Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

Subjects: Get full text

Effect of thermal stress on the life of DC link capacitors for smart grid by Xiao-Wu Sun, Ying Qiao, Yin-Da Li, Chong-Feng Cao, Xiang-Ming Guo

Subjects: Get full text

L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

Subjects: “…advanced glycation end products (AGEs)…”
Get full text

Assessment of the living standard of elderly people and their well-being in a changing social environment by R. M. Sadykov

Subjects: Get full text

Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Sco... by Cui N, Li Q, Cheng J, Xing T, Shi P, Wang Y, Luo M, Dun Y, Liu S

Subjects: “…aging population health…”
Get full text

STUDY THE EFFECT OF ZIRCONIUM, NICKEL AND HEAT-TREATMENTS ON THE MICROSTRUCTURE AND MECHANICAL PROPERTIES OF COLD-ROLLED AA6111 ALLOY by Saba Jameel Hassan, Basem Al-Zubaidy, Saad Hameed Al-Shafaie

Subjects: Get full text

Evaluation of In Vitro Inhibitory Activity of Rye-Buckwheat Ginger Cakes with Rutin on the Formation of Advanced Glycation End-Products (AGEs) by Przygodzka Małgorzata, Zieliński Henryk

Subjects: “…rye-buckwheat ginger cakes enhanced with rutin…”
Get full text

The mediating role of body surface area-adjusted basal metabolic rate: effects of low muscle mass and central obesity on cognitive impairment in Chinese patients with type 2 diabetes mellitus by Ya-Jie Zhai, Ya-Jie Zhai, Fang Li, Chen-Ying Lin, Chen-Ying Lin, Fan Wu, Hui-Na Qiu, Jing-Bo Li, Jing-Na Lin

Subjects: Get full text

Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…Because of its structural difference from natural GLP-1, it is not easy to be degraded by dipeptidyl peptidase-4 (DPP-4), thus prolonging the action time. GLP-1RAs have been recognized as a new type of hypoglycemic drugs and widely used in the treatment of type 2 diabetes mellitus (T2DM). …”
Get full text

Development and validation of a machine learning model to predict the risk of lymph node metastasis in early-stage supraglottic laryngeal cancer by Hongyu Wang, Hongyu Wang, Hongyu Wang, Zhiqiang He, Zhiqiang He, Zhiqiang He, Jiayang Xu, Jiayang Xu, Ting Chen, Ting Chen, Ting Chen, Jingtian Huang, Jingtian Huang, Jingtian Huang, Lihong Chen, Lihong Chen, Lihong Chen, Xin Yue, Xin Yue, Xin Yue

“…All six ML models performed well, and in both internal and independent external validations, the eXtreme Gradient Boosting (XGB) model outperformed the other models, with AUC values of 0.87 and 0.80, respectively. …”
Get full text

Modeling the influence of age on the technical efficiency by sector and time periods by V. V. Spitsin, L. Yu. Spitsina, E. B. Gribanova

Subjects: Get full text

A Bayesian analysis of birth pulse effects on the probability of detecting Ebola virus in fruit bats by Pleydell, David R.J., Ndong Bass, Innocent, Mba Djondzo, Flaubert Auguste, Meta Djomsi, Dowbiss, Kouanfack, Charles, Peeters, Martine, Cappelle, Julien

Subjects: “…age-structured model…”
Get full text

Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy by Jian Huang, Shuangna Song, Yihua Yin, Yinyan He, Huimin Wang, Ye Gu, Laman He, Xintao Wang, Xiaocao Miao, Zhigang Zhang, Xueli Zhang, Yiran Li, Yiran Li

“…Importantly, by using an organoid model of EC, we further confirmed the antitumor potential of T cells that were specific to the POLEP286R mutation.ConclusionsOur study uncovers the pronounced immunogenicity of POLE-mutant EC and characterizes neoantigens that are unique to the POLEP286R mutation, thus providing a promising new immunotherapeutic strategy for EC.…”
Get full text

Portable Handheld Slit-Lamp Based on a Smartphone Camera for Cataract Screening by Shenming Hu, Hong Wu, Xinze Luan, Zhuoshi Wang, Mary Adu, Xiaoting Wang, Chunhong Yan, Bo Li, Kewang Li, Ying Zou, Xiaoya Yu, Xiangdong He, Wei He

“…This means a microlens is designed that would work with a phone’s camera. The phone’s photo taking function is used in capturing the image of the eyes lens to replace the observation system of the desktop slit-lamp. …”
Get full text

The immunological landscape of CCL26High invasive oral squamous cell carcinoma by Lingyun Liu, Lingyun Liu, Shuo Guan, Shuo Guan, Yizhuo Xue, Yizhuo Xue, Yijia He, Yijia He, Liang Ding, Yong Fu, Sheng Chen, Zhiyong Wang, Yi Wang

“…We also determined the invasive phenotype of tumor cells with distinct CCL26 level and explored its immune checkpoint and immunocytes relevance by differentially expressed gene (DEG) analysis, GSEA, and GO analysis. …”
Get full text

Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…Eligible RCTs will be included in accordance with the pre-specified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation system. …”
Get full text

Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis by Mengqi Liu, Mengqi Liu, Jie Tang, Jie Tang, Gaoyang Xu, Gaoyang Xu, Xu Chen, Xu Chen, Kun Fang, Fan He, Fan He, Yi Zheng, Yi Zheng

Subjects: Get full text

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…Thus, we co-load anti-inflammatory drug triptolide (TP) and anti-fibrotic drug nintedanib (BIBF) on bHDL nanoparticles to treat CKD. …”
Get full text

Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice by Chi Lieu Kim Nguyen, Yumeno Kuba, Hoai Thu Le, Hossam Hassan Shawki, Natsuki Mikami, Madoka Aoki, Nanako Yasuhara, Hayate Suzuki, Saori Mizuno-Iijima, Shinya Ayabe, Yuki Osawa, Tomoyuki Fujiyama, Tra Thi Huong Dinh, Miyuki Ishida, Yoko Daitoku, Yoko Tanimoto, Kazuya Murata, Woojin Kang, Masatsugu Ema, Yuji Hirao, Atsuo Ogura, Satoru Takahashi, Fumihiro Sugiyama, Seiya Mizuno

“…Our study reveals that the exocyst complex, a heterotetrameric protein complex important for tethering in vesicular transport, is important for proper intra-oocyte trafficking of c-KIT and GDF9 in mice. We found that depletion of oocyte-specific EXOC1, a component of the exocyst complex, impaired oocyte re-awakening and cyst breakdown, and inhibited granulosa cell proliferation during follicle growth. …”
Get full text

ĐỊNH LƯỢNG ĐỒNG THỜI AMLODIPIN VÀ ATORVASTATIN TRONG THUỐC ĐA THÀNH PHẦN BẰNG PHƯƠNG PHÁP QUANG PHỔ UV-VIS KẾT HỢP VỚI PHÂN TÍCH ĐA BIẾN by Duy Luu Nguyen, Nguyen Thi Thanh Tram, Pham Phu Quoc, Nguyễn Hùng Nhật Duy, Nguyễn Đình Luyện, Trần Thúc Bình

Subjects: “…Amlodipin (AML), Atorvastatin (ATO), bình phương tối thiểu cổ điển (CLS); Hồi quy thành phần chính (PCR), bình phương tối thiểu riêng phần (PLS1).…”
Get full text