoid model of EC, we further confirmed the antitumor potential of T cells that were specific to the POLEP286R mutation.ConclusionsOur study uncovers the pronounced immunogenicity of POLE-mutant EC and characterizes neoantigens that are unique to the POLEP286R mutation, thus providing a promising new immunotherapeutic strategy for EC.…”
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Portable Handheld Slit-Lamp Based on a Smartphone Camera for Cataract Screening by Shenming Hu, Hong Wu, Xinze Luan, Zhuoshi Wang, Mary Adu, Xiaoting Wang, Chunhong Yan, Bo Li, Kewang Li, Ying Zou, Xiaoya Yu, Xiangdong He, Wei He

“…This means a microlens is designed that would work with a phone’s camera. The phone’s photo taking function is used in capturing the image of the eyes lens to replace the observation system of the desktop slit-lamp. …”
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The immunological landscape of CCL26High invasive oral squamous cell carcinoma by Lingyun Liu, Lingyun Liu, Shuo Guan, Shuo Guan, Yizhuo Xue, Yizhuo Xue, Yijia He, Yijia He, Liang Ding, Yong Fu, Sheng Chen, Zhiyong Wang, Yi Wang

“…We also determined the invasive phenotype of tumor cells with distinct CCL26 level and explored its immune checkpoint and immunocytes relevance by differentially expressed gene (DEG) analysis, GSEA, and GO analysis. …”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…Eligible RCTs will be included in accordance with the pre-specified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation system. …”
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections by Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin

Subjects: “…tertiary lymphoid structure (TLS)…”
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Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis by Mengqi Liu, Mengqi Liu, Jie Tang, Jie Tang, Gaoyang Xu, Gaoyang Xu, Xu Chen, Xu Chen, Kun Fang, Fan He, Fan He, Yi Zheng, Yi Zheng

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Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment by Yuyi Feng, Danxia Qiu, Yangcheng He, Hai Jin, Liping Chen, Fen Xi, Zhiwen Hu, Yanlin Xie, Yucai Li, Minhua Lin, Pengxiao Sun, Yan He, Jianhua Liu

“…The changes in tumor tissue hypoxia before and after treatment were observed by measuring oxygen partial pressure directly with in tumor tissue and immunohistochemical staining for hypoxia-inducible factor-1α (HIF-1α).ResultsResults indicated that low frequency, non-focused ultrasound at 0.5 MPa/20 Hz and 0.5 MPa/40 Hz, when combined with microbubbles, could increase tumor tissue blood perfusion and improve the hypoxia in tumor tissues.DiscussionThis study provides a new method for improving hypoxia in the tumor microenvironment (TME) which could potentially improve the cancer treatments resistance.…”
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Effect of Allium mongolicum Regel Powder Addition to the Diet and Aging Time on Physicochemical Properties and Antioxidant Capacity of Angus Beef by XIE Yaodi, GAO Huixia, HE Jianjian, SUN Chenxu, YU Aihuan, YAO Haibo, XU Lei, HU Jinsheng, WANG He, DUAN Yueyan, TANG Defu, LEI Zhaomin, LIU Wangjing

Subjects: “…allium mongolicum regel powder; angus beef; aging time; antioxidant capacity…”
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High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…Thus, we co-load anti-inflammatory drug triptolide (TP) and anti-fibrotic drug nintedanib (BIBF) on bHDL nanoparticles to treat CKD. …”
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ĐỊNH LƯỢNG ĐỒNG THỜI AMLODIPIN VÀ ATORVASTATIN TRONG THUỐC ĐA THÀNH PHẦN BẰNG PHƯƠNG PHÁP QUANG PHỔ UV-VIS KẾT HỢP VỚI PHÂN TÍCH ĐA BIẾN by Duy Luu Nguyen, Nguyen Thi Thanh Tram, Pham Phu Quoc, Nguyễn Hùng Nhật Duy, Nguyễn Đình Luyện, Trần Thúc Bình

Subjects: “…Amlodipin (AML), Atorvastatin (ATO), bình phương tối thiểu cổ điển (CLS); Hồi quy thành phần chính (PCR), bình phương tối thiểu riêng phần (PLS1).…”
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Acute Renal Replacement Therapy in Children with Diarrhea-Associated Hemolytic Uremic Syndrome: A Single Center 16 Years of Experience by Silviu Grisaru, Melissa A. Morgunov, Susan M. Samuel, Julian P. Midgley, Andrew W. Wade, James B. Tee, Lorraine A. Hamiwka

“…In our cohort, all but one patient were started on peritoneal dialysis (PD). …”
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Mid- to long-term clinical outcomes of modified technique skip-level titanium plate fixation in cervical laminoplasty compared to continuous fixation by Shuo Feng, QiRui Zhu, Yang Sun, ZiYao Ding, Zhe Zhuang, Heng-Heng Yu, Ma-Ji Sun, Feng Yuan

