Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

“…However, in the subgroup of patients with blood eosinophils ≥300/mcL, both tezepelumab (MD 0.15 [95% CI 0.05 to 0.26]) and dupilumab (MD 0.13 [95% CI 0.06 to 0.19]) probably improved FEV1 above the MCID.Conclusion Dupilumab is effective at improving patient-relevant outcomes in COPD with higher eosinophil levels. Other biological therapies, including tezepelumab, have no important effect on patient-relevant outcomes.…”
Get full text

Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets? by Athina Kladi-Skandali, Kleita Michaelidou, Andreas Scorilas, Konstantinos Mavridis

“…Here, we provide an overview of recent findings regarding the emerging role of lncRNAs not only as key regulators of cancer initiation and progression in colon, stomach, pancreatic, liver, and esophageal cancers, but also as reliable tumor markers and therapeutic tools. lncRNAs can be easily, rapidly, and cost-effectively determined in tissues, serum, and gastric juice, making them highly versatile analytes. …”
Get full text

Is it possible to do theology without philosophical presuppositions? by D. F. M. Strauss

Subjects: Get full text

Neural Stem and Progenitor Cells in Nervous System Function and Therapy by Tara Walker, Jeffrey Huang, Kaylene Young

Get full text

Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis by Aylin Babalik, Sharyn Mannix, Denis Francis, Dick Menzies

“…Therapeutic drug monitoring ensures optimal dosing while aiming to reduce toxicity. …”
Get full text

Microstructural evolution, thermal stability and nanoindentation behaviour of (MgAl)70Zn20(BiSn)10 light weight high entropy alloy by Henil Thakkar, Sai Sri Harsha G．V, Renuga Devi K, Sreekanth Dondapati

Subjects: Get full text

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications by Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei

“…Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. …”
Get full text

Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials by Jia Chen, Juan Liu, Yuan-yuan Ye, Ni-ka Chen, Ling Lin, Ya-zhen Liu, Ying Lang, Xun-jun Li, Xin-ju Yang, Xiao-jiang Jiang

“…Objective To evaluate the effectiveness of internet-based cognitive–behavioural therapy for insomnia (ICBT-i) in adults.Design A meta-analysis of ICBT-i.Data sources Systematic searches of randomised controlled trials of ICBT-i were performed in the PubMed, EMBASE, PsycINFO and Cochrane Library databases up to 19 June 2016.Review method 2 reviewers independently performed study selection, quality assessment and data extraction. …”
Get full text

A multidimensional limit theorem for powers of the Riemann zeta-function by Rasa Šleževičienė

Get full text

The Influence of Social Support Theory on AI Acceptance: Examining Educational Support and Perceived Usefulness Using SEM Analysis by Ahmed A. Aldraiweesh, Uthman Alturki

Subjects: Get full text

Decreased Clostridium Abundance after Electroconvulsive Therapy in the Gut Microbiota of a Patient with Schizophrenia by Misako Kanayama, Maiko Hayashida, Sadayuki Hashioka, Tsuyoshi Miyaoka, Masatoshi Inagaki

“…Our results indicate that studies focusing on Clostridium to clarify the pathogenesis of schizophrenia as well as potential therapeutic mechanisms may be beneficial. However, further studies are needed.…”
Get full text

“They willfully themselves exile from light”: Exile in Space, Stage and Metatheatre in William Shakespeare’s A Midsummer Night’s Dream by Zied Ben Amor

“…Theatre Academy…”
Get full text

Α Byzantine icon of the Theotokos Hodegetria (Temple Gallery, London) by Triviza Eleni

Subjects: “…theotokos hodegetria…”
Get full text

Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma by Juan Ge, Miaomiao Zuo, Qirong Wang, Zhen Li

Subjects: Get full text

Static and Dynamic Model Calibration for Upper Thermosphere Determination by Haibing Ruan, Jiuhou Lei, Jianyong Lu

Subjects: Get full text

Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…This review considers various IgG-like BsAb generation approaches, summarizes the clinical applications of promising new BsAbs, and describes the mechanism of BsAbs in tumor therapy.…”
Get full text

Thermodynamic and economic analysis, optimization of SOFC/GT/SCO2/ORC hybrid power systems for methanol reforming-powered ships with carbon capture by Shouguang Yao, Xuan Yan, Minjie Xia, Chuang Wang, Shaofan Wang

Subjects: Get full text

A Riesz representation theorem for cone-valued functions by Walter Roth

Get full text

Editorial: Two decades of targeted therapies in hematology: new targets and novel combinations by Bruno António Cardoso, Bruno António Cardoso, Natalia Neparidze

Subjects: Get full text

Observing versus creating flowers: a review of relevance for art therapy by Ephrat Huss, Mitsue Nagamine, Michele Zaccai

“…These findings are discussed in terms of methodological relevance for art therapy and nature therapy. While it is known that flowers arouse positive emotions, this more nuanced comparison has interesting implications for visual art therapy, and for the therapeutic effects of nature photos, as opposed to drawn interpretations of nature.…”
Get full text