HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells by Masanobu Tsubaki, Taira Matsuo, Rie Komori, Noriaki Nagai, Tetsushi Yamamoto, Shozo Nishida

“…Conclusion These findings indicate inhibition of HSP90 such as KW-2478 and NVP-AUY922 as potential candidates for CML therapy.…”
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You are what you don’t eat - fasting, ethics, and ethnography, in Serbia and beyond by Lackenby Nicholas

“…It does so through the theoretical lens of ‘ethical affordances’, suggesting that food and fasting practices allow a range of people to articulate different ethical evaluations. …”
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Mapping Your World with Community Analyst: An Easy to Use Tool to Map the Characteristics of U.S. Communities by Robert Swett, Lisa Krimsky

“…This is good news because it allows many more of us to capitalize on the power and unique insights that such tools can provide without having to spend inordinate amounts of time learning how to use them. This article presents Community Analyst, a web application that provides access to thousands of business, demographic, economic, education, and health data variables for the United States. …”
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Glycosaminoglycan Storage Disorders: A Review by Maria Francisca Coutinho, Lúcia Lacerda, Sandra Alves

“…Here, we provide an overview of the molecular basis, enzymatic defects, clinical manifestations, and diagnosis of each MPS, focusing also on the available animal models and describing potential perspectives of therapy for each one.…”
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Multidimensional analysis and enhancement strategies for ecological environment quality at the county level under dual carbon goals: a case study of Shaanxi Province, China by Jianfeng Li, Jianfeng Li, Jianfeng Li, Yongxin Hu, Yongxin Hu, Jian Li, Liangyan Yang, Liangyan Yang, Jie Yan

“…The results not only propose targeted approaches to reinforce carbon storage but also offer valuable policy guidance, thereby making a significant contribution to achieving the dual carbon goals at the county level.…”
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Research on Pressure Drop in the Accelerate Zone of Horizontal Conveying of Concrete Spraying by Guanguo Ma, Zhaoxia Liu, Xiaobing Gong, Lianjun Chen, Guoming Liu, Gang Pan, Qizheng Dong

“…The momentum equation was introduced during the experiment, which interpreted the pressure drop caused by the accelerated conveying of concrete. The theoretical equation was corrected based on the results of theoretical experiments by introducing the value of α, and the experimental results were then optimized, thus obtaining an approximate model of pressure drop during the conveying of concrete. …”
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Radioprotective Effects of Vitis vinifera L. Seed against Radiation-Induced Short-Term Memory Loss in Young Adult Wistar Rats by Ayomide Abe, Fatai Balogun, Olugbenga Ayannuga

“…Introduction: Brain radiation therapy often results in short-term memory loss that progresses to cognitive impairment. …”
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Separable spatio-temporal covariance functions by Kęstutis Dučinskas, Edita Lesauskienė

“… Ther is not abstract. …”
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Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections by Jennifer Molle, Sarah Duponchel, Jennifer Rieusset, Michel Ovize, Alexander V. Ivanov, Fabien Zoulim, Birke Bartosch

“…Furthermore, most studies investigating the role of Cyps in viral hepatitis did not investigate the potential therapeutic effects of their inhibition in already-established infections but have rather been performed in the context of neo-infections. …”
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Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

“…Taken together, melongosides need further attention for more scientific studies as a DENV inhibitory agent, which if proven, in vivo and in clinical trials, can be a useful therapeutic agent against at least DENV-2.…”
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The Egyptian Revolution: First Impressions from the Field by Mohammed A. Bamyeh

“…It is clear that it is providing a new generation with a grand spectacle of the type that had shaped the political consciousness of every generation before them in modern Arab history. All those common formative experiences of past generations were also grand national moments: whether catastrophic defeats or triumphs against colonial powers or allies.…”
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Influence of iron ore concentrate on the characteristics of sintering and reduction of sinter by Guo H., Shen F.-M., Jiang X., Xiang D.-W., Zheng H.-Y.

“…The influence mechanism of iron ore on the fluidity was further analyzed by using SEM and ion theory of slag. With the increase SiO2 content of iron ore, the fluidity index increased, the main reason was that the amount of liquid phase increased and the melting point decreased during the sintering. …”
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Miniaturization Potential of Additive-Manufactured 3D Mechatronic Integrated Device Components Produced by Stereolithography by Niklas Piechulek, Lei Xu, Jan Fröhlich, Patrick Bründl, Jörg Franke

“…Existing research highlights the thermal stability of ceramic substrates; yet, their reliability under high-stress and complex mechanical loading conditions remains a challenge. …”
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Examining the mental health of siblings of children with a mental disorder: A scoping review protocol. by John E Krzeczkowski, Terrance J Wade, Brendan F Andrade, Dillon Browne, Busra Yalcinoz-Ucan, Negin A Riazi, Elizabeth Yates, Andrea Tagalakis, Karen A Patte

“…Indeed, the siblings of these children are not insulated from these consequences and may experience elevated levels of psychological distress, placing them at increased risk for developing mental disorders. …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…However, the diversity of non-pharmacological therapies and the inconsistencies in efficacy challenge clinical decision-making. …”
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Understanding recruitment to a perioperative randomised controlled trial: protocol for a mixed-methods substudy nested within a feasibility trial of octreotide infusion during live... by Duncan Wagstaff, S Ramani Moonesinghe, Jez Fabes, Michael Spiro, Edgar Brodkin, Ee-Neng Loh, Vivienne Hannon

“…First, after consent to the randomised controlled trial is sought, all patients will be invited to complete a questionnaire to explore their perceptions of the information given to them and motivating factors that influenced their decision to consent or not. …”
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Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study by Abraham Desta Aregay, Kibriti Mehari Kidane, Asfawosen Berhe Aregay, Kiros Ajemu Fenta, Ataklti Gebretsadik Woldegebriel, Hagos Godefay, Tewolde Wubayehu Woldearegay

“…WHO clinical staging has long been used to assess the immunological status of HIV-infected patients at initiation of antiretroviral therapy and during treatment follow-up. In setups where CD4 count determination is not readily available, WHO clinical staging is a viable option. …”
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The Economics of Raising Replacement Heifers: Estimating Direct Costs Using the Replacement Heifer Calculator by Hannah Baker

“…There are two options for the females: sell them as weaned heifers or keep them to raise as replacements to build the herd. …”
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CO2, quality of life and economic growth in mena countries by Tuncer Gövdeli

“…This paper examines thenexus between CO2 emissions, quality of life and economic growth in12 MENA countries over the period of 1970–2014. …”
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The influence of agile leadership, motivation of entrepreneurial, and organizational culture on the Performance of Creative Economy MSMEs on Lombok Island by Santi Nururly, Burhanudin Burhanudin, Djoko Suprayetno, Siti Sriningsih

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