Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…We also evaluated the therapeutic potential of an innovative inhibitor targeting these epigenetic effectors. …”
Get full text

HYDRAULIC ELEVATOR INSTALLATION ESTIMATION FOR THE WATER SOURCE WELL SAND-PACK CLEANING UP by V. V. Ivashechkin

“…The paper adduces equations for fluid motion in the supply and the water-jet pipelines and offers expressions for evaluating the required heads in them. For determining water flow in the supply and the water-jet pipe lines the author proposes to employ graphical approach allowing finding the regime point in Q–H chart by means of building characteristics of the pump and the pipe-lines. …”
Get full text

Probing non-standard neutrino interactions with supernova neutrinos at Hyper-K by Minjie Lei, Noah Steinberg, James D. Wells

Get full text

Network analyses of brain tumor multiomic data reveal pharmacological opportunities to alter cell state transitions by Brandon Bumbaca, Jonah R. Huggins, Marc R. Birtwistle, James M. Gallo

“…Such protein nodes and the associated signaling pathways provide potential drug targets that can be further tested in vitro and support cell state-directed (CSD) therapy.…”
Get full text

Information Security Management in Small Public Sector Organizations: Requirements and Design of a Procedural Approach by Frank Moses, Kurt Sandkuhl

“…In this context, this article analyses the requirements of the NIS-2 Directive and complements them with the obstacles and reasons for success in the introduction of ISMS in small public sector organizations (SPSO). …”
Get full text

La construction de l’image du corps de l’élite égyptienne à l’époque amarnienne by Cathie Spieser, Pierre Sprumont

“…They eventually mention the ideological and theological context surrounding these representations.…”
Get full text

Active Control Optimization for Minimizing the Dynamic Response of Functionally Graded Plate by M. E. Fares, M. Kh. Elmarghany, Doaa Atta

“…A control optimization problem for functionally graded (FG) plates is presented using a first-order shear deformation plate theory including through-the-thickness normal strain effect. …”
Get full text

On Some Recent Developments in Ulam's Type Stability by Nicole Brillouët-Belluot, Janusz Brzdęk, Krzysztof Ciepliński

“…We present a survey of some selected recent developments (results and methods) in the theory of Ulam's type stability. In particular we provide some information on hyperstability and the fixed point methods.…”
Get full text

Problems of developing a strategic planning methodology for regional socio-economic systems by A. G. Ataeva

“…This happens both through their participation in determining strategic priorities and selecting specific strategic projects at the goal setting stage, and through the use of special model tools, which are characterized by the presence of built-in interaction loops for different classes of economic situations and allowing them to adapt their resource strategies while agreeing on common goals of functioning. …”
Get full text

A Green Demand-Responsive Airport Shuttle Service Problem with Time-Varying Speeds by Ming Wei, Binbin Jing, Jian Yin, Yang Zang

“…The approach aims to assign a set of alternative fuel vehicles (AFVs) located at different depots to visit each demand point within the specified time and transport all of them to the airport. The proposed model effectively captures the interactions between path selection and environmental protection. …”
Get full text

Existence of Solution to a Second-Order Boundary Value Problem via Noncompactness Measures by Wen-Xue Zhou, Jigen Peng

“…The existence and uniqueness of the solutions to the Dirichlet boundary value problem in the Banach spaces is discussed by using the fixed point theory of condensing mapping, doing precise computation of measure of noncompactness, and calculating the spectral radius of linear operator.…”
Get full text

Effect of the Initial Support of the Tunnel on the Characteristics of Rockburst: Case Study and Mechanism Analysis by Chunchi Ma, Junqi Fan, Xiang Ji, Xiaoyan Shi, Jun Zeng

“…Our research is helpful to clarify the rockburst problem in the field of engineering geology, specifically to reveal the mechanism of rockburst and the early warning criteria of rockburst hazard under the action of supporting structure, which can provide practical data and theoretical support for scientific and reasonable prevention and control of rockburst risk in tunnel and underground engineering.…”
Get full text

Role of Endoscopy in the Investigation of Upper Gastrointestinal Symptoms in HIV-Infected Patients by C Mel Wilcox

“…Indications for which endoscopy has a high yield include AIDS with esophageal symptoms refractory to empirical antifungal therapy, small bowel biopsy for chronic severe diarrhea and upper gastrointestinal bleeding. …”
Get full text

Experimental and Numerical Study on Tensile Strength of Concrete under Different Strain Rates by Fanlu Min, Zhanhu Yao, Teng Jiang

“…In the quasistatic strain rate regime, the existing models often underestimate the experimental results. The thermodynamic theory for the splitting tensile strength of concrete satisfactorily describes the experimental findings of strength as effect of strain rates.…”
Get full text

Asymptotic analysis of American call options by Ghada Alobaidi, Roland Mallier

“…However, an exact solution cannot be found, and therefore by using asymptotic techniques employed in the study of boundary layers in fluid mechanics, we find an asymptotic expression for the location of the optimal exercise boundary and the value of the option near to expiration.…”
Get full text

Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature by Christopher R. Newey, Naresh Mullaguri, Stephen Hantus, Vineet Punia, Pravin George

“…A larger, prospective study is needed to further assess this therapy.…”
Get full text

France in the Vienna System of International Relations (the First Half of The 19^th Century) by I. V. Ignatchenko

“…In 1840, during the second Oriental crisis, the French government has opposed themselves to the rest of Europe for the first time since the Napoleonic wars. …”
Get full text

Development and validation of questionnaire to assess preschool teachers’ knowledge, attitude, and self-efficacy on performing first-aid in children by Damar Prasetya, Rose Mini Agoes Salim

Get full text

“Be Proud, and Loud”: Linguistic Markers of Pride in Drag Queens’ Spoken Discourse by Natacha Marjanovic

“…Many studies have shown how drag queens blur the boundaries between genders and identities through their performances and their language, thereby disturbing the political status quo on binary gender. …”
Get full text

Approximating fixed points of λ-firmly nonexpansive mappings in Banach spaces by Gang-Eun Kim

“…We study the convergence of the Ishikawa iteration methods to fixed points for the result of Smarzewski (1991). Our theorems also improve recent theorems due to Sharma and Sahu (1996).…”
Get full text