“…The sagittal diameter of the spinal canal from C3 to C7 significantly increased (P < 0.05), but there were no significant differences in the improvement of C3, C5, and C7 between the two groups (P > 0.05). At 3 months postoperatively, the opening angles of the C4 and C6 laminae in Group A were smaller than those in Group B (P < 0.05), but there were no significant differences at the last follow-up (P > 0.05). …”
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Simultaneous Recognition of Species, Quality Grades, and Multivariate Calibration of Antioxidant Activities for 12 Famous Green Teas Using Mid- and Near-Infrared Spectroscopy Coupled with Chemometrics by Haiyan Fu, Ou Hu, Lu Xu, Yao Fan, Qiong Shi, Xiaoming Guo, Wei Lan, Tianming Yang, Shunping Xie, Yuanbin She

“…In this paper, mid- and near-infrared spectroscopy fingerprints were combined to simultaneously discriminate 12 famous green teas and quantitatively characterize their antioxidant activities using chemometrics. …”
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Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4 by Hong-Min Wang, Zhe Zhou, Jie Miao, Bo Zhu, Xiao-Qiu Dai, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…We found that B16-tmCRT/39-272 cells subcutaneously inoculated into C57BL/6 mice exhibited stronger tumorigenicity than the B16-EGFP control cells. …”
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Thulium laser enucleation of the prostate plus thulium fiber laser therapy for benign prostatic hyperplasia combined with bladder stones by Chen Wang, Yuanwei Li, Yongjun Yang, Junjie Chen, Zhuo Li, Guangqing Song, Jia Chen, Liu Zhe, Yili Teng, Qiang Lu

“…Videosurgery and Other Miniinvasive Techniques…”
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Comparison of Risks Factors for Unplanned ICU Transfer after ED Admission in Patients with Infections and Those without Infections by Jeffrey Che-Hung Tsai, Ching-Wan Cheng, Shao-Jen Weng, Chin-Yin Huang, David Hung-Tsang Yen, Hsiu-Ling Chen

“…The objectives of this study were to compare the risk factors for unplanned intensive care unit (ICU) transfer after emergency department (ED) admission in patients with infections and those without infections and to explore the feasibility of using risk stratification tools for sepsis to derive a prediction system for such unplanned transfer. …”
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Machine learning-assisted quantitative prediction of thermal decomposition temperatures of energetic materials and their thermal stability analysis by Zhi-xiang Zhang, Yi-lin Cao, Chao Chen, Lin-yuan Wen, Yi-ding Ma, Bo-zhou Wang, Ying-zhe Liu

“…The modeling was performed based on a dataset consisting of 885 various compounds using linear and nonlinear algorithms. The tree-based models established demonstrated acceptable predictive abilities, yielding a low mean absolute error (MAE) of 31°C. …”
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Evaluation of Telenomus remus (Hymenoptera: Platygastridae) as a biocontrol agent of Spodoptera litura (Lepidoptera: Noctuidae) based on two-sex life table and functional response analyses by Zhen Shen, Li-Hui Liu, Lian-Sheng Zang, Tie-Jun Deng, Zhen-Bao Luo, Jun-Yi Gao, Liang-De Tang

“…In addition, most females emerged from 24 h-old eggs, whereas most males emerged from 48 h-old eggs. …”
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Clinical Efficacy of Probiotic Therapy on Bowel-Related Symptoms in Patients with Ulcerative Colitis during Endoscopic Remission: An Observational Study by Jin Lee, Su Bum Park, Hyung Wook Kim, Hong Sub Lee, Sam Ryong Jee, Jong Hun Lee, Tae Oh Kim

“…Endoscopic remission was defined as a Mayo endoscopic score≤1, and IBS-like symptoms were defined as those meeting the ROME-IV diagnostic criteria. A Biotop capsule® (Lactobacillus acidophilus, 75 mg; Clostridium butyricum TO-A, 25 mg; Bacillus mesentericus TO-A, 25 mg; and Streptococcus faecalis T-110, 5 mg) was administered three times daily for one month. …”
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Association between rs20456 and rs6930913 of Kinesin-Like Family 6 and Hypertension in a Chinese Cohort by Yan-li Chen, Li-Qiang Zheng, Tie-Jun Li, Zhao-Qing Sun, Ying Hao, Bao-Gang Wu, Ying-Xian Sun

“…After adjusting for confounding factors, significantly lower risk of hypertension was observed in participants with genotype TC (0.416 (CI 0.299–0.578), p<0.001) and CC (0.577 (0.389–0.857), p=0.007) of rs20456 compared with TT. …”
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